Determination of water penetration and drug concentration profiles in HPMC-based matrix tablets by near infrared chemical imaging

Journal of Pharmaceutical Sciences

Volumn 99, Issue 7, 2010, Pages 3081-3088

  Li, Weiyong ^a   Woldu, Abraham ^a   Araba, Lola ^a   Winstead, Denita ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Controlled release; Hydration; Hydrogels; Image analysis; Near infrared spectroscopy; Partial least squares; Principal component analysis

Indexed keywords

HYDROPHILIC POLYMER HYDROXYPROPYLMETHYLCELLULOSE; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; CHEMOMETRIC ANALYSIS; DRUG DETERMINATION; DRUG DIFFUSION; DRUG RELEASE; DRUG SYNTHESIS; ENVIRONMENTAL TEMPERATURE; HUMAN; HYDRATION; HYDROGEL; IMAGE ANALYSIS; MATRIX TABLET; NEAR INFRARED SPECTROSCOPY; PARTIAL LEAST SQUARES REGRESSION; PHASE TRANSITION; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE ANALYSIS; SWELLING;

EID: 77953308201     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22084     Document Type: Article

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