메뉴 건너뛰기




Volumn 9, Issue 11, 2011, Pages 2176-2187

Pectenotoxin-2 from marine sponges: A potential anti-cancer agent - A Review

Author keywords

Apoptosis; Cancer; Cell cycle; Pectenotoxin 2

Indexed keywords

CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DEATH RECEPTOR 4; DEATH RECEPTOR 5; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; MARINE TOXIN; PECTENOTOXIN 2; PROTEIN BAX; PROTEIN BCL 2; PROTEIN TYROSINE PHOSPHATASE; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

EID: 82655185052     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md9112176     Document Type: Review
Times cited : (32)

References (43)
  • 1
    • 0032829103 scopus 로고    scopus 로고
    • New anti-actin drugs in the study of the organization and function of the actin cytoskeleton
    • DOI 10.1002/(SICI)1097-0029(19991001)47:1<18::AID-JEMT3>3.0.CO;2-E
    • Spector, I.; Braet, F.; Shochet, N.R.; Bubb, M.R. New anti-actin drugs in the study of the organization and function of the actin cytoskeleton. Microsc. Res. Tech. 1999, 47, 18-37. (Pubitemid 29474832)
    • (1999) Microscopy Research and Technique , vol.47 , Issue.1 , pp. 18-37
    • Spector, I.1    Braet, F.2    Shochet, N.R.3    Bubb, M.R.4
  • 3
    • 34547121749 scopus 로고    scopus 로고
    • A Structural Basis for Regulation of Actin Polymerization by Pectenotoxins
    • DOI 10.1016/j.jmb.2007.05.056, PII S0022283607007036
    • Allingham, J.S.; Miles, C.O.; Rayment, I. A structural basis for regulation of actin polymerization by pectenotoxins. J. Mol. Biol. 2007, 371, 959-970. (Pubitemid 47101811)
    • (2007) Journal of Molecular Biology , vol.371 , Issue.4 , pp. 959-970
    • Allingham, J.S.1    Miles, C.O.2    Rayment, I.3
  • 5
    • 33749059234 scopus 로고    scopus 로고
    • Actin-targeting natural products: Structures, properties and mechanisms of action
    • DOI 10.1007/s00018-006-6157-9
    • Allingham, J.S.; Klenchin, V.A.; Rayment, I. Actin-targeting natural products: structures, properties and mechanisms of action. Cell. Mol. Life Sci. 2006, 63, 2119-2134. (Pubitemid 44465686)
    • (2006) Cellular and Molecular Life Sciences , vol.63 , Issue.18 , pp. 2119-2134
    • Allingham, J.S.1    Klenchin, V.A.2    Rayment, I.3
  • 7
    • 46649112472 scopus 로고    scopus 로고
    • Induction of G2/M arrest, endoreduplication, and apoptosis by actin depolymerization agent pextenotoxin-2 in human leukemia cells, involving activation of ERK and JNK
    • Moon, D.O.; Kim, M.O.; Kang, S.H.; Lee, K.J.; Heo, M.S.; Choi, K.S.; Choi, Y.H.; Kim, G.Y. Induction of G2/M arrest, endoreduplication, and apoptosis by actin depolymerization agent pextenotoxin-2 in human leukemia cells, involving activation of ERK and JNK. Biochem. Pharmacol. 2008, 76, 312-321.
    • (2008) Biochem. Pharmacol. , vol.76 , pp. 312-321
    • Moon, D.O.1    Kim, M.O.2    Kang, S.H.3    Lee, K.J.4    Heo, M.S.5    Choi, K.S.6    Choi, Y.H.7    Kim, G.Y.8
  • 8
    • 79953035125 scopus 로고    scopus 로고
    • Actin disruption agents induce phosphorylation of histone H2AX in human breast adenocarcinoma MCF-7 cells
    • Shin, I.J.; Ahn, Y.T.; Kim, Y.; Kim, J.M.; An, W.G. Actin disruption agents induce phosphorylation of histone H2AX in human breast adenocarcinoma MCF-7 cells. Oncol. Rep. 2011, 25, 1313-1319.
    • (2011) Oncol. Rep. , vol.25 , pp. 1313-1319
    • Shin, I.J.1    Ahn, Y.T.2    Kim, Y.3    Kim, J.M.4    An, W.G.5
  • 9
    • 0343742594 scopus 로고    scopus 로고
    • Cdc25 protein phosphatases in cell proliferation
    • Draetta, G.; Eckstein, J. Cdc25 protein phosphatases in cell proliferation. Biochim. Biophys. Acta 1997, 1332, 53-63.
    • (1997) Biochim. Biophys. Acta , vol.1332 , pp. 53-63
    • Draetta, G.1    Eckstein, J.2
  • 10
    • 13244269810 scopus 로고    scopus 로고
    • The Plk3-Cdc25 circuit
    • DOI 10.1038/sj.onc.1208278
    • Myer, D.L.; Bahassi, E.M.; Stambrook, P.J. The Plk3-Cdc25 circuit. Oncogene 2005, 24, 299-305. (Pubitemid 40188611)
    • (2005) Oncogene , vol.24 , Issue.2 , pp. 299-305
    • Myer, D.L.1    Bahassi, E.M.2    Stambrook, P.J.3
  • 11
    • 0030867582 scopus 로고    scopus 로고
    • Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
    • DOI 10.1126/science.277.5331.1497
    • Sanchez, Y.; Wong, C.; Thoma, R.S.; Richman, R.; Wu, Z.; Piwnica-Worms, H.; Elledge, S.J. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25. Science 1997, 277, 1497-1501. (Pubitemid 27449236)
    • (1997) Science , vol.277 , Issue.5331 , pp. 1497-1501
    • Sanchez, Y.1    Wong, C.2    Thoma, R.S.3    Richman, R.4    Wu, Z.5    Piwnica-Worms, H.6    Elledge, S.J.7
  • 12
    • 33645716061 scopus 로고    scopus 로고
    • P14ARF triggers G2 arrest through ERK-mediated Cdc25C phosphorylation, ubiquitination and proteasomal degradation
    • Eymin, B.; Claverie, P.; Salon, C.; Brambilla, C.; Brambilla, E.; Gazzeri, S. p14ARF triggers G2 arrest through ERK-mediated Cdc25C phosphorylation, ubiquitination and proteasomal degradation. Cell Cycle 2006, 5, 759-765.
    • (2006) Cell Cycle , vol.5 , pp. 759-765
    • Eymin, B.1    Claverie, P.2    Salon, C.3    Brambilla, C.4    Brambilla, E.5    Gazzeri, S.6
  • 13
    • 77952970159 scopus 로고    scopus 로고
    • Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C
    • Moon, D.O.; Kim, M.O.; Nam, T.J.; Kim, S.K.; Choi, Y.H.; Kim, G.Y. Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C. Oncol. Rep. 2010, 24, 271-276.
    • (2010) Oncol. Rep. , vol.24 , pp. 271-276
    • Moon, D.O.1    Kim, M.O.2    Nam, T.J.3    Kim, S.K.4    Choi, Y.H.5    Kim, G.Y.6
  • 15
    • 0031961995 scopus 로고    scopus 로고
    • 2/M cell cycle transitions: PRb is a critical determinant in blocking DNA replication and in preventing endoreduplication
    • 2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol. Cell Biol. 1998, 18, 629-643.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 629-643
    • Niculescu, A.B.1    Chen, X.2    Smeets, M.3    Hengst, L.4    Prives, C.5    Reed, S.I.6
  • 16
    • 0029365005 scopus 로고
    • Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27
    • Landry, J.; Huot, J. Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27. Biochem. Cell. Biol. 1995, 73, 703-707.
    • (1995) Biochem. Cell. Biol. , vol.73 , pp. 703-707
    • Landry, J.1    Huot, J.2
  • 18
    • 15744395163 scopus 로고    scopus 로고
    • The cytoskeleton as a regulator and target of biotic interactions in plants
    • DOI 10.1104/pp.104.052159
    • Takemoto, D.; Hardham, A.R. The cytoskeleton as a regulator and target of biotic interactions in plants. Plant Physiol. 2004, 136, 3864-3876. (Pubitemid 41096266)
    • (2004) Plant Physiology , vol.136 , Issue.4 , pp. 3864-3876
    • Takemoto, D.1    Hardham, A.R.2
  • 19
    • 0034689774 scopus 로고    scopus 로고
    • p21(Waf1/Cip1/Sdi1)-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells
    • Chang, B.D.; Broude, E.V.; Fang, J.; Kalinichenko, T.V.; Abdryashitov, R.; Poole, J.C.; Roninson, I.B. p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosiscontrol proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene 2000, 19, 2165-2170. (Pubitemid 30251382)
    • (2000) Oncogene , vol.19 , Issue.17 , pp. 2165-2170
    • Chang, B.-D.1    Broude, E.V.2    Fang, J.3    Kalinichenko, T.V.4    Abdryashitov, R.5    Poole, J.C.6    Roninson, I.B.7
  • 20
    • 33749475259 scopus 로고    scopus 로고
    • Inhibition of the Janus kinase family increases extracellular signal-regulated kinase 1/2 phosphorylation and causes endoreduplication
    • DOI 10.1158/0008-5472.CAN-06-0972
    • Reiterer, G.; Yen, A. Inhibition of the janus kinase family increases extracellular signal-regulated kinase 1/2 phosphorylation and causes endoreduplication. Cancer Res. 2006, 66, 9083-9089. (Pubitemid 44521127)
    • (2006) Cancer Research , vol.66 , Issue.18 , pp. 9083-9089
    • Reiterer, G.1    Yen, A.2
  • 21
    • 37249023811 scopus 로고    scopus 로고
    • Actin dysfunction activates ERK1/2 and delays entry into mitosis in mammalian cells
    • Lee, K.; Song, K. Actin dysfunction activates ERK1/2 and delays entry into mitosis in mammalian cells. Cell Cycle 2007, 6, 1487-1495.
    • (2007) Cell Cycle , vol.6 , pp. 1487-1495
    • Lee, K.1    Song, K.2
  • 23
    • 67649401960 scopus 로고    scopus 로고
    • Transcriptome and functional analysis of the eukaryotic-type serine/threonine kinase PknB in Staphylococcus aureus
    • Donat, S.; Streker, K.; Schirmeister, T.; Rakette, S.; Stehle, T.; Liebeke, M.; Lalk, M.; Ohlsen, K. Transcriptome and functional analysis of the eukaryotic-type serine/threonine kinase PknB in Staphylococcus aureus. J. Bacteriol. 2009, 191, 4056-4069.
    • (2009) J. Bacteriol. , vol.191 , pp. 4056-4069
    • Donat, S.1    Streker, K.2    Schirmeister, T.3    Rakette, S.4    Stehle, T.5    Liebeke, M.6    Lalk, M.7    Ohlsen, K.8
  • 24
    • 0036782706 scopus 로고    scopus 로고
    • Transcription factors as targets for cancer therapy
    • Darnell, J.E., Jr. Transcription factors as targets for cancer therapy. Nat. Rev. Cancer 2002, 2, 740-749.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 740-749
    • Darnell Jr., J.E.1
  • 26
    • 1842555356 scopus 로고    scopus 로고
    • Modulatory properties of various natural chemopreventive agents on the activation of NF-κB signaling pathway
    • Jeong, W.S.; Kim, I.W.; Hu, R.; Kong, A.N. Modulatory properties of various natural chemopreventive agents on the activation of NF-κB signaling pathway. Pharm. Res. 2004, 21, 661-670.
    • (2004) Pharm. Res. , vol.21 , pp. 661-670
    • Jeong, W.S.1    Kim, I.W.2    Hu, R.3    Kong, A.N.4
  • 27
    • 0032588186 scopus 로고    scopus 로고
    • NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1
    • Guttridge, D.C.; Albanese, C.; Reuther, J.Y.; Pestell, R.G.; Baldwin, A.S., Jr. NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 1999, 19, 5785-5799.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5785-5799
    • Guttridge, D.C.1    Albanese, C.2    Reuther, J.Y.3    Pestell, R.G.4    Baldwin Jr., A.S.5
  • 28
    • 53049093846 scopus 로고    scopus 로고
    • Pectenotoxin-2 abolishes constitutively activated NF-κB, leading to suppression of NF-κB related gene products and potentiation of apoptosis
    • Kim, M.O.; Moon, D.O.; Heo, M.S.; Lee, J.D.; Jung, J.H.; Kim, S.K.; Choi, Y.H.; Kim, G.Y. Pectenotoxin-2 abolishes constitutively activated NF-κB, leading to suppression of NF-κB related gene products and potentiation of apoptosis. Cancer Lett. 2008, 271, 25-33.
