Regulation of neutrophil survival/apoptosis by Mcl-1

TheScientificWorldJournal

Volumn 11, Issue , 2011, Pages 1948-1962

  Milot, Eric ^a   Filep, János G ^a  

^a UNIVERSITY OF MONTREAL   (Canada)

Author keywords

2 integrin; apoptosis; caspase; cyclin dependent kinase inhibitors; formyl peptide receptors; gene transcription; inflammation; lipoxins; Mcl 1 (myeloid cell leukemia 1); mitochondria; MNDA (myeloid nuclear differentiation antigen); Neutrophils; phosphorylation; proteasomal degradation; resolution of inflammation; sepsis

Indexed keywords

ACETYLSALICYLIC ACID; MEVINOLIN; PROTEIN BCL 2; PROTEIN MCL 1; PYRROLIDINE DITHIOCARBAMATE; ROLIPRAM; ROSCOVITINE;

APOPTOSIS; ARTICLE; CELL FATE; CELL NUCLEUS; CELL SURVIVAL; DRUG TARGETING; HUMAN; INFLAMMATION; NEUTROPHIL; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

APOPTOSIS; CELL SURVIVAL; HUMANS; NEUTROPHILS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 81455139909     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/2011/131539     Document Type: Article

References (135)

1. Savill J., Dransfield I., Gregory C., Haslett C., A blast from the past: clearance of apoptotic cells regulates immune responses Nature Reviews Immunology 2002 2 12 965 975 (Pubitemid 37323217)
2. Gilroy D. W., Lawrence T., Perretti M., Rossi A. G., Inflammatory resolution: new opportunities for drug discovery Nature Reviews Drug Discovery 2004 3 5 401 416 (Pubitemid 38618123)
3. Luo H. R., Loison F., Constitutive neutrophil apoptosis: mechanisms and regulation The American Journal of Hematology 2008 83 4 288 295 (Pubitemid 351458006)
4. Simon H. U., Neutrophil apoptosis pathways and their modifications in inflammation Immunological Reviews 2003 193 101 110
5. El Kebir D., Filep J. G., Role of neutrophil apoptosis in the resolution of inflammation TheScientificWorldJOURNAL 2010 10 1731 1748
6. Nathan C., Neutrophils and immunity: challenges and opportunities Nature Reviews Immunology 2006 6 3 173 182 (Pubitemid 43290987)
7. Nauseef W. M., How human neutrophils kill and degrade microbes: an integrated view Immunological Reviews 2007 219 1 88 102 (Pubitemid 47390004)
8. Elbim C., Katsikis P.D., Estaquier J., Neutrophil apoptosis during viral infections The Open Virology Journal 2009 3 52 59
9. Ramirez M. J., Titos E., Claria J., Navasa M., Fernandez J. Rodes J., Increased apoptosis dependent on caspase-3 activity in polymorphonuclear leukocytes from patients with cirrhosis and ascites Journal of Hepatology 2004 41 44 48 (Pubitemid 39005151)
10. Savill J. S., Wyllie A. H., Henson J. E., Walport M. J., Henson P. M., Haslett C., Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages Journal of Clinical Investigation 1989 83 3 865 875 (Pubitemid 19080618)
11. El Kebir D., Jozsef L., Pan W., Filep J. G., Myeloperoxidase delays neutrophil apoptosis through CD11b/CD18 integrins and prolongs inflammation Circulation Research 2008 103 4 352 359
12. Jonsson H., Allen P., Peng S. L., Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis Nature Medicine 2005 11 6 666 671 (Pubitemid 40868308)
13. Khanna S., Biswas S., Shang Y., Collard E., Azad A., Kauh C., Bhasker V., Gordillo G. M., Sen C. K., Roy S., Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice PLoS One 2010 5 3
14. Serhan C. N., Brain S. D., Buckley C. D., Gilroy D. W., Haslett C., O'Neill L. A. J., Perretti M., Rossi A. G., Wallace J. L., Resolution of inflammation: state of the art, definitions and terms FASEB Journal 2007 21 2 325 332 (Pubitemid 46213480)
15. Serhan C. N., Chiang N., Van Dyke T. E., Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators Nature Reviews Immunology 2008 8 5 349 361 (Pubitemid 351595216)
16. Edwards S. W., Derouet M., Howse M., Moots R. J., Regulation of neutrophil apoptosis by Mcl-1 Biochemical Society Transactions 2004 32 3 489 492 (Pubitemid 38813545)
