High throughput object-based image analysis of β-amyloid plaques in human and transgenic mouse brain

Journal of Neuroscience Methods

Volumn 204, Issue 1, 2012, Pages 179-188

  Samaroo, Harry D ^a   Opsahl, Alan C ^a   Schreiber, Jan ^b   O'Neill, Sharon M ^a   Marconi, Michael ^a   Qian, Jessie ^a   Carvajal Gonzalez, Santos ^a   Tate, Barbara ^a   Milici, Anthony J ^a   Bales, Kelly R ^a   Stephenson, Diane T ^a  

^a PFIZER INC   (United States)

^b Definiens Imaging GmbH   (Germany)

Author keywords

Alzheimer's disease; High throughput; Object based image analysis; PS1APP

Indexed keywords

AMYLOID BETA PROTEIN;

AGED; AGING; ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CADAVER; CONTROLLED STUDY; FEMALE; FRONTAL GYRUS; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MALE; NEUROCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENILE PLAQUE; TRANSGENIC MOUSE;

AGED; AGED, 80 AND OVER; ALGORITHMS; ANIMALS; BRAIN; FEMALE; HUMANS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; MALE; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; PATTERN RECOGNITION, AUTOMATED; PLAQUE, AMYLOID; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 82955247114     PISSN: 01650270     EISSN: 1872678X     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2011.10.003     Document Type: Article

References (57)

1. Apfeldorfer C., Ulrich K., Jones G., Goodwin D., Collins S., Schenck E., et al. Object orientated automated image analysis: quantitative and qualitative estimation of inflammation in mouse lung. Diagn Pathol 2008, 3(Suppl. 1):S16.
2. Baatz M., Zimmermann J., Blackmore C.G. Automated analysis and detailed quantification of biomedical images using Definiens Cognition Network Technology. Comb Chem High Throughput Screen 2009, 12:908-916.
3. Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 1991, 82:239-259.
4. Buckner R.L., Snyder A.Z., Shannon B.J., LaRossa G., Sachs R., Fotenos A.F., et al. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci 2005, 25:7709-7717.
5. Byrne U.T., Ross J.M., Faull R.L., Dragunow M. High-throughput quantification of Alzheimer's disease pathological markers in the post-mortem human brain. J Neurosci Methods 2009, 176:298-309.
6. Chishti M.A., Yang D.S., Janus C., Phinney A.L., Horne P., Pearson J., et al. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem 2001, 276:21562-21570.
7. Chubb C., Inagaki Y., Sheu P., Cummings B., Wasserman A., Head E., et al. BioVision: an application for the automated image analysis of histological sections. Neurobiol Aging 2006, 27:1462-1476.
8. Chung J.H., Bell A.C., Felsenfeld G. Characterization of the chicken beta-globin insulator. Proc Natl Acad Sci USA 1997, 94:575-580.
9. Creed M.C., Milgram N.W. Amyloid-modifying therapies for Alzheimer's disease: therapeutic progress and its implications. Age (Dordr) 2010, 32:365-384.
10. Cummings B.J., Mason A.J., Kim R.C., Sheu P.C., Anderson A.J. Optimization of techniques for the maximal detection and quantification of Alzheimer's-related neuropathology with digital imaging. Neurobiol Aging 2002, 23:161-170.
11. Dragunow M. High-content analysis in neuroscience. Nat Rev Neurosci 2008, 9:779-788.
12. Evans N.A., Facci L., Owen D.E., Soden P.E., Burbidge S.A., Prinjha R.K., et al. Abeta(1-42) reduces synapse number and inhibits neurite outgrowth in primary cortical and hippocampal neurons: a quantitative analysis. J Neurosci Methods 2008, 175:96-103.
13. Feki A., Teboul O., Dubois A., Bozon B., Faure A., Hantraye P., et al. Fully automated and adaptive detection of amyloid plaques in stained brain sections of Alzheimer transgenic mice. Med Image Comput Comput Assist Interv 2007, 10:960-968.
14. Fishman C.E., Cummins D.J., Bales K.R., DeLong C.A., Esterman M.A., Hanson J.C., et al. Statistical aspects of quantitative image analysis of beta-amyloid in the APP(V717F) transgenic mouse model of Alzheimer's disease. J Neurosci Methods 2001, 108:145-152.
15. Furst A.J., Rabinovici G.D., Rostomian A.H., Steed T., Alkalay A., Racine C., et al. Cognition, glucose metabolism and amyloid burden in Alzheimer's disease. Neurobiol Aging 2010, 10.1016/j.neurobiolaging.2010.03.011.
16. Gordon M.N., Holcomb L.A., Jantzen P.T., DiCarlo G., Wilcock D., Boyett K.W., et al. Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse. Exp Neurol 2002, 173:183-195.
17. Hanzel D.K., Trojanowski J.Q., Johnston R.F., Loring J.F. High-throughput quantitative histological analysis of Alzheimer's disease pathology using a confocal digital microscanner. Nat Biotechnol 1999, 17:53-57.
18. Hedden T., Van Dijk K.R., Becker J.A., Mehta A., Sperling R.A., Johnson K.A., et al. Disruption of functional connectivity in clinically normal older adults harboring amyloid burden. J Neurosci 2009, 29:12686-12694.
19. Higgins G.A., Jacobsen H. Transgenic mouse models of Alzheimer's disease: phenotype and application. Behav Pharmacol 2003, 14:419-438.
20. Hogan B.F., Constantini F., Lacy E. Manipulating the mouse embryo: a laboratory manual 1986, Cold Spring Harbor Laboratory Press, New York.
21. Holcomb L., Gordon M.N., McGowan E., Yu X., Benkovic S., Jantzen P., et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 1998, 4:97-100.
22. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996, 274:99-102.
23. Jack C.R., Lowe V.J., Weigand S.D., Wiste H.J., Senjem M.L., Knopman D.S., et al. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain 2009, 132:1355-1365.
24. Jack C.R., Wengenack T.M., Reyes D.A., Garwood M., Curran G.L., Borowski B.J., et al. In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice. J Neurosci 2005, 25:10041-10048.
25. Josephs K.A., Whitwell J.L., Ahmed Z., Shiung M.M., Weigand S.D., Knopman D.S., et al. Beta-amyloid burden is not associated with rates of brain atrophy. Ann Neurol 2008, 63:204-212.
26. Krajewska M., Xu L., Xu W., Krajewski S., Kress C.L., Cui J., et al. Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury. Brain Res 2010, 1370:227-237.
27. Kumar R.K., Velan G.M., Korell S.O., Kandara M., Dee F.R., Wakefield D. Virtual microscopy for learning and assessment in pathology. J Pathol 2004, 204:613-618.
