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Volumn 12, Issue 8, 2011, Pages 526-541

Immunogenetic mechanisms leading to thyroid autoimmunity: Recent advances in identifying susceptibility genes and regions

Author keywords

Association; Autoimmune thyroid disease; Genes; Graves' disease

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HLA ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; THYROTROPIN RECEPTOR;

EID: 82155203114     PISSN: 13892029     EISSN: 18755488     Source Type: Journal    
DOI: 10.2174/138920211798120790     Document Type: Article
Times cited : (14)

References (169)
  • 1
    • 0029982537 scopus 로고    scopus 로고
    • Genetic analysis of autoimmune disease
    • Vyse, T.J.; Todd, J.A. Genetic analysis of autoimmune disease. Cell, 1996, 85, 311-318.
    • (1996) Cell , vol.85 , pp. 311-318
    • Vyse, T.J.1    Todd, J.A.2
  • 2
    • 0031240055 scopus 로고    scopus 로고
    • Epidemiology and estimated population burden of selected autoimmune diseases in the United States
    • Jacobson, D.L.; Gange, S.J.; Rose, N.R.; Graham, N.M. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin. Immunol. Immunopathol., 1997, 84, 223-243.
    • (1997) Clin. Immunol. Immunopathol , vol.84 , pp. 223-243
    • Jacobson, D.L.1    Gange, S.J.2    Rose, N.R.3    Graham, N.M.4
  • 3
    • 0033851221 scopus 로고    scopus 로고
    • Autoimmune diseases: A leading cause of death among young and middle-aged women in the United States
    • Walsh, S.J.; Rau, L.M. Autoimmune diseases: a leading cause of death among young and middle-aged women in the United States. Am. J. Public Health, 2000, 90, 1463-1466.
    • (2000) Am. J. Public Health , vol.90 , pp. 1463-1466
    • Walsh, S.J.1    Rau, L.M.2
  • 5
    • 0031976429 scopus 로고    scopus 로고
    • Hyperthyroidism. Current treatment guidelines
    • Gittoes, N.J.; Franklyn, J.A. Hyperthyroidism. Current treatment guidelines. Drugs, 1998, 55, 543-553.
    • (1998) Drugs , vol.55 , pp. 543-553
    • Gittoes, N.J.1    Franklyn, J.A.2
  • 8
    • 0035095887 scopus 로고    scopus 로고
    • Evidence for a major role of heredity in Graves' disease: A population-based study of two Danish twin cohorts
    • Brix, T.H.; Kyvik, K.O.; Christensen, K.; Hegedus, L. Evidence for a major role of heredity in Graves' disease: a population-based study of two Danish twin cohorts. J. Clin. Endocrinol. Metab., 2001, 86, 930-934.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 930-934
    • Brix, T.H.1    Kyvik, K.O.2    Christensen, K.3    Hegedus, L.4
  • 10
    • 33947274768 scopus 로고    scopus 로고
    • Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs
    • Brand, O.J.; Lowe, C.E.; Heward, J.M.; Franklyn, J.A.; Cooper, J.D.; Todd, J.A.; Gough, S.C. Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs. Clin. Endocrinol. (Oxf), 2007, 66, 508-512.
    • (2007) Clin. Endocrinol. (Oxf) , vol.66 , pp. 508-512
    • Brand, O.J.1    Lowe, C.E.2    Heward, J.M.3    Franklyn, J.A.4    Cooper, J.D.5    Todd, J.A.6    Gough, S.C.7
  • 15
    • 0029022917 scopus 로고
    • Genetic analysis of type 1 diabetes using whole genome approaches
    • Todd, J.A. Genetic analysis of type 1 diabetes using whole genome approaches. Proc. Natl. Acad. Sci. U S A, 1995, 92, 8560-8565.
    • (1995) Proc. Natl. Acad. Sci. U S A , vol.92 , pp. 8560-8565
    • Todd, J.A.1
  • 16
    • 0033304849 scopus 로고    scopus 로고
    • Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: Evidence for genetic heterogeneity and gene interactions
    • Tomer, Y.; Barbesino, G.; Greenberg, D.A.; Concepcion, E.; Davies, T.F. Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: evidence for genetic heterogeneity and gene interactions. J. Clin. Endocrinol. Metab., 1999, 84, 4656-4664.
    • (1999) J. Clin. Endocrinol. Metab , vol.84 , pp. 4656-4664
    • Tomer, Y.1    Barbesino, G.2    Greenberg, D.A.3    Concepcion, E.4    Davies, T.F.5
  • 17
    • 0142059659 scopus 로고    scopus 로고
    • Common and unique susceptibility loci in Graves and Hashimoto diseases: Results of whole-genome screening in a data set of 102 multiplex families
    • Tomer, Y.; Ban, Y.; Concepcion, E.; Barbesino, G.; Villanueva, R.; Greenberg, D.A.; Davies, T.F. Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families. Am. J. Hum. Genet., 2003, 73, 736-747.
    • (2003) Am. J. Hum. Genet , vol.73 , pp. 736-747
    • Tomer, Y.1    Ban, Y.2    Concepcion, E.3    Barbesino, G.4    Villanueva, R.5    Greenberg, D.A.6    Davies, T.F.7
  • 19
    • 0035875097 scopus 로고    scopus 로고
    • Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23- q24 by multipoint affected sib-pair linkage analysis in Japanese
    • Sakai, K.; Shirasawa, S.; Ishikawa, N.; Ito, K.; Tamai, H.; Kuma, K.; Akamizu, T.; Tanimura, M.; Furugaki, K.; Yamamoto, K.; Sasazuki, T. Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23- q24 by multipoint affected sib-pair linkage analysis in Japanese. Hum. Mol. Genet., 2001, 10, 1379-1386.
    • (2001) Hum. Mol. Genet , vol.10 , pp. 1379-1386
    • Sakai, K.1    Shirasawa, S.2    Ishikawa, N.3    Ito, K.4    Tamai, H.5    Kuma, K.6    Akamizu, T.7    Tanimura, M.8    Furugaki, K.9    Yamamoto, K.10    Sasazuki, T.11
  • 23
    • 0026032055 scopus 로고
    • Gene for non-insulindependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q
    • Bell, G.I.; Xiang, K.S.; Newman, M.V.; Wu, S.H.; Wright, L.G.; Fajans, S.S.; Spielman, R.S.; Cox, N.J. Gene for non-insulindependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q. Proc. Natl. Acad. Sci. U S A, 1991, 88, 1484-1488.
