-
1
-
-
52949145604
-
Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice
-
Singer A., Adoro S., Park J.H. Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat Rev Immunol 2008, 8:788-801.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 788-801
-
-
Singer, A.1
Adoro, S.2
Park, J.H.3
-
2
-
-
70349247895
-
CD4-CD8 lineage differentiation: Thpok-ing into the nucleus
-
Wang L., Bosselut R. CD4-CD8 lineage differentiation: Thpok-ing into the nucleus. J Immunol 2009, 183:2903-2910.
-
(2009)
J Immunol
, vol.183
, pp. 2903-2910
-
-
Wang, L.1
Bosselut, R.2
-
3
-
-
58849086223
-
RUNX proteins in transcription factor networks that regulate T-cell lineage choice
-
Collins A., Littman D.R., Taniuchi I. RUNX proteins in transcription factor networks that regulate T-cell lineage choice. Nat Rev Immunol 2009, 9:106-115.
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 106-115
-
-
Collins, A.1
Littman, D.R.2
Taniuchi, I.3
-
4
-
-
0028467791
-
Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity
-
Corbella P., Moskophidis D., Spanopoulou E., Mamalaki C., Tolaini M., Itano A., et al. Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity. Immunity 1994, 1:269-276.
-
(1994)
Immunity
, vol.1
, pp. 269-276
-
-
Corbella, P.1
Moskophidis, D.2
Spanopoulou, E.3
Mamalaki, C.4
Tolaini, M.5
Itano, A.6
-
5
-
-
0029988961
-
MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent
-
Matechak E.O., Killeen N., Hedrick S.M., Fowlkes B.J. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity 1996, 4:337-347.
-
(1996)
Immunity
, vol.4
, pp. 337-347
-
-
Matechak, E.O.1
Killeen, N.2
Hedrick, S.M.3
Fowlkes, B.J.4
-
6
-
-
77954901331
-
Decision checkpoints in the thymus
-
Carpenter A.C., Bosselut R. Decision checkpoints in the thymus. Nat Immunol 2010, 11:666-673.
-
(2010)
Nat Immunol
, vol.11
, pp. 666-673
-
-
Carpenter, A.C.1
Bosselut, R.2
-
8
-
-
74049110516
-
Checkpoints in lymphocyte development and autoimmune disease
-
von Boehmer H., Melchers F. Checkpoints in lymphocyte development and autoimmune disease. Nat Immunol 2010, 11:14-20.
-
(2010)
Nat Immunol
, vol.11
, pp. 14-20
-
-
von Boehmer, H.1
Melchers, F.2
-
9
-
-
52649167708
-
CD4 T cells: fates, functions, and faults
-
Zhu J., Paul W.E. CD4 T cells: fates, functions, and faults. Blood 2008, 112:1557-1569.
-
(2008)
Blood
, vol.112
, pp. 1557-1569
-
-
Zhu, J.1
Paul, W.E.2
-
10
-
-
65549115862
-
Plasticity of CD4+ T cell lineage differentiation
-
Zhou L., Chong M.M., Littman D.R. Plasticity of CD4+ T cell lineage differentiation. Immunity 2009, 30:646-655.
-
(2009)
Immunity
, vol.30
, pp. 646-655
-
-
Zhou, L.1
Chong, M.M.2
Littman, D.R.3
-
11
-
-
77649220954
-
Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
-
O'Shea J.J., Paul W.E. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 2010, 327:1098-1102.
-
(2010)
Science
, vol.327
, pp. 1098-1102
-
-
O'Shea, J.J.1
Paul, W.E.2
-
12
-
-
14544288635
-
The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment
-
He X., He X., Dave V.P., Zhang Y., Hua X., Nicolas E., et al. The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature 2005, 433:826-833.
-
(2005)
Nature
, vol.433
, pp. 826-833
-
-
He, X.1
He, X.2
Dave, V.P.3
Zhang, Y.4
Hua, X.5
Nicolas, E.6
-
13
-
-
52549133772
-
Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells
-
Wang L., Wildt K.F., Zhu J., Zhang X., Feigenbaum L., Tessarollo L., et al. Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol 2008, 9:1122-1130.
-
(2008)
Nat Immunol
, vol.9
, pp. 1122-1130
-
-
Wang, L.1
Wildt, K.F.2
Zhu, J.3
Zhang, X.4
Feigenbaum, L.5
Tessarollo, L.6
-
14
-
-
52549124338
-
Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate
-
Muroi S., Naoe Y., Miyamoto C., Akiyama K., Ikawa T., Masuda K., et al. Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat Immunol 2008, 9:1113-1121.
-
(2008)
Nat Immunol
, vol.9
, pp. 1113-1121
-
-
Muroi, S.1
Naoe, Y.2
Miyamoto, C.3
Akiyama, K.4
Ikawa, T.5
Masuda, K.6
-
15
-
-
52549101132
-
ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage
-
Egawa T., Littman D.R. ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol 2008, 9:1131-1139.
