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Volumn 7, Issue 23, 2005, Pages 1-15

HLA, CTLA-4 and PTPN22: The shared genetic master-key to autoimmunity?

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HLA ANTIGEN CLASS 2; PROTEIN TYROSINE PHOSPHATASE;

EID: 31044438675     PISSN: 14623994     EISSN: 14623994     Source Type: Journal    
DOI: 10.1017/S1462399405009981     Document Type: Review
Times cited : (85)

References (85)
  • 1
    • 0029982537 scopus 로고    scopus 로고
    • Genetic analysis of autoimmune disease
    • PubMed: 8616887
    • Vyse, T.J. and Todd, J.A. (1996) Genetic analysis of autoimmune disease. Cell 85, 311-318, PubMed: 8616887
    • (1996) Cell , vol.85 , pp. 311-318
    • Vyse, T.J.1    Todd, J.A.2
  • 2
    • 0030716833 scopus 로고    scopus 로고
    • Genetic susceptibility to the development of autoimmune disease
    • PubMed: 9497784
    • Heward, J. and Gough, S.C. (1997) Genetic susceptibility to the development of autoimmune disease. Clin Sci (Lond) 93, 479-491, PubMed: 9497784
    • (1997) Clin Sci (Lond) , vol.93 , pp. 479-491
    • Heward, J.1    Gough, S.C.2
  • 3
    • 0033032379 scopus 로고    scopus 로고
    • Comparative genetics of type 1 diabetes and autoimmune disease: Common loci, common pathways?
    • PubMed: 10389838
    • Becker, K.G. (1999) Comparative genetics of type 1 diabetes and autoimmune disease: Common loci, common pathways? Diabetes 48, 1353-1358, PubMed: 10389838
    • (1999) Diabetes , vol.48 , pp. 1353-1358
    • Becker, K.G.1
  • 4
    • 0031893204 scopus 로고    scopus 로고
    • Genetic susceptibility to systemic lupus erythematosus
    • PubMed: 9597131
    • Vyse, T.J. and Kotzin, B.L. (1998) Genetic susceptibility to systemic lupus erythematosus. Annu Rev Immunol 16, 261-292, PubMed: 9597131
    • (1998) Annu Rev Immunol , vol.16 , pp. 261-292
    • Vyse, T.J.1    Kotzin, B.L.2
  • 5
    • 1842529365 scopus 로고    scopus 로고
    • Clustering of autoimmune disease in parents of siblings from the Type 1 diabetes Warren repository
    • PubMed: 15049939
    • Tait, K.F. et al. (2004) Clustering of autoimmune disease in parents of siblings from the Type 1 diabetes Warren repository. Diabet Med 21, 358-362, PubMed: 15049939
    • (2004) Diabet Med , vol.21 , pp. 358-362
    • Tait, K.F.1
  • 6
    • 0026554270 scopus 로고
    • Genetic analysis of HLA class II alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects
    • PubMed: 1521722
    • Awata, T. et al. (1992) Genetic analysis of HLA class II alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects. Diabetologia 35, 419-424, PubMed: 1521722
    • (1992) Diabetologia , vol.35 , pp. 419-424
    • Awata, T.1
  • 7
    • 0029038612 scopus 로고
    • Susceptibility and resistance alleles of human leukocyte antigen (HLA) DQA1 and HLA DQB1 are shared in endocrine autoimmune disease
    • PubMed: 7608264
    • Badenhoop, K. et al. (1995) Susceptibility and resistance alleles of human leukocyte antigen (HLA) DQA1 and HLA DQB1 are shared in endocrine autoimmune disease. J Clin Endocrinol Metab 80, 2112-2117, PubMed: 7608264
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 2112-2117
    • Badenhoop, K.1
  • 8
    • 19944422075 scopus 로고    scopus 로고
    • Regression mapping of association between the human leukocyte antigen region and Graves disease
    • PubMed: 15558498
    • Simmonds, M.J. et al. (2005) Regression mapping of association between the human leukocyte antigen region and Graves disease. Am J Hum Genet 76, 157-163, PubMed: 15558498
    • (2005) Am J Hum Genet , vol.76 , pp. 157-163
    • Simmonds, M.J.1
  • 9
    • 0037648405 scopus 로고    scopus 로고
    • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    • PubMed: 12724780
    • Ueda, H. et al. (2003) Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423, 506-511, PubMed: 12724780
