Novel biodegradable polyester poly(propylene succinate): Synthesis and application in the preparation of solid dispersions and nanoparticles of a water-soluble drug

AAPS PharmSciTech

Volumn 10, Issue 1, 2009, Pages 138-146

  Bikiaris, Dimitrios N ^a   Papageorgiou, George Z ^a   Papadimitriou, Sofia A ^a   Karavas, Evangelos ^b   Avgoustakis, Konstantinos ^c  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b Pharmaceutical Industry   (Greece)

^c UNIVERSITY OF PATRAS   (Greece)

Author keywords

Fluvastatin; Melt mixing; Nanoparticles; Poly(propylene succinate); Solid dispersions

Indexed keywords

FLUINDOSTATIN; NANOPARTICLE; POLY(PROPYLENE SUCCINATE); POLYESTER; POLYLACTIDE; UNCLASSIFIED DRUG; DRUG CARRIER; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INDOLE DERIVATIVE; MONOUNSATURATED FATTY ACID;

ARTICLE; BIODEGRADABILITY; CELL VIABILITY; CONCENTRATION PROCESS; CONTROLLED STUDY; CRYSTALLIZATION; DISPERSION; DRUG CYTOTOXICITY; DRUG FORMULATION; DRUG RELEASE; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LOW TEMPERATURE; MOLECULAR WEIGHT; TEMPERATURE SENSITIVITY; UMBILICAL VEIN; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; FEASIBILITY STUDY; KINETICS; METHODOLOGY; PATHOLOGY; PHARMACEUTICS; SOLUBILITY; TRANSITION TEMPERATURE;

CELL SURVIVAL; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG CARRIERS; DRUG COMPOUNDING; ENDOTHELIAL CELLS; FATTY ACIDS, MONOUNSATURATED; FEASIBILITY STUDIES; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INDOLES; KINETICS; MOLECULAR WEIGHT; NANOPARTICLES; POLYESTERS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TRANSITION TEMPERATURE;

EID: 67549095649     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-008-9184-z     Document Type: Article

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