High-throughput quantitative histological analysis of Alzheimer's disease pathology using a confocal digital microscanner

Nature Biotechnology

Volumn 17, Issue 1, 1999, Pages 53-57

  Hanzel, David K ^a   Trojanowski, John Q ^b   Johnston, Richard F ^a   Loring, Jeanne F ^a,c  

^a Molecular Dynamics   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Division of Genomics Research   (United States)

Author keywords

Alzheimer's disease; Amyloid; Confocal scanner; Fluorescent; Quantitative morphology

Indexed keywords

AMYLOID BETA PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN;

ALZHEIMER DISEASE; AMYLOIDOSIS; ARTICLE; CONFOCAL LASER MICROSCOPY; FLUORESCENCE MICROSCOPY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; SENILE PLAQUE;

ALGORITHMS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; AUTOMATION; BRAIN; FLUORESCENCE; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; REPRODUCIBILITY OF RESULTS;

ANIMALIA; MUS MUSCULUS;

EID: 0032903819     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/5225     Document Type: Article

References (18)

1. Goedert, M., Trojanowski, J., and Lee, V.-Y. 1997. The neurofibrillary pathology of Alzheimer's disease, pp. 613-627, in The Molecular and genetic basis of neurological disease, 2nd ed. Prusiner, S., Rosenberg, R., Di Mauro, S., and Barchi, R. (eds.). Butterworth Heineman Press. Boston, MA.
2. Morrison-Bogorad, M., Weiner, M., Rosenberg, R., Bigio, E., and White, C.I. 1997. Alzheimer's disease, pp. 581-600, in The molecular and genetic basis of neurological disease, 2nd ed. Prusiner, S., Rosenberg, R., Di Mauro, S., and Barchi, R. (eds.). Butterworth Heineman Press, Boston, MA.
3. Selkoe, D. 1997. Cellular and molecular biology of the beta-amyloid precursor protein and Alzheimer's disease, pp. 601-612, in The molecular and genetic basis of neurological disease, 2nd ed. Prusiner, S., Rosenberg, R., Di Mauro, S., and Barchi, R. Butterworth Heineman Press, Boston, MA.
4. National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Phelps, C., Khachaturian, Z., and Trojanowski, J.Q., Working Group Chairs. 1997. Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. Neurobiol Aging 18:S1-2.
5. McKee, A.C., Kosik, K.S., and Kowall, N.W. 1991. Neuritic pathology and dementia in Alzheimer's disease. Ann. Neurol. 30:156-165.
6. Arriagada, P.V., Growdon, J.H., Hedley-Whyte, E.T., and Hyman, B.T. 1992. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42:631-639.
7. Dickson, D.W., Crystal, H.A., Mattiace, L.A., Masur, D.M., Blau, A.D., Davies, P. et al. et al. 1992. Identification of normal and pathological aging in prospectively studied nondemented elderly humans. Neurobiol. Aging 13:179-189.
8. Cummings, B.J., Pike, C.J., Shankle, R., and Cotman, C.W. 1996. Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease. Neurobiol. Aging 17:921-933.
9. Guillery, R.W. and Herrup, K. 1997. Quantification without pontification: choosing a method for counting objects in sectioned tissues. J. Comp. Neurol. 386:2-7.
10. Games, D., Adams, D., Alessandrini, R., Barbour, R., Berthelette, P., Blackwell, C. et al. 1995. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 373:523-527.
11. Irizarry, M.C., Soriano, F., McNamara, M., Page, K., Schenk, D., Games, D., and Hyman, B. 1997. A-beta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J. Neurosci. 17:7053-70539.
12. Smith, D.H., Nakamura, M., McIntosh, T.K., Wang, J., Rodriguez, A., Chen, X. et al. 1998. Brain trauma induces massive hippocampal neuron death linked to a surge in Aβ1-42 levels in mice overexpressing mutant APP. Am. J. Pathol. 153:1005-1010.
13. Schmidt, M.L., DiDario, A.G., Lee, V.M., and Trojanowski, J.Q. 1994. An extensive network of PHF tau-rich dystrophic neurites permeates neocortex and nearly all neuritic and diffuse amyloid plaques in Alzheimer disease. FEBS Lett. 344:69-73.
14. Schmidt, M.L., Lee, V.M., Saido, T., Perl, D., Schuck, T., Iwatsubo, T., and Trojanowski, J.Q. 1998. Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging Acta. Neuropathol. (Berl) 95:117-122.
15. Alexay, C., Kain, R., Hanzel, D., and Johnston, R. 1996. Fluorescence scanner employing a macro scanning objective. Proc. SPIE 2705:63-72. US patent 5646411, 5672880, 5719391.
16. Belichenko, P., Fedorov, A., and Dahlstrom, A. 1996. Quantitative analysis of immunofluorescence and lipofuscin distribution in human cortical areas by dual-channel confocal laser scanning microscopy. J. Neurosci. Methods 69:155-161.
17. Masliah, E., Sisk, A., Mallory, M., Mucke, L., Schenk, D., and Games, D. 1996. Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease. J. Neurosci. 16:5795-5811.
18. Russ, J. 1995.The image processing handbook. CRC Press, Boca Raton, FL.