    • (2003) Nature , vol.423 , pp. 506-511
    • Ueda, H.1
  • 10
    • 0032776137 scopus 로고    scopus 로고
    • The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locus
    • PubMed: 10369864
    • Vaidya, B. et al. (1999) The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locus. Hum Mol Genet 8, 1195-1199, PubMed: 10369864
    • (1999) Hum Mol Genet , vol.8 , pp. 1195-1199
    • Vaidya, B.1
  • 11
    • 12144291502 scopus 로고    scopus 로고
    • A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
    • PubMed: 15004560
    • Bottini, N. et al. (2004) A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet 36, 337-338, PubMed: 15004560
    • (2004) Nat Genet , vol.36 , pp. 337-338
    • Bottini, N.1
  • 12
    • 7044253358 scopus 로고    scopus 로고
    • Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus
    • PubMed: 15504986
    • Smyth, D. et al. (2004) Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes 53, 3020-3023, PubMed: 15504986
    • (2004) Diabetes , vol.53 , pp. 3020-3023
    • Smyth, D.1
  • 13
    • 11044226181 scopus 로고    scopus 로고
    • A functional polymorphism (1858C/T) in the PTPN22 gene is linked and associated with type I diabetes in multiplex families
    • PubMed: 15526003
    • Onengut-Gumuscu, S. et al. (2004) A functional polymorphism (1858C/T) in the PTPN22 gene is linked and associated with type I diabetes in multiplex families. Genes Immun 5, 678-680, PubMed: 15526003
    • (2004) Genes Immun , vol.5 , pp. 678-680
    • Onengut-Gumuscu, S.1
  • 14
    • 20144387851 scopus 로고    scopus 로고
    • Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: The PTPN22 620W allele associates with multiple autoimmune phenotypes
    • PubMed: 15719322
    • Criswell, L.A. et al. (2005) Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: The PTPN22 620W allele associates with multiple autoimmune phenotypes. Am J Hum Genet 76, 561-571, PubMed: 15719322
    • (2005) Am J Hum Genet , vol.76 , pp. 561-571
    • Criswell, L.A.1
  • 15
    • 11144266638 scopus 로고    scopus 로고
    • Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes
    • PubMed: 15620463
    • Ladner, M.B. et al. (2005) Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes. Hum Immunol 66, 60-64, PubMed: 15620463
    • (2005) Hum Immunol , vol.66 , pp. 60-64
    • Ladner, M.B.1
  • 16
    • 8744266374 scopus 로고    scopus 로고
    • The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease
    • PubMed: 15531553
    • Velaga, M.R. et al. (2004) The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease. J Clin Endocrinol Metab 89, 5862-5865, PubMed: 15531553
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5862-5865
    • Velaga, M.R.1
  • 17
    • 4143105691 scopus 로고    scopus 로고
    • Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE
    • PubMed: 15273934
    • Kyogoku, C. et al. (2004) Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Am J Hum Genet 75, 504-507, PubMed: 15273934
    • (2004) Am J Hum Genet , vol.75 , pp. 504-507
    • Kyogoku, C.1
  • 18
    • 19944433325 scopus 로고    scopus 로고
    • Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus
    • PubMed: 15641066
    • Orozco, G. et al. (2005) Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Rheum 52, 219-224, PubMed: 15641066
    • (2005) Arthritis Rheum , vol.52 , pp. 219-224
    • Orozco, G.1
  • 19
    • 3242713277 scopus 로고    scopus 로고
    • A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
    • PubMed: 15208781
    • Begovich, A.B. et al. (2004) A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet 75, 330-337, PubMed: 15208781
    • (2004) Am J Hum Genet , vol.75 , pp. 330-337
    • Begovich, A.B.1
  • 20
    • 20144388808 scopus 로고    scopus 로고
    • The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status
    • PubMed: 15674368
