Theophylline and cAMP inhibit lysophosphatidic acid-induced hyperresponsiveness of bovine tracheal smooth muscle cells

Journal of Physiology

Volumn 549, Issue 1, 2003, Pages 171-180

  Sakai, Jiro ^a   Oike, Masahiro ^a   Hirakawa, Masakazu ^a   Ito, Yushi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ADENOSINE TRIPHOSPHATE; ALPHA ACTIN; BUCLADESINE; CALCIUM ION; COLLAGEN GEL; CYCLIC AMP; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; LYSOPHOSPHATIDIC ACID; POTASSIUM ION; RHO FACTOR; THEOPHYLLINE; ALPHA SMOOTH MUSCLE ACTIN; POTASSIUM; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ARTICLE; BRONCHUS HYPERREACTIVITY; CALCIUM MOBILIZATION; CELL LEVEL; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; IN VITRO STUDY; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER; STATISTICAL ANALYSIS; WESTERN BLOTTING; CALF (BOVINE); DEPOLARIZATION; RESPIRATORY TRACT ALLERGY; SMOOTH MUSCLE CONTRACTION; TRACHEA MUCUS;

ACTINS; ANIMALS; BRONCHIAL HYPERREACTIVITY; BRONCHODILATOR AGENTS; CALCIUM; CATTLE; CELLS, CULTURED; CYCLIC AMP; LYSOPHOSPHOLIPIDS; MUSCLE CONTRACTION; MYOCYTES, SMOOTH MUSCLE; RHOA GTP-BINDING PROTEIN; THEOPHYLLINE; TRACHEA;

EID: 0038526427     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.039024     Document Type: Article

References (32)

