Sensory Functions for Degenerin/Epithelial Sodium Channels (DEG/ENaC)

Advances in Genetics

Volumn 76, Issue , 2011, Pages 1-26

  Ben Shahar, Yehuda ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

Acid sensitive ion channel; Amiloride sensitive cation channel; Chemosensation; Degenerin; Epithelial sodium channel; Mechanosensation; Pain; Pickpocket

Indexed keywords

DEGENERIN EPITHELIAL SODIUM CHANNELS; EPITHELIAL SODIUM CHANNEL; NERVE PROTEIN;

ANIMAL; CHEMISTRY; GENETICS; HUMAN; MECHANOTRANSDUCTION; METABOLISM; PAIN; PATHOPHYSIOLOGY; PERIPHERAL NERVOUS SYSTEM; PHYSIOLOGY; REVIEW; SENSATION;

ANIMALS; EPITHELIAL SODIUM CHANNEL; HUMANS; MECHANOTRANSDUCTION, CELLULAR; NERVE TISSUE PROTEINS; PAIN; PERIPHERAL NERVOUS SYSTEM; SENSATION;

EID: 81455143585     PISSN: 00652660     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-386481-9.00001-8     Document Type: Chapter

References (164)

1. Adams C.M., Anderson M.G., Motto D.G., Price M.P., Johnson W.A., Welsh M.J. Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons. J. Cell Biol. 1998, 140:143-152.
2. Adams C.M., Snyder P.M., Price M.P., Welsh M.J. Protons activate brain Na+ channel 1 by inducing a conformational change that exposes a residue associated with neurodegeneration. J. Biol. Chem. 1998, 273:30204-30207.
3. Ainsley J.A., Pettus J.M., Bosenko D., Gerstein C.E., Zinkevich N., Anderson M.G., Adams C.M., Welsh M.J., Johnson W.A. Enhanced locomotion caused by loss of the Drosophila DEG/ENaC protein Pickpocket1. Curr. Biol. 2003, 13:1557-1563.
4. Albeg A., Smith C., Chatzigeorgiou M., Feitelson D.G., Hall D.H., Schafer W.R., Miller D.M., Treinin M. C. elegans multi-dendritic sensory neurons: Morphology and function. Mol. Cell. Neurosci. 2010, 46:308-317.
5. Arnadottir J., Chalfie M. Eukaryotic mechanosensitive channels. Annu. Rev. Biophys. 2010, 39:111-137.
6. Ashcroft F.M. Ion Channels and Disease Channelopathies 2000, ScienceDirect (Online service), Academic Press, San Diego, pp. xxi, 481 pp.
7. Askwith C.C., Cheng C., Ikuma M., Benson C., Price M.P., Welsh M.J. Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels. Neuron 2000, 26:133-141.
8. Askwith C.C., Benson C.J., Welsh M.J., Snyder P.M. DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature. Proc. Natl. Acad. Sci. USA 2001, 98:6459-6463.
9. Askwith C.C., Wemmie J.A., Price M.P., Rokhlina T., Welsh M.J. Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons. J. Biol. Chem. 2004, 279:18296-18305.
10. Bassilana F., Champigny G., Waldmann R., de Weille J.R., Heurteaux C., Lazdunski M. The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties. J. Biol. Chem. 1997, 272:28819-28822.
11. Bazopoulou D., Voglis G., Tavernarakis N. The role of DEG/ENaC ion channels in sensory mechanotransduction. Molecular Sensors for Cardiovascular Homeostasis 2007, 3-31. Springer, USA. D.H. Wang (Ed.).
12. Ben-Shahar Y., Nannapaneni K., Casavant T.L., Scheetz T.E., Welsh M.J. Eukaryotic operon-like transcription of functionally related genes in Drosophila. Proc. Natl. Acad. Sci. USA 2007, 104:222-227.
13. Ben-Shahar Y., Lu B., Collier D.M., Snyder P.M., Schnizler M., Welsh M.J. The Drosophila gene CheB42a is a novel modifier of Deg/ENaC channel function. PLoS One 2010, 5:e9395.
14. Benson C.J., Xie J., Wemmie J.A., Price M.P., Henss J.M., Welsh M.J., Snyder P.M. Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Proc. Natl. Acad. Sci. USA 2002, 99:2338-2343.
