Tryptase activates TGFβ in human airway smooth muscle cells via direct proteolysis

Biochemical and Biophysical Research Communications

Volumn 370, Issue 2, 2008, Pages 239-242

  Tatler, Amanda L ^a   Porte, Joanne ^a   Knox, Alan ^a   Jenkins, Gisli ^a   Pang, Linhua ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Airway remodelling; Airway smooth muscle; Asthma; Mast cells; PAR2; TGF ; Tryptase

Indexed keywords

LEUPEPTIN; NAFAMSTAT MESILATE; PROTEINASE ACTIVATED RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA; TRYPTASE; GUANIDINE DERIVATIVE; NAFAMSTAT; OLIGOPEPTIDE; SERYL LEUCYL ISOLEUCYL GLYCYL LYSYL VALINAMIDE; SERYL-LEUCYL-ISOLEUCYL-GLYCYL-LYSYL-VALINAMIDE; TRYPSIN INHIBITOR;

AIRWAY; ANIMAL CELL; ARTICLE; ASTHMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; MINK; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; BRONCHUS; CYTOLOGY; DRUG ANTAGONISM; ENZYMOLOGY; METABOLISM;

BRONCHI; GUANIDINES; HUMANS; LEUPEPTINS; MYOCYTES, SMOOTH MUSCLE; OLIGOPEPTIDES; RECEPTOR, PAR-2; TRANSFORMING GROWTH FACTOR BETA; TRYPSIN INHIBITORS; TRYPTASES;

EID: 42249092990     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.03.064     Document Type: Article

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