17. Dzhagalov I., John A. S., He Y. W., The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages Blood 2007 109 4 1620 1626 (Pubitemid 46239596)
18. Moulding D. A., Akgul C., Derouet M., White M. R. H., Edwards S. W., BCL-2 family expression in human neutrophils during delayed and accelerated apoptosis Journal of Leukocyte Biology 2001 70 5 783 792 (Pubitemid 33127013)
19. Craig R. W., MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis Leukemia 2002 16 4 444 454 (Pubitemid 34449724)
20. Dancey J. T., Deubelbeiss K. A., Harker C. A., Finch C.A., Neutrophil kinetics in man Journal of Clinical Investigation 1976 58 3 705 715
21. Basu S., Hodgson G., Katz M., Dunn A. R., Evaluation of role of G-CSF in the production, survival, and release of neutrophils from bone marrow into circulation Blood 2002 100 3 854 861 (Pubitemid 34832610)
22. Pillay J., den Braber I., Vrisekoop N., Kwast L. M., De Boer R. J., Borghans J. A. M., Tesselaar K., Koenderman L., In vivo labeling with 2 H 2 O reveals a human neutrophil lifespan of 5.4 days Blood 2010 116 4 625 627
23. Martin C., Burdon P. C. E., Bridger G., Gutierrez-Ramos J. C., Williams T. J., Rankin S. M., Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence Immunity 2003 19 4 583 593 (Pubitemid 37311439)
24. Watson R. W. G., Rotstein O. D., Nathens A. B., Parodo J., Marshall J. C., Neutrophil apoptosis modulated by endothelial transmigration and adhesion molecules engagement Journal of Immunology 1997 158 2 945 953 (Pubitemid 127492675)
25. Lee A., Whyte M. K., Haslett C., Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators Journal of Leukocyte Biology 1993 54 4 283 288 (Pubitemid 23317694)
26. Colotta F., Re F., Polentarutti N., Sozzani S., Mantovani A., Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products Blood 1992 80 8 2012 2020
27. El Kebir D., Jzsef L., Khreiss T., Pan W., Petasis N. A., Serhan C. N., Filep J. G., Aspirin-triggered lipoxins override the apoptosis-delaying action of serum amyloid A in human neutrophils: a novel mechanism for resolution of inflammation Journal of Immunology 2007 179 1 616 622 (Pubitemid 46986579)
28. Khreiss T., Jzsef L., Hossain S., Chan J. S. D., Potempa L. A., Filep J. G., Loss of pentameric symmetry of C-reactive protein is associated with delayed apoptosis of human neutrophils Journal of Biological Chemistry 2002 277 43 40775 40781 (Pubitemid 35215662)
29. Renshaw S. A., Parmar J. S., Singleton V., Rowe S. J., Dockrell D. H., Dower S. K., Bingle C. D., Chilvers E. R., Whyte M. K. B., Acceleration of human neutrophil apoptosis by TRAIL Journal of Immunology 2003 170 2 1027 1033 (Pubitemid 36070558)
30. Mayadas T. N., Cullere X., Neutrophil 2 integrins: moderators of life or death decisions Trends in Immunology 2005 26 7 388 395 (Pubitemid 40835845)
31. Savill J., Dransfield I., Hogg N., Haslett C., Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis Nature 1990 343 6254 170 173
32. Allen L., Dockrell D. H., Pattery T., Lee D. G., Cornelis P., Hellewell P. G., Whyte M. K. B., Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivo Journal of Immunology 2005 174 6 3643 3649 (Pubitemid 40354074)
33. Colamussi M. L., White M. R., Crouch E., Hartshorn K. L., Influenza A virus accelerates neutrophil apoptosis and markedly potentiates apoptotic effects of bacteria Blood 1999 93 7 2395 2403 (Pubitemid 29153644)
34. Courtney P. A., Crockard A. D., Williamson K., Irvine A. E., Kennedy R. J., Bell A. L., Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: relations with disease activity, antibodies to double stranded DNA, and neutropenia Annals of the Rheumatic Diseases 1999 58 5 309 314 (Pubitemid 29232144)
35. Ertel W., Keel M., Infanger M., Ungethm U., Steckholzer U., Trentz O., Circulating mediators in serum of injured patients with septic complications inhibit neutrophil apoptosis through up-regulation of protein- tyrosine phosphorylation Journal of Trauma 1998 44 5 767 776 (Pubitemid 28233021)
