β-Oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts

Biochemical and Biophysical Research Communications

Volumn 357, Issue 3, 2007, Pages 718-723

  Dirkx, Ruud ^a   Meyhi, Els ^b   Asselberghs, Stanny ^b   Reddy, Janardan ^c   Baes, Myriam ^a   Van Veldhoven, Paul P ^b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Oxidation; Branched chain fatty acid; Dicarboxylic fatty acid; Hepatocyte culture; Mitochondria; Peroxisome; THCA

Indexed keywords

2 METHYLHEXADECANOIC ACID; BILE ACID; DICARBOXYLIC ACID; MULTIFUNCTIONAL PROTEIN 1; MULTIFUNCTIONAL PROTEIN 2; MYRISTIC ACID; PALMITIC ACID; RNA BINDING PROTEIN; TRIHYDROXYCHOLESTANOIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; FATTY ACID OXIDATION; LIVER CELL CULTURE; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANIMALS; CARBON DIOXIDE; CELLS, CULTURED; CHOLESTANOLS; DECANOIC ACIDS; DICARBOXYLIC ACIDS; HEPATOCYTES; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MULTIENZYME COMPLEXES; OXIDATION-REDUCTION; PALMITATES; PALMITIC ACIDS; PEROXISOMES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SUBSTRATE SPECIFICITY;

MUS;

EID: 34247533633     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.03.198     Document Type: Article

References (39)