    • (1991) Proc. Natl. Acad. Sci. U S A , vol.88 , pp. 1484-1488
    • Bell, G.I.1    Xiang, K.S.2    Newman, M.V.3    Wu, S.H.4    Wright, L.G.5    Fajans, S.S.6    Spielman, R.S.7    Cox, N.J.8
  • 24
    • 0032452535 scopus 로고    scopus 로고
    • Linkage analysis of candidate genes in autoimmune thyroid disease. III. Detailed analysis of chromosome 14 localizes Graves' disease-1 (GD-1) close to multinodular goiter-1 (MNG-1)
    • International Consortium for the Genetics of Autoimmune Thyroid Disease
    • Tomer, Y.; Barbesino, G.; Greenberg, D.A.; Concepcion, E.; Davies, T.F. Linkage analysis of candidate genes in autoimmune thyroid disease. III. Detailed analysis of chromosome 14 localizes Graves' disease-1 (GD-1) close to multinodular goiter-1 (MNG-1). International Consortium for the Genetics of Autoimmune Thyroid Disease. J. Clin. Endocrinol. Metab., 1998, 83, 4321-4327.
    • (1998) J. Clin. Endocrinol. Metab , vol.83 , pp. 4321-4327
    • Tomer, Y.1    Barbesino, G.2    Greenberg, D.A.3    Concepcion, E.4    Davies, T.F.5
  • 25
    • 0029062430 scopus 로고
    • A polymorphism in the extracellular domain of the thyrotropin receptor is highly associated with autoimmune thyroid disease in females
    • Cuddihy, R.M.; Dutton, C.M.; Bahn, R.S. A polymorphism in the extracellular domain of the thyrotropin receptor is highly associated with autoimmune thyroid disease in females. Thyroid, 1995, 5, 89-95.
    • (1995) Thyroid , vol.5 , pp. 89-95
    • Cuddihy, R.M.1    Dutton, C.M.2    Bahn, R.S.3
  • 26
    • 0030952262 scopus 로고    scopus 로고
    • No association between a thyrotropin receptor gene polymorphism and Graves' disease in the female population
    • Kotsa, K.D.; Watson, P.F.; Weetman, A.P. No association between a thyrotropin receptor gene polymorphism and Graves' disease in the female population. Thyroid, 1997, 7, 31-33.
    • (1997) Thyroid , vol.7 , pp. 31-33
    • Kotsa, K.D.1    Watson, P.F.2    Weetman, A.P.3
  • 28
    • 15144361587 scopus 로고    scopus 로고
    • Linkage disequilibrium between the human leukocyte antigen class II region of the major histocompatibility complex and Graves' disease: Replication using a population case control and family-based study
    • Heward, J.M.; Allahabadia, A.; Daykin, J.; Carr-Smith, J.; Daly, A.; Armitage, M.; Dodson, P.M.; Sheppard, M.C.; Barnett, A.H.; Franklyn, J.A.; Gough, S.C. Linkage disequilibrium between the human leukocyte antigen class II region of the major histocompatibility complex and Graves' disease: replication using a population case control and family-based study. J. Clin. Endocrinol. Metab., 1998, 83, 3394-3397.
    • (1998) J. Clin. Endocrinol. Metab , vol.83 , pp. 3394-3397
    • Heward, J.M.1    Allahabadia, A.2    Daykin, J.3    Carr-Smith, J.4    Daly, A.5    Armitage, M.6    Dodson, P.M.7    Sheppard, M.C.8    Barnett, A.H.9    Franklyn, J.A.10    Gough, S.C.11
  • 29
    • 0033237644 scopus 로고    scopus 로고
    • HLA-DRB1*08, DRB1*03/DRB3*0101, and DRB3*0202 are susceptibility genes for Graves' disease in North American Caucasians, whereas DRB1*07 is protective
    • Chen, Q.Y.; Huang, W.; She, J.X.; Baxter, F.; Volpe, R.; Maclaren, N.K. HLA-DRB1*08, DRB1*03/DRB3*0101, and DRB3*0202 are susceptibility genes for Graves' disease in North American Caucasians, whereas DRB1* 07 is protective. J. Clin. Endocrinol. Metab., 1999, 84, 3182-3186.
    • (1999) J. Clin. Endocrinol. Metab , vol.84 , pp. 3182-3186
    • Chen, Q.Y.1    Huang, W.2    She, J.X.3    Baxter, F.4    Volpe, R.5    Maclaren, N.K.6
  • 31
  • 32
    • 0038807883 scopus 로고    scopus 로고
    • CTLA4 gene and Graves' disease: Association of Graves' disease with the CTLA4 exon 1 and intron 1 polymorphisms, but not with the promoter polymorphism
    • Vaidya, B.; Oakes, E.J.; Imrie, H.; Dickinson, A.J.; Perros, P.; Kendall-Taylor, P.; Pearce, S.H. CTLA4 gene and Graves' disease: association of Graves' disease with the CTLA4 exon 1 and intron 1 polymorphisms, but not with the promoter polymorphism. Clin Endocrinol (Oxf), 2003, 58, 732-735.
    • (2003) Clin Endocrinol (Oxf) , vol.58 , pp. 732-735
    • Vaidya, B.1    Oakes, E.J.2    Imrie, H.3    Dickinson, A.J.4    Perros, P.5    Kendall-Taylor, P.6    Pearce, S.H.7
  • 33
    • 0016806621 scopus 로고
    • HL-A system and diabetes mellitus
    • Cudworth, A.G.; Woodrow, J.C. HL-A system and diabetes mellitus. Diabetes, 1975, 24, 345-349.
    • (1975) Diabetes , vol.24 , pp. 345-349
    • Cudworth, A.G.1    Woodrow, J.C.2
  • 35
    • 0015883122 scopus 로고
    • Histocompatibility (HL-A) antigens, lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus
    • Singal, D.P.; Blajchman, M.A. Histocompatibility (HL-A) antigens, lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus. Diabetes, 1973, 22, 429-432.
    • (1973) Diabetes , vol.22 , pp. 429-432
    • Singal, D.P.1    Blajchman, M.A.2
  • 36
    • 0030043260 scopus 로고    scopus 로고
    • Lack of an independent association between the human leukocyte antigen allele DQA1*0501 and Graves' disease
    • Cuddihy, R.M.; Bahn, R.S. Lack of an independent association between the human leukocyte antigen allele DQA1*0501 and Graves' disease. J. Clin. Endocrinol. Metab., 1996, 81, 847-849.
