The consequence of the chemical composition of HPMC in matrix tablets on the release behaviour of model drug substances having different solubility

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 77, Issue 1, 2011, Pages 99-110

  Viridén, Anna ^a   Wittgren, Bengt ^b   Larsson, Anette ^a  

^a CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Chemical heterogeneous; Drug release; HPMC; Hydrophilic matrix tablets; Polymer erosion; Solubility

Indexed keywords

BUTYL PARABEN; HYDROXYPROPYLMETHYLCELLULOSE; METHYL PARABEN;

ARTICLE; CHEMICAL COMPOSITION; CHEMICAL INTERACTION; CROSS LINKING; DRUG RELEASE; DRUG SOLUBILITY; GEL; HYDROPHILICITY; HYPOTHESIS; LIPOPHILICITY; MATRIX TABLET;

DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; EXCIPIENTS; GELS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; METHYLCELLULOSE; PARABENS; PHARMACEUTICAL PREPARATIONS; PHYSICOCHEMICAL PHENOMENA; REPRODUCIBILITY OF RESULTS; SOLUBILITY; TABLETS; TRANSITION TEMPERATURE; VISCOSITY;

EID: 78650713948     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2010.11.004     Document Type: Article

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