Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression

Journal of Biological Chemistry

Volumn 286, Issue 49, 2011, Pages 42162-42179

  Peeters, Annelies ^a   Fraisl, Peter ^b,c   Van Den Berg, Sjoerd ^c   Van Themaat, Emiel Ver Loren ^d   Van Kampen, Antoine ^d   Rider, Mark H ^e   Takemori, Hiroshi ^f   Van Dijk, Ko Willems ^c   Van Veldhoven, Paul P ^a   Carmeliet, Peter ^a,b   Baes, Myriam ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

^e UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^f NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMP-ACTIVATED KINASE; AMP-ACTIVATED PROTEIN KINASE; BILE ACID; CARBOHYDRATE METABOLISM; COACTIVATORS; DOCOSAHEXAENOIC ACID; DOWN-REGULATION; ENERGY DEFICIT; FOOD INTAKE; GLUCONEOGENESIS; GLYCOGEN SYNTHESIS; HEPATOCYTES; LOWER BODY; METABOLIC CHANGES; MITOCHONDRIAL DYSFUNCTION; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; UP-REGULATION;

BIOSYNTHESIS; CARBOHYDRATES; CHEMICAL ACTIVATION; ENZYME ACTIVITY; FATTY ACIDS; MAMMALS; METABOLISM; MITOCHONDRIA; PATHOLOGY; PHYSIOLOGY;

CYTOLOGY;

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENOVIRUS VECTOR; CRE RECOMBINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ADAPTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; ENZYME ACTIVATION; FOOD INTAKE; GENE; GENE SILENCING; GLUCONEOGENESIS; GLYCOGEN SYNTHESIS; GLYCOLYSIS; LIVER CELL; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PEROXISOME; PEX5 GENE; PRIORITY JOURNAL; UPREGULATION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CALORIMETRY; CARBOHYDRATE METABOLISM; CARBOHYDRATES; GLUCOSE; GLYCOLYSIS; HEPATOCYTES; LIPIDS; LIVER; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MODELS, BIOLOGICAL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANS-ACTIVATORS;

EID: 82755183520     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.299727     Document Type: Article

References (66)