    • Lee, A.T. et al. (2005) The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status. Genes Immun 6, 129-133, PubMed: 15674368
    • (2005) Genes Immun , vol.6 , pp. 129-133
    • Lee, A.T.1
  • 21
    • 0035960410 scopus 로고    scopus 로고
    • The thymus and central tolerance
    • PubMed: 11888152
    • Sprent, J. and Kishimoto, H. (2001) The thymus and central tolerance. Transplantation 72, S25-28, PubMed: 11888152
    • (2001) Transplantation , vol.72
    • Sprent, J.1    Kishimoto, H.2
  • 22
    • 0034773019 scopus 로고    scopus 로고
    • Mechanisms for the induction of autoimmunity by infectious agents
    • PubMed: 11602615
    • Wucherpfennig, K.W. (2001) Mechanisms for the induction of autoimmunity by infectious agents. J Clin Invest 108, 1097-1104, PubMed: 11602615
    • (2001) J Clin Invest , vol.108 , pp. 1097-1104
    • Wucherpfennig, K.W.1
  • 23
    • 0036360019 scopus 로고    scopus 로고
    • The enemy within: Keeping self-reactive T cells at bay in the periphery
    • PubMed: 11908514
    • Walker, L.S. and Abbas, A.K. (2002) The enemy within: Keeping self-reactive T cells at bay in the periphery. Nat Rev Immunol 2, 11-19, PubMed: 11908514
    • (2002) Nat Rev Immunol , vol.2 , pp. 11-19
    • Walker, L.S.1    Abbas, A.K.2
  • 24
    • 16444366859 scopus 로고    scopus 로고
    • Genetic insights into disease mechanisms of autoimmunity
    • PubMed: 15701924
    • Simmonds, M.J. and Gough, S.C. (2004) Genetic insights into disease mechanisms of autoimmunity. Br Med Bull 71, 93-113, PubMed: 15701924
    • (2004) Br Med Bull , vol.71 , pp. 93-113
    • Simmonds, M.J.1    Gough, S.C.2
  • 25
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmmunity
    • PubMed: 10837065
    • Shevach, E.M. (2000) Regulatory T cells in autoimmmunity*. Annu Rev Immunol 18, 423-449, PubMed: 10837065
    • (2000) Annu Rev Immunol , vol.18 , pp. 423-449
    • Shevach, E.M.1
  • 26
    • 0016177620 scopus 로고
    • HL-A antigens and diabetes mellitus
    • PubMed: 4137711
    • Nerup, J. et al. (1974) HL-A antigens and diabetes mellitus. Lancet 2, 864-866, PubMed: 4137711
    • (1974) Lancet , vol.2 , pp. 864-866
    • Nerup, J.1
  • 27
    • 0036043065 scopus 로고    scopus 로고
    • Genetics of multiple sclerosis: Linkage and association studies
    • PubMed: 12083953
    • Giordano, M., D'Alfonso, S. and Momigliano-Richiardi, P. (2002) Genetics of multiple sclerosis: Linkage and association studies. Am J Pharmacogenomics 2, 37-58, PubMed: 12083953
    • (2002) Am J Pharmacogenomics , vol.2 , pp. 37-58
    • Giordano, M.1    D'Alfonso, S.2    Momigliano-Richiardi, P.3
  • 28
    • 3242784052 scopus 로고    scopus 로고
    • A review of the MHC genetics of rheumatoid arthritis
    • PubMed: 14749714
    • Newton, J.L. et al. (2004) A review of the MHC genetics of rheumatoid arthritis. Genes Immun 5, 151-157, PubMed: 14749714
    • (2004) Genes Immun , vol.5 , pp. 151-157
    • Newton, J.L.1
  • 29
    • 15144361587 scopus 로고    scopus 로고
    • Linkage disequilibrium between the human leukocyte antigen class II region of the major histocompatibility complex and Graves' disease: Replication using a population case control and family-based study
    • PubMed: 9768636
    • Heward, J.M. et al. (1998) Linkage disequilibrium between the human leukocyte antigen class II region of the major histocompatibility complex and Graves' disease: Replication using a population case control and family-based study. J Clin Endocrinol Metab 83, 3394-3397, PubMed: 9768636
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3394-3397
    • Heward, J.M.1
  • 30
    • 0025874086 scopus 로고
    • HLA associations with autoimmune Addison's disease
    • PubMed: 1926131
    • Weetman, A.P. et al. (1991) HLA associations with autoimmune Addison's disease. Tissue Antigens 38, 31-33, PubMed: 1926131