36. Chitnis D., Dickerson C., Munster A. M., Winchurch R. A., Inhibition of apoptosis in polymorphonuclear neutrophils from burn patients Journal of Leukocyte Biology 1996 59 6 835 839 (Pubitemid 26238479)
37. Matute-bello G., Liles W. C., Radella F. II, Steinberg K. P., Ruzinski J. T., Jonas M., Chi E. Y., Hudson L. D., Martin T. R., Neutrophil apoptosis in the acute respiratory distress syndrome The American Journal of Respiratory and Critical Care Medicine 1997 156 6 1969 1977 (Pubitemid 28011809)
38. Garlichs C. D., Eskafi S., Cicha I., Schmeisser A., Walzog B., Raaz D., Stumpf C., Yilmaz A., Bremer J., Ludwig J., Daniel W. G., Delay of neutrophil apoptosis in acute coronary syndromes Journal of Leukocyte Biology 2004 75 5 828 835 (Pubitemid 38580063)
39. Brown V., Elborn J. S., Bradley J., Ennis M., Dysregulated apoptosis and NFkappaB expression in COPD subjects Respiratory research 2009 10 24
40. Lindemans C. A., Coffer P. J., Schellens I. M. M., De Graaff P. M. A., Kimpen J. L. L., Koenderman L., Respiratory syncytial virus inhibits granulocyte apoptosis through a phosphatidylinositol 3-kinase and NF- B-dependent mechanism Journal of Immunology 2006 176 9 5529 5537
41. Wong S. H., Francis N., Chahal H., Raza K., Salmon M., Scheel-toellner D., Lord J. M., Lactoferrin is a survival factor for neutrophils in rheumatoid synovial fluid Rheumatology 2009 48 1 39 44
42. Christenson K., Bjrkman L., Tngemo C., Bylund J., Serum amyloid A inhibits apoptosis of human neutrophils via a P2X7-sensitive pathway independent of formyl peptide receptor-like 1 Journal of Leukocyte Biology 2008 83 1 139 148
43. O'Neill S., O'Neill A. J., Conroy E., Brady H. R., Fitzpatrick J. M., Watson R. W. G., Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatitis Journal of Leukocyte Biology 2000 68 1 15 20
44. Finkelstein E. I., Nardini M., Van Der Vliet A., Inhibition of neutrophil apoptosis by acrolein: a mechanism of tobacco-related lung disease? The American Journal of Physiology 2001 281 3 L732 L739
45. Laskay T., van Zandbergen G., Solbach W., Neutrophil granulocytes as host cells and transport vehicles for intracellular pathogens: apoptosis as infection-promoting factor Immunobiology 2008 213 3-4 183 191
46. Rupp J., Pfleiderer L., Jugert C., Moeller S., Klinger M., Dalhoff K., Solbach W., Stenger S., Laskay T., van Zandbergen G., Chlamydia pneumoniae hides inside apoptotic neutrophils to silently infect and propagate in macrophages PLoS One 2009 4 6
47. Moulding D. A., Akgul C., Derouet M., White M. R. H., Edwards S. W., BCL-2 family expression in human neutrophils during delayed and accelerated apoptosis Journal of Leukocyte Biology 2001 70 5 783 792 (Pubitemid 33127013)
48. Akgul C., Moulding D. A., Edwards S. W., Molecular control of neutrophil apoptosis FEBS Letters 2001 487 3 318 322 (Pubitemid 32121749)
49. Hamasaki A., Sendo F., Nakayama K., Ishida N., Negishi I., Nakayama K. I., Hatakeyama S., Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene Journal of Experimental Medicine 1998 188 11 1985 1992 (Pubitemid 28562516)
50. Moulding D. A., Quayle J. A., Anthony Hart C., Edwards S. W., Mcl-1 expression in human neutrophils: regulation by cytokines and correlation with cell survival Blood 1998 92 7 2495 2502 (Pubitemid 28452993)
51. Kato T., Kutsuna H., Oshitani N., Kitagawa S., Cyclic AMP delays neutrophil apoptosis via stabilization of Mcl-1 FEBS Letters 2006 580 19 4582 4586 (Pubitemid 44189375)
52. Leuenroth S. J., Grutkoski P. S., Ayala A., Simms H. H., Suppression of PMN apoptosis by hypoxia is dependent on Mcl-1 and MAPK activity Surgery 2000 128 2 171 177 (Pubitemid 30622480)