28. Lockhart A., Lamb J.R., Osredkar T., Sue L.I., Joyce J.N., Ye L., et al. PIB is a non-specific imaging marker of amyloid-beta (Abeta) peptide-related cerebral amyloidosis. Brain 2007, 130:2607-2615.
29. Maximova O.A., Murphy B.R., Pletnev A.G. High-throughput automated image analysis of neuroinflammation and neurodegeneration enables quantitative assessment of virus neurovirulence. Vaccine 2010, 28:8315-8326.
30. McGowan E., Sanders S., Iwatsubo T., Takeuchi A., Saido T., Zehr C., et al. Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiol Dis 1999, 6:231-244.
31. Mech F., Thywissen A., Guthke R., Brakhage A.A., Figge M.T. Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus. PLoS ONE 2011, 6:e19591.
32. Mikula S., Trotts I., Stone J.M., Jones E.G. Internet-enabled high-resolution brain mapping and virtual microscopy. Neuroimage 2007, 35:9-15.
33. Morris J.C., Price A.L. Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease. J Mol Neurosci 2001, 17:101-118.
34. Morrissette D.A., Parachikova A., Green K.N., LaFerla F.M. Relevance of transgenic mouse models to human Alzheimer disease. J Biol Chem 2009, 284:6033-6037.
35. Mouton P.R., Chachich M.E., Quigley C., Spangler E., Ingram D.K. Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice. Neurosci Lett 2009, 464:184-187.
36. Mucke L., Masliah E., Yu G.Q., Mallory M., Rockenstein E.M., Tatsuno G., et al. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci 2000, 20:4050-4058.
37. Mulrane L., Rexhepaj E., Penney S., Callanan J.J., Gallagher W.M. Automated image analysis in histopathology: a valuable tool in medical diagnostics. Expert Rev Mol Diagn 2008, 8:707-725.
38. Narayan P.J., Dragunow M. High content analysis of histone acetylation in human cells and tissues. J Neurosci Methods 2010, 193:54-61.
39. Noble J.M., Scarmeas N. Application of pet imaging to diagnosis of Alzheimer's disease and mild cognitive impairment. Int Rev Neurobiol 2009, 84:133-149.
40. Paris D., Ganey N.J., Laporte V., Patel N.S., Beaulieu-Abdelahad D., Bachmeier C., et al. Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease. J Neuroinflammation 2010, 7:17.
41. Paxinos G., Franklin K. The mouse brain in stereotaxic coordinates 2001, Academic Press, San Diego. 2nd edition.
42. Rabinovici G.D., Jagust W.J. Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo. Behav Neurol 2009, 21:117-128.
43. Radde R., Bolmont T., Kaeser S.A., Coomaraswamy J., Lindau D., Stoltze L., et al. Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep 2006, 7:940-946.
44. Reilly J.F., Games D., Rydel R.E., Freedman S., Schenk D., Young W.G., et al. Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model. Proc Natl Acad Sci USA 2003, 100:4837-4842.
45. Reiman E.M., Chen K., Liu X., Bandy D., Yu M., Lee W., et al. Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease. Proc Natl Acad Sci USA 2009, 106:6820-6825.
46. Rogers J., Morrison J.H. Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease. J Neurosci 1985, 5:2801-2808.
47. Rojo M.G., Bueno G., Slodkowska J. Review of imaging solutions for integrated quantitative immunohistochemistry in the Pathology daily practice. Folia Histochem Cytobiol 2009, 47:349-354.
48. Sankaranarayanan S. Genetically modified mice models for Alzheimer's disease. Curr Top Med Chem 2006, 6:609-627.
49. Shi J.Q., Shen W., Chen J., Wang B.R., Zhong L.L., Zhu Y.W., et al. Anti-TNF-alpha reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains. Brain Res 2010, 1368:239-247.
50. Steiner H., Kostka M., Romig H., Basset G., Pesold B., Hardy J., et al. Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. Nat Cell Biol 2000, 2:848-851.
51. Teboul O., Feki A., Dubois A., Bozon B., Faure A., Hantraye P., et al. A standardized method to automatically segment amyloid plaques in Congo Red stained sections from Alzheimer transgenic mice. Conf Proc IEEE Eng Med Biol Soc 2007, 2007:5593-5596.
52. Thal D.R., Capetillo-Zarate E., Del Tredici K., Braak H. The development of amyloid beta protein deposits in the aged brain. Sci Aging Knowledge Environ 2006, 2006:re1.
53. Weiner M.W., Aisen P.S., Jack C.R., Jagust W.J., Trojanowski J.Q., Shaw L., et al. The Alzheimer's disease neuroimaging initiative: progress report and future plans. Alzheimers Dement 2010, 6. 202-11 e7.
54. Wengenack T.M., Whelan S., Curran G.L., Duff K.E., Poduslo J.F. Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain. Neuroscience 2000, 101:939-944.
55. Willuweit A., Velden J., Godemann R., Manook A., Jetzek F., Tintrup H., et al. Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease. PLoS ONE 2009, 4:e7931.
56. Ying X., Monticello T.M. Modern imaging technologies in toxicologic pathology: an overview. Toxicol Pathol 2006, 34:815-826.
57. Zehntner S.P., Chakravarty M.M., Bolovan R.J., Chan C., Bedell B.J. Synergistic tissue counterstaining and image segmentation techniques for accurate, quantitative immunohistochemistry. J Histochem Cytochem 2008, 56:873-880.