Correlation of inter-locus polyglutamine toxicity with CAG•CTG triplet repeat expandability and flanking genomic DNA GC content

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Nestor, Colm E ^a,b   Monckton, Darren G ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; MESSENGER RNA; POLYGLUTAMINE; PEPTIDE; TATA BINDING PROTEIN; TBP PROTEIN, HUMAN;

ALLELE; ARTICLE; CAG REPEAT; CONTROLLED STUDY; CTG REPEAT; DISEASE ASSOCIATION; DNA BASE COMPOSITION; DNA FLANKING REGION; DNA SEQUENCE; DNA STRUCTURE; GENE LOCATION; GENE LOCUS; GENE NUMBER; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC DIFFERENCE; GENOTOXICITY; HUNTINGTON CHOREA; NUCLEOTIDE SEQUENCE; ONSET AGE; SOMATIC MUTATION; SPINOCEREBELLAR DEGENERATION; TRINUCLEOTIDE REPEAT; ADOLESCENT; ADULT; AMINO ACID SEQUENCE; BRAIN; DEGENERATIVE DISEASE; GENETICS; GENOMICS; HUMAN; HUMAN GENOME; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN SECONDARY STRUCTURE; REGRESSION ANALYSIS;

ADOLESCENT; ADULT; AGE OF ONSET; AMINO ACID SEQUENCE; BRAIN; GENOME, HUMAN; GENOMICS; HUMANS; HUNTINGTON DISEASE; MOLECULAR SEQUENCE DATA; MUTATION; NEURODEGENERATIVE DISEASES; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; REGRESSION ANALYSIS; SEQUENCE ANALYSIS, DNA; SPINOCEREBELLAR ATAXIAS; TATA-BOX BINDING PROTEIN; TRINUCLEOTIDE REPEAT EXPANSION; TRINUCLEOTIDE REPEATS;

EID: 82755192455     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028260     Document Type: Article

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