Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase κ opposite the 7,8-dihydro-8-oxo-2′-deoxyguanosine adduct

Journal of Biological Chemistry

Volumn 284, Issue 33, 2009, Pages 22467-22480

  Irimia, Adriana ^a,b   Eoff, Robert L ^a   Guengerich, F Peter ^a   Egli, Martin ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SIDNEY KIMMEL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARCHAEAL; BENZO [A] PYRENE; CELLULAR RESPONSE; COMPLEX FORMATIONS; DNA POLYMERASE; ERROR PRONES; HUMAN DNA POLYMERASE; MECHANISTIC ASPECTS; SIDE CHAINS;

AMINO ACIDS; AROMATIC HYDROCARBONS; BIOMOLECULES; DNA; GENES; NUCLEIC ACIDS; POLYMERS; PYRENE;

FUNCTIONAL POLYMERS;

8 HYDROXYDEOXYGUANOSINE; DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE; DNA POLYMERASE; HUMAN POLYMERASE KAPPA; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; MUTATION; PRIORITY JOURNAL;

BASE SEQUENCE; CATALYSIS; DEOXYGUANOSINE; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; FUNGAL PROTEINS; HUMANS; KINETICS; MODELS, BIOLOGICAL; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, TERTIARY; SULFOLOBUS; X-RAY DIFFRACTION;

ARCHAEA; EUKARYOTA;

EID: 69249101227     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.003905     Document Type: Article

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