    • (1991) Tissue Antigens , vol.38 , pp. 31-33
    • Weetman, A.P.1
  • 31
    • 1842455656 scopus 로고    scopus 로고
    • Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond
    • PubMed: 15030506
    • Simmonds, M.J. and Gough, S.C. (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clin Exp Immunol 136, 1-10, PubMed: 15030506
    • (2004) Clin Exp Immunol , vol.136 , pp. 1-10
    • Simmonds, M.J.1    Gough, S.C.2
  • 32
    • 18544367934 scopus 로고    scopus 로고
    • Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus
    • PubMed: 12145745
    • Graham, R.R. et al. (2002) Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. Am J Hum Genet 71, 543-553, PubMed: 12145745
    • (2002) Am J Hum Genet , vol.71 , pp. 543-553
    • Graham, R.R.1
  • 33
    • 0023252262 scopus 로고
    • HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
    • PubMed: 3309680
    • Todd, J.A., Bell, J.I. and McDevitt, H.O. (1987) HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329, 599-604, PubMed: 3309680
    • (1987) Nature , vol.329 , pp. 599-604
    • Todd, J.A.1    Bell, J.I.2    McDevitt, H.O.3
  • 34
    • 3242784051 scopus 로고    scopus 로고
    • Arginine at position 74 of the HLA-DR beta1 chain is associated with Graves' disease
    • PubMed: 15029234
    • Ban, Y. et al. (2004) Arginine at position 74 of the HLA-DR beta1 chain is associated with Graves' disease. Genes Immun 5, 203-208, PubMed: 15029234
    • (2004) Genes Immun , vol.5 , pp. 203-208
    • Ban, Y.1
  • 35
    • 0027237554 scopus 로고
    • Combinations of specific DRB1, DQA1, DQB1 haplotypes are associated with insulin-dependent diabetes mellitus in Sardinia
    • PubMed: 8226139
    • Cucca, F. et al. (1993) Combinations of specific DRB1, DQA1, DQB1 haplotypes are associated with insulin-dependent diabetes mellitus in Sardinia. Hum Immunol 37, 85-94, PubMed: 8226139
    • (1993) Hum Immunol , vol.37 , pp. 85-94
    • Cucca, F.1
  • 36
    • 0029166110 scopus 로고
    • The distribution of DR4 haplotypes in Sardinia suggests a primary association of type I diabetes with DRB1 and DQB1 loci
    • PubMed: 7499178
    • Cucca, F. et al. (1995) The distribution of DR4 haplotypes in Sardinia suggests a primary association of type I diabetes with DRB1 and DQB1 loci. Hum Immunol 43, 301-308, PubMed: 7499178
    • (1995) Hum Immunol , vol.43 , pp. 301-308
    • Cucca, F.1
  • 37
    • 0023500817 scopus 로고
    • The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
    • PubMed: 2446635
    • Gregersen, P.K., Silver, J. and Winchester, R.J. (1987) The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 30, 1205-1213, PubMed: 2446635
    • (1987) Arthritis Rheum , vol.30 , pp. 1205-1213
    • Gregersen, P.K.1    Silver, J.2    Winchester, R.J.3
  • 38
    • 0036222676 scopus 로고    scopus 로고
    • Reshaping the shared epitope hypothesis: HLA-associated risk for rheumatoid arthritis is encoded by amino acid substitutions at positions 67-74 of the HLA-DRB1 molecule
    • PubMed: 11953968
    • de Vries, N. et al. (2002) Reshaping the shared epitope hypothesis: HLA-associated risk for rheumatoid arthritis is encoded by amino acid substitutions at positions 67-74 of the HLA-DRB1 molecule. Arthritis Rheum 46, 921-928, PubMed: 11953968
    • (2002) Arthritis Rheum , vol.46 , pp. 921-928
    • de Vries, N.1
  • 39
    • 0026502380 scopus 로고
    • Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics
    • PubMed: 1309938
    • Jorgensen, J.L. et al. (1992) Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature 355, 224-230, PubMed: 1309938
    • (1992) Nature , vol.355 , pp. 224-230
    • Jorgensen, J.L.1
  • 40
    • 0025296990 scopus 로고
    • Analysis of peptide residues interacting with MHC molecule or T cell receptor. Can a peptide bind in more than one way to the same MHC molecule?