    • (1996) J. Clin. Endocrinol. Metab , vol.81 , pp. 847-849
    • Cuddihy, R.M.1    Bahn, R.S.2
  • 37
    • 0027989666 scopus 로고
    • Combined segregation and linkage analysis of Graves disease with a thyroid autoantibody diathesis
    • Shields, D.C.; Ratanachaiyavong, S.; McGregor, A.M.; Collins, A.; Morton, N.E. Combined segregation and linkage analysis of Graves disease with a thyroid autoantibody diathesis. Am. J. Hum. Genet., 1994, 55, 540-554.
    • (1994) Am. J. Hum. Genet , vol.55 , pp. 540-554
    • Shields, D.C.1    Ratanachaiyavong, S.2    McGregor, A.M.3    Collins, A.4    Morton, N.E.5
  • 38
    • 0027315449 scopus 로고
    • Human histocompatibility leukocyte antigen-DQA1*0501 allele associated with genetic susceptibility to Graves' disease in a Caucasian population
    • Yanagawa, T.; Mangklabruks, A.; Chang, Y.B.; Okamoto, Y.; Fisfalen, M.E.; Curran, P.G.; DeGroot, L.J. Human histocompatibility leukocyte antigen-DQA1*0501 allele associated with genetic susceptibility to Graves' disease in a Caucasian population. J. Clin. Endocrinol. Metab., 1993, 76, 1569-1574.
    • (1993) J. Clin. Endocrinol. Metab , vol.76 , pp. 1569-1574
    • Yanagawa, T.1    Mangklabruks, A.2    Chang, Y.B.3    Okamoto, Y.4    Fisfalen, M.E.5    Curran, P.G.6    Degroot, L.J.7
  • 41
    • 0019197036 scopus 로고
    • Graves' disease and HLA: Clinical and epidemiologic associations
    • Farid, N.R.; Stone, E.; Johnson, G. Graves' disease and HLA: clinical and epidemiologic associations. Clin. Endocrinol. (Oxf), 1980, 13, 535-544.
    • (1980) Clin. Endocrinol. (Oxf) , vol.13 , pp. 535-544
    • Farid, N.R.1    Stone, E.2    Johnson, G.3
  • 45
    • 10044235010 scopus 로고    scopus 로고
    • Tag SNP selection for association studies
    • Stram, D.O. Tag SNP selection for association studies. Genet. Epidemiol., 2004, 27, 365-374.
    • (2004) Genet. Epidemiol , vol.27 , pp. 365-374
    • Stram, D.O.1
  • 46
    • 30344441392 scopus 로고    scopus 로고
    • A comparison of five methods for selecting tagging singlenucleotide polymorphisms
    • Burkett, K.M.; Ghadessi, M.; McNeney, B.; Graham, J.; Daley, D. A comparison of five methods for selecting tagging singlenucleotide polymorphisms. BMC Genet., 2005, 6 Suppl 1, S71.
    • (2005) BMC Genet , vol.6 , Issue.SUPPL. 1
    • Burkett, K.M.1    Ghadessi, M.2    McNeney, B.3    Graham, J.4    Daley, D.5
  • 49
    • 26844482093 scopus 로고    scopus 로고
    • A fine-scale map of recombination rates and hotspots across the human genome
    • Myers, S.; Bottolo, L.; Freeman, C.; McVean, G.; Donnelly, P. A fine-scale map of recombination rates and hotspots across the human genome. Science, 2005, 310, 321-324.
    • (2005) Science , vol.310 , pp. 321-324
    • Myers, S.1    Bottolo, L.2    Freeman, C.3    McVean, G.4    Donnelly, P.5
  • 52
    • 79955829952 scopus 로고    scopus 로고
    • The -112G > A polymorphism of the secretoglobin 3A2 (SCGB3A2) gene encoding uteroglobin-related protein 1 (UGRP1) increases risk for the development of Graves' disease in subsets of patients with elevated levels of immunoglobulin
    • Chistiakov, D.A.; Voronova, N.V.; Turakulov, R.I.; Savost'anov, K.V. The -112G > A polymorphism of the secretoglobin 3A2 (SCGB3A2) gene encoding uteroglobin-related protein 1 (UGRP1) increases risk for the development of Graves' disease in subsets of patients with elevated levels of immunoglobulin E. J. Appl. Genet., 2011, 52, 201-207.
    • (2011) E. J. Appl. Genet , vol.52 , pp. 201-207
    • Chistiakov, D.A.1    Voronova, N.V.2    Turakulov, R.I.3    Savost'anov, K.V.4
  • 54
  • 55
    • 77952883913 scopus 로고    scopus 로고
    • Genetics of thyroid autoimmunity and the role of the TSHR
    • Brand, O.J.; Gough, S.C. Genetics of thyroid autoimmunity and the role of the TSHR. Mol. Cell Endocrinol., 2010, 322, 135-143.
    • (2010) Mol. Cell Endocrinol , vol.322 , pp. 135-143
    • Brand, O.J.1    Gough, S.C.2
  • 59
    • 13444310498 scopus 로고    scopus 로고
    • Lack of association between IL-12B gene polymorphism and autoimmune thyroid disease in Japanese patients
    • Ikeda, Y.; Yoshida, W.; Noguchi, T.; Asaba, K.; Nishioka, T.; Takao, T.; Hashimoto, K. Lack of association between IL-12B gene polymorphism and autoimmune thyroid disease in Japanese patients. Endocr. J., 2004, 51, 609-613.
    • (2004) Endocr. J , vol.51 , pp. 609-613
    • Ikeda, Y.1    Yoshida, W.2    Noguchi, T.3    Asaba, K.4    Nishioka, T.5    Takao, T.6    Hashimoto, K.7
  • 60
    • 33845986371 scopus 로고    scopus 로고
    • Interleukin-12B gene polymorphism does not confer susceptibility to Graves' ophthalmopathy in Japanese population
    • Hiromatsu, Y.; Fukutani, T.; Ichimura, M.; Mukai, T.; Kaku, H.; Miyake, I.; Yamada, K. Interleukin-12B gene polymorphism does not confer susceptibility to Graves' ophthalmopathy in Japanese population. Endocr. J., 2006, 53, 753-759.
    • (2006) Endocr. J , vol.53 , pp. 753-759
    • Hiromatsu, Y.1    Fukutani, T.2    Ichimura, M.3    Mukai, T.4    Kaku, H.5    Miyake, I.6    Yamada, K.7
  • 61
    • 27944466084 scopus 로고    scopus 로고
    • Association study between the IL4, IL13, IRF1 and UGRP1 genes in chromosomal 5q31 region and Chinese Graves' disease
    • Yang, Y.; Lingling, S.; Ying, J.; Yushu, L.; Zhongyan, S.; Wei, H.; Weiping, T. Association study between the IL4, IL13, IRF1 and UGRP1 genes in chromosomal 5q31 region and Chinese Graves' disease. J. Hum. Genet., 2005, 50, 574-582.
