Oocyte-based screening of cytokinesis inhibitors and identification of pectenotoxin-2 that induces Bim/Bax-mediated apoptosis in p53-deficient tumors

Oncogene

Volumn 24, Issue 30, 2005, Pages 4813-4819

  Chae, Hee Don ^a,b   Choi, Tae Saeng ^a,c   Kim, Byeong Mo ^a   Jung, Jee H ^d   Bang, Yung Jue ^b   Shin, Deug Y ^a,b,c  

^a Dankook University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c GenCross Biotech Institute   (South Korea)

^d Pusan National University   (South Korea)

Author keywords

Actin inhibitor; Apoptosis; Bim, Bax; Chemosensitivity; p53

Indexed keywords

BIM PROTEIN; CASPASE INHIBITOR; NATURAL PRODUCT; PECTENOTOXIN 2; PROTEIN BAX; PROTEIN P53; SMALL INTERFERING RNA; TOXIN; UNCLASSIFIED DRUG; ACTIN; APOPTOSIS REGULATORY PROTEIN; BAX PROTEIN, HUMAN; BAX PROTEIN, MOUSE; BCL 2 BINDING PROTEIN, BIM; BCL-2-BINDING PROTEIN, BIM; CARRIER PROTEIN; FURAN DERIVATIVE; MEMBRANE PROTEIN; ONCOPROTEIN; PROTEIN BCL 2; PYRAN DERIVATIVE;

ACTIN FILAMENT; ANIMAL CELL; APOPTOSIS; ARTICLE; CHEMOSENSITIVITY; CONFORMATIONAL TRANSITION; CYTOKINESIS; DEPOLYMERIZATION; ENZYME ACTIVATION; MITOSIS INHIBITION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SCREENING; SPONGE (PORIFERA); TOXIN ANALYSIS; TUMOR CELL; ANIMAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENETICS; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MOUSE; TUMOR CELL LINE;

ACTINS; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; CARRIER PROTEINS; CELL LINE, TUMOR; CYTOKINESIS; FEMALE; FURANS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, INBRED ICR; OOCYTES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRANS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 23044471179     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208640     Document Type: Article

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