Plasma Orexin-A Levels in Obstructive Sleep Apnea-Hypopnea Syndrome

Chest

Volumn 124, Issue 4, 2003, Pages 1381-1385

  Igarashi, Natsuhiko ^a   Tatsumi, Koichiro ^a   Nakamura, Akira ^a   Sakao, Seiichiro ^a   Takiguchi, Yuichi ^a   Nishikawa, Tetsuo ^b   Kuriyama, Takayuki ^a  

^a CHIBA UNIVERSITY   (Japan)

^b YOKOHAMA ROSAI HOSPITAL   (Japan)

Author keywords

Arousal index; Arousal mechanisms; Epworth sleepiness scale

Indexed keywords

OREXIN A; OXYGEN;

ADULT; ARTERIAL OXYGEN SATURATION; ARTICLE; BREATHING DISORDER; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC PROCEDURE; HUMAN; MALE; POLYSOMNOGRAPHY; PRIORITY JOURNAL; SCALE UP; SLEEP APNEA SYNDROME; SLEEP PATTERN; WAKEFULNESS;

EID: 0142074254     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.124.4.1381     Document Type: Article

References (22)

1. Sakurai T, Amemiya A, Ishii M, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998; 92:573-585
2. de Lecea L, Kilduff TS, Peyron C, et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 1998; 95:322-327
3. Date Y, Ueda Y, Yamashita H, et al. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci U S A 1999; 96:748-753
4. Peyron C, Tighe DK, van den Pol AN, et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 1998; 18:9996-10015
5. Samson WK, Gosnell B, Chang JK, et al. Cardiovascular regulatory actions of the hypocretins in brain. Brain Res 1999; 831:248-253
6. Shirasaka T, Nakazato M, Takasaki M, et al. Sympathetic and cardiovascular actions of orexins in conscious rats. Am J Physiol 1999; 46:R1780-R1785
7. Chemelli RM, Willie JT, Sinton CM, et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 1999; 98:437-451
8. Hagan JJ, Leslie RA, Patel S, et al. Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc Natl Acad Sci U S A 1999; 96:10911-10916
9. Johns MW. Daytime sleepiness, snoring and obstructive sleep apneas: The Epworth Sleepiness Scale. Chest 1993; 103: 30-36
10. Rechtschaffen A, Kales AA, eds. A manual of standardized terminology, techniques and scoring for sleep stages of human subjects. Washington, DC: US Government Printing Office, 1968; NIH Publication No. 204
11. American Sleep Disorders Association. EEG arousals: scoring rules and examples; ASDA report. Sleep 1992; 15:173-184
12. American Academy of Sleep Medicine. The report of an American Academy of Sleep Medicine task force: sleep-related breathing disorders in adults; recommendations for syndrome definition and measurement techniques in clinical research. Sleep 1999; 22:667-689
13. Nishino S, Repley B, Overeem S, et al. Hypocretin (orexin) deficiency in human narcolepsy. Lancet 2000; 355:39-40
14. Higuchi S, Usui A, Murasaki M, et al. Plasma orexin-A is lower in patients with narcolepsy. Neurosci Lett 2002; 318: 61-64
15. Adam JA, Menheere PPCA, van Dielen FMH, et al. Decreased plasma orexin-A levels in obese individuals. Int J Obes Relat Metab Disord 2002; 26:274-276
16. Nambu T, Sakurai T, Mizukami K, et al. Distribution of orexin neurons in the adult rat brain. Brain Res 1999; 827:243-260
17. Kastin AJ, Akerstrom V. Orexin A but not orexin B rapidly enters brain from blood by simple diffusion. J Pharmacol Exp Ther 1999; 289:219-223
18. Kirchgessner AL, Liu MT. Orexin synthesis and response in the gut. Neuron 1999; 24:941-951
19. Thannickal TC, Moore RY, Nienhuis R, et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 2000; 27:469-474
20. Adam JA, Menheere PPCA, van Dielen FMH, et al. Decreased plasma orexin-A levels in obese individuals. Int J Obes Relat Metab Disord 2002; 26:274-276
21. Horvath TL, Peyron C, Diano S, et al. Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. J Comp Neurol 1999; 415:145-159
22. Karadeniz D, Ondze B, Besset A, et al. EEG arousals and awakenings in relation with periodic leg movements during sleep. J Sleep Res 2000; 9:273-277