Simultaneous probing of swelling, erosion and dissolution by NMR-microimaging-Effect of solubility of additives on HPMC matrix tablets

European Journal of Pharmaceutical Sciences

Volumn 37, Issue 2, 2009, Pages 89-97

  Tajarobi, Farhad ^a,b   Abrahmsén Alami, Susanna ^a   Carlsson, Anders S ^a   Larsson, Anette ^b  

^a ASTRAZENECA R AND D   (Sweden)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

Diffusion; Front movement; HPMC; MRI; Osmotic pressure; Swellable matrices

Indexed keywords

CALCIUM PHOSPHATE DIBASIC; HYDROXYPROPYLMETHYLCELLULOSE; MANNITOL; PEARLITOL 50; UNCLASSIFIED DRUG;

ARTICLE; DIFFUSION; DRUG SOLUBILITY; FOCUSED BEAM REFLECTANCE MEASUREMENT; IMAGE ANALYSIS; IMAGING SYSTEM; KINETICS; MEASUREMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; OSMOTIC PRESSURE; PRIORITY JOURNAL; TABLET DISINTEGRATION; TABLET EROSION; TABLET FORMULATION; TABLET PROPERTY; TABLET SWELLING;

MAGNETIC RESONANCE SPECTROSCOPY; MANNITOL; METHYLCELLULOSE; PARTICLE SIZE; SOLUBILITY; TABLETS;

EID: 62649148773     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.01.008     Document Type: Article

References (29)