    • (2008) Cancer Lett. , vol.271 , pp. 25-33
    • Kim, M.O.1    Moon, D.O.2    Heo, M.S.3    Lee, J.D.4    Jung, J.H.5    Kim, S.K.6    Choi, Y.H.7    Kim, G.Y.8
  • 29
    • 1542357606 scopus 로고    scopus 로고
    • Apoptosis pathways in cancer and cancer therapy
    • Debatin, K.M. Apoptosis pathways in cancer and cancer therapy. Cancer Immunol. Immunother. 2004, 53, 153-159.
    • (2004) Cancer Immunol. Immunother. , vol.53 , pp. 153-159
    • Debatin, K.M.1
  • 30
    • 25144489068 scopus 로고    scopus 로고
    • Over view of cell death signaling pathways
    • Jin, Z.; el-Deiry, W.S. Over view of cell death signaling pathways. Cancer Biol. Ther. 2005, 4, 139-163.
    • (2005) Cancer Biol. Ther. , vol.4 , pp. 139-163
    • Jin, Z.1    El-Deiry, W.S.2
  • 31
    • 33846445804 scopus 로고    scopus 로고
    • Current concepts in apoptosis: The physiological suicide program revisited
    • DOI 10.2478/s11658-006-0041-3
    • Chowdhury, I.; Tharakan, B.; Bhat, G.K. Current concepts in apoptosis: the physiological suicide program revisited. Cell. Mol. Biol. Lett. 2006, 11, 506-525. (Pubitemid 46708878)
    • (2006) Cellular and Molecular Biology Letters , vol.11 , Issue.4 , pp. 506-525
    • Chowdhury, I.1    Tharakan, B.2    Bhat, G.K.3
  • 32
    • 33746886979 scopus 로고    scopus 로고
    • Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
    • Fulda, S.; Debatin, K.M. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 2006, 25, 4798-4811.
    • (2006) Oncogene , vol.25 , pp. 4798-4811
    • Fulda, S.1    Debatin, K.M.2
  • 33
    • 34247610328 scopus 로고    scopus 로고
    • P53 translational control: A new facet of p53 regulation and its implication for tumorigenesis and cancer therapeutics
    • Halaby, M.J.; Yang, D.Q. p53 translational control: a new facet of p53 regulation and its implication for tumorigenesis and cancer therapeutics. Gene 2007, 395, 1-7.
    • (2007) Gene , vol.395 , pp. 1-7
    • Halaby, M.J.1    Yang, D.Q.2
  • 34
    • 70350317603 scopus 로고    scopus 로고
    • Induction of apoptosis by lupeol in human epidermoid carcinoma A431 cells through regulation of mitochondrial, Akt/PKB and NFkappaB signaling pathways
    • Prasad, S.; Madan, E.; Nigam, N.; Roy, P.; George, J.; Shukla, Y. Induction of apoptosis by lupeol in human epidermoid carcinoma A431 cells through regulation of mitochondrial, Akt/PKB and NFkappaB signaling pathways. Cancer Biol. Ther. 2009, 8, 1632-1639.
    • (2009) Cancer Biol. Ther. , vol.8 , pp. 1632-1639
    • Prasad, S.1    Madan, E.2    Nigam, N.3    Roy, P.4    George, J.5    Shukla, Y.6
  • 35
    • 38749138067 scopus 로고    scopus 로고
    • Induction of apoptosis by pectenotoxin-2 is mediated with the induction of DR4/DR5, Egr-1 and NAG-1, activation of caspases and modulation of the Bcl-2 family in p53-deficient Hep3B hepatocellular carcinoma cells
    • Shin, D.Y.; Kim, G.Y.; Kim, N.D.; Jung, J.H.; Kim, H.S.; Choi, Y.H. Induction of apoptosis by pectenotoxin-2 is mediated with the induction of DR4/DR5, Egr-1 and NAG-1, activation of caspases and modulation of the Bcl-2 family in p53-deficient Hep3B hepatocellular carcinoma cells. Oncol. Rep. 2008, 19, 517-526. (Pubitemid 351176115)
    • (2008) Oncology Reports , vol.19 , Issue.2 , pp. 517-526
    • Shin, D.Y.1    Kim, G.Y.2    Kim, N.D.3    Jung, J.H.4    Kim, S.-K.5    Kang, H.S.6    Choi, Y.H.7
  • 36
    • 0036594890 scopus 로고    scopus 로고
    • The role of the cyclin-dependent kinase inhibitor p21 in apoptosis
    • Gartel, A.L.; Tyner, A.L. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol. Cancer Ther. 2002, 1, 639-649.
