Importance of the C2, N7, and C8 positions to the mutagenic potential of 8-Oxo-2′-deoxyguanosine with two a family polymerases

Biochemistry

Volumn 50, Issue 49, 2011, Pages 10713-10723

  Hamm, Michelle L ^a   Crowley, Kelly A ^a   Ghio, Michael ^a   Del Giorno, Laura ^a   Gustafson, Margaret A ^a   Kindler, Kevin E ^a   Ligon, Claire W ^a   Lindell, Maria A M ^a   McFadden, Emily J ^a   Siekavizza Robles, Carlos ^a   Summers, Matthew R ^a  

^a UNIVERSITY OF RICHMOND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACILLUS STEAROTHERMOPHILUS; BASE PAIRS; CRYSTALLOGRAPHIC STUDIES; DEOXYGUANOSINE (DG); DNA LESIONS; ELECTRONIC CHANGES; GAIN INSIGHT; MUTAGENICITY; REACTIVE OXYGEN SPECIES; STABILITY STUDY; STEADY-STATE KINETICS; STRUCTURAL PERTURBATION; STRUCTURAL STUDIES;

BACTERIOLOGY; ENZYMES; NUCLEOTIDES; PLANTS (BOTANY);

POLYMERS;

5' O DIMETHOXYTRITYL 8 [2 (TRIMETHYLSILYL)ETHYL]THIO 2 DEOXYINOSINE; 5' O DIMETHOXYTRITYL 8 [2 (TRIMETHYLSILYL)ETHYL]THIO 2 DEOXYINOSINE 3' YL-BETA CYANOETHYL N,N DIISOPROPYLPHOSPHORAMIDITE; 8 [2 (TRIMETHYLSILYL)ETHYL]THIO 2' DEOXYINOSINE; 8 HYDROXYDEOXYGUANOSINE; DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE; DNA POLYMERASE; PHOSPHORAMIDOUS ACID; UNCLASSIFIED DRUG;

ARTICLE; CRYSTALLOGRAPHY; GENE INSERTION; GEOBACILLUS STEAROTHERMOPHILUS; MOLECULAR STABILITY; MUTAGENICITY; PRIORITY JOURNAL;

BASE PAIRING; DEOXYADENINE NUCLEOTIDES; DEOXYCYTOSINE NUCLEOTIDES; DEOXYGUANOSINE; DNA POLYMERASE I; GEOBACILLUS STEAROTHERMOPHILUS; KINETICS; MUTAGENS; OLIGONUCLEOTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 82955172922     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201383c     Document Type: Article

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