-
(2008)
Nat Immunol
, vol.9
, pp. 1131-1139
-
-
Egawa, T.1
Littman, D.R.2
-
16
-
-
16844375768
-
The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection
-
Sun G., Liu X., Mercado P., Jenkinson S.R., Kypriotou M., Feigenbaum L., et al. The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection. Nat Immunol 2005, 6:373-381.
-
(2005)
Nat Immunol
, vol.6
, pp. 373-381
-
-
Sun, G.1
Liu, X.2
Mercado, P.3
Jenkinson, S.R.4
Kypriotou, M.5
Feigenbaum, L.6
-
17
-
-
0033527615
-
Regulation of lineage commitment distinct from positive selection
-
Keefe R., Dave V., Allman D., Wiest D., Kappes D.J. Regulation of lineage commitment distinct from positive selection. Science 1999, 286:1149-1153.
-
(1999)
Science
, vol.286
, pp. 1149-1153
-
-
Keefe, R.1
Dave, V.2
Allman, D.3
Wiest, D.4
Kappes, D.J.5
-
18
-
-
33847153126
-
Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation
-
Jenkinson S.R., Intlekofer A.M., Sun G., Feigenbaum L., Reiner S.L., Bosselut R. Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation. J Exp Med 2007, 204:267-272.
-
(2007)
J Exp Med
, vol.204
, pp. 267-272
-
-
Jenkinson, S.R.1
Intlekofer, A.M.2
Sun, G.3
Feigenbaum, L.4
Reiner, S.L.5
Bosselut, R.6
-
19
-
-
57449108862
-
The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells
-
Wang L., Wildt K.F., Castro E., Xiong Y., Feigenbaum L., Tessarollo L., et al. The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells. Immunity 2008, 29:876-887.
-
(2008)
Immunity
, vol.29
, pp. 876-887
-
-
Wang, L.1
Wildt, K.F.2
Castro, E.3
Xiong, Y.4
Feigenbaum, L.5
Tessarollo, L.6
-
20
-
-
0036636857
-
Core-binding factors in haematopoiesis and leukaemia
-
Speck N.A., Gilliland D.G. Core-binding factors in haematopoiesis and leukaemia. Nat Rev Cancer 2002, 2:502-513.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 502-513
-
-
Speck, N.A.1
Gilliland, D.G.2
-
21
-
-
1642351580
-
Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression
-
Lorsbach R.B., Moore J., Ang S.O., Sun W., Lenny N., Downing J.R. Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression. Blood 2004, 103:2522-2529.
-
(2004)
Blood
, vol.103
, pp. 2522-2529
-
-
Lorsbach, R.B.1
Moore, J.2
Ang, S.O.3
Sun, W.4
Lenny, N.5
Downing, J.R.6
-
22
-
-
15244342946
-
Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes
-
Sato T., Ohno S., Hayashi T., Sato C., Kohu K., Satake M., et al. Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes. Immunity 2005, 22:317-328.
-
(2005)
Immunity
, vol.22
, pp. 317-328
-
-
Sato, T.1
Ohno, S.2
Hayashi, T.3
Sato, C.4
Kohu, K.5
Satake, M.6
-
23
-
-
34547744867
-
The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
-
Egawa T., Tillman R.E., Naoe Y., Taniuchi I., Littman D.R. The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med 2007, 204:1945-1957.
-
(2007)
J Exp Med
, vol.204
, pp. 1945-1957
-
-
Egawa, T.1
Tillman, R.E.2
Naoe, Y.3
Taniuchi, I.4
Littman, D.R.5
-
24
-
-
18744398397
-
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
-
Taniuchi I., Osato M., Egawa T., Sunshine M.J., Bae S.C., Komori T., et al. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 2002, 111:621-633.
-
(2002)
Cell
, vol.111
, pp. 621-633
-
-
Taniuchi, I.1
Osato, M.2
Egawa, T.3
Sunshine, M.J.4
Bae, S.C.5
Komori, T.6
-
25
-
-
0038610795
-
Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis
-
Woolf E., Xiao C., Fainaru O., Lotem J., Rosen D., Negreanu V., et al. Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis. Proc Natl Acad Sci USA 2003, 100:7731-7736.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 7731-7736
-
-
Woolf, E.1
Xiao, C.2
Fainaru, O.3
Lotem, J.4
Rosen, D.5
Negreanu, V.6
-
26
-
-
1542377327
-
Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo
-
Liu X., Bosselut R. Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo. Nat Immunol 2004, 5:280-288.
-
(2004)
Nat Immunol
, vol.5
, pp. 280-288
-
-
Liu, X.1
Bosselut, R.2
-
27
-
-
38949185052
-
Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development
-
Setoguchi R., Tachibana M., Naoe Y., Muroi S., Akiyama K., Tezuka C., et al. Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science 2008, 319:822-825.
-
(2008)
Science
, vol.319
, pp. 822-825
-
-
Setoguchi, R.1
Tachibana, M.2
Naoe, Y.3
Muroi, S.4
Akiyama, K.5
Tezuka, C.6
-
28
-
-
60549090859
-
Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs
-
Cruz-Guilloty F., Pipkin M.E., Djuretic I.M., Levanon D., Lotem J., Lichtenheld M.G., et al. Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs. J Exp Med 2009, 206:51-59.
-
(2009)
J Exp Med
, vol.206
, pp. 51-59
-
-
Cruz-Guilloty, F.1
Pipkin, M.E.2
Djuretic, I.M.3
Levanon, D.4
Lotem, J.5
Lichtenheld, M.G.6
-
29
-
-
0028242609
-
A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development
-
Sawada S., Scarborough J.D., Killeen N., Littman D.R. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 1994, 77:917-929.
-
(1994)
Cell
, vol.77
, pp. 917-929
-
-
Sawada, S.1
Scarborough, J.D.2
Killeen, N.3
Littman, D.R.4
-
30
-
-
0036864610
-
Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation
-
Taniuchi I., Sunshine M.J., Festenstein R., Littman D.R. Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation. Mol Cell 2002, 10:1083-1096.
-
(2002)
Mol Cell
, vol.10
, pp. 1083-1096
-
-
Taniuchi, I.1
Sunshine, M.J.2
Festenstein, R.3
Littman, D.R.4
-
31
-
-
40249095991
-
CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus
-
He X., Park K., Wang H., He X., Zhang Y., Hua X., et al. CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus. Immunity 2008, 28:346-358.
-
(2008)
Immunity
, vol.28
, pp. 346-358
-
-
He, X.1
Park, K.2
Wang, H.3
He, X.4
Zhang, Y.5
Hua, X.6
-
32
-
-
73049167504
-
Teleonomic mechanisms in cellular metabolism, growth, and differentiation
-
Monod J., Jacob F. Teleonomic mechanisms in cellular metabolism, growth, and differentiation. Cold Spring Harb Symp Quant Biol 1961, 26:389-401.
-
(1961)
Cold Spring Harb Symp Quant Biol
, vol.26
, pp. 389-401
-
-
Monod, J.1
Jacob, F.2
-
33
-
-
0036532226
-
Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability
-
Ferrell J.E.J. Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr Opin Cell Biol 2002, 14:140-148.
-
(2002)
Curr Opin Cell Biol
, vol.14
, pp. 140-148
-
-
Ferrell, J.E.J.1
-
34
-
-
22544451206
-
Runx3 regulates integrin {alpha}E/CD103 and CD4 expression during development of CD4-/CD8+ T cells
-
Grueter B., Petter M., Egawa T., Laule-Kilian K., Aldrian C.J., Wuerch A., et al. Runx3 regulates integrin {alpha}E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. J Immunol 2005, 175:1694-1705.
-
(2005)
J Immunol
, vol.175
, pp. 1694-1705
-
-
Grueter, B.1
Petter, M.2
Egawa, T.3
Laule-Kilian, K.4
Aldrian, C.J.5
Wuerch, A.6
-
35
-
-
77951284245
-
The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes
-
Sakaguchi S., Hombauer M., Bilic I., Naoe Y., Schebesta A., Taniuchi I., et al. The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes. Nat Immunol 2010, 11:442-448.
-
(2010)
Nat Immunol
, vol.11
, pp. 442-448
-
-
Sakaguchi, S.1
Hombauer, M.2
Bilic, I.3
Naoe, Y.4
Schebesta, A.5
Taniuchi, I.6
-
36
-
-
77950484789
-
Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells
-
Chong M.M., Simpson N., Ciofani M., Chen G., Collins A., Littman D.R. Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. Genes Dev 2010, 24:659-669.
-
(2010)
Genes Dev
, vol.24
, pp. 659-669
-
-
Chong, M.M.1
Simpson, N.2
Ciofani, M.3
Chen, G.4
Collins, A.5
Littman, D.R.6
-
37
-
-
0035190986
-
Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage
-
Zou Y.R., Sunshine M.J., Taniuchi I., Hatam F., Killeen N., Littman D.R. Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage. Nat Genet 2001, 29:332-336.
-
(2001)
Nat Genet
, vol.29
, pp. 332-336
-
-
Zou, Y.R.1
Sunshine, M.J.2
Taniuchi, I.3
Hatam, F.4
Killeen, N.5
Littman, D.R.6
-
38
-
-
0035202314
-
Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment
-
Leung R.K., Thomson K., Gallimore A., Jones E., Van dBM, Sierro S., et al. Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment. Nat Immunol 2001, 2:1167-1173.
-
(2001)
Nat Immunol
, vol.2
, pp. 1167-1173
-
-
Leung, R.K.1
Thomson, K.2
Gallimore, A.3
Jones, E.4
Van, D.B.M.5
Sierro, S.6
-
39
-
-
2442688211
-
The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell development
-
Taniuchi I., Ellmeier W., Littman D.R. The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell development. Adv Immunol 2004, 83:55-89.
-
(2004)
Adv Immunol
, vol.83
, pp. 55-89
-
-
Taniuchi, I.1
Ellmeier, W.2
Littman, D.R.3
-
40
-
-
38949192274
-
The transcription factor zbtb7b promotes CD4 expression by antagonizing runx-mediated activation of the CD4 silencer
-
Wildt K.F., Sun G., Grueter B., Fischer M., Zamisch M., Ehlers M., et al. The transcription factor zbtb7b promotes CD4 expression by antagonizing runx-mediated activation of the CD4 silencer. J Immunol 2007, 179:4405-4414.
-
(2007)
J Immunol
, vol.179
, pp. 4405-4414
-
-
Wildt, K.F.1
Sun, G.2
Grueter, B.3
Fischer, M.4
Zamisch, M.5
Ehlers, M.6
-
41
-
-
70449730937
-
ThPOK derepression is required for robust CD8 T cell responses to viral infection
-
Setoguchi R., Taniuchi I., Bevan M.J. ThPOK derepression is required for robust CD8 T cell responses to viral infection. J Immunol 2009, 183:4467-4474.
-
(2009)
J Immunol
, vol.183
, pp. 4467-4474
-
-
Setoguchi, R.1
Taniuchi, I.2
Bevan, M.J.3
-
42
-
-
77956479293
-
The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4(+) NKT cells
-
Wang L., Carr T., Xiong Y., Wildt K.F., Zhu J., Feigenbaum L., et al. The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4(+) NKT cells. Eur J Immunol 2010, 40:2385-2390.
-
(2010)
Eur J Immunol
, vol.40
, pp. 2385-2390
-
-
Wang, L.1
Carr, T.2
Xiong, Y.3
Wildt, K.F.4
Zhu, J.5
Feigenbaum, L.6
-
43
-
-
10644253554
-
Centromeric repositioning of coreceptor loci predicts their stable silencing and the CD4/CD8 lineage choice
-
Merkenschlager M., Amoils S., Roldan E., Rahemtulla A., O'connor E., Fisher A.G., et al. Centromeric repositioning of coreceptor loci predicts their stable silencing and the CD4/CD8 lineage choice. J Exp Med 2004, 200:1437-1444.
-
(2004)
J Exp Med
, vol.200
, pp. 1437-1444
-
-
Merkenschlager, M.1
Amoils, S.2
Roldan, E.3
Rahemtulla, A.4
O'connor, E.5
Fisher, A.G.6
-
44
-
-
10644289346
-
Dynamic repositioning of CD4 and CD8 genes during T cell development
-
Delaire S., Huang Y.H., Chan S.W., Robey E.A. Dynamic repositioning of CD4 and CD8 genes during T cell development. J Exp Med 2004, 200:1427-1435.
-
(2004)
J Exp Med
, vol.200
, pp. 1427-1435
-
-
Delaire, S.1
Huang, Y.H.2
Chan, S.W.3
Robey, E.A.4
-
45
-
-
14244260068
-
DNA methylation and the expanding epigenetics of T cell lineage commitment
-
Wilson C.B., Makar K.W., Shnyreva M., Fitzpatrick D.R. DNA methylation and the expanding epigenetics of T cell lineage commitment. Semin Immunol 2005, 17:105-119.
-
(2005)
Semin Immunol
, vol.17
, pp. 105-119
-
-
Wilson, C.B.1
Makar, K.W.2
Shnyreva, M.3
Fitzpatrick, D.R.4
-
46
-
-
34249026300
-
High-resolution profiling of histone methylations in the human genome
-
Barski A., Cuddapah S., Cui K., Roh T.Y., Schones D.E., Wang Z., et al. High-resolution profiling of histone methylations in the human genome. Cell 2007, 129:823-837.
-
(2007)
Cell
, vol.129
, pp. 823-837
-
-
Barski, A.1
Cuddapah, S.2
Cui, K.3
Roh, T.Y.4
Schones, D.E.5
Wang, Z.6
-
47
-
-
58849092225
-
Epigenetic control of T-helper-cell differentiation
-
Wilson C.B., Rowell E., Sekimata M. Epigenetic control of T-helper-cell differentiation. Nat Rev Immunol 2009, 9:91-105.
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 91-105
-
-
Wilson, C.B.1
Rowell, E.2
Sekimata, M.3
-
48
-
-
41649119809
-
Nucleoprotein structure of the CD4 locus: implications for the mechanisms underlying CD4 regulation during T cell development
-
Yu M., Wan M., Zhang J., Wu J., Khatri R., Chi T. Nucleoprotein structure of the CD4 locus: implications for the mechanisms underlying CD4 regulation during T cell development. Proc Natl Acad Sci USA 2008, 105:3873-3878.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 3873-3878
-
-
Yu, M.1
Wan, M.2
Zhang, J.3
Wu, J.4
Khatri, R.5
Chi, T.6
-
49
-
-
77952300549
-
Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function
-
Lehnertz B., Northrop J.P., Antignano F., Burrows K., Hadidi S., Mullaly S.C., et al. Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function. J Exp Med 2010, 207:915-922.
-
(2010)
J Exp Med
, vol.207
, pp. 915-922
-
-
Lehnertz, B.1
Northrop, J.P.2
Antignano, F.3
Burrows, K.4
Hadidi, S.5
Mullaly, S.C.6
-
50
-
-
47949091985
-
Functional analysis of histone methyltransferase g9a in B and T lymphocytes
-
Thomas L.R., Miyashita H., Cobb R.M., Pierce S., Tachibana M., Hobeika E., et al. Functional analysis of histone methyltransferase g9a in B and T lymphocytes. J Immunol 2008, 181:485-493.