15. Bianchi L. Mechanotransduction: Touch and feel at the molecular level as modeled in Caenorhabditis elegans. Mol. Neurobiol. 2007, 36:254-271.
16. Bianchi L., Driscoll M. Protons at the gate: DEG/ENaC ion channels help us feel and remember. Neuron 2002, 34:337-340.
17. Bianchi L., Gerstbrein B., Frokjaer-Jensen C., Royal D.C., Mukherjee G., Royal M.A., Xue J., Schafer W.R., Driscoll M. The neurotoxic MEC-4(d) DEG/ENaC sodium channel conducts calcium: Implications for necrosis initiation. Nat. Neurosci. 2004, 7:1337-1344.
18. Bounoutas A., Chalfie M. Touch sensitivity in Caenorhabditis elegans. Pflugers Arch. 2007, 454:691-702.
19. Brown A.L., Fernandez-Illescas S.M., Liao Z., Goodman M.B. Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade. J. Gen. Physiol. 2007, 129:161-173.
20. Cameron P., Hiroi M., Ngai J., Scott K. The molecular basis for water taste in Drosophila. Nature 2010, 465:91-95.
21. Canessa C.M., Horisberger J.D., Rossier B.C. Epithelial sodium channel related to proteins involved in neurodegeneration. Nature 1993, 361:467-470.
22. Canessa C.M., Merillat A.M., Rossier B.C. Membrane topology of the epithelial sodium channel in intact cells. Am. J. Physiol. 1994, 267:C1682-C1690.
23. Canessa C.M., Schild L., Buell G., Thorens B., Gautschi I., Horisberger J.D., Rossier B.C. Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature 1994, 367:463-467.
24. Chalfie M. Neurosensory mechanotransduction. Nat. Rev. Mol. Cell Biol. 2009, 10:44-52.
25. Chalfie M., Driscoll M., Huang M. Degenerin similarities. Nature 1993, 361:504.
26. Chandrashekar J., Yarmolinsky D., von Buchholtz L., Oka Y., Sly W., Ryba N.J., Zuker C.S. The taste of carbonation. Science 2009, 326:443-445.
27. Chandrashekar J., Kuhn C., Oka Y., Yarmolinsky D.A., Hummler E., Ryba N.J., Zuker C.S. The cells and peripheral representation of sodium taste in mice. Nature 2010, 464:297-301.
28. Chapleau M.W., Cunningham J.T., Sullivan M.J., Wachtel R.E., Abboud F.M. Structural versus functional modulation of the arterial baroreflex. Hypertension 1995, 26:341-347.
29. Chapleau M.W., Hajduczok G., Sharma R.V., Wachtel R.E., Cunningham J.T., Sullivan M.J., Abboud F.M. Mechanisms of baroreceptor activation. Clin. Exp. Hypertens. 1995, 17:1-13.
30. Chatzigeorgiou M., Yoo S., Watson J.D., Lee W.H., Spencer W.C., Kindt K.S., Hwang S.W., Miller D.M., Treinin M., Driscoll M., et al. Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors. Nat. Neurosci. 2010, 13:861-868.
31. Chelur D.S., Ernstrom G.G., Goodman M.B., Yao C.A., Chen L.R.O.H., Chalfie M. The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel. Nature 2002, 420:669-673.
32. Chen Z., Wang Q., Wang Z. The amiloride-sensitive epithelial Na+ channel PPK28 is essential for drosophila gustatory water reception. J. Neurosci. 2010, 30:6247-6252.
33. Cho J.H., Askwith C.C. Potentiation of acid-sensing ion channels by sulfhydryl compounds. Am. J. Physiol. Cell Physiol. 2007, 292:C2161-C2174.
34. Christensen A.P., Corey D.P. TRP channels in mechanosensation: Direct or indirect activation?. Nat. Rev. Neurosci. 2007, 8:510-521.
35. Chu X.P., Wemmie J.A., Wang W.Z., Zhu X.M., Saugstad J.A., Price M.P., Simon R.P., Xiong Z.G. Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels. J. Neurosci. 2004, 24:8678-8689.
36. Corey D.P. What is the hair cell transduction channel?. J. Physiol. 2006, 576:23-28.
37. Corey D.P., Garcia-Anoveros J. Mechanosensation and the DEG/ENaC ion channels. Science 1996, 273:323-324.
38. Coryell M.W., Ziemann A.E., Westmoreland P.J., Haenfler J.M., Kurjakovic Z., Zha X.M., Price M., Schnizler M.K., Wemmie J.A. Targeting ASIC1a reduces innate fear and alters neuronal activity in the fear circuit. Biol. Psychiatry 2007, 62:1140-1148.