    • (2005) J. Hum. Genet , vol.50 , pp. 574-582
    • Yang, Y.1    Lingling, S.2    Ying, J.3    Yushu, L.4    Zhongyan, S.5    Wei, H.6    Weiping, T.7
  • 62
    • 28844501756 scopus 로고    scopus 로고
    • IL-13 and chromosome 5q31-q33: Problems of identifying association within regions of linkage to Graves' disease
    • Simmonds, M.J.; Heward, J.M.; Franklyn, J.A.; Gough, S.C. IL-13 and chromosome 5q31-q33: problems of identifying association within regions of linkage to Graves' disease. Clin. Endocrinol. (Oxf), 2005, 63, 695-697.
    • (2005) Clin. Endocrinol. (Oxf) , vol.63 , pp. 695-697
    • Simmonds, M.J.1    Heward, J.M.2    Franklyn, J.A.3    Gough, S.C.4
  • 64
    • 64049089235 scopus 로고    scopus 로고
    • Polymorphisms in the ADRB2 gene and Graves disease: A case-control study and a metaanalysis of available evidence
    • Chu, X.; Dong, Y.; Shen, M.; Sun, L.; Dong, C.; Wang, Y.; Wang, B.; Zhang, K.; Hua, Q.; Xu, S.; Huang, W. Polymorphisms in the ADRB2 gene and Graves disease: a case-control study and a metaanalysis of available evidence. BMC Med. Genet., 2009, 10, 26.
    • (2009) BMC Med. Genet , vol.10 , pp. 26
    • Chu, X.1    Dong, Y.2    Shen, M.3    Sun, L.4    Dong, C.5    Wang, Y.6    Wang, B.7    Zhang, K.8    Hua, Q.9    Xu, S.10    Huang, W.11
  • 65
    • 77952411922 scopus 로고    scopus 로고
    • Confirmation of association of chromosome 5q31-33 with United Kingdom Caucasian Graves' disease
    • Simmonds, M.J.; Yesmin, K.; Newby, P.R.; Brand, O.J.; Franklyn, J.A.; Gough, S.C. Confirmation of association of chromosome 5q31-33 with United Kingdom Caucasian Graves' disease. Thyroid, 2010, 20, 413-417.
    • (2010) Thyroid , vol.20 , pp. 413-417
    • Simmonds, M.J.1    Yesmin, K.2    Newby, P.R.3    Brand, O.J.4    Franklyn, J.A.5    Gough, S.C.6
  • 67
    • 0033559313 scopus 로고    scopus 로고
    • Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp
    • Cohen, S.; Dadi, H.; Shaoul, E.; Sharfe, N.; Roifman, C.M. Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp. Blood, 1999, 93, 2013-2024.
    • (1999) Blood , vol.93 , pp. 2013-2024
    • Cohen, S.1    Dadi, H.2    Shaoul, E.3    Sharfe, N.4    Roifman, C.M.5
  • 74
    • 4544241811 scopus 로고    scopus 로고
    • Tolerance, not immunity, crucially depends on IL-2
    • Malek, T.R.; Bayer, A.L. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol, 2004, 4, 665-674.
    • (2004) Nat Rev Immunol , vol.4 , pp. 665-674
    • Malek, T.R.1    Bayer, A.L.2
  • 75
    • 0036011273 scopus 로고    scopus 로고
    • Generalized T2 test for genome association studies
    • Xiong, M.; Zhao, J.; Boerwinkle, E. Generalized T2 test for genome association studies. Am. J. Hum. Genet., 2002, 70, 1257-1268.
    • (2002) Am. J. Hum. Genet , vol.70 , pp. 1257-1268
    • Xiong, M.1    Zhao, J.2    Boerwinkle, E.3
  • 76
    • 0344033602 scopus 로고    scopus 로고
    • Detecting disease associations due to linkage disequilibrium using haplotype tags: A class of tests and the determinants of statistical power
    • Chapman, J.M.; Cooper, J.D.; Todd, J.A.; Clayton, D.G. Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum. Hered., 2003, 56, 18-31.
    • (2003) Hum. Hered , vol.56 , pp. 18-31
    • Chapman, J.M.1    Cooper, J.D.2    Todd, J.A.3    Clayton, D.G.4
  • 77
    • 77955285797 scopus 로고    scopus 로고
    • Association of the protein tyrosine phosphatase nonreceptor 22 haplotypes with autoimmune thyroid disease in the Japanese population
    • Ban, Y.; Tozaki, T.; Taniyama, M.; Nakano, Y.; Hirano, T. Association of the protein tyrosine phosphatase nonreceptor 22 haplotypes with autoimmune thyroid disease in the Japanese population. Thyroid, 2010, 20, 893-899.
    • (2010) Thyroid , vol.20 , pp. 893-899
    • Ban, Y.1    Tozaki, T.2    Taniyama, M.3    Nakano, Y.4    Hirano, T.5
  • 84
    • 10344260663 scopus 로고    scopus 로고
    • Common allelic variants of exons 10, 12, and 33 of the thyroglobulin gene are not associated with autoimmune thyroid disease in the United Kingdom
    • Collins, J.E.; Heward, J.M.; Howson, J.M.; Foxall, H.; Carr-Smith, J.; Franklyn, J.A.; Gough, S.C. Common allelic variants of exons 10, 12, and 33 of the thyroglobulin gene are not associated with autoimmune thyroid disease in the United Kingdom. J. Clin. Endocrinol. Metab., 2004, 89, 6336-6339.
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , pp. 6336-6339
    • Collins, J.E.1    Heward, J.M.2    Howson, J.M.3    Foxall, H.4    Carr-Smith, J.5    Franklyn, J.A.6    Gough, S.C.7
  • 85
    • 3042787719 scopus 로고    scopus 로고
    • The thyroglobulin gene as the first thyroid-specific susceptibility gene for autoimmune thyroid disease
    • Tomer, Y.; Greenberg, D. The thyroglobulin gene as the first thyroid-specific susceptibility gene for autoimmune thyroid disease. Trends Mol. Med., 2004, 10, 306-308.
    • (2004) Trends Mol. Med , vol.10 , pp. 306-308
    • Tomer, Y.1    Greenberg, D.2
  • 86
  • 88
    • 18844421908 scopus 로고    scopus 로고
    • A Graves' disease-associated Kozak sequence single-nucleotide polymorphism enhances the efficiency of CD40 gene translation: A case for translational pathophysiology
    • Jacobson, E.M.; Concepcion, E.; Oashi, T.; Tomer, Y. A Graves' disease-associated Kozak sequence single-nucleotide polymorphism enhances the efficiency of CD40 gene translation: a case for translational pathophysiology. Endocrinology, 2005, 146, 2684-2691.