-
(2008)
J Immunol
, vol.181
, pp. 485-493
-
-
Thomas, L.R.1
Miyashita, H.2
Cobb, R.M.3
Pierce, S.4
Tachibana, M.5
Hobeika, E.6
-
51
-
-
21044451441
-
Polycomb group protein ezh2 controls actin polymerization and cell signaling
-
Su I.H., Dobenecker M.W., Dickinson E., Oser M., Basavaraj A., Marqueron R., et al. Polycomb group protein ezh2 controls actin polymerization and cell signaling. Cell 2005, 121:425-436.
-
(2005)
Cell
, vol.121
, pp. 425-436
-
-
Su, I.H.1
Dobenecker, M.W.2
Dickinson, E.3
Oser, M.4
Basavaraj, A.5
Marqueron, R.6
-
52
-
-
55949132133
-
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
-
Margueron R., Li G., Sarma K., Blais A., Zavadil J., Woodcock C.L., et al. Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell 2008, 32:503-518.
-
(2008)
Mol Cell
, vol.32
, pp. 503-518
-
-
Margueron, R.1
Li, G.2
Sarma, K.3
Blais, A.4
Zavadil, J.5
Woodcock, C.L.6
-
53
-
-
55949124844
-
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency
-
Shen X., Liu Y., Hsu Y.J., Fujiwara Y., Kim J., Mao X., et al. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell 2008, 32:491-502.
-
(2008)
Mol Cell
, vol.32
, pp. 491-502
-
-
Shen, X.1
Liu, Y.2
Hsu, Y.J.3
Fujiwara, Y.4
Kim, J.5
Mao, X.6
-
54
-
-
77953747413
-
Tools and landscapes of epigenetics
-
Tarakhovsky A. Tools and landscapes of epigenetics. Nat Immunol 2010, 11:565-568.
-
(2010)
Nat Immunol
, vol.11
, pp. 565-568
-
-
Tarakhovsky, A.1
-
55
-
-
18244365863
-
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival
-
Lee P.P., Fitzpatrick D.R., Beard C., Jessup H.K., Lehar S., Makar K.W., et al. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 2001, 15:763-774.
-
(2001)
Immunity
, vol.15
, pp. 763-774
-
-
Lee, P.P.1
Fitzpatrick, D.R.2
Beard, C.3
Jessup, H.K.4
Lehar, S.5
Makar, K.W.6
-
56
-
-
0346752253
-
Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells
-
Makar K.W., Perez-Melgosa M., Shnyreva M., Weaver W.M., Fitzpatrick D.R., Wilson C.B. Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells. Nat Immunol 2003, 4:1183-1190.
-
(2003)
Nat Immunol
, vol.4
, pp. 1183-1190
-
-
Makar, K.W.1
Perez-Melgosa, M.2
Shnyreva, M.3
Weaver, W.M.4
Fitzpatrick, D.R.5
Wilson, C.B.6
-
57
-
-
0242410712
-
Control of effector CD8+ T cell function by the transcription factor Eomesodermin
-
Pearce E.L., Mullen A.C., Martins G.A., Krawczyk C.M., Hutchins A.S., Zediak V.P., et al. Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science 2003, 302:1041-1043.
-
(2003)
Science
, vol.302
, pp. 1041-1043
-
-
Pearce, E.L.1
Mullen, A.C.2
Martins, G.A.3
Krawczyk, C.M.4
Hutchins, A.S.5
Zediak, V.P.6
-
58
-
-
30044440799
-
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
-
Intlekofer A.M., Takemoto N., Wherry E.J., Longworth S.A., Northrup J.T., Palanivel V.R., et al. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol 2005, 6:1236-1244.
-
(2005)
Nat Immunol
, vol.6
, pp. 1236-1244
-
-
Intlekofer, A.M.1
Takemoto, N.2
Wherry, E.J.3
Longworth, S.A.4
Northrup, J.T.5
Palanivel, V.R.6
-
59
-
-
47749141467
-
Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin
-
Intlekofer A.M., Banerjee A., Takemoto N., Gordon S.M., Dejong C.S., Shin H., et al. Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science 2008, 321:408-411.
-
(2008)
Science
, vol.321
, pp. 408-411
-
-
Intlekofer, A.M.1
Banerjee, A.2
Takemoto, N.3
Gordon, S.M.4
Dejong, C.S.5
Shin, H.6
-
60
-
-
33846489173
-
Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells
-
Djuretic I.M., Levanon D., Negreanu V., Groner Y., Rao A., Ansel K.M. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol 2007, 8:145-153.
-
(2007)
Nat Immunol
, vol.8
, pp. 145-153
-
-
Djuretic, I.M.1
Levanon, D.2
Negreanu, V.3
Groner, Y.4
Rao, A.5
Ansel, K.M.6
-
61
-
-
34547727747
-
Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer
-
Naoe Y., Setoguchi R., Akiyama K., Muroi S., Kuroda M., Hatam F., et al. Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med 2007, 204:1749-1755.