    • PubMed: 2141038
    • Kurata, A. and Berzofsky, J.A. (1990) Analysis of peptide residues interacting with MHC molecule or T cell receptor. Can a peptide bind in more than one way to the same MHC molecule? J Immunol 144, 4526-4535, PubMed: 2141038
    • (1990) J Immunol , vol.144 , pp. 4526-4535
    • Kurata, A.1    Berzofsky, J.A.2
  • 41
    • 0024325587 scopus 로고
    • Analysis of peptide binding patterns in different major histocompatibility complex/T cell receptor complexes using pigeon cytochrome c-specific T cell hybridomas. Evidence that a single peptide binds major histocompatibility complex in different conformations
    • PubMed: 2553848
    • Bhayani, H. and Paterson, Y. (1989) Analysis of peptide binding patterns in different major histocompatibility complex/T cell receptor complexes using pigeon cytochrome c-specific T cell hybridomas. Evidence that a single peptide binds major histocompatibility complex in different conformations. J Exp Med 170, 1609-1625, PubMed: 2553848
    • (1989) J Exp Med , vol.170 , pp. 1609-1625
    • Bhayani, H.1    Paterson, Y.2
  • 42
    • 0034777837 scopus 로고    scopus 로고
    • A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins
    • PubMed: 11590120
    • Cucca, F. et al. (2001) A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins. Hum Mol Genet 10, 2025-2037, PubMed: 11590120
    • (2001) Hum Mol Genet , vol.10 , pp. 2025-2037
    • Cucca, F.1
  • 43
    • 0029129476 scopus 로고
    • Recognition of multiple peptide cores by a single T cell receptor
    • PubMed: 7629510
    • Nanda, N.K. et al. (1995) Recognition of multiple peptide cores by a single T cell receptor. J Exp Med 182, 531-539, PubMed: 7629510
    • (1995) J Exp Med , vol.182 , pp. 531-539
    • Nanda, N.K.1
  • 44
    • 0025129103 scopus 로고
    • Polymorphic DQ alpha and DQ beta interactions dictate HLA class II determinants of allo-recognition
    • PubMed: 2104922
    • Kwok, W.W. et al. (1990) Polymorphic DQ alpha and DQ beta interactions dictate HLA class II determinants of allo-recognition. J Exp Med 171, 85-95, PubMed: 2104922
    • (1990) J Exp Med , vol.171 , pp. 85-95
    • Kwok, W.W.1
  • 45
    • 0028348369 scopus 로고
    • Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
    • PubMed: 8145819
    • Stern, L.J. et al. (1994) Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368, 215-221, PubMed: 8145819
    • (1994) Nature , vol.368 , pp. 215-221
    • Stern, L.J.1
  • 46
    • 0029986734 scopus 로고    scopus 로고
    • Recognition of altered self major histocompatibility complex molecules modulated by specific peptide interactions
    • PubMed: 8625994
    • Nepom, G.T. et al. (1996) Recognition of altered self major histocompatibility complex molecules modulated by specific peptide interactions. Eur J Immunol 26, 949-952, PubMed: 8625994
    • (1996) Eur J Immunol , vol.26 , pp. 949-952
    • Nepom, G.T.1
  • 47
    • 0031847984 scopus 로고    scopus 로고
    • Molecular basis for HLA-DQ associations with IDDM
    • PubMed: 9703314
    • Nepom, G.T. and Kwok, W.W. (1998) Molecular basis for HLA-DQ associations with IDDM. Diabetes 47, 1177-1184, PubMed: 9703314
    • (1998) Diabetes , vol.47 , pp. 1177-1184
    • Nepom, G.T.1    Kwok, W.W.2
  • 48
    • 0025131118 scopus 로고
    • A unified hypothesis for the complex genetics of HLA associations with IDDM
    • PubMed: 2210067
    • Nepom, G.T. (1990) A unified hypothesis for the complex genetics of HLA associations with IDDM. Diabetes 39, 1153-1157, PubMed: 2210067
    • (1990) Diabetes , vol.39 , pp. 1153-1157
    • Nepom, G.T.1
  • 49
    • 0036301503 scopus 로고    scopus 로고
    • CTLA-4: New insights into its biological function and use in tumor immunotherapy
    • PubMed: 12087419
    • Egen, J.G., Kuhns, M.S. and Allison, J.P. (2002) CTLA-4: New insights into its biological function and use in tumor immunotherapy. Nat Immunol 3, 611-618, PubMed: 12087419
    • (2002) Nat Immunol , vol.3 , pp. 611-618
    • Egen, J.G.1    Kuhns, M.S.2    Allison, J.P.3
  • 50
    • 0024327899 scopus 로고
    • Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
    • PubMed: 2653373
    • Mueller, D.L., Jenkins, M.K. and Schwartz, R.H. (1989) Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu Rev Immunol 7, 445-480, PubMed: 2653373