39. Coryell M.W., Wunsch A.M., Haenfler J.M., Allen J.E., Schnizler M., Ziemann A.E., Cook M.N., Dunning J.P., Price M.P., Rainier J.D., et al. Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior. J. Neurosci. 2009, 29:5381-5388.
40. Cueva J.G., Mulholland A., Goodman M.B. Nanoscale organization of the MEC-4 DEG/ENaC sensory mechanotransduction channel in Caenorhabditis elegans touch receptor neurons. J. Neurosci. 2007, 27:14089-14098.
41. Cunningham J.T., Wachtel R.E., Abboud F.M. Mechanosensitive currents in putative aortic baroreceptor neurons in vitro. J. Neurophysiol. 1995, 73:2094-2098.
42. Cunningham J.T., Wachtel R.E., Abboud F.M. Mechanical stimulation of neurites generates an inward current in putative aortic baroreceptor neurons in vitro. Brain Res. 1997, 757:149-154.
43. Deval E., Baron A., Lingueglia E., Mazarguil H., Zajac J.M., Lazdunski M. Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability. Neuropharmacology 2003, 44:662-671.
44. Deval E., Noel J., Lay N., Alloui A., Diochot S., Friend V., Jodar M., Lazdunski M., Lingueglia E. ASIC3, a sensor of acidic and primary inflammatory pain. EMBO J. 2008, 27:3047-3055.
45. Deval E., Gasull X., Noel J., Salinas M., Baron A., Diochot S., Lingueglia E. Acid-sensing ion channels (ASICs): Pharmacology and implication in pain. Pharmacol. Ther. 2010, 128:549-558.
46. Donier E., Rugiero F., Jacob C., Wood J.N. Regulation of ASIC activity by ASIC4-New insights into ASIC channel function revealed by a yeast two-hybrid assay. Eur. J. Neurosci. 2008, 28:74-86.
47. Dotson C.D. The search for mechanisms underlying the sour taste evoked by acids continues. Chem. Senses 2010, 35:545-547.
48. Drew L.J., Rohrer D.K., Price M.P., Blaver K.E., Cockayne D.A., Cesare P., Wood J.N. Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. J. Physiol. 2004, 556:691-710.
49. Drummond H.A., Price M.P., Welsh M.J., Abboud F.M. A molecular component of the arterial baroreceptor mechanotransducer. Neuron 1998, 21:1435-1441.
50. Drummond H.A., Abboud F.M., Welsh M.J. Localization of beta and gamma subunits of ENaC in sensory nerve endings in the rat foot pad. Brain Res. 2000, 884:1-12.
51. Drummond H.A., Welsh M.J., Abboud F.M. ENaC subunits are molecular components of the arterial baroreceptor complex. Ann. N. Y. Acad. Sci. 2001, 940:42-47.
52. Dube G.R., Lehto S.G., Breese N.M., Baker S.J., Wang X., Matulenko M.A., Honore P., Stewart A.O., Moreland R.B., Brioni J.D. Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels. Pain 2005, 117:88-96.
53. Eddy M.C., Eschle B.K., Barrows J., Hallock R.M., Finger T.E., Delay E.R. Double P2X2/P2X3 purinergic receptor knockout mice do not taste NaCl or the artificial sweetener SC45647. Chem. Senses 2009, 34:789-797.
54. Eskandari S., Snyder P.M., Kreman M., Zampighi G.A., Welsh M.J., Wright E.M. Number of subunits comprising the epithelial sodium channel. J. Biol. Chem. 1999, 274:27281-27286.
55. Finger T.E., Restrepo D., Silver W.L. The Neurobiology of Taste and Smell 2000, Wiley-Liss, New York. 2nd edn.
56. Frank M.E., Lundy R.F., Contreras R.J. Cracking taste codes by tapping into sensory neuron impulse traffic. Prog. Neurobiol. 2008, 86:245-263.
57. Fricke B., Lints R., Stewart G., Drummond H., Dodt G., Driscoll M., von During M. Epithelial Na+ channels and stomatin are expressed in rat trigeminal mechanosensory neurons. Cell Tissue Res. 2000, 299:327-334.