1. Abrahmsén-Alami S., Körner A., Nilsson I., and Larsson A. New release cell for NMR microimaging of tablets. Swelling and erosion of poly(ethylene oxide). Int. J. Pharm. 342 (2007) 105-114
2. Alderman D.A. A review of cellulose ethers in hydrophilic matrices for oral controlled-release dosage forms. Int. J. Pharm. Tech. Prod. 5 (1984) 1-9
3. Bajwa S.G., Hoebler K., Sammon C., Timmins P., and Melia C. Microstructural imaging of early gel layer formation in HPMC matrices. J. Pharm. Sci. 95 (2006) 2145-2157
4. Bettini R., Catellani P.L., Santi P., Massimo G., Peppas A.N., and Colombo P. Translocation of drug particles in HPMC matrix gel layer: effect of drug solubility and influence on release rate. J. Control. Release 70 (2001) 383-391
5. Colombo P., Bettini R., Catellani P.L., Santi P., and Peppas A.N. Drug volume fraction profile in the gel phase and drug release kinetics in hydroxypropylmethyl cellulose matrices containing a soluble drug. Eur. J. Pharm. Sci. 9 (1999) 33-40
6. Colombo, P., Bettini, R., De Ascentiis, A., Peppas, N. A., 1996. Analysis of the swelling and release mechanisms from drug delivery systems with emphasis on drug solubility and water transport. J. Control. Release 39, 231-237.
7. Colombo P., Bettini R., Santi P., and Peppas A.N. Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanisms and optimal performance. Pharm. Sci. Technol. Today 3 (2000) 198-204
8. Conte U., Colombo P., Gazzaniga A., Sangalli M.E., and La Manna A. Swelling-activated drug delivery systems. Biomaterials 9 (1988) 489-493
9. Fell J.T., and Newton J.M. Determination of tablet strength by diametral compression test. J. Pharm. Sci. 59 (1970) 688-691
10. Ford J.L. Thermal analysis of hydroxypropylmethylcellulose and methylcellulose: powders, gels and matrix tablets. Int. J. Pharm. 179 (1999) 209-228
11. Gao P., and Fagerness P.E. Diffusion in HPMC gels. I. Determination of drug and water diffusivity by pulsed-field-gradient spin-echo NMR. Pharm. Res. 12 (1995) 955-964
12. Gao P., and Meury R.H. Swelling of hydroxypropyl methylcellulose matrix tablets. 1. Characterization of swelling using a novel optical imaging method. J. Pharm. Sci. 85 (1996) 725-731
13. Hancock C.B., Shamblin S.L., and Zografi G. Molecular mobility of amorphous pharmaceutical solids below their glass transition temperature. Pharm. Res. 12 (1995) 799-806
14. Heath A.R., Bahri P.A., Fawell P.D., and Farrow J.B. Fluid mechanics and transport phenomena; polymer flocculation of calcite: relating the aggregate size to the settling rate. AIChE J. 52 (2006) 1987-1994
15. Jamzad S., Tutunji L., and Fassihi R. Analysis of macromolecular changes and drug release from hydrophilic matrix systems. Int. J. Pharm. 292 (2005) 75-85
16. Jeffers P., Raposo S., Lima-Costa M.E., Connolly P., Glennon B., and Kieran M. Focused beam reflectance measurement (FBRM) monitoring of particle size and morphology in suspension cultures of Morinda Citrifolia and Centaurea calcitrapa. Biotech. Lett. 25 (2004) 2023-2028
17. Johansson J., Folestad S., and Abrahamsson B. Novel Process Analytical Methodology to Establish Design Space and Real Time Prediction of Dissolution AAPS Workshop on Calleges for Dissolution Testing for the 21th Century. Arlington, VA, USA, May 1-3, 2006 (2006)
18. Ju R.T., Nixon P.R., and Patel M.V. Drug release from hydrphilic matrices. 1. New scaling law for predicting polymer and drug release based on the polymer disentanglement concentration and the diffusion layer. J. Pharm. Sci. 84 (1995) 1455-1463
19. Kazarian S.G., and Van der Weerd J. Simultaneous FTIR spectroscopic imaging and visible photography to monitor tablet dissolution and drug release. Pharm. Res. 25 (2008) 853-860
20. Konrad R., Christ A., Zessin G., and Cobet U. The use of ultrasound and penetrometer to characterize the advancement of swelling and eroding fronts in HPMC matrices. Int. J. Pharm. 163 (1998) 123-131
21. Kougoulos E., Jones A.G., Jennings K.H., and Wood-Kaczmar M.W. Use of focused beam reflectance measurement (FBRM) and process video imaging (PVI) in a modified mixed suspension mixed product removal (MSMPR) cooling crystallizer. J. Cryst. Growth 273 (2005) 529-534
22. Körner, A., 2006. Dissolution of polydisperse polymers in water. Ph.D. Thesis. Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden.
23. Körner A., Larsson A., Piculell L., and Wittgren B. Molecular Information on dissolution of polydisperse polymers: mixtures of long and short poly(ethylene oxide). J. Phys. Chem. (2005) 109
24. Lapidus H., and Lordi N.G. Drug release from compressed hydrophilic matrices. J. Pharm. Sci. 57 (1968) 1292-1301
25. Peppas A.N., Gurny R., Doelker E., and Buri P. Modelling of drug diffusion through swellable polymeric systems. J. Membr. Sci. 7 (1980)
26. Rajabi-Siahboomi A.R., Bowtell R.W., Mansfield P., Henderson A., Davies M.C., and Melia C.D. Structure and behaviour in hydrophilic matrix sustained release dosage forms. 2. NMR-imaging studies of dimensional changes in the gel layer and core of HPMC tablets undergoing hydration. J. Control. Release 31 (1994) 121-128
27. Richardson J.C., Bowtell R.W., Mäder K., and Melia C. Pharmaceutical applications of magnetic resonance imaging (MRI). Adv. Drug Del. Rev. 57 (2005) 1191-1209
28. Trotzig, C., 2006. Water diffusion and free volume in hydrophilic polymers. Ph.D. Thesis. Lund University, Lund, Sweden, p. 294.
29. Xinhui H., Cunningham C.J., and Winstead D. Study growth kinetics in fluidized bed granulation with at-line FBRM. Int. J. Pharm. 347 (2007) 54-61