    • (2005) Endocrinology , vol.146 , pp. 2684-2691
    • Jacobson, E.M.1    Concepcion, E.2    Oashi, T.3    Tomer, Y.4
  • 89
    • 0036959340 scopus 로고    scopus 로고
    • A C/T singlenucleotide polymorphism in the region of the CD40 gene is associated with Graves' disease
    • Tomer, Y.; Concepcion, E.; Greenberg, D.A. A C/T singlenucleotide polymorphism in the region of the CD40 gene is associated with Graves' disease. Thyroid, 2002, 12, 1129-1135.
    • (2002) Thyroid , vol.12 , pp. 1129-1135
    • Tomer, Y.1    Concepcion, E.2    Greenberg, D.A.3
  • 90
    • 34249309946 scopus 로고    scopus 로고
    • The regulatory T cell gene FOXP3 and genetic susceptibility to thyroid autoimmunity: An association analysis in Caucasian and Japanese cohorts
    • Ban, Y.; Tozaki, T.; Tobe, T.; Jacobson, E.M.; Concepcion, E.S.; Tomer, Y. The regulatory T cell gene FOXP3 and genetic susceptibility to thyroid autoimmunity: an association analysis in Caucasian and Japanese cohorts. J. Autoimmun., 2007, 28, 201-207.
    • (2007) J. Autoimmun , vol.28 , pp. 201-207
    • Ban, Y.1    Tozaki, T.2    Tobe, T.3    Jacobson, E.M.4    Concepcion, E.S.5    Tomer, Y.6
  • 91
    • 33747892641 scopus 로고    scopus 로고
    • Genetic association studies of the FOXP3 gene in Graves' disease and autoimmune Addison's disease in the United Kingdom population
    • Owen, C.J.; Eden, J.A.; Jennings, C.E.; Wilson, V.; Cheetham, T.D.; Pearce, S.H. Genetic association studies of the FOXP3 gene in Graves' disease and autoimmune Addison's disease in the United Kingdom population. J. Mol. Endocrinol., 2006, 37, 97-104.
    • (2006) J. Mol. Endocrinol , vol.37 , pp. 97-104
    • Owen, C.J.1    Eden, J.A.2    Jennings, C.E.3    Wilson, V.4    Cheetham, T.D.5    Pearce, S.H.6
  • 93
    • 28344444764 scopus 로고    scopus 로고
    • Vitamin D receptor polymorphisms are associated with Graves' disease in German and Polish but not in Serbian patients
    • Ramos-Lopez, E.; Kurylowicz, A.; Bednarczuk, T.; Paunkovic, J.; Seidl, C.; Badenhoop, K. Vitamin D receptor polymorphisms are associated with Graves' disease in German and Polish but not in Serbian patients. Thyroid, 2005, 15, 1125-1130.
    • (2005) Thyroid , vol.15 , pp. 1125-1130
    • Ramos-Lopez, E.1    Kurylowicz, A.2    Bednarczuk, T.3    Paunkovic, J.4    Seidl, C.5    Badenhoop, K.6
  • 94
    • 24344497018 scopus 로고    scopus 로고
    • Association of vitamin D receptor gene polymorphism with susceptibility to Graves' disease in Eastern Croatian population: Case-control study
    • Stefanic, M.; Karner, I.; Glavas-Obrovac, L.; Papic, S.; Vrdoljak, D.; Levak, G.; Krstonosic, B. Association of vitamin D receptor gene polymorphism with susceptibility to Graves' disease in Eastern Croatian population: case-control study. Croat. Med. J., 2005, 46, 639-646.
    • (2005) Croat. Med. J , vol.46 , pp. 639-646
    • Stefanic, M.1    Karner, I.2    Glavas-Obrovac, L.3    Papic, S.4    Vrdoljak, D.5    Levak, G.6    Krstonosic, B.7
  • 95
    • 33745279056 scopus 로고    scopus 로고
    • Evaluating coverage of genome-wide association studies
    • Barrett, J.C.; Cardon, L.R. Evaluating coverage of genome-wide association studies. Nat. Genet., 2006, 38, 659-662.
    • (2006) Nat. Genet , vol.38 , pp. 659-662
    • Barrett, J.C.1    Cardon, L.R.2
  • 102
    • 84969213492 scopus 로고    scopus 로고
    • WTCCC Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • WTCCC Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 2007, 447, 661-678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 105
    • 79954672317 scopus 로고    scopus 로고
    • Genome structural variation discovery and genotyping
    • Alkan, C.; Coe, B.P.; Eichler, E.E. Genome structural variation discovery and genotyping. Nat. Rev. Genet., 2011, 12, 363-376.
    • (2011) Nat. Rev. Genet , vol.12 , pp. 363-376
    • Alkan, C.1    Coe, B.P.2    Eichler, E.E.3
  • 107
    • 78651334094 scopus 로고    scopus 로고
    • Copy number variation in common disease
    • Brand, O.J.; Gough, S.C. Copy number variation in common disease. Thyroid, 2011, 21, 1-4.
    • (2011) Thyroid , vol.21 , pp. 1-4
    • Brand, O.J.1    Gough, S.C.2
  • 109
    • 84975742565 scopus 로고    scopus 로고
    • A map of human genome variation from population-scale sequencing
    • Consortium, T.G.P. A map of human genome variation from population-scale sequencing. Nature, 2010, 467, 1061-1073.
    • (2010) Nature , vol.467 , pp. 1061-1073
    • Consortium, T.G.P.1
  • 110
    • 77953808473 scopus 로고    scopus 로고
    • Next-generation genomics: An integrative approach
    • Hawkins, R.D.; Hon, G.C.; Ren, B. Next-generation genomics: an integrative approach. Nat. Rev. Genet., 2010, 11, 476-486.
    • (2010) Nat. Rev. Genet , vol.11 , pp. 476-486
    • Hawkins, R.D.1    Hon, G.C.2    Ren, B.3
  • 111
    • 33744955355 scopus 로고    scopus 로고
    • Thyrotropin receptor epitopes and their relation to histocompatibility leukocyte antigen-DR molecules in Graves' disease
    • Inaba, H.; Martin, W.; De Groot, A.S.; Qin, S.; De Groot L.J. Thyrotropin receptor epitopes and their relation to histocompatibility leukocyte antigen-DR molecules in Graves' disease. J. Clin. Endocrinol. Metab., 2006, 91, 2286-2294.