1. Ali S, Metzger WJ & Mustafa SJ (1996). Simultaneous measurement of cyclopentyladenosine-induced contraction and intracellular calcium in bronchial rings from allergic rabbits and it's antagonism. J Pharmacol Exp Ther 278, 639-644.
2. Barnes PJ & Pauwels RA (1994). Theophylline in the management of asthma: time for reappraisal? Eur Respir J 7, 579-591.
3. Beavo JA & Reifsnyder DH (1990). Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol Sci 11, 150-155.
4. Busca R, Bertolotto C, Abbe P, Englaro W, Ishizaki T, Narumiya S, Boquet P, Ortonne JP & Ballotti R (1998). Inhibition of Rho is required for cAMP-induced melanoma cell differentiation. Mol Biol Cell 9, 1367-1378.
5. Cerutis DR, Nogami M, Anderson JL, Churchill JD, Romberger DJ, Rennard SI & Toews ML (1997). Lysophosphatidic acid and EGF stimulate mitogenesis in human airway smooth muscle cells. Am J Physiol 273, L10-15.
6. Chamley JH, Campbell GR, McConnell JD & Groschel-Stewart U (1977). Comparison of vascular smooth muscle cells from adult human, monkey and rabbit in primary culture and in subculture. Cell Tissue Res 177, 503-522.
7. Faucheux N & Nagel MD (2002). Cyclic AMP-dependent aggregation of Swiss 3T3 cells on a cellulose substratum (Cuprophan) and decreased cell membrane Rho A. Biomaterials 23, 2295-2301.
8. Fredholm BB & Persson CG (1982). Xanthine derivatives as adenosine receptor antagonists. Eur J Pharmacol 81, 673-676.
9. ++ of human adult vascular smooth muscle cells in culture. Thromb Res 94, 317-326.
10. Hashimoto K, Peebles RS Jr, Sheller JR, Jarzecka K, Furlong J, Mitchell DB, Hartert TV & Graham BS (2002a). Suppression of airway hyperresponsiveness induced by ovalbumin sensitisation and RSV infection with Y-27632, a Rho kinase inhibitor. Thorax 57, 524-527.
11. Hashimoto T, Nakano Y, Ohata H & Momose K (2001). Lysophosphatidic acid enhances airway response to acetylcholine in guinea pigs. Life Sci 70, 199-205.
12. Hashimoto T, Nakano Y, Yamashita M, Fang YI, Ohata H & Momose K (2002b). Role of Rho-associated protein kinase and histamine in lysophosphatidic acid-induced airway hyperresponsiveness in guinea pigs. Jpn J Pharmacol 88, 256-261.
13. Iizuka K, Shimizu Y, Tsukagoshi H, Yoshii A, Harada T, Dobashi K, Murozono T, Nakazawa T & Mori M (2000). Evaluation of Y-27632, a rho-kinase inhibitor, as a bronchodilator in guinea pigs. Eur J Pharmacol 406, 273-279.
14. A3/EDG-7 in neuronal cell lines using a retrovirus expression system. Mol Pharmacol 58, 895-902.
15. Ito Y (1991). Prejunctional control of excitatory neuroeffector transmission by prostaglandins in the airway smooth muscle tissue. Am Rev Respir Dis 143, S6-10.
16. Kimura C, Cheng W, Hisadome K, Wang YP, Koyama T, Karashima Y, Oike M & Ito Y (2002). Superoxide anion impairs contractility in cultured aortic smooth muscle cells. Am J Physiol Heart Circ Physiol 283, H382-390.
17. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A & Kaibuchi K (1996 . Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273, 245-248.
18. Kranenburg O, Poland M, Gebbink M, Oomen L & Moolenaar WH (1997). Dissociation of LPA-induced cytoskeletal contraction from stress fiber formation by differential localization of RhoA. J Cell Sci 110, 2417-2427.
19. Moolenaar WH (1995). Lysophosphatidic acid signalling. Curr Opin Cell Biol 7, 203-210.
20. Ogawa K, Takagi K & Satake T (1989). Mechanism of xanthine-induced relaxation of guinea-pig isolated trachealis muscle. Br J Pharmacol 97, 542-546.
21. 2+ responses in bovine aortic endothelial cells. Am J Physiol Heart Circ Physiol 279, H630-638.
22. Pfitzer G (2001). Invited review: regulation of myosin phosphorylation in smooth muscle. J Appl Physiol 91, 497-503.
23. Seewald S, Sachinidis A, Dusing R, Ko Y, Seul C, Epping P & Vetter H (1997). Lysophosphatidic acid and intracellular signalling in vascular smooth muscle cells. Atherosclerosis 130, 121-131.
24. 4 enhances the contraction of porcine tracheal smooth muscle through the activation of Y-27632, a rho kinase inhibitor, sensitive pathway. Br J Pharmacol 132, 111-118.
25. Shen Z, Belinson J, Morton RE & Xu Y (1998). Phorbol 12-myristate 13-acetate stimulates lysophosphatidic acid secretion from ovarian and cervical cancer cells but not breast or leukemia cells. Gynecol Oncology 71, 364-368.
26. Solway J & Fredberg JJ (1997). Perhaps airway smooth muscle dysfunction contributes to asthmatic bronchial hyperrersponsiveness after all. Am J Respir Cell Mol Biol 17, 144-146.
27. Ten Broeke, Folkerts G, Leusink-Muis T, Vander der Linde HJ, Villain M, Manion MK, De Clerk F, Blalock JE & Nijkamp FP (2001). Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J 15, 1831-1833.
28. Thomson RJ, Bramley AM & Schellenberg RR (1996). Airway muscle stereology: implications for increased shortening in asthma. Am J Respir Crit Care Med 154, 749-757.
29. Toews ML, Ediger TL, Romberger DJ & Rennard SI (2002). Lysophosphatidic acid in airway function and disease. Biochim Biophys Acta 1582, 240-250.
30. Toews ML, Ustinova EE & Schultz HD (1997). Lysophosphatidic acid enhances contractility of isolated airway smooth muscle. J Appl Physiol 83, 1216-1222.
31. Tokumura A (2002). Physiological and pathophysiological roles of lysophosphatidic acids produced by secretory lysophospholipase D in body fluids. Biochim Biophys Acta 1582, 18-25.
32. 2+ sensitization. Am J Respir Cell Mol Biol 20, 1190-1200.