Actin-targeting natural products: Structures, properties and mechanisms of action

Cellular and Molecular Life Sciences

Volumn 63, Issue 18, 2006, Pages 2119-2134

  Allingham, J S ^a   Klenchin, V A ^a   Rayment, I ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Actin filament dynamics; Anti cancer drugs; Capping; Cytotoxic compound; Filament stabilization; Sequestering; Severing

Indexed keywords

ACTIN; APLYRONINE A; BISTHEONELLIDE A; BISTRAMIDE A; CHRONDRAMIDE; CYTOTOXIN; HALICHONDRAMIDE; JASPAMIDE; JASPISAMIDE A; KABIRAMIDE; KABIRAMIDE C; LATRUNCULEIC ACID; LATRUNCULIN A; LATRUNCULIN B; LATRUNCULIN C; LOBOPHOROLIDE; MISAKINOLIDE B; MYCALOLIDE; NATURAL PRODUCT; PECTENOTOXIN 2; PECTENOTOXIN 6; PHALLOTOXIN; PYRROLE DERIVATIVE; REIDISPONGIOLIDE A; REIDISPONGIOLIDE C; SPHINXOLIDE B; SWINHOLIDE A; TOLYTOXIN; ULAPUALIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ALLOSTERISM; BINDING AFFINITY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG BINDING; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; HUMAN; MOLECULAR INTERACTION; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN DOMAIN; REVIEW; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; X RAY DIFFRACTION;

ACTINS; ANIMALS; BIOLOGICAL PRODUCTS; CELL MOVEMENT; CYTOSKELETON; GTP-BINDING PROTEINS; HUMANS; MARINE TOXINS; MICROFILAMENT PROTEINS; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 33749059234     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-006-6157-9     Document Type: Review

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