    • (1989) Annu Rev Immunol , vol.7 , pp. 445-480
    • Mueller, D.L.1    Jenkins, M.K.2    Schwartz, R.H.3
  • 51
    • 0033306461 scopus 로고    scopus 로고
    • The development of Graves' disease and the CTLA-4 gene on chromosome 2q33
    • PubMed: 10404810
    • Heward, J.M. et al. (1999) The development of Graves' disease and the CTLA-4 gene on chromosome 2q33. J Clin Endocrinol Metab 84, 2398-2401, PubMed: 10404810
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 2398-2401
    • Heward, J.M.1
  • 52
    • 8944259914 scopus 로고    scopus 로고
    • The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes
    • Belgian Diabetes Registry. PubMed: 8817351
    • Nistico, L. et al. (1996) The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry. Hum Mol Genet 5, 1075-1080, PubMed: 8817351
    • (1996) Hum Mol Genet , vol.5 , pp. 1075-1080
    • Nistico, L.1
  • 53
    • 0036146702 scopus 로고    scopus 로고
    • Polymorphism of the CTLA-4 gene is associated with autoimmune hypothyroidism in the United Kingdom
    • PubMed: 11842815
    • Nithiyananthan, R. et al. (2002) Polymorphism of the CTLA-4 gene is associated with autoimmune hypothyroidism in the United Kingdom. Thyroid 12, 3-6, PubMed: 11842815
    • (2002) Thyroid , vol.12 , pp. 3-6
    • Nithiyananthan, R.1
  • 54
    • 17744373659 scopus 로고    scopus 로고
    • Association analysis of the cytotoxic T lymphocyte antigen-4 (CTLA-4) and autoimmune regulators (AIRE-1) genes in sporadic autoimmune Addison's disease
    • PubMed: 10690877
    • Vaidya, B. et al. (2000) Association analysis of the cytotoxic T lymphocyte antigen-4 (CTLA-4) and autoimmune regulators (AIRE-1) genes in sporadic autoimmune Addison's disease. J Clin Endocrinol Metab 85, 688-691, PubMed: 10690877
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 688-691
    • Vaidya, B.1
  • 55
    • 3242732770 scopus 로고    scopus 로고
    • Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison's disease
    • PubMed: 15240634
    • Blomhoff, A. et al. (2004) Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison's disease. J Clin Endocrinol Metab 89, 3474-3476, PubMed: 15240634
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3474-3476
    • Blomhoff, A.1
  • 56
    • 2442496304 scopus 로고    scopus 로고
    • An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells
    • PubMed: 15142525
    • Vijayakrishnan, L. et al. (2004) An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity 20, 563-575, PubMed: 15142525
    • (2004) Immunity , vol.20 , pp. 563-575
    • Vijayakrishnan, L.1
  • 57
    • 0036172220 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
    • PubMed: 11825563
    • Egen, J.G. and Allison, J.P. (2002) Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity 16, 23-35, PubMed: 11825563
    • (2002) Immunity , vol.16 , pp. 23-35
    • Egen, J.G.1    Allison, J.P.2
  • 58
    • 0030443168 scopus 로고    scopus 로고
    • Regulation of surface and intracellular expression of CTLA4 on mouse T cells
    • PubMed: 8943377
    • Alegre, M.L. et al. (1996) Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J Immunol 157, 4762-4770, PubMed: 8943377
    • (1996) J Immunol , vol.157 , pp. 4762-4770
    • Alegre, M.L.1
  • 59
    • 0031132467 scopus 로고    scopus 로고
    • Synergistic induction of CTLA-4 expression by costimulation with TCR plus CD28 signals mediated by increased transcription and messenger ribonucleic acid stability
    • PubMed: 9126965
    • Finn, P.W. et al. (1997) Synergistic induction of CTLA-4 expression by costimulation with TCR plus CD28 signals mediated by increased transcription and messenger ribonucleic acid stability. J Immunol 158, 4074-4081, PubMed: 9126965
    • (1997) J Immunol , vol.158 , pp. 4074-4081
    • Finn, P.W.1
  • 60
    • 0030001318 scopus 로고    scopus 로고
    • Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
    • PubMed: 8638161
    • Marengere, L.E. et al. (1996) Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272, 1170-1173, PubMed: 8638161
    • (1996) Science , vol.272 , pp. 1170-1173
    • Marengere, L.E.1
  • 61
    • 0034658408 scopus 로고    scopus 로고
    • Structural analysis of CTLA-4 function in vivo
    • PubMed: 10799894
    • Masteller, E.L. et al. (2000) Structural analysis of CTLA-4 function in vivo. J Immunol 164, 5319-5327, PubMed: 10799894
