Activation of paracrine TGF-β1 signaling upon stimulation and degranulation of rat serosal mast cells: A novel function for chymase

FASEB Journal

Volumn 15, Issue 8, 2001, Pages 1377-1388

  Lindstedt, Ken A ^a   Wang, Yenfeng ^a   Shiota, Naotaka ^a   Saarinen, Juhani ^b   Hyytiäinen, Marko ^c   Kokkonen, Jorma O ^a   Keski Oja, Jorma ^c   Kovanen, Petri T ^a  

^a WIHURI RESEARCH INSTITUTE   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Gene regulation; Proteolysis; Recombinant chymase; TGF activation; TGF receptors

Indexed keywords

CHYMASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN SERINE THREONINE KINASE; RECOMBINANT ENZYME; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; CELL STIMULATION; DEGRANULATION; EFFECTOR CELL; ENZYME ACTIVATION; GENE CONTROL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; NONHUMAN; PARACRINE SIGNALING; PERITONEUM MAST CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROSA; SIGNAL TRANSDUCTION; TARGET CELL;

ANIMALS; CELL DEGRANULATION; CHYMASES; HUMANS; MALE; MAST CELLS; PARACRINE COMMUNICATION; PERITONEAL CAVITY; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLEURA; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; SEROUS MEMBRANE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMALIA;

EID: 0034995590     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.00-0273com     Document Type: Article

References (55)

1. Transforming growth factor type-β: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
2. Transforming growth factor-β in disease: The dark side of tissue repair
3. Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-β1 transgenic mice
4. Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions
5. The prodomain of pre-protransforming growth factor β1 when independently expressed is a functional binding protein for the mature growth factor
6. TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences
7. A role of the latent TGF-β1-binding protein in the assembly and secretion of TGF-β1
8. Latent transforming growth factor-β-binding proteins (LTBPs): Structural extracellular matrix proteins for targeting TGF-β action
9. Growth factors in the extracellular matrix
10. Dog mastocytoma cells produce transforming growth factor beta
11. εRI. Role for mast cell-derived transforming growth factor β and tumor necrosis factor α
12. Dermal mast cell degranulation in systemic sclerosis
13. Mast cells and pulmonary fibrosis: Identification of a histamine releasing factor in bronchoalveolar lavage fluid
14. Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy
15. The relationship of mast cells and their secreted products to the volume of fibrosis in posttransplant hearts
16. Activation of mast cells for mediator release through IgE receptors
17. Production of a histamine-releasing lymphokine by antigen- or mitogen-stimulated human peripheral T cell
18. Human lung macrophage-derived histamine-releasing activity is due to IgE-dependent factors
19. The mast cell
20. Electron microscope observations on compound 48/80-induced degranulation in rat mast cells. Evidence for sequential exocytosis of storage granules
21. The mast cell - A potential link between inflammation and cellular cholesterol deposition in atherogenesis
22. Stimulation of mast cells leads to cholesterol accumulation in macrophages in vitro by a mast cell granule-mediated uptake of low density lipoprotein
23. Mast cell granule remnants carry LDL into smooth muscle cells of the synthetic phenotype and induce their conversion into foam cells
24. Human mast cells use conservation and condensation mechanisms during recovery from degranulation
25. Human mast cell chymase and leukocyte elastase release latent transforming growth factor-β1 from extracellular matrix of cultured human epithelial and endothelial cells
26. Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations
27. Regulation of exocytosis from rat peritoneal mast cells by G-protein beta gamma-subunits
28. Accumulation of low-density lipoproteins in stimulated rat serosal mast cells during recovery from degranulation
29. Nerve growth factor prevents apoptosis of rat peritoneal mast cells through the trk proto-oncogene receptor
30. Chymase in exocytosed rat mast cell granules effectively proteolyses apolipoprotein Al-containing lipoproteins, so reducing the cholesterol efflux-inducing ability of serum and aortic intimal fluid
31. Soluble heparin proteoglycans released from stimulated mast cells induce uptake of low density, lipoproteins by macrophages via scavenger receptor-mediated phagocytosis
32. Detection of mouse mast cell-associated mRNA. Heparinase treatment greatly improves RT-PCR of tissues containing mast cell heparin
33. Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via a latent TGF-β binding protein
34. Release of transforming growth factor-β1 from the pericellular matrix of cultured fibroblasts and fibrosarcoma cells by plasmin and thrombin
35. Isolation of the pericellular matrix of human fibroblast cultures
36. A second messenger RNA species of transforming growth factor β1 in infarcted rat heart
37. Low density, lipoprotein degradation by rat mast cells. Demonstration of extracellular proteolysis by mast cell granules
38. Identification of a highly specific chymase as the major angiotensin-forming enzyme in the human heart
39. Proteolytic activation of latent transforming growth factor-β from fibroblast-conditioned medium
40. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
41. Physiological consequences of loss of plasminogen activator gene function in mice
42. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
43. Authentic matrix vesicles contain active metalloproteases: A role for matrix vesicle-associated MMP-13 in activation of TGFβ
44. Angiotensin II-forming activity in a reconstructed ancestral chymase
45. Distinct multisite synergistic interactions determine substrate specificities of human chymase and rat chymase-1 for angiotensin II formation and degradation
46. Angiotensin II generation by mast cell alpha- and beta-chymases
47. The interaction of the transforming growth factor-βs with heparin and heparan sulfate is isoform-specific
48. Characterization of gene expression in resting and activated mast cells
49. Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin
50. Cord blood-derived human cultured mast cells produce transforming growth factor β1
51. TGF-β1 inhibits the release of histamine and tumor necrosis factor-α from mast cells through an autocrine pathway
52. The mast cell as site of tissue-type plasminogen activator expression and fibrinolysis
53. Characterization of the activation of latent TGF-β by cocultures of endothelial cells and pericytes or smooth muscle cells: A self-regulating system
54. Active transforming growth factor-β in wound repair: Determination using a new assay