58. Garty H., Palmer L.G. Epithelial sodium channels: Function, structure, and regulation. Physiol. Rev. 1997, 77:359-396.
59. Geerling J.C., Loewy A.D. Central regulation of sodium appetite. Exp. Physiol. 2008, 93:177-209.
60. Gillespie P.G., Muller U. Mechanotransduction by hair cells: Models, molecules, and mechanisms. Cell 2009, 139:33-44.
61. Goodman M.B., Schwarz E.M. Transducing touch in Caenorhabditis elegans. Annu. Rev. Physiol. 2003, 65:429-452.
62. Goodman M.B., Ernstrom G.G., Chelur D.S., O'Hagan R., Yao C.A., Chalfie M. MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation. Nature 2002, 415:1039-1042.
63. Green K.A., Falconer S.W., Cottrell G.A. The neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) directly gates two ion channels in an identified Helix neurone. Pflugers Arch. 1994, 428:232-240.
64. Hattori T., Chen J., Harding A.M., Price M.P., Lu Y., Abboud F.M., Benson C.J. ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons. Circ. Res. 2009, 105:279-286.
65. Heck G.L., Mierson S., DeSimone J.A. Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway. Science 1984, 223:403-405.
66. Horisberger J.D., Chraibi A. Epithelial sodium channel: A ligand-gated channel?. Nephron Physiol. 2004, 96:37-41.
67. Huang M., Gu G., Ferguson E.L., Chalfie M. A stomatin-like protein necessary for mechanosensation in C. elegans. Nature 1995, 378:292-295.
68. Huang A.L., Chen X., Hoon M.A., Chandrashekar J., Guo W., Trankner D., Ryba N.J., Zuker C.S. The cells and logic for mammalian sour taste detection. Nature 2006, 442:934-938.
69. Huque T., Cowart B.J., Dankulich-Nagrudny L., Pribitkin E.A., Bayley D.L., Spielman A.I., Feldman R.S., Mackler S.A., Brand J.G. Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue. PLoS One 2009, 4:e7347.
70. Hwang R.Y., Zhong L., Xu Y., Johnson T., Zhang F., Deisseroth K., Tracey W.D. Nociceptive neurons protect Drosophila larvae from parasitoid wasps. Curr. Biol. 2007, 17:2105-2116.
71. Ikeuchi M., Kolker S.J., Burnes L.A., Walder R.Y., Sluka K.A. Role of ASIC3 in the primary and secondary hyperalgesia produced by joint inflammation in mice. Pain 2008, 137:662-669.
72. Ikeuchi M., Kolker S.J., Sluka K.A. Acid-sensing ion channel 3 expression in mouse knee joint afferents and effects of carrageenan-induced arthritis. J. Pain 2009, 10:336-342.
73. Ishii S., Misaka T., Kishi M., Kaga T., Ishimaru Y., Abe K. Acetic acid activates PKD1L3-PKD2L1 channel-A candidate sour taste receptor. Biochem. Biophys. Res. Commun. 2009, 385:346-350.
74. Ishimaru Y., Inada H., Kubota M., Zhuang H., Tominaga M., Matsunami H. Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc. Natl. Acad. Sci. USA 2006, 103:12569-12574.
75. Jacob H.J., Lazar J., Dwinell M.R., Moreno C., Geurts A.M. Gene targeting in the rat: Advances and opportunities. Trends Genet. 2010, 26:510-518.
76. Jasti J., Furukawa H., Gonzales E.B., Gouaux E. Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature 2007, 449:316-323.
77. Ji H.L., Su X.F., Kedar S., Li J., Barbry P., Smith P.R., Matalon S., Benos D.J. Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction. J. Biol. Chem. 2006, 281:8233-8241.
78. Jones D.T., Taylor W.R., Thornton J.M. The rapid generation of mutation data matrices from protein sequences. Comput. Appl. Biosci. 1992, 8:275.
79. Jorgensen F., Ohmori H. Amiloride blocks the mechano-electrical transduction channel of hair cells of the chick. J. Physiol. 1988, 403:577-588.
80. Kang L., Gao J., Schafer W.R., Xie Z., Xu X.Z. C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel. Neuron 2010, 67:381-391.
81. Kataoka S., Yang R., Ishimaru Y., Matsunami H., Sevigny J., Kinnamon J.C., Finger T.E. The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse. Chem. Senses 2008, 33:243-254.