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 639-649
    • Gartel, A.L.1    Tyner, A.L.2
  • 37
    • 23044471179 scopus 로고    scopus 로고
    • Oocyte-based screening of cytokinesis inhibitors and identification of pectenotoxin-2 that induces Bim/Bax-mediated apoptosis in p53-deficient tumors
    • DOI 10.1038/sj.onc.1208640
    • Chae, H.D.; Choi, T.S.; Kim, B.M.; Jung, J.H.; Bang, Y.J.; Shin, D.Y. Oocyte-based screening of cytokinesis inhibitors and identification of pectenotoxin-2 that induces Bim/Bax-mediated apoptosis in p53-deficient tumors. Oncogene 2005, 24, 4813-4819. (Pubitemid 41076299)
    • (2005) Oncogene , vol.24 , Issue.30 , pp. 4813-4819
    • Chae, H.-D.1    Choi, T.-S.2    Kim, B.-M.3    Jung, J.H.4    Bang, Y.-J.5    Shin, D.Y.6
  • 38
    • 20744448037 scopus 로고    scopus 로고
    • Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stability
    • DOI 10.1128/MCB.25.13.5567-5578.2005
    • Bunch, J.T.; Bae, N.S.; Leonardi, J.; Baumann, P. Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stability. Mol. Cell. Biol. 2005, 25, 5567-5578. (Pubitemid 40853591)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.13 , pp. 5567-5578
    • Bunch, J.T.1    Bae, N.S.2    Leonardi, J.3    Baumann, P.4
  • 39
    • 77955414830 scopus 로고    scopus 로고
    • Telomerase as an emerging target to fight cancer-Opportunities and challenges for nanomedicine
    • Philippi, C.; Loretz, B.; Schaefer, U.F.; Lehr, C.M. Telomerase as an emerging target to fight cancer-Opportunities and challenges for nanomedicine. J. Control. Releases 2010, 146, 228-240.
    • (2010) J. Control. Releases , vol.146 , pp. 228-240
    • Philippi, C.1    Loretz, B.2    Schaefer, U.F.3    Lehr, C.M.4
  • 41
    • 0032962953 scopus 로고    scopus 로고
    • The human telomerase catalytic subunit hTERT: Organization of the gene and characterization of the promoter
    • DOI 10.1093/hmg/8.1.137
    • Cong, Y.S.; Wen, J.; Bacchetti, S. The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter. Hum. Mol. Genet. 1999, 8, 137-142. (Pubitemid 29039059)
    • (1999) Human Molecular Genetics , vol.8 , Issue.1 , pp. 137-142
    • Cong, Y.-S.1    Wen, J.2    Bacchetti, S.3
  • 42
    • 53049108889 scopus 로고    scopus 로고
    • Pectenotoxin-2 represses telomerase activity in human leukemia cells through suppression of hTERT gene expression and Akt-dependent hTERT phosphorylation
    • Kim, M.O.; Moon, D.O.; Kang, S.H.; Heo, M.S.; Choi, Y.H.; Jung, J.H.; Lee, J.D.; Kim, G.Y. Pectenotoxin-2 represses telomerase activity in human leukemia cells through suppression of hTERT gene expression and Akt-dependent hTERT phosphorylation. FEBS Lett. 2008, 582, 3263-3269.
    • (2008) FEBS Lett. , vol.582 , pp. 3263-3269
    • Kim, M.O.1    Moon, D.O.2    Kang, S.H.3    Heo, M.S.4    Choi, Y.H.5    Jung, J.H.6    Lee, J.D.7    Kim, G.Y.8
  • 43
    • 0033532056 scopus 로고    scopus 로고
    • Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit
    • Kang, S.S.; Kwon, T.; Kwon, D.Y.; Do, S.I. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J. Biol. Chem. 1999, 274, 13085-13090.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13085-13090
    • Kang, S.S.1    Kwon, T.2    Kwon, D.Y.3    Do, S.I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.