53. Moulding D. A., Giles R. V., Spiller D. G., White M. R. H., Tidd D. M., Edwards S. W., Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells Blood 2000 96 5 1756 1763 (Pubitemid 30661059)
54. Catarzi S., Marcucci T., Papucci L., Favilli F., Donnini M., Tonelli F., Vincenzini M. T., Iantomasi T., Apoptosis and bax, Bcl-2, Mcl-1 expression in neutrophils of Crohn's disease patients Inflammatory Bowel Diseases 2008 14 6 819 825 (Pubitemid 351898067)
55. Fotouhi-Ardakani N., El Kebir D., Pierre-Charles N., Wang L., Ahern S. P., Filep J. G., Milot E., Role for myeloid nuclear differentiation antigen in the regulation of neutrophil apoptosis during sepsis The American Journal of Respiratory and Critical Care Medicine 2010 182 3 341 350
56. Fox S., Leitch A. E., Duffin R., Haslett C., Rossi A. G., Neutrophil apoptosis: relevance to the innate immune response and inflammatory disease Journal of Innate Immunity 2010 2 3 216 227
57. Filep J. G., El Kebir D., Neutrophil apoptosis: a target for enhancing the resolution of inflammation Journal of Cellular Biochemistry 2009 108 5 1039 1046
58. Zhang B., Hirahashi J., Cullere X., Mayadas T. N., Elucidation of molecular events leading to neutrophil apoptosis following phagocytosis: cross-talk between caspase 8, reactive oxygen species, and MAPK/ERK activation Journal of Biological Chemistry 2003 278 31 28443 28454 (Pubitemid 36935746)
59. Kanayama A., Miyamoto Y., Apoptosis triggered by phagocytosis-related oxidative stress through FLIPS down-regulation and JNK activation Journal of Leukocyte Biology 2007 82 5 1344 1352 (Pubitemid 350133532)
60. Ye R. D., Boulay F., Ji M. W., Dahlgren C., Gerard C., Parmentier M., Serhan C. N., Murphy P. M., International union of basic and clinical pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family Pharmacological Reviews 2009 61 2 119 161
61. Chiang N., Serhan C. N., Dahlén S. -E., Drazen J. M., Hay D. W.P., Enrico Rovati G., Shimizu T., Yokomizo T., Brink C., The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo Pharmacological Reviews 2006 58 3 463 487 (Pubitemid 44394909)
62. Perretti M., Chiang N., La M., Fierro I. M., Marullo S., Getting S. J., Solito E., Serhan C. N., Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A 4 receptor Nature Medicine 2002 8 11 1296 1302 (Pubitemid 35373563)
63. Nagaoka I., Tamura H., Hirata M., An antimicrobial cathelicidin peptide, human CAP18/LL-37, suppresses neutrophil apoptosis via the activation of formyl-peptide receptor-like 1 and P2X 7 Journal of Immunology 2006 176 5 3044 3052
64. Altznauer F., Conus S., Cavalli A., Folkers G., Simon H. U., Calpain-1 regulates Bax and subsequent Smac-dependant caspase-3 activation in neutrophil apoptosis Journal of Biological Chemistry 2004 279 7 5947 5957 (Pubitemid 38220627)
65. Michels J., Johnson P. W. M., Packham G., Molecules in focus. Mcl-1 The International Journal of Biochemistry Cell Biology 2005 37 267 271
66. Thomas L. W., Lam C., Edwards S. W., Mcl-1; the molecular regulation of protein function FEBS Letters 2010 584 14 2981 2989
67. Gross A., McDonnell J. M., Korsmeyer S. J., BCL-2 family members and the mitochondria in apoptosis Genes and Development 1999 13 15 1899 1911 (Pubitemid 29407357)
68. Yang T., Kozopas K. M., Craig R. W., The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2 Journal of Cell Biology 1995 128 6 1173 1184
69. Craig R. W., MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis Leukemia 2002 16 4 444 454 (Pubitemid 34449724)
70. Cuconati A., Mukherjee C., Perez D., White E., DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells Genes and Development 2003 17 23 2922 2932 (Pubitemid 37523156)
71. Reed J. C., Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities Cell Death and Differentiation 2006 13 8 1378 1386 (Pubitemid 44057473)
72. Brenner D., Mak T. W., Mitochondrial cell death effectors Current Opinion in Cell Biology 2009 21 6 871 877