82. Kellenberger S., Schild L. Epithelial sodium channel/degenerin family of ion channels: A variety of functions for a shared structure. Physiol. Rev. 2002, 82:735-767.
83. Kraske S., Cunningham J.T., Hajduczok G., Chapleau M.W., Abboud F.M., Wachtel R.E. Mechanosensitive ion channels in putative aortic baroreceptor neurons. Am. J. Physiol. 1998, 275:H1497-H1501.
84. Krishtal O.A., Pidoplichko V.I. Receptor for protons in the membrane of sensory neurons. Brain Res. 1981, 214:150-154.
85. Krishtal O.A., Pidoplichko V.I. A " receptor" for protons in small neurons of trigeminal ganglia: Possible role in nociception. Neurosci. Lett. 1981, 24:243-246.
86. Le T., Saier M.H. Phylogenetic characterization of the epithelial Na+ channel (ENaC) family. Mol. Membr. Biol. 1996, 13:149-157.
87. Lee J., Moon S., Cha Y., Chung Y.D. Drosophila TRPN(=NOMPC) channel localizes to the distal end of mechanosensory cilia. PLoS One 2010, 5:e11012.
88. Lin W., Ogura T., Kinnamon S.C. Acid-activated cation currents in rat vallate taste receptor cells. J. Neurophysiol. 2002, 88:133-141.
89. Lin W., Burks C.A., Hansen D.R., Kinnamon S.C., Gilbertson T.A. Taste receptor cells express pH-sensitive leak K+ channels. J. Neurophysiol. 2004, 92:2909-2919.
90. Lin H., Mann K.J., Starostina E., Kinser R.D., Pikielny C.W. A Drosophila DEG/ENaC channel subunit is required for male response to female pheromones. Proc. Natl. Acad. Sci. USA 2005, 102:12831-12836.
91. Lingueglia E. Acid-sensing ion channels in sensory perception. J. Biol. Chem. 2007, 282:17325-17329.
92. Lingueglia E., Renard S., Voilley N., Waldmann R., Chassande O., Lazdunski M., Barbry P. Molecular cloning and functional expression of different molecular forms of rat amiloride-binding proteins. Eur. J. Biochem. 1993, 216:679-687.
93. Lingueglia E., Voilley N., Waldmann R., Lazdunski M., Barbry P. Expression cloning of an epithelial amiloride-sensitive Na+ channel. A new channel type with homologies to Caenorhabditis elegans degenerins. FEBS Lett. 1993, 318:95-99.
94. Lingueglia E., Champigny G., Lazdunski M., Barbry P. Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel. Nature 1995, 378:730-733.
95. Liu L., Johnson W.A., Welsh M.J. Drosophila DEG/ENaC pickpocket genes are expressed in the tracheal system, where they may be involved in liquid clearance. Proc. Natl. Acad. Sci. USA 2003, 100:2128-2133.
96. Liu L., Leonard A.S., Motto D.G., Feller M.A., Price M.P., Johnson W.A., Welsh M.J. Contribution of Drosophila DEG/ENaC genes to salt taste. Neuron 2003, 39:133-146.
97. Lu Y., Ma X., Sabharwal R., Snitsarev V., Morgan D., Rahmouni K., Drummond H.A., Whiteis C.A., Costa V., Price M., et al. The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation. Neuron 2009, 64:885-897.
98. Lundy R.F., Contreras R.J. Gustatory neuron types in rat geniculate ganglion. J. Neurophysiol. 1999, 82:2970-2988.
99. Lyall V., Heck G.L., Vinnikova A.K., Ghosh S., Phan T.H., Desimone J.A. A novel vanilloid receptor-1 (VR-1) variant mammalian salt taste receptor. Chem. Senses 2005, 30(Suppl. 1):i42-i43.
100. Ma X., Abboud F.M., Chapleau M.W. Analysis of afferent, central, and efferent components of the baroreceptor reflex in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2002, 283:R1033-R1040.
101. Martinez-Salgado C., Benckendorff A.G., Chiang L.Y., Wang R., Milenkovic N., Wetzel C., Hu J., Stucky C.L., Parra M.G., Mohandas N., et al. Stomatin and sensory neuron mechanotransduction. J. Neurophysiol. 2007, 98:3802-3808.
102. Mogil J.S., Breese N.M., Witty M.F., Ritchie J., Rainville M.L., Ase A., Abbadi N., Stucky C.L., Seguela P. Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuli. J. Neurosci. 2005, 25:9893-9901.