-
(2007)
J Exp Med
, vol.204
, pp. 1749-1755
-
-
Naoe, Y.1
Setoguchi, R.2
Akiyama, K.3
Muroi, S.4
Kuroda, M.5
Hatam, F.6
-
62
-
-
1642357581
-
Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytes
-
Telfer J.C., Hedblom E.E., Anderson M.K., Laurent M.N., Rothenberg E.V. Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytes. J Immunol 2004, 172:4359-4370.
-
(2004)
J Immunol
, vol.172
, pp. 4359-4370
-
-
Telfer, J.C.1
Hedblom, E.E.2
Anderson, M.K.3
Laurent, M.N.4
Rothenberg, E.V.5
-
63
-
-
20044383185
-
Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage
-
Kohu K., Sato T., Ohno S., Hayashi K., Uchino R., Abe N., et al. Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage. J Immunol 2005, 174:2627-2636.
-
(2005)
J Immunol
, vol.174
, pp. 2627-2636
-
-
Kohu, K.1
Sato, T.2
Ohno, S.3
Hayashi, K.4
Uchino, R.5
Abe, N.6
-
64
-
-
33845655553
-
The role of BTB domain-containing zinc finger proteins in T cell development and function
-
Bilic I., Ellmeier W. The role of BTB domain-containing zinc finger proteins in T cell development and function. Immunol Lett 2007, 108:1-9.
-
(2007)
Immunol Lett
, vol.108
, pp. 1-9
-
-
Bilic, I.1
Ellmeier, W.2
-
65
-
-
0033598779
-
A transgenic mouse model to analyze CD8(+) effector T cell differentiation in vivo
-
Manjunath N., Shankar P., Stockton B., Dubey P.D., Lieberman J., von Andrian U.H. A transgenic mouse model to analyze CD8(+) effector T cell differentiation in vivo. Proc Natl Acad Sci USA 1999, 96:13932-13937.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 13932-13937
-
-
Manjunath, N.1
Shankar, P.2
Stockton, B.3
Dubey, P.D.4
Lieberman, J.5
von Andrian, U.H.6
-
66
-
-
77958114918
-
P300-mediated acetylation stabilizes the Th-inducing POK factor
-
Zhang M., Zhang J., Rui J., Liu X. p300-mediated acetylation stabilizes the Th-inducing POK factor. J Immunol 2010, 185:3960-3969.
-
(2010)
J Immunol
, vol.185
, pp. 3960-3969
-
-
Zhang, M.1
Zhang, J.2
Rui, J.3
Liu, X.4
-
67
-
-
0030725991
-
A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice
-
Hostert A., Tolaini M., Roderick K., Harker N., Norton T., Kioussis D. A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice. Immunity 1997, 7:525-536.
-
(1997)
Immunity
, vol.7
, pp. 525-536
-
-
Hostert, A.1
Tolaini, M.2
Roderick, K.3
Harker, N.4
Norton, T.5
Kioussis, D.6
-
68
-
-
0030670312
-
An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells
-
Ellmeier W., Sunshine M.J., Losos K., Hatam F., Littman D.R. An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells. Immunity 1997, 7:537-547.
-
(1997)
Immunity
, vol.7
, pp. 537-547
-
-
Ellmeier, W.1
Sunshine, M.J.2
Losos, K.3
Hatam, F.4
Littman, D.R.5
-
69
-
-
0038195719
-
Molecular mechanisms regulating Th1 immune responses
-
Szabo S.J., Sullivan B.M., Peng S.L., Glimcher L.H. Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol 2003, 21:713-758.
-
(2003)
Annu Rev Immunol
, vol.21
, pp. 713-758
-
-
Szabo, S.J.1
Sullivan, B.M.2
Peng, S.L.3
Glimcher, L.H.4
-
70
-
-
0037059462
-
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
-
Szabo S.J., Sullivan B.M., Stemmann C., Satoskar A.R., Sleckman B.P., Glimcher L.H. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 2002, 295:338-342.
-
(2002)
Science
, vol.295
, pp. 338-342
-
-
Szabo, S.J.1
Sullivan, B.M.2
Stemmann, C.3
Satoskar, A.R.4
Sleckman, B.P.5
Glimcher, L.H.6
-
71
-
-
77951920474
-
The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma
-
Yagi R., Junttila I.S., Wei G., Urban J.F.J., Zhao K., Paul W.E., et al. The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity 2010, 32:507-517.
-
(2010)
Immunity
, vol.32
, pp. 507-517
-
-
Yagi, R.1
Junttila, I.S.2
Wei, G.3
Urban, J.F.J.4
Zhao, K.5
Paul, W.E.6
-
72
-
-
77958587958
-
The intrathymic crossroads of T and NK cell differentiation
-
Klein Wolterink R.G., Garcia-Ojeda M.E., Vosshenrich C.A., Hendriks R.W., Di Santo J.P. The intrathymic crossroads of T and NK cell differentiation. Immunol Rev 2010, 238:126-137.