73. Maianski N. A., Geissler J., Srinivasula S. M., Alnemri E. S., Roos D., Kuijpers T. W., Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis Cell Death and Differentiation 2004 11 2 143 153 (Pubitemid 38159638)
74. Akgul C., Turner P. C., White M. R. H., Edwards S. W., Functional analysis of the human MCL-1 gene Cellular and Molecular Life Sciences 2000 57 4 684 691 (Pubitemid 30311437)
75. Derouet M., Thomas L., Cross A., Moots R. J., Edwards S. W., Granulocyte macrophage colony-stimulating factor signaling and proteasome inhibition delay neutrophil apoptosis by increasing the stability of Mcl-1 Journal of Biological Chemistry 2004 279 26 26915 26921 (Pubitemid 38812526)
76. Negrotto S., Malaver E., Alvarez M. E., Pacienza N., D'Atri L. P., Pozner R. G., Gmez R. M., Schattner M., Aspirin and salicylate suppress polymorphonuclear apoptosis delay mediated by proinflammatory stimuli Journal of Pharmacology and Experimental Therapeutics 2006 319 2 972 979
77. Drewniak A., van Raam B. J., Geissler J., Tool A. T. J., Mook O. R. F., Van Den Berg T. K., Baas F., Kuijpers T. W., Changes in gene expression of granulocytes during in vivo granulocyte colony-stimulating factor/dexamethasone mobilization for transfusion purposes Blood 2009 113 23 5979 5998
78. Kasahara Y., Iwai K., Yachie A., Ohta K., Konno A., Seki H., Miyawaki T., Taniguchi N., Involvement of reactive oxygen intermediates in spontaneous and CD95(Fas/APO-1)-mediated apoptosis of neutrophils Blood 1997 89 5 1748 1753 (Pubitemid 27097470)
79. Hannah S., Mecklenburgh K., Rahman I., Bellingan G. J., Greening A., Haslett C., Chilvers E. R., Hypoxia prolongs neutrophil survival in vitro FEBS Letters 1995 372 2-3 233 237
80. Ward C., Walker A., Dransfield I., Haslett C., Rossi A. G., Regulation of granulocyte apoptosis by NF- B Biochemical Society Transactions 2004 32 3 465 467
81. Croxton R., Ma Y., Song L., Haura E. B., Cress W. D., Direct repression of the Mcl-1 promoter by E2F1 Oncogene 2002 21 9 1359 1369 (Pubitemid 34214501)
82. Kim J. H., Sim S. H., Ha H. J., Ko J. J., Lee K., Bae J., MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death FEBS Letters 2009 583 17 2758 2764
83. Bae J., Leo C. P., Sheau Yu Hsu, Hsueh A. J. W., MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain Journal of Biological Chemistry 2000 275 33 25255 25261
84. Marriott H. M., Bingle C. D., Read R. C., Braley K. E., Kroemer G., Hellewell P. G., Craig R. W., Whyte M. K. B., Dockrell D. H., Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance Journal of Clinical Investigation 2005 115 2 359 368 (Pubitemid 40385477)
85. Mott J. L., Kobayashi S., Bronk S. F., Gores G. J., mir-29 regulates Mcl-1 protein expression and apoptosis Oncogene 2007 26 42 6133 6140 (Pubitemid 47414372)
86. Kobayashi S., Lee S. H., Meng X. W., Mott J. L., Bronk S. F., Werneburg N. W., Craig R. W., Kaufmann S. H., Gores G. J., Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1 Journal of Biological Chemistry 2007 282 25 18407 18417 (Pubitemid 47100259)
87. Ding Q., Huo L., Yang J. Y., Xia W., Wei Y., Liao Y., Chang C. J., Yang Y., Lai C. C., Lee D. F., Yen C. J., Chen Y. J. R., Hsu J. M., Kuo H. P., Lin C. Y., Tsai F. J., Li L. Y., Tsai C. H., Hung M. C., Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer Cancer Research 2008 68 15 6109 6117
88. Ding Q., He X., Hsu J. M., Xia W., Chen C. T., Li L. Y., Lee D. F., Liu J. C., Zhong Q., Wang X., Hung M. C., Degradation of Mcl-1 by -TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization Molecular and Cellular Biology 2007 27 11 4006 4017 (Pubitemid 47010998)
89. Maurer U., Charvet C., Wagman A. S., Dejardin E., Green D. R., Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1 Molecular Cell 2006 21 6 749 760 (Pubitemid 43376126)
90. Morel C., Carlson S. M., White F. M., Davis R. J., Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis Molecular and Cellular Biology 2009 29 14 3845 3852
91. Alvarado-Kristensson M., Melander F., Leandersson K., Rnnstrand L., Wernstedt C., Andersson T., p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils Journal of Experimental Medicine 2004 199 4 449 458 (Pubitemid 38233829)
92. Klein J. B., Rane M. J., Scherzer J. A., Coxon P. Y., Kettritz R., Mathiesen J. M., Buridi A., McLeish K. R., Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways Journal of Immunology 2000 164 8 4286 4291 (Pubitemid 30215090)
93. Fujise K., Zhang D., Liu J. L., Yeh E. T. H., Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen Journal of Biological Chemistry 2000 275 50 39458 39465 (Pubitemid 32058971)
94. Jamil S., Sobouti R., Hojabrpour P., Raj M., Kast J., Duronio V., A proteolytic fragment of Mcl-1 exhibits nuclear localization and regulates cell growth by interaction with Cdk1 Biochemical Journal 2005 387 3 659 667 (Pubitemid 40685699)
95. Germain M., Duronio V., The N terminus of the anti-apoptotic BCL-2 homologue MCL-1 regulates its localization and function Journal of Biological Chemistry 2007 282 44 32233 32242 (Pubitemid 350106470)
96. Gardai S. J., Hildeman D. A., Frankel S. K., Whitlock B. B., Frasch S. C., Borregaard N., Marrack P., Bratton D. L., Henson P. M., Phosphorylation of Bax ser184 by Akt regulates its activity and apoptosis in neutrophils Journal of Biological Chemistry 2004 279 20 21085 21095 (Pubitemid 38656511)
97. Wang J. Y. J., Nucleo-cytoplasmic communication in apoptotic response to genotoxic and inflammatory stress Cell Research 2005 15 1 43 48 (Pubitemid 41653964)
98. Mihara M., Erster S., Zaika A., Petrenko O., Chittenden T., Pancoska P., Moll U. M., p53 has a direct apoptogenic role at the mitochondria Molecular Cell 2003 11 3 577 590 (Pubitemid 36385115)
99. Dumont P., Leu J. I. J., Della Pietra A. C., George D. L., Murphy M., The codon 72 polymorphic variants of p53 have markedly different apoptotic potential Nature Genetics 2003 33 3 357 365 (Pubitemid 36278852)
100. Chipuk J. E., Maurer U., Green D. R., Schuler M., Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription Cancer Cell 2003 4 5 371 381 (Pubitemid 37491098)
101. Chipuk J. E., Green D. R., Cytoplasmic p53: bax and forward Cell Cycle 2004 3 4 429 431 (Pubitemid 40278229)
102. Zhang Y., Wang L., Nuclear receptor small heterodimer partner in apoptosis signaling and liver cancer Cancers 2011 3 1 198 212
103. Witko-Sarsat V., Mocek J., Bouayad D., Tamassia N., Ribeil J. A., Candalh C., Davezac N., Reuter N., Mouthon L., Hermine O., Pederzoli-Ribeil M., Cassatella M. A., Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival Journal of Experimental Medicine 2010 207 12 2631 2645
104. Naryzhny S. N., Proliferating cell nuclear antigen: a proteomics view Cellular and Molecular Life Sciences 2008 65 23 3789 3808
105. Choubey D., Panchanathan R., Interferon-inducible Ifi200-family genes in systemic lupus erythematosus Immunology Letters 2008 119 1-2 32 41
106. Zhong Q., Gao W., Du F., Wang X., Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis Cell 2005 121 7 1085 1095 (Pubitemid 40884398)
107. Schwickart M., Huang X., Lill J. R., Liu J., Ferrando R., French D. M., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang D. C. S., Dixit V. M., Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival Nature 2010 463 7277 103 107
108. Clohessy J. G., Zhuang J., Brady H. J. M., Characterisation of Mcl-1 cleavage during apoptosis of haematopoietic cells The British Journal of Haematology 2004 125 5 655 665 (Pubitemid 38747969)
109. Weng C., Li Y., Xu D., Shi Y., Tang H., Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells Journal of Biological Chemistry 2005 280 11 10491 10500 (Pubitemid 40395908)
