Microstructural imaging of early gel layer formation in HPMC matrices

Journal of Pharmaceutical Sciences

Volumn 95, Issue 10, 2006, Pages 2145-2157

  Bajwa, Gurjit S ^a   Hoebler, Katrin ^b   Sammon, Chris ^c   Timmins, Peter ^d   Melia, Colin D ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

^d BRISTOL MYERS SQUIBB   (United States)

Author keywords

Confocal microscopy; Controlled release; Fluorescence; Hydrophilic matrix; Imaging methods

Indexed keywords

BETA DEXTRO GLUCOPYRANOSYL; CONGO RED; GLUCOSE DERIVATIVE; HYDROXYPROPYLMETHYLCELLULOSE; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG FORMULATION; DRUG STRUCTURE; GEL; HYDRATION; IMAGE ANALYSIS; STRUCTURE ANALYSIS;

EID: 33750001738     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20656     Document Type: Article

References (34)

1. Konrad R, Christ A, Zessin G, Cobet U. 1998. The use of ultrasound and penetrometer to characterize the advancement of swelling and eroding fronts in HPMC matrices. Int J Pharm 163:123-131.
2. Alderman DA. 1984. A review of cellulose ethers in hydrophilic matrices for oral controlled-release dosage forms. Int J Pharm Tech Prod Mfr 5:1-9.
3. Melia CD. 1991. Hydrophilic matrix sustained release systems based on polysaccharide carriers. Crit Rev Ther Drug Carrier Syst 8:395-421.
4. Colombo P, Bettini R, Santi P, Peppas NA. 2000. Swellable matrices for controlled drug deliver: Gel-layer behaviour, mechanisms and optimal performance. Res Focus 3:198-204.
5. Pham AT, Lee PI. 1994. Probing the mechanisms of drug release from hydroxypropylmethyl cellulose matrices. Pharm Res 11:1379-1384.
6. Ford JL. 1999. Thermal analysis of hydroxypropylmethylcellulose and methylcellulose: Powders, gels and matrix tablets. Int J Pharm 179:209-228.
7. Lee PI, Peppas NA. 1987. Prediction of polymer dissolution in swellable controlled-release systems. J Control Release 6:207-215.
8. Ju RCT, Nixon PR, Patel MV. 1995. Drug release from hydrophilic matrices. 1. New scaling laws for predicting polymer and drug release based on the polymer disentanglement concentration and the diffusion layer. J Pharm Sci 84:1455-1463.
9. Yang LB, Johnson B, Fassihi R. 1998. Determination of continuous changes in the gel layer thickness of poly(ethylene oxide) and HPMC tablets undergoing hydration: A texture analysis study. Pharm Res 15:1902-1906.
10. Colombo P, Bettini R, Massimo G, Catellani PL, Santi P, Peppas NA. 1995. Drug diffusion front movement is important in drug-release control from swellable matrix tablets. J Pharm Sci 84:991-997.
11. Cheong LWS, Heng PWS, Wong LF. 1992. Relationship between polymer viscosity and drug release from a matrix system. Pharm Res 9:1510-1514.
12. Lee PI. 1985. Kinetics of drug release from hydrogel matrices. J Control Release 2:277-288.
13. Ford JL, Mitchell K. 1995. Thermal-analysis of gels and matrix tablets containing cellulose ethers. Thermochim Acta 248:329-345.
14. Mitchell K, Ford JL, Armstrong DL, Elliott PNC, Hogan JE, Rostron C. 1993. The influence of drugs on the properties of gels and swelling characteristics of matrices containing methylcellulose or hydroxypropylmethylcellulose. Int J Pharm 100:165-173.
15. Melia CD, Rajabi-Siahboomi AR, Davies MC. 1992. The development of structural features in the surface gel layer of hydrating HPMC hydrophilic matrices. Control Release Soc 19:28-29.
16. Papadimitriou E, Buckton G, Efentakis M. 1993. Probing the mechanisms of swelling of hydroxypropylmethylcellulose matrices. Int J Pharm 98:57-62.
