In vitro quantitative 1H and 19F nuclear magnetic resonance spectroscopy and imaging studies of fluvastatin™ in Lescol® XL tablets in a USP-IV dissolution cell

Journal of Controlled Release

Volumn 156, Issue 3, 2011, Pages 345-354

  Zhang, Qilei ^a   Gladden, Lynn ^a   Avalle, Paolo ^b   Mantle, Michael ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Merck Sharp & Dohme Limited   (United Kingdom)

Author keywords

Controlled release; Dissolution; Drug release; Magnetic resonance imaging; RARE imaging; USP IV

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; BULK SOLUTIONS; COMPLETE DISSOLUTION; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE; DRUG DISSOLUTION; DRUG RELEASE; FLOW-THROUGH CELLS; FLUVASTATIN; GASTRIC FLUIDS; GEL LAYERS; GEL MATRIX; HIGH FIELD; HYDROXYPROPYL METHYLCELLULOSE; IMAGING METHOD; IN-VITRO; IN-VIVO; INTESTINAL FLUID; KEY SYSTEMS; MATRIX; MATRIX SWELLING; MOBILISATION; MULTI-NUCLEAR; NMR SPECTRUM; OFFLINE; PHYSICAL MOBILITY; POLYMER SWELLING; POLYMERIC MATRICES; TRANSPORT DYNAMICS; ULTRA-FAST; UNITED STATES PHARMACOPEIAS; USP-IV;

DISSOLUTION; DRUG PRODUCTS; DYNAMICS; GELS; HYDRODYNAMICS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROMETERS; MAGNETISM; NUCLEAR MAGNETIC RESONANCE; POLYMERS; RESONANCE; SPECTROMETRY; SWELLING;

NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

FLUINDOSTATIN; HYDROXYPROPYLMETHYLCELLULOSE;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; FLUORINE NUCLEAR MAGNETIC RESONANCE; GEL; HYDRODYNAMICS; IN VITRO STUDY; INTESTINE FLUID; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ASSAY; STOMACH JUICE; SWELLING; TABLET FORMULATION; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTICHOLESTEREMIC AGENTS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; EQUIPMENT DESIGN; FATTY ACIDS, MONOUNSATURATED; HYDRODYNAMICS; INDOLES; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; SOLUBILITY; TABLETS;

EID: 82755189391     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.08.039     Document Type: Article

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