    • (2000) J Immunol , vol.164 , pp. 5319-5327
    • Masteller, E.L.1
  • 62
    • 0033521596 scopus 로고    scopus 로고
    • Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase
    • PubMed: 9874568
    • Cloutier, J.F. and Veillette, A. (1999) Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase. J Exp Med 189, 111-121, PubMed: 9874568
    • (1999) J Exp Med , vol.189 , pp. 111-121
    • Cloutier, J.F.1    Veillette, A.2
  • 63
    • 0032545452 scopus 로고    scopus 로고
    • Molecular basis of T cell inactivation by CTLA-4
    • PubMed: 9856951
    • Lee, K.M. et al. (1998) Molecular basis of T cell inactivation by CTLA-4. Science 282, 2263-2266, PubMed: 9856951
    • (1998) Science , vol.282 , pp. 2263-2266
    • Lee, K.M.1
  • 64
    • 10344259631 scopus 로고    scopus 로고
    • Cutting edge: Cbl-b: One of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation
    • PubMed: 15585834
    • LO, D. et al. (2004) Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation. J Immunol 173, 7135-7139, PubMed: 15585834
    • (2004) J Immunol , vol.173 , pp. 7135-7139
    • Li, D.1
  • 65
    • 3142726114 scopus 로고    scopus 로고
    • The Cbl family and other ubiquitin ligases: Destructive forces in control of antigen receptor signaling
    • PubMed: 15345216
    • Duan, L. et al. (2004) The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling. Immunity 21, 7-17, PubMed: 15345216
    • (2004) Immunity , vol.21 , pp. 7-17
    • Duan, L.1
  • 66
    • 0034642499 scopus 로고    scopus 로고
    • Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
    • PubMed: 10646608
    • Bachmaier, K. et al. (2000) Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 403, 211-216, PubMed: 10646608
    • (2000) Nature , vol.403 , pp. 211-216
    • Bachmaier, K.1
  • 67
    • 0036699521 scopus 로고    scopus 로고
    • Cblb is a major susceptibility gene for rat type 1 diabetes mellitus
    • PubMed: 12118252
    • Yokoi, N. et al. (2002) Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat Genet 31, 391-394, PubMed: 12118252
    • (2002) Nat Genet , vol.31 , pp. 391-394
    • Yokoi, N.1
  • 68
    • 3042654973 scopus 로고    scopus 로고
    • Protein tyrosine phosphatases in T cell physiology
    • PubMed: 15220004
    • Mustelin, T. et al. (2004) Protein tyrosine phosphatases in T cell physiology. Mol Immunol 41, 687-700, PubMed: 15220004
    • (2004) Mol Immunol , vol.41 , pp. 687-700
    • Mustelin, T.1
  • 69
    • 0033559313 scopus 로고    scopus 로고
    • Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp
    • PubMed: 10068674
    • Cohen, S. et al. (1999) Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp. Blood 93, 2013-2024, PubMed: 10068674
    • (1999) Blood , vol.93 , pp. 2013-2024
    • Cohen, S.1
  • 70
    • 0033842973 scopus 로고    scopus 로고
    • Subcellular localization of intracellular protein tyrosine phosphatases in T cells
    • PubMed: 10940933
    • Gjorloff-Wingren, A. et al. (2000) Subcellular localization of intracellular protein tyrosine phosphatases in T cells. Eur J Immunol 30, 2412-2421, PubMed: 10940933
    • (2000) Eur J Immunol , vol.30 , pp. 2412-2421
    • Gjorloff-Wingren, A.1
  • 71
    • 0036186527 scopus 로고    scopus 로고
    • The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation
    • PubMed: 11882361
    • Hill, R.J. et al. (2002) The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation. Exp Hematol 30, 237-244, PubMed: 11882361
    • (2002) Exp Hematol , vol.30 , pp. 237-244
    • Hill, R.J.1
  • 72
    • 20844452226 scopus 로고    scopus 로고
    • Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases
    • PubMed: 15759012
    • Viken, M.K. et al. (2005) Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases. Genes Immun 6, 271-273, PubMed: 15759012
    • (2005) Genes Immun , vol.6 , pp. 271-273
    • Viken, M.K.1
  • 73
    • 11144292728 scopus 로고    scopus 로고
    • The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis
    • PubMed: 15580548
    • Begovich, A.B. et al. (2005) The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis. Am J Hum Genet 76, 184-187, PubMed: 15580548
    • (2005) Am J Hum Genet , vol.76 , pp. 184-187
    • Begovich, A.B.1
  • 74
    • 23844551123 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase gene (PTPN22) polymorphism in multiple sclerosis