1. Reddy J.K., and Hashimoto T. Peroxisomal β-oxidation and peroxisome proliferator-activated receptor α: an adaptive metabolic system. Annu. Rev. Nutr. 21 (2001) 193-230
2. Casteels M., Foulon V., Mannaerts G.P., and Van Veldhoven P.P. Alpha-oxidation of 3-methyl-substituted fatty acids and its thiamine dependence. Eur. J. Biochem. 270 (2003) 1619-1627
3. Foulon V., Sniekers M., Huysmans E., Asselberghs S., Mahieu V., Mannaerts G.P., Van Veldhoven P.P., and Casteels M. Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase. J. Biol. Chem. 280 (2005) 9802-9812
4. Suzuki H., Yamada J., Watanabe T., and Suga T. Compartmentation of dicarboxylic acid β-oxidation in rat liver: importance of peroxisomes in the metabolism of dicarboxylic acids. Biochim. Biophys. Acta 990 (1989) 25-30
5. Bergseth S., Poisson J.-P., and Bremer J. Metabolism of dicarboxylic acids in rat hepatocytes. Biochim. Biophys. Acta 1042 (1990) 182-187
6. Leighton F., Bergseth S., RØrtveit T., Christiansen E.N., and Bremer J. Free acetate production by rat hepatocytes during peroxisomal fatty acid and dicarboxylic acid oxidation. J. Biol. Chem. 264 (1989) 10347-10350
7. Cerdan S., Kunnecke B., Dolle A., and Seelig J. In situ metabolism of 1,omega medium chain dicarboxylic acids in the liver of intact rats as detected by 13C and 1H NMR. J. Biol. Chem. 263 (1988) 11664-11674
8. Vamecq J., and Draye J.-P. Peroxisomal and mitochondrial β-oxidation of monocarboxylyl- CoA, ω-hydroxymonocarboxylyl-CoA and dicarboxylyl-CoA esters in tissues from untreated and clofibrate-treated rats. J. Biochem. 106 (1989) 216-222
9. Pourfarzam M., and Bartlett K. Intermediates of peroxisomal beta-oxidation of [U-14C]hexadecanedionoate. A study of the acyl-CoA esters which accumulate during peroxisomal beta-oxidation of [U-14C]hexadecanedionate and [U-14C]hexadecanedionoyl-mono-CoA. Eur. J. Biochem. 208 (1992) 301-307
10. Poosch M.S., and Yamazaki R.K. The oxidation of dicarboxylic acid CoA esters via peroxisomal fatty acyl-CoA oxidase. Biochim. Biophys. Acta 1006 (1989) 291-298
11. Mortensen P.B., Kolvraa S., Gregersen N., and Rasmussen K. Cyanide-insensitive and clofibrate enhanced beta-oxidation of dodecanedioic acid in rat liver. An indication of peroxisomal beta-oxidation of N-dicarboxylic acids. Biochim. Biophys. Acta 713 (1982) 393-397
12. Kolvraa S., and Gregersen N. In vitro studies on the oxidation of medium-chain dicarboxylic acids in rat liver. Biochim. Biophys. Acta 876 (1986) 515-525
13. Mortensen P.B., and Gregersen N. The biological origin of ketotic dicarboxylic aciduria. II. In vivo and in vitro investigations of the beta-oxidation of C8-C16-dicarboxylic acids in unstarved, starved and diabetic rats. Biochim. Biophys. Acta 710 (1982) 477-484
14. Mortensen P.B. Formation and degradation of dicarboxylic acids in relation to alterations in fatty acid oxidation in rats. Biochim. Biophys. Acta 1124 (1992) 71-79
15. 14C]hexadecanedionoyl- mono-CoA by rat liver peroxisomes and mitochondria. Biochem. J. 273 (1991) 205-210
16. Draye J.P., Veitch K., Vamecq J., and Van H.F. Comparison of the metabolism of dodecanedioic acid in vivo in control, riboflavin-deficient and clofibrate-treated rats. Eur. J. Biochem. 178 (1988) 183-189
17. van Grunsven E.G., van Berkel E., Ijlst L., De Klerk J.B.C., Vreken P., Adamski J., Lemonde H., Clayton P.T., Cuebas D.A., and Wanders R.J.A. Peroxisomal d-hydroxyacyl-CoA dehydrogenase deficiency: resolution of the enzyme defect and its molecular basis in bifunctional protein deficiency. Proc. Natl. Acad. Sci. USA 95 (1998) 2128-2133
18. Baes M., Huyghe S., Carmeliet P., Declercq P.E., Collen D., Mannaerts G.P., and Van Veldhoven P.P. Inactivation of the peroxisomal multifunctional protein-2 in mice impedes the degradation of not only 2-methyl branched fatty acids and bile acid intermediates but also of very-long-chain fatty acids. J. Biol. Chem. 275 (2000) 16329-16336
19. Qi C., Zhu Y., Pan J., Usuda N., Maeda N., Yeldandi A.V., Rao M.S., Hashimoto T., and Reddy J.K. Absence of spontaneous peroxisome proliferation in enoyl-CoA hydratase/L-3-hydroxyacyl-CoA dehydrogenase-deficient mouse liver. J. Biol. Chem. 274 (1999) 15775-15780