-
(2010)
Immunol Rev
, vol.238
, pp. 126-137
-
-
Klein Wolterink, R.G.1
Garcia-Ojeda, M.E.2
Vosshenrich, C.A.3
Hendriks, R.W.4
Di Santo, J.P.5
-
73
-
-
77954321988
-
An essential developmental checkpoint for production of the T cell lineage
-
Ikawa T., Hirose S., Masuda K., Kakugawa K., Satoh R., Shibano-Satoh A., et al. An essential developmental checkpoint for production of the T cell lineage. Science 2010, 329:93-96.
-
(2010)
Science
, vol.329
, pp. 93-96
-
-
Ikawa, T.1
Hirose, S.2
Masuda, K.3
Kakugawa, K.4
Satoh, R.5
Shibano-Satoh, A.6
-
74
-
-
77954329976
-
An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b
-
Li L., Leid M., Rothenberg E.V. An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b. Science 2010, 329:89-93.
-
(2010)
Science
, vol.329
, pp. 89-93
-
-
Li, L.1
Leid, M.2
Rothenberg, E.V.3
-
75
-
-
77954326626
-
Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion
-
Li P., Burke S., Wang J., Chen X., Ortiz M., Lee S.C., et al. Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion. Science 2010, 329:85-89.
-
(2010)
Science
, vol.329
, pp. 85-89
-
-
Li, P.1
Burke, S.2
Wang, J.3
Chen, X.4
Ortiz, M.5
Lee, S.C.6
-
76
-
-
79952921526
-
Control of the development of CD8alphaalpha+ intestinal intraepithelial lymphocytes by TGF-beta
-
Konkel J.E., Maruyama T., Carpenter A.C., Xiong Y., Zamarron B.F., Hall B.E., et al. Control of the development of CD8alphaalpha+ intestinal intraepithelial lymphocytes by TGF-beta. Nat Immunol 2011, 12:312-319.
-
(2011)
Nat Immunol
, vol.12
, pp. 312-319
-
-
Konkel, J.E.1
Maruyama, T.2
Carpenter, A.C.3
Xiong, Y.4
Zamarron, B.F.5
Hall, B.E.6
-
77
-
-
58149214356
-
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
-
Wei G., Wei L., Zhu J., Zang C., Hu-Li J., Yao Z., et al. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 2009, 30:155-167.
-
(2009)
Immunity
, vol.30
, pp. 155-167
-
-
Wei, G.1
Wei, L.2
Zhu, J.3
Zang, C.4
Hu-Li, J.5
Yao, Z.6
-
78
-
-
70350754328
-
Jmjd3 contributes to the control of gene expression in LPS-activated macrophages
-
De Santa F., Narang V., Yap Z.H., Tusi B.K., Burgold T., Austenaa L., et al. Jmjd3 contributes to the control of gene expression in LPS-activated macrophages. EMBO J 2009, 28:3341-3352.
-
(2009)
EMBO J
, vol.28
, pp. 3341-3352
-
-
De Santa, F.1
Narang, V.2
Yap, Z.H.3
Tusi, B.K.4
Burgold, T.5
Austenaa, L.6
-
79
-
-
66149135288
-
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS
-
Barradas M., Anderton E., Acosta J.C., Li S., Banito A., Rodriguez-Niedenfuhr M., et al. Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev 2009, 23:1177-1182.
-
(2009)
Genes Dev
, vol.23
, pp. 1177-1182
-
-
Barradas, M.1
Anderton, E.2
Acosta, J.C.3
Li, S.4
Banito, A.5
Rodriguez-Niedenfuhr, M.6
-
80
-
-
44649163849
-
Mechanisms involved in the regulation of histone lysine demethylases
-
Lan F., Nottke A.C., Shi Y. Mechanisms involved in the regulation of histone lysine demethylases. Curr Opin Cell Biol 2008, 20:316-325.
-
(2008)
Curr Opin Cell Biol
, vol.20
, pp. 316-325
-
-
Lan, F.1
Nottke, A.C.2
Shi, Y.3
-
81
-
-
77958610119
-
Molecular mechanisms by which T-bet regulates T-helper cell commitment
-
Miller S.A., Weinmann A.S. Molecular mechanisms by which T-bet regulates T-helper cell commitment. Immunol Rev 2010, 238:233-246.
-
(2010)
Immunol Rev
, vol.238
, pp. 233-246
-
-
Miller, S.A.1
Weinmann, A.S.2
-
82
-
-
77956954197
-
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
-
Satoh T., Takeuchi O., Vandenbon A., Yasuda K., Tanaka Y., Kumagai Y., et al. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol 2010, 11:936-944.
-
(2010)
Nat Immunol
, vol.11
, pp. 936-944
-
-
Satoh, T.1
Takeuchi, O.2
Vandenbon, A.3
Yasuda, K.4
Tanaka, Y.5
Kumagai, Y.6
-
83
-
-
33748926082
-
RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription
-
Reed-Inderbitzin E., Moreno-Miralles I., Vanden-Eynden S.K., Xie J., Lutterbach B., Durst-Goodwin K.L., et al. RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription. Oncogene 2006, 25:5777-5786.
