Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: Evidence for genetic heterogeneity and gene interactions

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 12, 1999, Pages 4656-4664

  Tomer, Yaron ^a,b   Barbesino, Giuseppe ^a   Greenberg, David A ^a   Concepcion, Erlinda ^a   Davies, Terry F ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ARTICLE; AUTOIMMUNE DISEASE; CHROMOSOME 12; CHROMOSOME 13; CHROMOSOME 14; CHROMOSOME 6; CONTROLLED STUDY; FAMILIAL DISEASE; FEMALE; GENE LOCUS; GENETIC DISTANCE; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GRAVES DISEASE; HASHIMOTO DISEASE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; X CHROMOSOME;

EID: 0033304849     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.12.4656     Document Type: Article

References (69)

1. The pathogenesis of Graves' disease
2. Chronic autoimmune thyroiditis
3. The immunogenetics of autoimmune diabetes and autoimmune thyroid disease
4. Infection, thyroid disease and autoimmunity
5. HLA antigens and thyroid autoantibodies in patients with Graves' disease and their first degree relatives
6. Genetic analysis of autoimmune disease
7. A catamnestic investigation of Danish twins
8. Genetic vs. environment in Graves' disease - A population based twin study
9. Thyroid antibodies: A study of first degree relatives
10. The presence of thyroid autoantibodies in children and adolescents with AITD and in their siblings and parents
11. Autoimmune thyroid disease: Developments in our understanding
12. T-cell receptor V gene usage in autoimmune thyroid disease: Direct assessment by thyroid aspiration
13. The epidemiology of thyrotoxicosis in Denmark. Incidence and geographical variation in the Funen region 1972-1974
14. Familial studies of autoimmune thyroiditis
15. Graves' disease and Hashimoto's thyroiditis in monozygotic twins
16. Hypothyroidism as a late sequela in patients with Graves' disease treated with antithyroid agents
17. Linkage analysis of candidate genes in autoimmune thyroid disease. III. Detailed analysis of chromosome 14 localizes GD-1 close to MNG-1
18. A new Graves disease-susceptibility locus maps to chromosome 20q11.2
19. Linkage analysis of candidate genes in autoimmune thyroid disease. II. Selected gender-related genes and the X-chromosome
20. A simple salting out procedure for extracting DNA from human nucleated cells
21. A comprehensive genetic map of the human genome base on 5,264 microsatellites
22. Human DNA polymorphisms based on length variations in simple-sequence tandem repeats
23. A computer program for linkage analysis of general human pedigrees
24. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
25. The spectrum of thyroid disease in a community: The Whickham survey
26. The incidence of thyroid disorders in the community: A twenty-year collow-up of the Whickham survey
27. Parametric and nonparametric linkage analysis: A unified multipoint approach
28. Using lod score differences to determine mode of inheritance: Simple, robust method even in the presence of heterogeneity and reduced penetrance
29. Autoimmune thyroid disease
30. Thyroid autoimmunity in siblings: A population study
31. A population-based study of Graves' diseases in Danish twins
32. The human major histocompatibility complex and endocrine disease
33. IgG heavy chain allotypes (Gm) in atrophic and goitrous thyroiditis
34. T cell receptor beta chain gene polymorphisms in Graves' disease
35. Lack of an association between alleles of interleukin-1 alpha and interleukin-1 receptor antagonsit genes and Graves' disease in a north American Caucasian population
36. Interferon-γ gene microsatellite pollymorphisms in patients with Graves' disease
37. Analysis of the thyrotropin receptor as a candidate gene in familial Graves' disease
38. Lack of association between polymorphism of the thyrotropin receptor gene and Graves' disease in United Kingdom and Hong Kong Chinese patients: Case control and family-based studies
39. Thyroperoxidase microsatellite polymorphism in thyroid disease
40. CTLA-4 gene polymorphism associated with Graves' disease in a caucasian population
41. Genetic factors in autoimmune thyroid disease analyzed by restriction fragment length polymorphisms of candidate genes
42. Association of HLA-DQA1*0501 with Graves' disease in English caucasian men and women
43. Human histocompatibillty leukocyte antigen DQA1*0501 allele associated with genetic susceptibility to Graves' disease in a caucasian population
44. Differentiation of autoimmune ophthalmopathy from Graves' hyperthyroidism by analysis of genetic markers
45. Graves' disease and HLA: Clinical and epidemiologic associations
46. Linkage disequilibrium between the human leukocyte antigen class II region of the major histocompatibillty complex and Graves' disease: Replication using a population case control and family-based study
47. HLA associations with Hashimoto's thyroiditis
48. Lack of disease associated HLA-DQ restriction fragment length polymorphisms in families with autoimmune thyroid disease
49. Genetics of autoimmune thyroid disease: Lack of evidence for linkage to HLA within families
50. Combined segregation and linkage analysis of Graves' disease with a thyroid autoantibody diathesis
51. Linkage analysis of 'necessary' loci vs. 'susceptibility' loci
52. Linkage analysis of candidate genes in autoimmune thyroid disease: I. Selected immunoregulatory genes
53. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian diabetes registry
54. The development of Graves' disease and the CTLA-4 gene on chromosome 2q33
55. No evidence for allelic association of human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies
56. The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locus
57. Autosomal dominant transmission of autoantibodies to thyroglobulin and thyroid peroxidase
58. The association of autoimmune thyroiditis with systemic lupus erythematosus
59. Prevalence of thyroid disease and abnormal thyroid function test results in patients with systemic lupus erythematosus
60. A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families
61. Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees
62. Autoimmune polyglandular syndromes
63. A genome-wide search for human type1 diabetes susceptibility genes
64. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q
65. Affected sibpair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-27
66. Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, DDm5 and IDDM8
67. Genetics of systemic lupus erythematosus
68. Effector and predisposing genes in murine lupus
69. Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice