Quantitative NMR imaging study of the mechanism of drug release from swelling hydroxypropylmethylcellulose tablets

Journal of Controlled Release

Volumn 68, Issue 3, 2000, Pages 313-333

  Fyfe, C A ^a   Blazek Welsh, A I ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Drug release; Hydrophilic matrix tablets; Hydroxypropylmethylcellulose (HPMC); NMR imaging

Indexed keywords

DOW METHOCEL K4M; FLUOROURACIL; HYDROXYPROPYLMETHYLCELLULOSE; TRIFLUPROMAZINE; WATER;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; DRUG DIFFUSION; DRUG SOLUBILITY; HYDROGEL; MATRIX TABLET; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; TABLET PROPERTY;

CALIBRATION; FLUOROURACIL; MAGNETIC RESONANCE IMAGING; METHYLCELLULOSE; PHARMACEUTICAL PREPARATIONS; TIME FACTORS; TRIFLUPROMAZINE;

EID: 0034601659     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(00)00245-5     Document Type: Article

References (14)

1. Alderman D.A. A review of cellulose ethers in hydrophilic matrices for oral-controlled release dosage forms. Int. J. Pharm. Technol. Prod. Manuf. 5:(3):1984;1-9.
2. US Pharmacopeial Convention, Rockville, MD, USA. The US Pharmacopeia National Formulary, 1995. Dissolution〈711〉.
3. Gao P., Meury R.H. Swelling of hydroxypropyl methylcellulose matrix tablets. 1. Characterization of swelling using a novel optical imaging method. J. Pharm. Sci. 85:(7):1996;725-731.
4. Cutts L.S., Hibberd S., Adler J., Melia C.D. Characterising drug release processes within controlled release dosage forms using the confocal laser scanning microscope. J. Control. Rel. 42:1996;115-124.
5. Melia C.D., Marshal P., Stark P., Cunningham S., Kinahan A., Devane J. Investigating in vitro drug release mechanisms inside dosage forms monitoring liquid ingress into hpmc hydrophilic matrices using confocal microscopy. Young D., Devane J.G., Butler J. In Vivo-in Vitro Correlations. Advances in Experimental Medicine and Biology. Volume 23:1997;129 Plenum Press, New York.
6. Bowtell R., Sharp J.C., Peters A., Mansfield P., Rajabi-Siahboomi A.R., Davies M.C., Melia C.D. NMR microscopy of hydrating hydrophilic matrix pharmaceutical tablets. Magn. Res. Imag. 12:(2):1994;361-364.
7. Rajabi-Siahboomi A.R., Bowtell R.W., Mansfield P., Henderson A., Davies M.C., Melia C.D. Structure and behavior in hydrophilic matrix sustained release dosage forms: 2. NMR-imaging studies of dimensional changes in the gel layer and core of HPMC tablets undergoing hydration. J. Control. Rel. 31:1994;121-128.
8. Rajabi-Siahboomi A.R., Bowtell R.W., Mansfield P., Davies M.C., Melia C.D. Structure and behavior in hydrophilic matrix sustained release dosage forms: 4. Studies of water mobility and diffusion coefficients in the gel layer of HPMC tablets using NMR imaging. Pharm. Res. 13:(3):1996;376-380.
9. Ashraf M., Iuorno V.L., Coffin-Beach D., Evans C.A., Augsburger L.L. A novel nuclear magnetic resonance (NMR) imaging method for measuring the water front penetration rate in hydrophilic polymer matrix capsule plugs and its role in drug release. Pharm. Res. 11:(5):1994;733-737.
10. Fyfe C.A., Blazek A.I. Investigation of hydrogel formation from hydroxypropylmethylcellulose (HPMC) by NMR spectroscopy and NMR imaging techniques. Macromolecules. 30:(20):1997;6230-6237.
11. Fyfe C.A., Blazek A.I. Complications in investigations of the swelling of hydrogel matrices due to the presence of trapped gas. J. Control. Rel. 52:1998;221-225.
12. Vold R.L., Waugh J.S., Klein M.P., Phelps D.E. Measurement of spin relaxation in complex systems. J. Chem. Phys. 48:1968;3831-3832.
13. Carr H.Y., Purcell E.M. Effect of diffusion on free precession in nuclear magnetic resonance experiments. Phys. Rev. 94:(3):1954;630-638.
14. Stejskal E.O., Tanner J.E. Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J. Chem. Phys. 42:1965;288-292.