1. Wanders, R. J., and Waterham, H. R. (2006) Annu. Rev. Biochem. 75, 295-332
2. Schrader, M., and Fahimi, H. D. (2006) Biochim. Biophys. Acta 1763, 1755-1766
3. Steinberg, S. J., Dodt, G., Raymond, G. V., Braverman, N. E., Moser, A. B., and Moser, H. W. (2006) Biochim. Biophys. Acta 1763, 1733-1748
4. Jevon, G. P., and Dimmick, J. E. (1998) Pediatr. Dev. Pathol. 1, 179-199
5. Goldfischer, S., Moore, C. L., Johnson, A. B., Spiro, A. J., Valsamis, M. P., Wisniewski, H. K., Ritch, R. H., Norton, W. T., Rapin, I., and Gartner, L. M. (1973) Science 182, 62-64
6. Trijbels, J. M., Berden, J. A., Monnens, L. A., Willems, J. L., Janssen, A. J., Schutgens, R. B., and van den Broek-Van Essen, M. (1983) Pediatr. Res. 17, 514-517
7. Pfeifer, U., and Sandhage, K. (1979) Virchows Arch. A Pathol. Anat. Histol. 384, 269-284
8. Mooi, W. J., Dingemans, K. P., van den Bergh Weerman, M. A., Jöbsis, A. C., Heymans, H. S., and Barth, P. G. (1983) Ultrastruct. Pathol. 5, 135-144
9. Mathis, R. K., Watkins, J. B., Szczepanik-Van Leeuwen, P., and Lott, I. T. (1980) Gastroenterology 79, 1311-1317
10. Hughes, J. L., Poulos, A., Robertson, E., Chow, C. W., Sheffield, L. J., Christodoulou, J., and Carter, R. F. (1990) Virchows Arch. A Pathol. Anat. Histopathol. 416, 255-264
11. Dirkx, R., Vanhorebeek, I., Martens, K., Schad, A., Grabenbauer, M., Fahimi, D., Declercq, P., Van Veldhoven, P. P., and Baes, M. (2005) Hepatology 41, 868-878
12. Baes, M., Dewerchin, M., Janssen, A., Collen, D., and Carmeliet, P. (2002) Genesis 32, 177-178
13. Postic, C., Shiota, M., Niswender, K. D., Jetton, T. L., Chen, Y., Moates, J. M., Shelton, K. D., Lindner, J., Cherrington, A. D., and Magnuson, M. A. (1999) J. Biol. Chem. 274, 305-315
14. Lee, S. S., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernandez-Salguero, P. M., Westphal, H., and Gonzalez, F. J. (1995) Mol. Cell. Biol. 15, 3012-3022
15. van den Berg, S. A., Nabben, M., Bijland, S., Voshol, P. J., van Klinken, J. B., Havekes, L. M., Romijn, J. A., Hoeks, J., Hesselink, M. K., Schrauwen, P., and van Dijk, K. W. (2010) Metabolism 59, 1612-1618
16. Péronnet, F., and Massicotte, D. (1991) Can. J. Sport Sci. 16, 23-29
17. Baes, M., Huyghe, S., Carmeliet, P., Declercq, P. E., Collen, D., Mannaerts, G. P., and Van Veldhoven, P. P. (2000) J. Biol. Chem. 275, 16329-16336
18. Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., and Puigserver, P. (2005) Nature 434, 113-118
19. Katoh, Y., Takemori, H., Lin, X. Z., Tamura, M., Muraoka, M., Satoh, T., Tsuchiya, Y., Min, L., Doi, J., Miyauchi, A., Witters, L. A., Nakamura, H., and Okamoto, M. (2006) FEBS J. 273, 2730-2748
20. Uebi, T., Tamura, M., Horike, N., Hashimoto, Y. K., and Takemori, H. (2010) Am. J. Physiol. Endocrinol. Metab 299, E413-E425
21. Jomain-Baum, M., and Schramm, V. L. (1978) J. Biol. Chem. 253, 3648-3659
22. Rajas, F., Croset, M., Zitoun, C., Montano, S., and Mithieux, G. (2000) Diabetes 49, 1165-1168
23. Van Veldhoven, P. P., Baumgart, E., and Mannaerts, G. P. (1996) Anal. Biochem. 237, 17-23
24. Keppler, D., and Decker, K. (1984) in Methods of Enzymatic Analysis. Metabolites 1: Carbohydrates (Bergmeyer, H. U., ed) pp. 11-18, Verlag Chemie, Weinheim, Germany
25. Van Veldhoven, P., Declercq, P. E., Debeer, L. J., and Mannaerts, G. P. (1984) Biochem. Pharmacol. 33, 1153-1155
26. Manfredi, G., Yang, L., Gajewski, C. D., and Mattiazzi, M. (2002) Methods 26, 317-326
27. Van Schaftingen, E., Lederer, B., Bartrons, R., and Hers, H. G. (1982) Eur. J. Biochem. 129, 191-195
28. Dirkx, R., Meyhi, E., Asselberghs, S., Reddy, J., Baes, M., and Van Veldhoven, P. P. (2007) Biochem. Biophys. Res. Commun. 357, 718-723
29. Lerin, C., Rodgers, J. T., Kalume, D. E., Kim, S. H., Pandey, A., and Puigserver, P. (2006) Cell Metab. 3, 429-438
30. Aragonés, J., Schneider, M., Van Geyte, K., Fraisl, P., Dresselaers, T., Mazzone, M., Dirkx, R., Zacchigna, S., Lemieux, H., Jeoung, N. H., Lambrechts, D., Bishop, T., Lafuste, P., Diez-Juan, A., Harten, S. K., Van Noten, P., De, Bock, K., Willam, C., Tjwa, M., Grosfeld, A., Navet, R., Moons, L., Vandendriessche, T., Deroose, C., Wijeyekoon, B., Nuyts, J., Jordan, B., Silasi- Mansat, R., Lupu, F., Dewerchin, M., Pugh, C., Salmon, P., Mortelmans, L., Gallez, B., Gorus, F., Buyse, J., Sluse, F., Harris, R. A., Gnaiger, E., Hespel, P., Van Hecke, P., Schuit, F., Van Veldhoven, P., Ratcliffe, P., Baes, M., Maxwell, P., and Carmeliet, P. (2008) Nat. Genet. 40, 170-180
31. Martens, K., Ver Loren van Themaat, E., van Batenburg, M. F., Heinäniemi, M., Huyghe, S., Van Hummelen, P., Carlberg, C., Van Veldhoven, P. P., Van Kampen, A., and Baes, M. (2008) Biochim. Biophys. Acta 1781, 694-702