    • (2006) J. Clin. Endocrinol. Metab , vol.91 , pp. 2286-2294
    • Inaba, H.1    Martin, W.2    de Groot, A.S.3    Qin, S.4    de Groot, L.J.5
  • 112
    • 0034453002 scopus 로고    scopus 로고
    • Binding of human thyrotropin receptor peptides to a Graves' disease-predisposing human leukocyte antigen class II molecule
    • Sawai, Y.; DeGroot, L.J. Binding of human thyrotropin receptor peptides to a Graves' disease-predisposing human leukocyte antigen class II molecule. J. Clin. Endocrinol. Metab., 2000, 85, 1176-1179.
    • (2000) J. Clin. Endocrinol. Metab , vol.85 , pp. 1176-1179
    • Sawai, Y.1    Degroot, L.J.2
  • 117
    • 0026802536 scopus 로고
    • Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain
    • Graves, P.N.; Tomer, Y.; Davies, T.F. Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain. Biochem. Biophys. Res. Commun., 1992, 187, 1135-1143.
    • (1992) Biochem. Biophys. Res. Commun , vol.187 , pp. 1135-1143
    • Graves, P.N.1    Tomer, Y.2    Davies, T.F.3
  • 119
    • 0028847909 scopus 로고
    • Novel splicing variants of the human thyrotropin receptor encode truncated polypeptides without a membrane-spanning domain
    • Hunt, N.; Wiley, K.P.; Abend, N.; Balvers, M.; Jahner, D.; Northemann, W.; Ivell, R. Novel splicing variants of the human thyrotropin receptor encode truncated polypeptides without a membrane-spanning domain. Endocrine, 1995, 3, 233-240.
    • (1995) Endocrine , vol.3 , pp. 233-240
    • Hunt, N.1    Wiley, K.P.2    Abend, N.3    Balvers, M.4    Jahner, D.5    Northemann, W.6    Ivell, R.7
  • 121
    • 18244421874 scopus 로고    scopus 로고
    • The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    • Pugliese, A.; Zeller, M.; Fernandez, A., Jr.; Zalcberg, L.J.; Bartlett, R.J.; Ricordi, C.; Pietropaolo, M.; Eisenbarth, G.S.; Bennett, S.T.; Patel, D.D. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat. Genet., 1997, 15, 293-297.
    • (1997) Nat. Genet , vol.15 , pp. 293-297
    • Pugliese, A.1    Zeller, M.2    Fernandez Jr., A.3    Zalcberg, L.J.4    Bartlett, R.J.5    Ricordi, C.6    Pietropaolo, M.7    Eisenbarth, G.S.8    Bennett, S.T.9    Patel, D.D.10
  • 122
    • 73249145617 scopus 로고    scopus 로고
    • Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
    • Wegner, N.; Lundberg, K.; Kinloch, A.; Fisher, B.; Malmstrom, V.; Feldmann, M.; Venables, P.J. Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. Immunol. Rev., 2010, 233, 34-54.
    • (2010) Immunol. Rev , vol.233 , pp. 34-54
    • Wegner, N.1    Lundberg, K.2    Kinloch, A.3    Fisher, B.4    Malmstrom, V.5    Feldmann, M.6    Venables, P.J.7
  • 124
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol, E.A.; Borriello, F.; Schweitzer, A.N.; Lynch, W.P.; Bluestone, J.A.; Sharpe, A.H. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity, 1995, 3, 541-547.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 125
    • 3042592443 scopus 로고    scopus 로고
    • Cooperative roles of ctla-4 and regulatory t cells in tolerance to an islet cell antigen
    • Eggena, M.P.; Walker, L.S.; Nagabhushanam, V.; Barron, L.; Chodos, A.; Abbas, A.K. Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen. J. Exp. Med., 2004, 199, 1725-1730.
    • (2004) J. Exp. Med , vol.199 , pp. 1725-1730
    • Eggena, M.P.1    Walker, L.S.2    Nagabhushanam, V.3    Barron, L.4    Chodos, A.5    Abbas, A.K.6
  • 126
    • 0036884729 scopus 로고    scopus 로고
    • CTLA-4 differentially regulates T cell responses to endogenous tissue protein versus exogenous immunogen
    • Walker, L.S.; Ausubel, L.J.; Chodos, A.; Bekarian, N.; Abbas, A.K. CTLA-4 differentially regulates T cell responses to endogenous tissue protein versus exogenous immunogen. J. Immunol., 2002, 169, 6202-6209.
    • (2002) J. Immunol , vol.169 , pp. 6202-6209
    • Walker, L.S.1    Ausubel, L.J.2    Chodos, A.3    Bekarian, N.4    Abbas, A.K.5
  • 130
    • 31044438675 scopus 로고    scopus 로고
    • HLA, CTLA-4 and PTPN22: The shared genetic master-key to autoimmunity
    • Brand, O.; Gough, S.; Heward, J. HLA, CTLA-4 and PTPN22: the shared genetic master-key to autoimmunity? Expert. Rev. Mol. Med., 2005, 7, 1-15.
    • (2005) Expert. Rev. Mol. Med , vol.7 , pp. 1-15
    • Brand, O.1    Gough, S.2    Heward, J.3
  • 134
    • 77956895769 scopus 로고    scopus 로고
    • Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis
    • Matsushita, T.; Horikawa, M.; Iwata, Y.; Tedder, T.F. Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis. J. Immunol., 2010, 185, 2240-2252.
    • (2010) J. Immunol , vol.185 , pp. 2240-2252
    • Matsushita, T.1    Horikawa, M.2    Iwata, Y.3    Tedder, T.F.4
  • 136
    • 0017081082 scopus 로고
    • The association of HLA with autoimmune thyroid disease in Newfoundland. The influence of HLA homozygosity in Graves' disease
    • Farid, N.R.; Barnard, J.M.; Marshall, W.H. The association of HLA with autoimmune thyroid disease in Newfoundland. The influence of HLA homozygosity in Graves' disease. Tissue Antigens, 1976, 8, 181-189.
    • (1976) Tissue Antigens , vol.8 , pp. 181-189
    • Farid, N.R.1    Barnard, J.M.2    Marshall, W.H.3
  • 137
    • 0016335428 scopus 로고
    • HL-A antigens as markers for disease susceptibility and autoimmunity in Graves' disease
    • Grumet, F.C.; Payne, R.O.; Konishi, J.; Kriss, J.P. HL-A antigens as markers for disease susceptibility and autoimmunity in Graves' disease. J. Clin. Endocrinol. Metab., 1974, 39, 1115-1119.