103. Nelson T.M., Lopezjimenez N.D., Tessarollo L., Inoue M., Bachmanov A.A., Sullivan S.L. Taste function in mice with a targeted mutation of the pkd1l3 gene. Chem. Senses 2010, 35:565-577.
104. O'Hagan R., Chalfie M., Goodman M.B. The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. Nat. Neurosci. 2005, 8:43-50.
105. Page A.J., Brierley S.M., Martin C.M., Martinez-Salgado C., Wemmie J.A., Brennan T.J., Symonds E., Omari T., Lewin G.R., Welsh M.J., et al. The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function. Gastroenterology 2004, 127:1739-1747.
106. Peng B.G., Ahmad S., Chen S., Chen P., Price M.P., Lin X. Acid-sensing ion channel 2 contributes a major component to acid-evoked excitatory responses in spiral ganglion neurons and plays a role in noise susceptibility of mice. J. Neurosci. 2004, 24:10167-10175.
107. Price M.P., Snyder P.M., Welsh M.J. Cloning and expression of a novel human brain Na+ channel. J. Biol. Chem. 1996, 271:7879-7882.
108. Price M.P., Lewin G.R., McIlwrath S.L., Cheng C., Xie J., Heppenstall P.A., Stucky C.L., Mannsfeldt A.G., Brennan T.J., Drummond H.A., et al. The mammalian sodium channel BNC1 is required for normal touch sensation. Nature 2000, 407:1007-1011.
109. Price M.P., McIlwrath S.L., Xie J., Cheng C., Qiao J., Tarr D.E., Sluka K.A., Brennan T.J., Lewin G.R., Welsh M.J. The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron 2001, 32:1071-1083.
110. Price M.P., Thompson R.J., Eshcol J.O., Wemmie J.A., Benson C.J. Stomatin modulates gating of acid-sensing ion channels. J. Biol. Chem. 2004, 279:53886-53891.
111. Pumplin D.W., Yu C., Smith D.V. Light and dark cells of rat vallate taste buds are morphologically distinct cell types. J. Comp. Neurol. 1997, 378:389-410.
112. Richter T.A., Dvoryanchikov G.A., Roper S.D., Chaudhari N. Acid-sensing ion channel-2 is not necessary for sour taste in mice. J. Neurosci. 2004, 24:4088-4091.
113. Roza C., Puel J.L., Kress M., Baron A., Diochot S., Lazdunski M., Waldmann R. Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing. J. Physiol. 2004, 558:659-669.
114. Rusch A., Hummler E. Mechano-electrical transduction in mice lacking the alpha-subunit of the epithelial sodium channel. Hear. Res. 1999, 131:170-176.
115. Sherwood T.W., Askwith C.C. Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a. J. Biol. Chem. 2008, 283:1818-1830.
116. Sherwood T.W., Askwith C.C. Dynorphin opioid peptides enhance acid-sensing ion channel 1a activity and acidosis-induced neuronal death. J. Neurosci. 2009, 29:14371-14380.
117. Shimada S., Ueda T., Ishida Y., Yamamoto T., Ugawa S. Acid-sensing ion channels in taste buds. Arch. Histol. Cytol. 2006, 69:227-231.
118. Simon A., Shenton F., Hunter I., Banks R.W., Bewick G.S. Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles. J. Physiol. 2010, 588:171-185.
119. Sluka K.A., Winter O.C., Wemmie J.A. Acid-sensing ion channels: A new target for pain and CNS diseases. Curr. Opin. Drug Discov. Devel. 2009, 12:693-704.
120. Snitsarev V., Whiteis C.A., Abboud F.M., Chapleau M.W. Mechanosensory transduction of vagal and baroreceptor afferents revealed by study of isolated nodose neurons in culture. Auton. Neurosci. 2002, 98:59-63.
121. Snitsarev V., Whiteis C.A., Chapleau M.W., Abboud F.M. Mechano- and chemosensitivity of rat nodose neurones-Selective excitatory effects of prostacyclin. J. Physiol. 2007, 582:177-194.
122. Snyder P.M. Minireview: Regulation of epithelial Na+ channel trafficking. Endocrinology 2005, 146:5079-5085.
123. Snyder P.M., Bucher D.B., Olson D.R. Gating induces a conformational change in the outer vestibule of ENaC. J. Gen. Physiol. 2000, 116:781.
