Swelling of hydroxypropyl methylcellulose matrix tablets. 1. Characterization of swelling using a novel optical imaging method

Journal of Pharmaceutical Sciences

Volumn 85, Issue 7, 1996, Pages 725-731

  Gao, Ping ^a   Meury, Richard H ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; METHYLCELLULOSE;

ARTICLE; CELL SWELLING; DOSE RESPONSE; DRUG ANALYSIS; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG RELEASE; IMAGE ANALYSIS; LIGHT SCATTERING; MATHEMATICAL MODEL; PHARMACEUTICS; TABLET; TURBIDITY;

EID: 0030057293     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js950458c     Document Type: Article

References (30)

1. Chien, T. W., Ed. Novel Drug Delivery Systems, 2nd ed.; Marcel Dekker: New York, 1992; Chapter 2.
2. Melia, C. D.; Rajabi-Siahboomi, A. R.; Davies, M. C. Proc. Int. Symp. Controlled Release Bioact. Mater., 19th 1992, 28-29.
3. Lee, P. T.; Pappas, N. A. J. Controlled Release 1987, 6, 207-215.
4. Hancock, B. C.; Zografi, G. Pharm. Res. 1988, 11, 471-477.
5. Ueberreiter, K. In Diffusion in Polymers; Crank, J., Park, G. S., Eds.; Academic Press: New York, 1968.
6. Melia, C. D.; Hodsdon, A. C.; Davies, M. C. Mitchell, J. R. Proc. Int. Symp. Controlled Release Bioact. Mater., 21st 1994, 724-725.
7. Colombo, P.; Conte, U.; Gazzaniga, A.; Maggi, L.; Sangalli, M. E.;Peppas, N. A.; La Manna, A. Int. J. Pharm. 1990, 63, 43-48.
8. Colombo, P.; Catellani, P. L.; Peppas, N. A.; Maggi, L.; Conte, U. Int. J. Pharm. 1992, 88, 99-109.
9. Bettini, R.; Colombo, P.; Massimo, G.; Santi, P.; Catellani, P. L.; Peppas, N. A. Proc. Int. Symp. Controlled Release Bioact. Mater., 21st 1994, 19-20.
10. Bettini, R.; Colombo, P.; Massimo, G.; Catellani, P. L.; Vitali, T. Eur. J. Pharm. Sci. 1994, 2, 213-219.
11. Colombo, P.; Bettini, R.; Massimo, G.; Catellani, P. L.; Santi, P.; Peppas, N. A. J. Pharm. Sci. 1995, 84, 991-997.
12. Papadimitriou, E.; Buckton, G.; Efentakis, M. Int. J. Pharm. 1993, 98, 57-62.
13. Lee, P. I. Pharm. Res. 1993, 10, 980-985.
14. Pham, A. T.; Lee; P. I. Pharm. Res. 1994, 11, 1379-1384.
15. Rajabi-Siahboomi, A. R.; Bowtell, R. W.; Mansfield, P.; Henderson, A.; Davies, M. C.; Melia, C. D. J. Controlled Release 1994, 31, 121-128.
16. Bowtell, R. W.; Sharp, J. C.; Peters, A.; Mansfield, P.; Rajabi-Siahboomi, A. R.; Davies, M. C.; Melia, C. D. Magn. Reson. Imaging 1994, 12, 361-364.
17. Rajabi-Siahboomi, A. R.; Bowtell, R. W.; Mansfield, P.; Davies, M. C.; Melia, C. D. Proc. Int. Symp. Controlled Release Bioact. Mater., 20th 1993, 292-293.
18. Cutts, L. S.; Bowtelll, R.; Paterson-Stephens, P.; Davies, M. C.; Melia, C. D. Proc. Int. Symp. Controlled Release Bioact. Mater., 22nd 1995, 236-237.
19. Koenig, J. L. Spectroscopy of Polymers; American Chemical Society: Washington DC, 1992; Chapter 11 and references therein.
20. Hyde, M. T.; Gladden, I. F.; Mackley, M. R.; Gao, P. J. Polym. Sci. A 1995, 33, 1795-1806.
21. Potter, K.; Carpenter, T. A.; Hall, L. D. Magn. Reson. Imaging 1994, 12, 309-311.
22. Ercken, M.; Adriaensens, P.; Vanderzande, D.; Gelan, J. Macromolecules 1995, 28, 8541-8547.
23. Valtier, M.; Tekely, P.; Kiene, L.; Canet D. Macromolecules 1995, 28, 4075-4079.
24. Gao, P.; Skoug, J. W.; Nixon, P. R.; Ju, T. R.; Stemm, N. L.; Sung, K.-C. J. Pharm. Sci. 1996, 85, 732-740.
25. Methocel Cellulose Ethers Technical Handbook; Dow Chemical Company: Midland, MI 48674.
26. Actually, the variable relevant to scattering intensity is the amount of HPMC per unit volume. The gel volume is determined by the content and hydration of HPMC and lactose. No attempt has been made to measure the gel volume of the samples in this work.
27. Huglin, M. B. Light Scattering from Polymer Solutions; Academic Press: New York, 1972; pp 796-799.
28. Kato, T.; Asami, H.; Takahashi, A. Kobunshi Ronbunshu 1986, 43, 399-404.
29. Alberty, R. A.; Silbey, R. J. Physical Chemistry; John Wiley & Sons, Inc.: New York, 1992; Chapter 22.
30. Gao, P.; Eagerness, P. E. Pharm. Res. 1995, 12, 955-964.