32. Peeters, A., Swinnen, J. V., Van Veldhoven, P. P., and Baes, M. (2011) Biochimie 93, 1828-1838
33. Peeters, A., and Baes, M. (2010) PPAR Res. 2010, ii, 572405
34. Du, K., Herzig, S., Kulkarni, R. N., and Montminy, M. (2003) Science 300, 1574-1577
35. Koo, S. H., Satoh, H., Herzig, S., Lee, C. H., Hedrick, S., Kulkarni, R., Evans, R. M., Olefsky, J., and Montminy, M. (2004) Nat. Med. 10, 530-534
36. Wang, Y. G., Shi, M., Wang, T., Shi, T., Wei, J., Wang, N., and Chen, X. M. (2009) World J. Gastroenterol. 15, 2329-2335
37. Okamoto, H., Latres, E., Liu, R., Thabet, K., Murphy, A., Valenzeula, D., Yancopoulos, G. D., Stitt, T. N., Glass, D. J., and Sleeman, M. W. (2007) Diabetes 56, 1350-1356
38. Iynedjian, P. B. (2005) Biochem. J. 386, 113-118
39. Koo, S. H., Flechner, L., Qi, L., Zhang, X., Screaton, R. A., Jeffries, S., Hedrick, S., Xu, W., Boussouar, F., Brindle, P., Takemori, H., and Montminy, M. (2005) Nature 437, 1109-1111
40. Viollet, B., Guigas, B., Leclerc, J., Hebrard, S., Lantier, L., Mounier, R., Andreelli, F., and Foretz, M. (2009) Acta Physiol. 196, 81-98
41. Cantó, C., and Auwerx, J. (2010) Cell. Mol. Life Sci. 67, 3407-3423
42. Horike, N., Sakoda, H., Kushiyama, A., Ono, H., Fujishiro, M., Kamata, H., Nishiyama, K., Uchijima, Y., Kurihara, Y., Kurihara, H., and Asano, T. (2008) J. Biol. Chem. 283, 33902-33910
43. Yoon, J. C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C. R., Granner, D. K., Newgard, C. B., and Spiegelman, B. M. (2001) Nature 413, 131-138
44. Puigserver, P., Rhee, J., Donovan, J., Walkey, C. J., Yoon, J. C., Oriente, F., Kitamura, Y., Altomonte, J., Dong, H., Accili, D., and Spiegelman, B. M. (2003) Nature 423, 550-555
45. Handschin, C., and Spiegelman, B. M. (2006) Endocr. Rev. 27, 728-735
46. Rhee, J., Ge, H., Yang, W., Fan, M., Handschin, C., Cooper, M., Lin, J., Li, C., and Spiegelman, B. M. (2006) J. Biol. Chem. 281, 14683-14690
47. Wu, P., Peters, J. M., and Harris, R. A. (2001) Biochem. Biophys. Res. Commun. 287, 391-396
48. Roche, T. E., Baker, J. C., Yan, X., Hiromasa, Y., Gong, X., Peng, T., Dong, J., Turkan, A., and Kasten, S. A. (2001) Prog. Nucleic Acid Res. Mol. Biol. 70, 33-75
49. Le Lay, J., Tuteja, G., White, P., Dhir, R., Ahima, R., and Kaestner, K. H. (2009) Cell Metab. 10, 55-62
50. She, P., Burgess, S. C., Shiota, M., Flakoll, P., Donahue, E. P., Malloy, C. R., Sherry, A. D., and Magnuson, M. A. (2003) Diabetes 52, 1649-1654
51. Mandard, S., Stienstra, R., Escher, P., Tan, N. S., Kim, I., Gonzalez, F. J., Wahli, W., Desvergne, B., Müller, M., and Kersten, S. (2007) Cell. Mol. Life Sci. 64, 1145-1157
52. Hardie, D. G., Hawley, S. A., and Scott, J. W. (2006) J. Physiol. 574, 7-15
53. Marsin, A. S., Bertrand, L., Rider, M. H., Deprez, J., Beauloye, C., Vincent, M. F., Van den Berghe, G., Carling, D., and Hue, L. (2000) Curr. Biol. 10, 1247-1255
54. Marsin, A. S., Bouzin, C., Bertrand, L., and Hue, L. (2002) J. Biol. Chem. 277, 30778-30783
55. Hardie, D. G. (2011) Am. J. Clin. Nutr. 93, 891S-6
56. Lee, W. S., and Sokol, R. J. (2007) Hepatology 45, 1555-1565
57. Carling, D., and Hardie, D. G. (1989) Biochim. Biophys. Acta 1012, 81-86
58. Jeninga, E. H., Schoonjans, K., and Auwerx, J. (2010) Oncogene 29, 4617-4624
59. Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., and Auwerx, J. (2009) Nature 458, 1056-1060
60. Lochhead, P. A., Salt, I. P., Walker, K. S., Hardie, D. G., and Sutherland, C. (2000) Diabetes 49, 896-903
61. Foretz, M., Ancellin, N., Andreelli, F., Saintillan, Y., Grondin, P., Kahn, A., Thorens, B., Vaulont, S., and Viollet, B. (2005) Diabetes 54, 1331-1339
62. Viana, A. Y., Sakoda, H., Anai, M., Fujishiro, M., Ono, H., Kushiyama, A., Fukushima, Y., Sato, Y., Oshida, Y., Uchijima, Y., Kurihara, H., and Asano, T. (2006) Diabetes Res. Clin. Pract. 73, 135-142
63. Purushotham, A., Schug, T. T., Xu, Q., Surapureddi, S., Guo, X., and Li, X. (2009) Cell Metab. 9, 327-338
64. Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., Landaker, E. J., Goldfine, A. B., Mun, E., DeFronzo, R., Finlayson, J., Kahn, C. R., and Mandarino, L. J. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 8466-8471
65. Mootha, V. K., Lindgren, C. M., Eriksson, K. F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., Houstis, N., Daly, M. J., Patterson, N., Mesirov, J. P., Golub, T. R., Tamayo, P., Spiegelman, B., Lander, E. S., Hirschhorn, J. N., Altshuler, D., and Groop, L. C. (2003) Nat. Genet. 34, 267-273
66. Kumashiro, N., Tamura, Y., Uchida, T., Ogihara, T., Fujitani, Y., Hirose, T., Mochizuki, H., Kawamori, R., and Watada, H. (2008) Diabetes 57, 2083-2091