20. Baes M., Gressens P., Huyghe S., De Nys K., Qi C., Jia Y., Mannaerts G.P., Evrard P., Van Veldhoven P.P., Declercq P.E., and Reddy J.K. The neuronal migration defect in mice with Zellweger syndrome (Pex5 knockout) is not caused by the inactivity of peroxisomal β-oxidation. J. Neuropath. Exp. Neur. 61 (2002) 368-374
21. Jia Y., Qi C., Zhang Z., Hashimoto T., Rao M.S., Huyghe S., Suzuki Y., Van Veldhoven P.P., Baes M., and Reddy J.K. Overexpression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both l- and d- forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal beta-oxidation system. J. Biol. Chem. 278 (2003) 47232-47239
22. Fan C.-Y., Pan J., Chu R., Lee D., Kluckman K.D., Usuda N., Singh I., Yeldandi A.V., Rao M.S., Maeda N., and Reddy J.K. Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J. Biol. Chem. 271 (1996) 24698-24710
23. Seedorf U., Raabe M., Ellinghaus P., Kannenberg F., Fobker M., Engel T., Denis S., Wouters F., Wirtz K.W.A., Wanders R.J.A., Maeda N., and Assmann G. Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function. Genes Dev. 12 (1998) 1189-1201
24. Savolainen K., Kotti T.J., Schmitz W., Savolainen T.I., Sormunen R.T., Ilves M., Vainio S.J., Conzelmann E., and Hiltunen J.K. A mouse model for α-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids. Hum. Mol. Genet. 13 (2004) 955-965
25. Chevillard G., Clemencet M.C., Latruffe N., and Nicolas-Francès V. Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal metabolism. Biochemie 86 (2004) 849-856
26. Wood P.A., kelly-Kurtz C.L., Hinsdale M.E., Hamm D.A., and Rhead W.J. Lessons learned from the mouse model of short-chain acyl-CoA dehydrogenase deficiency. Adv. Exp. Med. Biol. 466 (1999) 395-402
27. Cox K.B., Hamm D.A., Millington D.S., Matern D., Vockley J., Rinaldo P., Pinkert C.A., Rhead W.J., Lindsey J.R., and Wood P.A. Gestational, pathologic and biochemical differences between very long-chain acyl-CoA dehydrogenase deficiency and long-chain acyl-CoA dehydrogenase in the mouse. Hum. Mol. Genet. 10 (2001) 2069-2077
28. Tolwani R.J., Hamm D.A., Tian L., Sharer J.D., Vockley J., Rinaldo P., Matern D., Schoeb T.R., and Wood P.A. Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted mice. PLoS Genet. 1 (2005) e23
29. Dirkx R., Vanhorebeek I., Martens K., Schad A., Grabenbauer M., Fahimi D., Declercq P., Van Veldhoven P.P., and Baes M. Absence of peroxisomes in hepatocytes causes mitochondrial and ER abnormalities. Hepatology 41 (2005) 868-878
30. Sparrow J.T., Patel K.M., and Morrisett J.D. Synthesis of carbon-13 tetradecanoic acids. J. Lipid Res. 24 (1983) 938-941
31. Seglen O. Preparation of isolated rat liver cells. Methods Cell Biol. 13 (1976) 29-83
32. Vanhooren J.C.T., Asselberghs S., Eyssen H.J., Mannaerts G.P., and Van Veldhoven P.P. Activation of 3-methyl-branched fatty acids in rat liver. Int. J. Biochem. 26 (1994) 1095-1101
33. Vanhove G., Van Veldhoven P.P., Vanhoutte F., Parmentier G., Eyssen H.J., and Mannaerts G.P. Mitochondrial and peroxisomal β-oxidation of the branched chain fatty acid 2-methylpalmitate in rat liver. J. Biol. Chem. 266 (1991) 24670-24675
34. Casteels M., Schepers L., Van Eldere J., Eyssen H.J., and Mannaerts G.P. Inhibition of 3α,7α,12α-trihydroxy-5β-cholestanoic acid oxidation and of bile acid secretion in rat liver by fatty acids. J. Biol. Chem. 263 (1988) 4654-4661
35. Eaton S., Turnbull D.M., and Bartlett K. Redox control of β-oxidation in rat liver mitochondria. Eur. J. Biochem. 220 (1994) 671-681
36. Eaton S., Pourfarzam M., and Bartlett K. The effect of respiratory chain impairment on β-oxidation in rat heart mitochondria. Biochem. J. 319 (1996) 633-640
37. Enns G.M., Bennett M.J., Hoppel C.L., Goodman S.I., Weisiger K., Ohnstd C., Golabi M., and Packman S. Mitochondrial respiratory chain complex I deficiency with clinical and biochemical features of long-chain- 3-hydroxyacyl-coenzyme A dehydrogenase deficiency. J. Pediatr. 136 (2000) 251-254
38. Ferdinandusse S., Denis M., van Roermund C.W., Wanders R.J.A., and Dacremont G. Identification of the peroxisomal b-oxidation enzymes involved in the degradation of long-chain dicarboxylic acids. J. Lipid Res. 45 (2004) 1104-1111
39. Cuebas D.A., Phillips C., Schmitz W., Conzelmann E., and Novikov D.K. The role of α-methylacyl-CoA racemase in bile acid synthesis. Biochem. J. 363 (2002) 801-807