Female gender exacerbates respiratory depression in leptin-deficient obesity

American Journal of Respiratory and Critical Care Medicine

Volumn 164, Issue 8 I, 2001, Pages 1470-1475

  Polotsky, Vsevolod Y ^a,b   Wilson, Jessica A ^a   Smaldone, Marc C ^a   Haines, Abby S ^a   Hurn, Patricia D ^a   Tankersley, Clarke G ^a   Smith, Philip L ^a   Schwartz, Alan R ^a   O'Donnell, Christopher P ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

Estradiol; Leptin; Obesity; Sleep; Ventilation

Indexed keywords

LEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE PREDISPOSITION; FEMALE; GENDER; HORMONE BLOOD LEVEL; HORMONE DEFICIENCY; HYPERCAPNIA; LUNG VENTILATION; MALE; MOUSE; NONHUMAN; NONREM SLEEP; OBESITY; PRIORITY JOURNAL; RESPIRATION DEPRESSION; SLEEP WAKING CYCLE; TIDAL VOLUME;

EID: 0035888744     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.164.8.2101100     Document Type: Article

References (30)

1. The occurrence of sleep-disordered breathing among middle-aged adults
2. Effect of weight loss on upper airway collapsibility in obstructive sleep apnea
3. Upper airway obstruction in obese patients with sleep disturbance and somnolence
4. Extreme obesity associated with alveolar hypoventilation - A Pickwickian syndrome
5. Combined central alveolar hypoventilation and upper airway obstruction. Treatment by tracheostomy and diaphragm pacing
6. Chronic alveolar hypoventilation: A review for the clinician
7. Progesterone for outpatient treatment of Pickwickian syndrome
8. Decreased hypoxic ventilatory drive in the obesity-hypoventilation syndrome
9. Upper airway muscle activity in normal women: Influence of hormonal status
10. Effects of testosteron on hypoxic ventilatory and carotid body neural responsiveness
11. Effects of estrogen and progesteron on carotid body neural output responsiveness to hypoxia
12. Combined effects of female hormones and metabolic rate on ventilatory drives in women
13. The stimulation of respiration by progesteron in ovariectomized cat is mediated by an estrogen-dependent hypothalamic mechanism requiring gene expression
14. Leptin and the regulation of body weight in mammals
15. Modified control of breathing in genetically obese (ob/ob) mice
16. Leptin prevents respiratory depression in obesity
17. Leptin secretion from adipose tissue in women. Relationship to plasma levels and gene expression
18. Serum immunoreactive-leptin concentrations in normal-weight and obese humans
19. Depot- and sex-specific differences in human leptin mRNA expression
20. Effects of gender, body composition, and menopause on plasma concentrations of leptin
21. Serum leptin concentration in women: Effect of age, obesity, and estrogen administration
22. Leptin concentration in women in the San Antonio Heart Study: Effect of menopausal status and post-menopausal hormone replacement therapy
23. Hypoxic ventilatory response during sleep in normal premenopausal women
24. Hypercapnic ventilatory response in sleeping adults
25. Normal values for hypoxic and hypercapnic ventilatory drives in man
26. Sexual influence on the control of breathing
27. Influence of body size and gender on control of ventilation
28. Normal values for the hypercapnic ventilation response: Effects of age and the ability to ventilate
29. Leptin plasma concentrations are dependent on body fat distribution in obese patients
30. Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans