Serum aminotransferase levels are associated with markers of hypoxia in patients with obstructive sleep apnea

Sleep

Volumn 31, Issue 1, 2008, Pages 121-126

  Norman, Daniel ^a   Bardwell, Wayne A ^a   Arosemena, Farah ^a   Nelesen, Richard ^a   Mills, Paul J ^a   Loredo, Jose S ^a   Lavine, Joel E ^a   Dimsdale, Joel E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Fatty liver; Hypoxia; Metabolic syndrome X; Obstructive sleep apnea; Transaminases

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; GLUCOSE; LIPID; TRIACYLGLYCEROL;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD PRESSURE; BODY MASS; CHOLESTEROL BILE LEVEL; DISEASE SEVERITY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPOXIA; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OXYGEN SATURATION; PRIORITY JOURNAL; SLEEP APNEA SYNDROME; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 37549010264     PISSN: 01618105     EISSN: None     Source Type: Journal    
DOI: 10.1093/sleep/31.1.121     Document Type: Article

References (26)

1. Lee RG. Nonalcoholic steatohepatitis: a study of 49 patients. Hum Pathol 1989;20:594-8.
2. Marchesini G, Bugianesi E, Forlani G, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003;37:917-23.
3. Oh, SY, Cho, YK, Kang, MS, et al. The association between increased alanine aminotransferase activity and metabolic factors in nonalcoholic fatty liver disease. Metab Clin Exp 2006;55:1604-9.
4. Lee, S, Jin Kim, Y, Yong Jeon, T, et al. Obesity is the only independent factor associated with ultrasound-diagnosed non-alcoholic fatty liver disease: a cross-sectional case-control study. Scand J Gastroenterol 2006;41:566-72.
5. Sass DA, Chang P, Chopra KB. Nonalcoholic fatty liver disease: a clinical review. Dig Dis Sci 2005;50:171-80.
6. Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 1990;11:74-80.
7. Bacon BR, Farahvash MJ, Janney CG, Neuschwander-Tetri BA. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 1994;107:1103-9.
8. Vgontzas AN, Tan TL, Bixler EO, Martin LF, Shubert D, Kales A. Sleep apnea and sleep disruption in obese patients. Arch Intern Med 1994;154:1705-11.
9. McArdle N, Hillman D, Beilin L, Watts G. Metabolic risk factors for vascular disease in obstructive sleep apnea: a matched controlled study. Am J Respir Crit Care Med 2007; 175:190-5.
10. Norman D, Loredo JS, Nelesen RA, et al. Effects of continuous positive airway pressure versus supplemental oxygen on 24-hour ambulatory blood pressure. Hypertension 2006;47:840-5.
11. Singh H, Pollock R, Uhanova J, Kryger M, Hawkins K, Minuk GY. Symptoms of obstructive sleep apnea in patients with nonalcoholic fatty liver disease. Dig Dis Sci 2005;50:2338-43.
12. Tanne F, Gagnadoux F, Chazouilleres O, et al. Chronic liver injury during obstructive sleep apnea. Hepatology 2005;41:1290-6.
13. Tatsumi K, Saibara T. Effects of obstructive sleep apnea syndrome on hepatic steatosis and nonalcoholic steatohepatitis. Hepatol Res. 2005;33:100-04.
14. Chin K, Nakamura T, Takahashi K, et al. Effects of obstructive sleep apnea syndrome on serum aminotransferase levels in obese patients. Am J Med 2003;114:370-6.
15. Rechtschaffen A, Kales A. Manual of standardized techniques and scoring system for sleep stages of human subjects. Los Angeles: UCLA Brain Information Service and Brain Research Institute, 1968.
16. Day CP, Saksena S. Non-alcoholic steatohepatitis: definitions and pathogenesis. J Gastroenterol Hepatol 2002;17:S377-84.
17. Punjabi NM, Polotsky VY. Disorders of glucose metabolism in sleep apnea. J Appl Physiol 2005;99:1998-2007.
18. Suzuki YJ, Jain V, Park AM, Day RM. Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases. Free Radic Biol Med. 2006;40:1683-92.
19. Mishra P, Weinstein M, Vithiananthan S, et al. Mean nocturnal oxygen saturation is predictive of non-alcoholic fatty liver disease (NAFLD) activity score (NAS) in patients with morbid obesity. Sleep Med 2006;7(S2):S54.
20. Li J, Thone LN, Punjabi NM, et al. Intermittent hypoxia induces hyperlipidemia in lean mice. Circ Res 2005;97:698-706.
21. Li J, Grigoryev DN, Ye SQ, et al. Chronic intermittent hypoxia uprgulates genes of lipid biosynthesis in obese mice. J Appl Physiol 2005;99:1643-8.
22. Prabhakar NR, Kumar GK. Oxidative stress in the systemic and cellular responses to intermittent hypoxia. Biol Chem 2004;385:217-21.
23. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998;15:539-53.
24. Grundy, SM, Cleeman, JI, Daniels, SR, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112:2735.
25. Elinav, E, Ben-Dov, IZ, Ackerman, E, et al. Correlation between serum alanine aminotransferase activity and age: an inverted U curve pattern. Am J Gastroenterol 2005;100:2201-4.
26. Mohamadnejad, M, Pourshams, A, Malekzadeh, R, et al. Healthy ranges of serum alanine aminotransferase levels in Iranian blood donors. World J of Gastroenterol 2003;9:2322-4.