124. Snyder P.M., Price M.P., McDonald F.J., Adams C.M., Volk K.A., Zeiher B.G., Stokes J.B., Welsh M.J. Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel. Cell 1995, 83:969-978.
125. Sullivan M.J., Sharma R.V., Wachtel R.E., Chapleau M.W., Waite L.J., Bhalla R.C., Abboud F.M. Non-voltage-gated Ca2+ influx through mechanosensitive ion channels in aortic baroreceptor neurons. Circ. Res. 1997, 80:861-867.
126. Suzuki H., Kerr R., Bianchi L., Frokjaer-Jensen C., Slone D., Xue J., Gerstbrein B., Driscoll M., Schafer W.R. In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation. Neuron 2003, 39:1005-1017.
127. Tamura K., Dudley J., Nei M., Kumar S. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol. Biol. Evol. 2007, 24. 1596.
128. Tavernarakis N., Driscoll M. Caenorhabditis elegans degenerins and vertebrate ENaC ion channels contain an extracellular domain related to venom neurotoxins. J. Neurogenet. 2000, 13:257-264.
129. Tavernarakis N., Driscoll M. Degenerins. At the core of the metazoan mechanotransducer?. Ann. N. Y. Acad. Sci. 2001, 940:28-41.
130. Tavernarakis N., Driscoll M. Mechanotransduction in Caenorhabditis elegans: The role of DEG/ENaC ion channels. Cell Biochem. Biophys. 2001, 35:1-18.
131. Tracey W.D., Wilson R.I., Laurent G., Benzer S. Painless, a Drosophila gene essential for nociception. Cell 2003, 113:261-273.
132. Ugawa S. Identification of sour-taste receptor genes. Anat. Sci. Int. 2003, 78:205-210.
133. Ugawa S., Minami Y., Guo W., Saishin Y., Takatsuji K., Yamamoto T., Tohyama M., Shimada S. Receptor that leaves a sour taste in the mouth. Nature 1998, 395:555-556.
134. Ugawa S., Ueda T., Ishida Y., Nishigaki M., Shibata Y., Shimada S. Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors. J. Clin. Invest. 2002, 110:1185-1190.
135. Ugawa S., Yamamoto T., Ueda T., Ishida Y., Inagaki A., Nishigaki M., Shimada S. Amiloride-insensitive currents of the acid-sensing ion channel-2a (ASIC2a)/ASIC2b heteromeric sour-taste receptor channel. J. Neurosci. 2003, 23:3616-3622.
136. Vandenbeuch A., Clapp T.R., Kinnamon S.C. Amiloride-sensitive channels in type I fungiform taste cells in mouse. BMC Neurosci. 2008, 9:1.
137. Voglis G., Tavernarakis N. A synaptic DEG/ENaC ion channel mediates learning in C. elegans by facilitating dopamine signalling. EMBO J. 2008, 27:3288-3299.
138. Voilley N., Lingueglia E., Champigny G., Mattei M.G., Waldmann R., Lazdunski M., Barbry P. The lung amiloride-sensitive Na+ channel: Biophysical properties, pharmacology, ontogenesis, and molecular cloning. Proc. Natl. Acad. Sci. USA 1994, 91:247-251.
139. Walder R.Y., Rasmussen L.A., Rainier J.D., Light A.R., Wemmie J.A., Sluka K.A. ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury. J. Pain 2010, 11:210-218.
140. Waldmann R., Champigny G., Voilley N., Lauritzen I., Lazdunski M. The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. J. Biol. Chem. 1996, 271:10433-10436.
141. Waldmann R., Bassilana F., de Weille J., Champigny G., Heurteaux C., Lazdunski M. Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons. J. Biol. Chem. 1997, 272:20975-20978.
142. Waldmann R., Champigny G., Bassilana F., Heurteaux C., Lazdunski M. A proton-gated cation channel involved in acid-sensing. Nature 1997, 386:173-177.
143. Waldmann R., Champigny G., Lingueglia E., De Weille J.R., Heurteaux C., Lazdunski M. H(+)-gated cation channels. Ann. N. Y. Acad. Sci. 1999, 868:67-76.
144. Wang Y., Bianchi L. Insights into the molecular determinants of proton inhibition in an acid-inactivated degenerins and mammalian epithelial Na(+) channel. Biochemistry 2009, 48:10005-10013.
