DRASIC contributes to pH-gated currents in large dorsal root ganglion sensory neurons by forming heteromultimeric channels

Journal of Neurophysiology

Volumn 87, Issue 6, 2002, Pages 2835-2843

  Xie, Jinghui ^a   Price, Margaret P ^a   Berger, Allan L ^a   Welsh, Michael J ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATION CHANNEL; ION CHANNEL;

ALPHA HELIX; ANIMAL CELL; ARTICLE; CELL PH; CHANNEL GATING; DESENSITIZATION; MEMBRANE CURRENT; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE CELL; SKIN NERVE; SPINAL GANGLION; STIMULUS RESPONSE;

EID: 0036082804     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.2002.87.6.2835     Document Type: Article

References (54)

1. Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons
2. Interactions between subunits of the human epithelial sodium channel
3. Proton-induced current in neuronal cells
4. Structure and regulation of amiloride-sensitive sodium channels
5. Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels
6. 3+
7. Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties
8. +, coactivators of acid sensing ion channels (ASIC)
9. + channel with novel properties
10. Acid-evoked currents in cardiac sensory neurons: A possible mediator of myocardial ischemic sensation
11. Membrane topology of the epithelial sodium channel in intact cells
12. + channel is made of three homologous subunits
13. Impaired nociception and pain sensation in mice lacking the capsaicin receptor
14. The capsaicin receptor: A heat-activated ion channel in the pain pathway
15. + channel MDEG1
16. A sensory neuron-specific, proton-gated ion channel
17. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
18. Identification, functional expression and chromosomal localization of a sustained human proton-gated cation channel
19. The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration
20. Localization of β and γ subunits of ENaC in sensory nerve endings in the rat foot pad
21. Number of subunits comprising the epithelial sodium channel
22. The heterotetrameric architecture of the epithelial sodium channel (ENaC)
23. BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels
24. Transport and localization of the DEG/ENaC ion channel BNaCla to peripheral mechanosensory terminals of dorsal root ganglia neurons
25. Epithelial sodium channels: Function, structure, and regulation
26. Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans
27. + channel on ischemia-sensing neurons
28. Subunit stoichiometry of the epithelial sodium channel
29. A 'receptor' for protons in small neurons of trigeminal ganglia: Possible role in nociception
30. A receptor for protons in the membrane of sensory neurons may participate in nociception
31. Morphological and biochemical cell types of sensory neurons
32. Sensory neuron mechanotransduction: Its regulation and underlying molecular mechanisms
33. Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel
34. A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells
35. Interaction between a putative mechanosensory membrane channel and a collagen
36. DEG/ENaC channels: A touchy superfamily that watches its salt
37. Ligand: A versatile computerized approach for characterization of ligand-binding systems
38. An acid sensing ion channel (ASIC) localizes to small primary afferent neurons in rats
39. Subclassified acutely dissociated cells of rat DRG: Histochemistry and patterns of capsaicin-, proton-, and ATP-activated currents
40. The mammalian sodium channel BNC1 is required for normal touch sensation
41. The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice
42. + channel
43. + channel
44. Electrophysiological and biochemical evicence that DEG/ENaC cation channels are composed of nine subunits
45. Membrane topology of the amiloride-sensitive epithelial sodium channel
46. Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin in vitro
47. Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons
48. unc-8, a DEG/ENaC family member, encodes a subunit of a candidate mechanically gated channel that modulates C. elegans locomotion
49. The cloned capsaicin receptor integrates multiple pain-producing stimuli
50. + channel specific for sensory neurons
51. A proton-gated cation channel involved in acid-sensing
52. The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans
53. +-gated cation channels: Neuronal acid sensors in the NaC/DEG family of ion channels
54. Single-channel properties of recombinant acid-sensitive ion channels formed by the subunits ASIC2 and ASIC3 from dorsal root ganglion neurons expressed in Xenopus oocytes