    • PubMed: 15765267
    • Matesanz, F. et al. (2005) Protein tyrosine phosphatase gene (PTPN22) polymorphism in multiple sclerosis. J Neurol PubMed: 15765267
    • (2005) J Neurol
    • Matesanz, F.1
  • 75
    • 0029348006 scopus 로고
    • The Src and Csk families of tyrosine protein kinases in hemopoietic cells
    • PubMed: 8520026
    • Chow, L.M. and Veillette, A. (1995) The Src and Csk families of tyrosine protein kinases in hemopoietic cells. Semin Immunol 7, 207-226, PubMed: 8520026
    • (1995) Semin Immunol , vol.7 , pp. 207-226
    • Chow, L.M.1    Veillette, A.2
  • 76
    • 0027240587 scopus 로고
    • Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk
    • PubMed: 8371758
    • Chow, L.M. et al. (1993) Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk. Nature 365, 156-160, PubMed: 8371758
    • (1993) Nature , vol.365 , pp. 156-160
    • Chow, L.M.1
  • 77
    • 0032572720 scopus 로고    scopus 로고
    • Csk controls antigen receptor-mediated development and selection of T-lineage cells
    • PubMed: 9732874
    • Schmedt, C. et al. (1998) Csk controls antigen receptor-mediated development and selection of T-lineage cells. Nature 394, 901-904, PubMed: 9732874
    • (1998) Nature , vol.394 , pp. 901-904
    • Schmedt, C.1
  • 78
    • 0034753803 scopus 로고    scopus 로고
    • A novel, specific interaction involving the Csk SH3 domain and its natural ligand
    • PubMed: 11685249
    • Ghose, R. et al. (2001) A novel, specific interaction involving the Csk SH3 domain and its natural ligand. Nat Struct Biol 8, 998-1004, PubMed: 11685249
    • (2001) Nat Struct Biol , vol.8 , pp. 998-1004
    • Ghose, R.1
  • 79
    • 0242712698 scopus 로고    scopus 로고
    • Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP
    • PubMed: 10601992
    • Gjorloff-Wingren, A. et al. (1999) Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP. Eur J Immunol 29, 3845-3854, PubMed: 10601992
    • (1999) Eur J Immunol , vol.29 , pp. 3845-3854
    • Gjorloff-Wingren, A.1
  • 80
    • 0030889218 scopus 로고    scopus 로고
    • The product of the proto-oncogene c-cbl: A negative regulator of the Syk tyrosine kinase
    • PubMed: 9103201
    • Ota, Y. and Samelson, L.E. (1997) The product of the proto-oncogene c-cbl: A negative regulator of the Syk tyrosine kinase. Science 276, 418-420, PubMed: 9103201
    • (1997) Science , vol.276 , pp. 418-420
    • Ota, Y.1    Samelson, L.E.2
  • 81
    • 14444276991 scopus 로고    scopus 로고
    • The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70
    • PubMed: 9407100
    • Lupher, M.L., Jr. et al. (1997) The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. J Biol Chem 272, 33140-33144, PubMed: 9407100
    • (1997) J Biol Chem , vol.272 , pp. 33140-33144
    • Lupher Jr., M.L.1
  • 82
    • 0032478805 scopus 로고    scopus 로고
    • Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells
    • PubMed: 9525940
    • Feshchenko, E.A., Langdon, W.Y. and Tsygankov, A.Y. (1998) Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells. J Biol Chem 273, 8323-8331, PubMed: 9525940
    • (1998) J Biol Chem , vol.273 , pp. 8323-8331
    • Feshchenko, E.A.1    Langdon, W.Y.2    Tsygankov, A.Y.3
  • 83
    • 0028940733 scopus 로고
    • T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras
    • PubMed: 7737275
    • Schneider, H. et al. (1995) T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras. Eur J Immunol 25, 1044-1050, PubMed: 7737275
    • (1995) Eur J Immunol , vol.25 , pp. 1044-1050
    • Schneider, H.1
  • 84
    • 0031962106 scopus 로고    scopus 로고
    • Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling
    • PubMed: 9417079
    • Kim, H.H., Tharayil, M. and Rudd, C.E. (1998) Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling. J Biol Chem 273, 296-301, PubMed: 9417079
    • (1998) J Biol Chem , vol.273 , pp. 296-301
    • Kim, H.H.1    Tharayil, M.2    Rudd, C.E.3
  • 85
    • 0032516873 scopus 로고    scopus 로고
    • Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction
    • PubMed: 9694876
    • Okkenhaug, K. and Rottapel, R. (1998) Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction. J Biol Chem 273, 21194-21202, PubMed: 9694876
    • (1998) J Biol Chem , vol.273 , pp. 21194-21202
    • Okkenhaug, K.1    Rottapel, R.2


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