145. Wang Y., Apicella A., Lee S.K., Ezcurra M., Slone R.D., Goldmit M., Schafer W.R., Shaham S., Driscoll M., Bianchi L. A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans. EMBO J. 2008, 27:2388-2399.
146. Weber W.M., Asher C., Garty H., Clauss W. Expression of amiloride-sensitive Na+ channels of hen lower intestine in Xenopus oocytes: Electrophysiological studies on the dependence of varying NaCl intake. Biochim. Biophys. Acta 1992, 1111:159-164.
147. Weber W.M., Dannenmaier B., Clauss W. Ion transport across leech integument. I. Electrogenic Na+ transport and current fluctuation analysis of the apical Na+ channel. J. Comp. Physiol. B 1993, 163:153-159.
148. Wemmie J.A., Chen J., Askwith C.C., Hruska-Hageman A.M., Price M.P., Nolan B.C., Yoder P.G., Lamani E., Hoshi T., Freeman J.H., et al. The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron 2002, 34:463-477.
149. Wemmie J.A., Askwith C.C., Lamani E., Cassell M.D., Freeman J.H., Welsh M.J. Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning. J. Neurosci. 2003, 23:5496-5502.
150. Wemmie J.A., Price M.P., Welsh M.J. Acid-sensing ion channels: Advances, questions and therapeutic opportunities. Trends Neurosci. 2006, 29:578-586.
151. Xie J., Price M.P., Berger A.L., Welsh M.J. DRASIC contributes to pH-gated currents in large dorsal root ganglion sensory neurons by forming heteromultimeric channels. J. Neurophysiol. 2002, 87:2835-2843.
152. Xie J., Price M.P., Wemmie J.A., Askwith C.C., Welsh M.J. ASIC3 and ASIC1 mediate FMRFamide-related peptide enhancement of H+-gated currents in cultured dorsal root ganglion neurons. J. Neurophysiol. 2003, 89:2459-2465.
153. Xiong Z.G., Zhu X.M., Chu X.P., Minami M., Hey J., Wei W.L., MacDonald J.F., Wemmie J.A., Price M.P., Welsh M.J., et al. Neuroprotection in ischemia: Blocking calcium-permeable acid-sensing ion channels. Cell 2004, 118:687-698.
154. Yoshida R., Horio N., Murata Y., Yasumatsu K., Shigemura N., Ninomiya Y. NaCl responsive taste cells in the mouse fungiform taste buds. Neuroscience 2009, 159:795-803.
155. Yu Y., Chen Z., Li W.G., Cao H., Feng E.G., Yu F., Liu H., Jiang H., Xu T.L. A nonproton ligand sensor in the acid-sensing ion channel. Neuron 2010, 68:61-72.
156. Zha X.M., Costa V., Harding A.M., Reznikov L., Benson C.J., Welsh M.J. ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95. J. Neurosci. 2009, 29:8438-8446.
157. Zha X.M., Wang R., Collier D.M., Snyder P.M., Wemmie J.A., Welsh M.J. Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits. Proc. Natl. Acad. Sci. USA 2009, 106:3573-3578.
158. Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J. Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways. Cell 2003, 112:293-301.
159. Zhang S., Arnadottir J., Keller C., Caldwell G.A., Yao C.A., Chalfie M. MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain. Curr. Biol. 2004, 14:1888-1896.
160. Zhang W., Bianchi L., Lee W.H., Wang Y., Israel S., Driscoll M. Intersubunit interactions between mutant DEG/ENaCs induce synthetic neurotoxicity. Cell Death Differ. 2008, 15:1794-1803.
161. Zhao G.Q., Zhang Y., Hoon M.A., Chandrashekar J., Erlenbach I., Ryba N.J., Zuker C.S. The receptors for mammalian sweet and umami taste. Cell 2003, 115:255-266.
162. Zhong L., Hwang R.Y., Tracey W.D. Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae. Curr. Biol. 2010, 20:429-434.
163. Ziemann A.E., Schnizler M.K., Albert G.W., Severson M.A., Howard Iii M.A., Welsh M.J., Wemmie J.A. Seizure termination by acidosis depends on ASIC1a. Nat. Neurosci. 2008, 11:816-822.
164. Ziemann A.E., Allen J.E., Dahdaleh N.S., Drebot I.I., Coryell M.W., Wunsch A.M., Lynch C.M., Faraci F.M., Howard M.A., Welsh M.J., et al. The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior. Cell 2009, 139:1012-1021.