    • (1974) J. Clin. Endocrinol. Metab , vol.39 , pp. 1115-1119
    • Grumet, F.C.1    Payne, R.O.2    Konishi, J.3    Kriss, J.P.4
  • 139
    • 0038218263 scopus 로고    scopus 로고
    • The association of HLA -A, -B, and -DRB1 genotypes with Graves' disease in Taiwanese people
    • Huang, S.M.; Wu, T.J.; Lee, T.D.; Yang, E.K.; Shaw, C.K.; Yeh, C.C. The association of HLA -A, -B, and -DRB1 genotypes with Graves' disease in Taiwanese people. Tissue Antigens, 2003, 61, 154-158.
    • (2003) Tissue Antigens , vol.61 , pp. 154-158
    • Huang, S.M.1    Wu, T.J.2    Lee, T.D.3    Yang, E.K.4    Shaw, C.K.5    Yeh, C.C.6
  • 143
    • 34247610461 scopus 로고    scopus 로고
    • A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: The role of CD40 tissue-specific expression
    • Jacobson, E.M.; Huber, A.K.; Akeno, N.; Sivak, M.; Li, C.W.; Concepcion, E.; Ho, K.; Tomer, Y. A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression. Genes Immun., 2007, 8, 205-214.
    • (2007) Genes Immun , vol.8 , pp. 205-214
    • Jacobson, E.M.1    Huber, A.K.2    Akeno, N.3    Sivak, M.4    Li, C.W.5    Concepcion, E.6    Ho, K.7    Tomer, Y.8
  • 144
    • 33644824363 scopus 로고    scopus 로고
    • Contribution of single nucleotide polymorphisms within fcrl3 and map3k7ip2 to the pathogenesis of graves' disease
    • Simmonds, M.J.; Heward, J.M.; Carr-Smith, J.; Foxall, H.; Franklyn, J.A.; Gough, S.C. Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. J. Clin. Endocrinol. Metab., 2006, 91, 1056-1061.
    • (2006) J. Clin. Endocrinol. Metab , vol.91 , pp. 1056-1061
    • Simmonds, M.J.1    Heward, J.M.2    Carr-Smith, J.3    Foxall, H.4    Franklyn, J.A.5    Gough, S.C.6
  • 145
    • 33947546815 scopus 로고    scopus 로고
    • Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association
    • Owen, C.J.; Kelly, H.; Eden, J.A.; Merriman, M.E.; Pearce, S.H.; Merriman, T.R. Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association. J. Clin. Endocrinol. Metab., 2007, 92, 1106-1111.
    • (2007) J. Clin. Endocrinol. Metab , vol.92 , pp. 1106-1111
    • Owen, C.J.1    Kelly, H.2    Eden, J.A.3    Merriman, M.E.4    Pearce, S.H.5    Merriman, T.R.6
  • 146
    • 0022970126 scopus 로고
    • Immunoglobulin G subclasses of anti-thyroid peroxidase autoantibodies in human autoimmune thyroid diseases
    • Kotani, T.; Kato, E.; Hirai, K.; Kuma, K.; Ohtaki, S. Immunoglobulin G subclasses of anti-thyroid peroxidase autoantibodies in human autoimmune thyroid diseases. Endocrinol. Jpn., 1986, 33, 505-510.
    • (1986) Endocrinol. Jpn , vol.33 , pp. 505-510
    • Kotani, T.1    Kato, E.2    Hirai, K.3    Kuma, K.4    Ohtaki, S.5
  • 147
    • 0022621749 scopus 로고
    • Detection of autoantibodies to thyroid peroxidase in autoimmune thyroid diseases by micro-ELISA and immunoblotting
    • Kotani, T.; Umeki, K.; Matsunaga, S.; Kato, E.; Ohtaki, S. Detection of autoantibodies to thyroid peroxidase in autoimmune thyroid diseases by micro-ELISA and immunoblotting. J. Clin. Endocrinol. Metab., 1986, 62, 928-933.
    • (1986) J. Clin. Endocrinol. Metab , vol.62 , pp. 928-933
    • Kotani, T.1    Umeki, K.2    Matsunaga, S.3    Kato, E.4    Ohtaki, S.5
  • 148
    • 0025113072 scopus 로고
    • The molecular genetics of three thyroid autoantigens: Thyroglobulin, thyroid peroxidase and the thyrotropin receptor
    • Ludgate, M.; Vassart, G. The molecular genetics of three thyroid autoantigens: thyroglobulin, thyroid peroxidase and the thyrotropin receptor. Autoimmunity, 1990, 7, 201-211.
    • (1990) Autoimmunity , vol.7 , pp. 201-211
    • Ludgate, M.1    Vassart, G.2
  • 151
    • 8144230402 scopus 로고    scopus 로고
    • Screening of SNPs at 18 positional candidate genes, located within the GD-1 locus on chromosome 14q23-q32, for susceptibility to Graves' disease: A TDT study
    • Chistiakov, D.A.; Savost'anov, K.V.; Turakulov, R.I. Screening of SNPs at 18 positional candidate genes, located within the GD-1 locus on chromosome 14q23-q32, for susceptibility to Graves' disease: a TDT study. Mol. Genet. Metab., 2004, 83, 264-270.
    • (2004) Mol. Genet. Metab , vol.83 , pp. 264-270
    • Chistiakov, D.A.1    Savost'anov, K.V.2    Turakulov, R.I.3
  • 153
    • 40849119745 scopus 로고    scopus 로고
    • Interleukin (IL)-23 receptor is a major susceptibility gene for Graves' ophthalmopathy: The IL-23/T-helper 17 axis extends to thyroid autoimmunity
    • Huber, A.K.; Jacobson, E.M.; Jazdzewski, K.; Concepcion, E.S.; Tomer, Y. Interleukin (IL)-23 receptor is a major susceptibility gene for Graves' ophthalmopathy: the IL-23/T-helper 17 axis extends to thyroid autoimmunity. J. Clin. Endocrinol. Metab., 2008, 93, 1077-1081.
    • (2008) J. Clin. Endocrinol. Metab , vol.93 , pp. 1077-1081
    • Huber, A.K.1    Jacobson, E.M.2    Jazdzewski, K.3    Concepcion, E.S.4    Tomer, Y.5
  • 154
    • 8544272515 scopus 로고    scopus 로고
    • Proteasome subunits, low-molecular-mass polypeptides 2 and 7 are hyperexpressed by target cells in autoimmune thyroid disease but not in insulin-dependent diabetes mellitus: Implications for autoimmunity
    • Vives-Pi, M.; Vargas, F.; James, R.F.; Trowsdale, J.; Costa, M.; Sospedra, M.; Somoza, N.; Obiols, G.; Tampe, R.; Pujol-Borrell, R. Proteasome subunits, low-molecular-mass polypeptides 2 and 7 are hyperexpressed by target cells in autoimmune thyroid disease but not in insulin-dependent diabetes mellitus: implications for autoimmunity. Tissue Antigens, 1997, 50, 153-163.
    • (1997) Tissue Antigens , vol.50 , pp. 153-163
    • Vives-Pi, M.1    Vargas, F.2    James, R.F.3    Trowsdale, J.4    Costa, M.5    Sospedra, M.6    Somoza, N.7    Obiols, G.8    Tampe, R.9    Pujol-Borrell, R.10
  • 155
    • 0032777232 scopus 로고    scopus 로고
    • Association of the large multifunctional proteasome (LMP2) gene with Graves' disease is a result of linkage disequilibrium with the HLA haplotype DRB1 0304-DQB1 02-DQA1 0501
    • Heward, J.M.; Allahabadia, A.; Sheppard, M.C.; Barnett, A.H.; Franklyn, J.A.; Gough, S.C. Association of the large multifunctional proteasome (LMP2) gene with Graves' disease is a result of linkage disequilibrium with the HLA haplotype DRB 10304-DQB1 02-DQA1 0501. Clin. Endocrinol. (Oxf), 1999, 51, 115-118.
    • (1999) Clin. Endocrinol. (Oxf) , vol.51 , pp. 115-118
    • Heward, J.M.1    Allahabadia, A.2    Sheppard, M.C.3    Barnett, A.H.4    Franklyn, J.A.5    Gough, S.C.6
  • 159
    • 0024406049 scopus 로고
    • Thyroglobulin antibodies in Graves' disease are associated with T-cell receptor beta chain and major histocompatibility complex loci
    • Demaine, A.G.; Ratanachaiyavong, S.; Pope, R.; Ewins, D.; Millward, B.A.; McGregor, A.M. Thyroglobulin antibodies in Graves' disease are associated with T-cell receptor beta chain and major histocompatibility complex loci. Clin. Exp. Immunol., 1989, 77, 21-24.
    • (1989) Clin. Exp. Immunol , vol.77 , pp. 21-24
    • Demaine, A.G.1    Ratanachaiyavong, S.2    Pope, R.3    Ewins, D.4    Millward, B.A.5    McGregor, A.M.6
  • 161
    • 1542541443 scopus 로고    scopus 로고
    • Expression of T cell receptor V(alpha) gene families in intrathyroidal T cells of Chinese patients with Graves' disease
    • Zhang, J.; Hu, S.; Wang, H. Expression of T cell receptor V(alpha) gene families in intrathyroidal T cells of Chinese patients with Graves' disease. Chin. Med. Sci. J., 2000, 15, 175-178.
    • (2000) Chin. Med. Sci. J , vol.15 , pp. 175-178
    • Zhang, J.1    Hu, S.2    Wang, H.3
  • 164
    • 0028873472 scopus 로고
    • Association of Graves' disease with an allele of the interleukin-1 receptor antagonist gene
    • Blakemore, A.I.; Watson, P.F.; Weetman, A.P.; Duff, G.W. Association of Graves' disease with an allele of the interleukin-1 receptor antagonist gene. J. Clin. Endocrinol. Metab., 1995, 80, 111-115.
    • (1995) J. Clin. Endocrinol. Metab , vol.80 , pp. 111-115
    • Blakemore, A.I.1    Watson, P.F.2    Weetman, A.P.3    Duff, G.W.4
  • 165
    • 2642714950 scopus 로고    scopus 로고
    • Lack of association of Graves' disease with the A2 allele of the interleukin-1 receptor antagonist gene in a white European population
    • Muhlberg, T.; Kirchberger, M.; Spitzweg, C.; Herrmann, F.; Heberling, H.J.; Heufelder, A.E. Lack of association of Graves' disease with the A2 allele of the interleukin-1 receptor antagonist gene in a white European population. Eur. J. Endocrinol., 1998, 138, 686-690.
    • (1998) Eur. J. Endocrinol , vol.138 , pp. 686-690
    • Muhlberg, T.1    Kirchberger, M.2    Spitzweg, C.3    Herrmann, F.4    Heberling, H.J.5    Heufelder, A.E.6
  • 166
    • 0033917676 scopus 로고    scopus 로고
    • Vitamin D receptor initiation codon polymorphism in Japanese patients with Graves' disease
    • Ban, Y.; Taniyama, M.; Katagiri, T. Vitamin D receptor initiation codon polymorphism in Japanese patients with Graves' disease. Thyroid, 2000, 10, 475-480.
    • (2000) Thyroid , vol.10 , pp. 475-480
    • Ban, Y.1    Taniyama, M.2    Katagiri, T.3
  • 167
    • 0034489819 scopus 로고    scopus 로고
    • Vitamin D receptor gene polymorphism is associated with Graves' disease in the Japanese population
    • Ban, Y.; Taniyama, M. Vitamin D receptor gene polymorphism is associated with Graves' disease in the Japanese population. J. Clin. Endocrinol. Metab., 2000, 85, 4639-4643.
    • (2000) J. Clin. Endocrinol. Metab , vol.85 , pp. 4639-4643
    • Ban, Y.1    Taniyama, M.2
  • 168
    • 16544386016 scopus 로고    scopus 로고
    • Lobectomy for lung cancer in an elderly man on maintenance hemodialysis
    • Shirasawa, B.; Hanada, S.; Harada, M.; Tomozawa, N.; Hamano, K. Lobectomy for lung cancer in an elderly man on maintenance hemodialysis. Kyobu Geka, 2004, 57, 1094-1098.
    • (2004) Kyobu Geka , vol.57 , pp. 1094-1098
    • Shirasawa, B.1    Hanada, S.2    Harada, M.3    Tomozawa, N.4    Hamano, K.5
  • 169
    • 77952411922 scopus 로고    scopus 로고
    • Confirmation of association of chromosome 5q31-33 with United Kingdom Caucasian Graves' disease
    • Simmonds, M.J.; Yesmin, K.; Newby, P.R.; Brand, O.J.; Franklyn, J.A.; Gough, S.C.; Confirmation of association of chromosome 5q31-33 with United Kingdom Caucasian Graves' disease. Thyroid, 2010, 20, 413-417.
    • (2010) Thyroid , vol.20 , pp. 413-417
    • Simmonds, M.J.1    Yesmin, K.2    Newby, P.R.3    Brand, O.J.4    Franklyn, J.A.5    Gough, S.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.