17. Bettini R, Catellani PL, Santi P, Massimo G, Peppas NA, Colombo P. 2001. Translocation of drug particles in HPMC matrix gel layer: Effect of drug solubility and influence on release rate. J Control Release 70:383-391.
18. Gao P, Meury R. 1996. Swelling of hydroxypropyl methylcellulose matrix tablets. 1. Characterization of swelling using a novel optical imaging method. J Pharm Sci 85:725-731.
19. Bowtell R, Sharp JC, Peters A, Mansfield P, Rajabi-Siahboomi AR, Davies MC, Melia CD. 1994. NMR microscopy of hydrating hydrophilic matrix pharmaceutical tablets. Magn Reson Imaging 12:361-364.
20. Tritt-Goc J, Pislewski N. 2002. Magnetic resonance imaging study of the swelling kinetics of hydroxypropylmethylcellulose (HPMC) in water. J Control Release 80:79-86.
21. Rajabi-Siahboomi AR, Melia CD, Davies MC, Bowtell RW, McJury M, Sharp JC, Mansfield P. 1992. Imaging the internal structure of the gel layer in hydrophilic matrix systems by NMR microscopy. J Pharm Pharmacol Suppl 44:1062.
22. Rajabi-Siahboomi AR, Bowtell RW, Mansfield P, Henderson A, Davies MC, Melia CD. 1994. Structure and behavior in hydrophilic matrix sustained-release dosage Forms. 2. NMR-Imaging studies of dimensional changes in the gel layer and core of HPMC tablets undergoing hydration. J Control Release 31:121-128.
23. Fyfe CA, Blazek AI. 1997. Investigation of hydrogel formation from hydroxypropylmethylcellulose (HPMC) by NMR spectroscopy and NMR imaging techniques. Macromolecules 30:6230-6237.
24. van der Weerd J, Kazarian SG. 2004. Combined approach of FTIR imaging and conventional dissolution tests applied to drug release. J Control Release 98:295-305.
25. Adler J, Jayan A, Melia CD. 1999. A method for quantifying differential expansion within hydrating hydrophilic matrices by tracking embedded fluorescent microspheres. J Pharm Sci 88:371-377.
26. Melia CD, Marshall P, Stark P, Cunningham S, Kinahan A, Devane J. 1997. Investigating in vitro drug release mechanisms inside dosage forms-Monitoring liquid ingress in HPMC hydrophilic matrices using confocal microscopy. Adv Exp Med Biol 423:129-135.
27. Horobin RW. 2002. Dis-, tris- and polyazo dyes. In: Horobin RW, Kiernan JA, editors. Conn's biological stains: A handbook of dyes, stains and fluorochromes for use in biology and medicine, 10th edition. Oxford, UK: BIOS Scientific Publishers Ltd. pp 132-134.
28. Wood PJ. 1980. Specificity in the interaction of direct dyes with polysaccharides. Carbohydr Res 85:271-287.
29. Yamaki SB, Barros DS, Garcia CM, Socoloski P, Oliveira ON, Atvars TDZ. 2005. Spectroscopic studies of the intermolecular interactions of Congo Red and Tinopal CBS with modified cellulose fibers. Langmuir 21:5414-5420.
30. Haque A, Richardson RK, Morris ER, Gidley MJ, Caswell DC. 1993. Thermogelation of methylcellulose. Part II: Effect of hydroxypropyl substituents. Carbohydr Polym 22:175-186.
31. Mirza LM, Iqbal J, Aziz H. 1996. Sorption of Congo Red on cellulose. J Chem Soc Pak 18:233-236.
32. Sarkar N. 1979. Thermal gelation properties of methyl and hydroxypropyl methylcellulose. J Appl Polym Sci 24:1073-1087.
33. Mitchell K, Ford J, Armstrong DJ, Elliott PNC, Rostron C, Hogan JE. 1990. The influence of additives on the cloud point, disintegration and dissolution of hydroxypropylmethylcellulose gels and matrix tablets. Int J Pharm 66:233-242.
34. Hodsdon AC, Mitchell JR, Davies MC, Melia CD. 1995. Structure and behaviour in hydrophilic matrix sustained release dosage forms: 3. The influence of pH on the sustaied-release performance and internal gel structure of sodium alginate matrices. J Control Release 33:143-152.