-
(2006)
Oncogene
, vol.25
, pp. 5777-5786
-
-
Reed-Inderbitzin, E.1
Moreno-Miralles, I.2
Vanden-Eynden, S.K.3
Xie, J.4
Lutterbach, B.5
Durst-Goodwin, K.L.6
-
84
-
-
77952236323
-
RNAi-dependent formation of heterochromatin and its diverse functions
-
Grewal S.I. RNAi-dependent formation of heterochromatin and its diverse functions. Curr Opin Genet Dev 2010, 20:134-141.
-
(2010)
Curr Opin Genet Dev
, vol.20
, pp. 134-141
-
-
Grewal, S.I.1
-
85
-
-
67649671961
-
Long noncoding RNAs: functional surprises from the RNA world
-
Wilusz J.E., Sunwoo H., Spector D.L. Long noncoding RNAs: functional surprises from the RNA world. Genes Dev 2009, 23:1494-1504.
-
(2009)
Genes Dev
, vol.23
, pp. 1494-1504
-
-
Wilusz, J.E.1
Sunwoo, H.2
Spector, D.L.3
-
86
-
-
78649339069
-
Long noncoding RNA in genome regulation: prospects and mechanisms
-
Hung T., Chang H.Y. Long noncoding RNA in genome regulation: prospects and mechanisms. RNA Biol 2010, 7.
-
(2010)
RNA Biol
, vol.7
-
-
Hung, T.1
Chang, H.Y.2
-
87
-
-
77954572735
-
Long noncoding RNA as modular scaffold of histone modification complexes
-
Tsai M.C, Manor O., Wan Y., Mosammaparast N., Wang J.K., Lan F., et al. Long noncoding RNA as modular scaffold of histone modification complexes. Science 2010, 329:689-693.
-
(2010)
Science
, vol.329
, pp. 689-693
-
-
Tsai, M.C.1
Manor, O.2
Wan, Y.3
Mosammaparast, N.4
Wang, J.K.5
Lan, F.6
-
88
-
-
77951118936
-
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
-
Gupta R.A., Shah N., Wang K.C., Kim J., Horlings H.M., Wong D.J., et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010, 464:1071-1076.
-
(2010)
Nature
, vol.464
, pp. 1071-1076
-
-
Gupta, R.A.1
Shah, N.2
Wang, K.C.3
Kim, J.4
Horlings, H.M.5
Wong, D.J.6
-
89
-
-
38049155825
-
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
-
Yu W., Gius D., Onyango P., Muldoon-Jacobs K., Karp J., Feinberg A.P., et al. Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature 2008, 451:202-206.
-
(2008)
Nature
, vol.451
, pp. 202-206
-
-
Yu, W.1
Gius, D.2
Onyango, P.3
Muldoon-Jacobs, K.4
Karp, J.5
Feinberg, A.P.6
-
90
-
-
37549010335
-
Launching the T-cell-lineage developmental programme
-
Rothenberg E.V., Moore J.E., Yui M.A. Launching the T-cell-lineage developmental programme. Nat Rev Immunol 2008, 8:9-21.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 9-21
-
-
Rothenberg, E.V.1
Moore, J.E.2
Yui, M.A.3
-
91
-
-
65249096624
-
Untangling the T branch of the hematopoiesis tree
-
Chi A.W., Bell J.J., Zlotoff D.A., Bhandoola A. Untangling the T branch of the hematopoiesis tree. Curr Opin Immunol 2009, 21:121-126.
-
(2009)
Curr Opin Immunol
, vol.21
, pp. 121-126
-
-
Chi, A.W.1
Bell, J.J.2
Zlotoff, D.A.3
Bhandoola, A.4
-
92
-
-
61449184521
-
Cutting edge: phenotypic characterization and differentiation of human CD8+ T cells producing IL-17
-
Kondo T., Takata H., Matsuki F., Takiguchi M. Cutting edge: phenotypic characterization and differentiation of human CD8+ T cells producing IL-17. J Immunol 2009, 182:1794-1798.
-
(2009)
J Immunol
, vol.182
, pp. 1794-1798
-
-
Kondo, T.1
Takata, H.2
Matsuki, F.3
Takiguchi, M.4
-
93
-
-
73349101421
-
Tc17 CD8 T cells: functional plasticity and subset diversity
-
Yen H.R., Harris T.J., Wada S., Grosso J.F., Getnet D., Goldberg M.V., et al. Tc17 CD8 T cells: functional plasticity and subset diversity. J Immunol 2009, 183:7161-7168.
-
(2009)
J Immunol
, vol.183
, pp. 7161-7168
-
-
Yen, H.R.1
Harris, T.J.2
Wada, S.3
Grosso, J.F.4
Getnet, D.5
Goldberg, M.V.6
-
94
-
-
68949143060
-
IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferons
-
Curtis M.M., Way S.S., Wilson C.B. IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferons. J Immunol 2009, 183:381-387.
-
(2009)
J Immunol
, vol.183
, pp. 381-387
-
-
Curtis, M.M.1
Way, S.S.2
Wilson, C.B.3
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