Substitution of Ala for Tyr567 in RB69 DNA polymerase allows dAMP to be inserted opposite 7,8-dihydro-8-oxoguanine

Biochemistry

Volumn 49, Issue 19, 2010, Pages 4116-4125

  Beckman, Jeff ^a   Wang, Mina ^a   Blaha, Gregor ^a   Wang, Jimin ^a   Konigsberg, William H ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8-OXOGUANINE; ANTI-CONFORMATIONS; BASE PAIRS; BINDING POCKETS; DELETERIOUS EFFECTS; DNA POLYMERASE; MINOR GROOVES; ORDERS OF MAGNITUDE; REACTIVE OXYGEN SPECIES; STEADY-STATE KINETICS; TEMPLATING; WILD TYPES;

DNA; OXYGEN; POLYMERS;

GENES;

8 HYDROXYGUANINE; ALANINE; DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE; DNA POLYMERASE; TYROSINE;

ARTICLE; BASE PAIRING; CHEMICAL STRUCTURE; CONFORMATION; CONTROLLED STUDY; INFORMATION PROCESSING; KINETICS; MUTANT; NONHUMAN; PRIORITY JOURNAL; STEADY STATE;

AMINO ACID SUBSTITUTION; BASE PAIRING; BINDING SITES; DEOXYADENINE NUCLEOTIDES; DNA PRIMERS; DNA-DIRECTED DNA POLYMERASE; GUANINE; KINETICS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; TYROSINE;

EID: 77952407219     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100102s     Document Type: Article

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