110. Wardle D. J., Burgon J., Sabroe I., Bingle C. D., Whyte M. K.B., Renshaw S. A., Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation PLoS One 2011 6 1
111. Miles K., Clarke D. J., Lu W., Sibinska Z., Beaumont P. E., Davidson D. J., Barr T. A., Campopiano D. J., Gray M., Dying and necrotic neutrophils are anti-inflammatory secondary to the release of alpha-defensins Journal of Immunology 2009 183 3 2122 2132
112. Ariel A., Fredman G., Sun Y. P., Kantarci A., Van Dyke T. E., Luster A. D., Serhan C. N., Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression Nature Immunology 2006 7 11 1209 1216 (Pubitemid 44594317)
113. Ren Y., Xie Y., Jiang G., Fan J., Yeung J., Li W., Tam P. K. H., Savill J., Apoptotic cells protect mice against lipopolysaccharide-induced shock Journal of Immunology 2008 180 7 4978 4985
114. Murray P. J., Wynn T. A., Obstacles and opportunities for understanding macrophage polarization Journal of Leukocyte Biology 2011 89 4 557 563
115. Pinho V., Russo R. D. C., Amaral F. A., de Sousa L. P., Barsante M. M., de Souza D. G., Alves-Filho J. C., Cara D. C., Hayflick J. S., Rommel C., Ruckle T., Rossi A. G., Teixeira M. M., Tissue- and stimulus-dependent role of phosphatidylinositol 3-kinase isoforms for neutrophil recruitment induced by chemoattractants in vivo Journal of Immunology 2007 179 11 7891 7898
116. Sawatzky D. A., Willoughby D. A., Colville-Nash P. R., Rossi A. G., The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-x L and Bax in the resolution of acute inflammation in vivo The American Journal of Pathology 2006 168 1 33 41 (Pubitemid 43062557)
117. Derouet M., Thomas L., Moulding D. A., Akgul C., Cross A., Moots R. J., Edwards S. W., Sodium salicylate promotes neutrophil apoptosis by stimulating caspase-dependent turnover of Mcl-1 Journal of Immunology 2006 176 2 957 965 (Pubitemid 43099694)
118. Sousa L. P., Lopes F., Silva D. M., Tavares L. P., Vieira A. T., Rezende B. M., Carmo A. F., Russo R. C., Garcia C. C., Bonjardim C. A., Alessandri A. L., Rossi A. G., Pinho V., Teixeira M. M., PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF- B-independent manner Journal of Leukocyte Biology 2010 87 5 895 904
119. El Kebir D., Jzsef L., Pan W., Wang L., Petasis N. A., Serhan C. N., Filep J. G., 15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury The American Journal of Respiratory and Critical Care Medicine 2009 180 4 311 319
120. Brovkovych V., Gao X. P., Ong E., Brovkovych S., Brennan M. L., Su X., Hazen S. L., Malik A. B., Skidgel R. A., Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice The American Journal of Physiology 2008 295 1 L96 L103
121. Matthijsen R. A., Huugen D., Hoebers N. T., De Vries B., Peutz-Kootstra C. J., Aratani Y., Daha M. R., Tervaert J. W.C., Buurman W. A., Heeringa P., Myeloperoxidase is critically involved in the induction of organ damage after renal ischemia reperfusion The American Journal of Pathology 2007 171 6 1743 1752
122. Fukunaga K., Kohli P., Bonnans C., Fredenburgh L. E., Levy B. D., Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury Journal of Immunology 2005 174 8 5033 5039
123. Planagum A., Pfeffer M. A., Rubin G., Croze R., Uddin M., Serhan C. N., Levy B. D., Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A 4 Mucosal Immunology 2010 3 3 270 279
124. Jzsef L., Zouki C., Petasis N. A., Serhan C. N., Filep J. G., Lipoxin A 4 and aspirin-triggered 15-epi-lipoxin A 4 inhibit peroxynitrite formation, NF- B and AP-1 activation, and IL-8 gene expression in human leukocytes Proceedings of the National Academy of Sciences of the United States of America 2002 99 20 13266 13271
125. Iglesias-Serret D., Pique M., Barragan M., Cosialls A. M., Santidrian A. F., Gonzalez-Girones D. M., Coll-Mullet L., de Frias M., Pons G., Gil J., Aspirin induces apoptosis in human leukemia cells independently of NF- B and MAPKs through alteration of the Mcl-1/Noxa balance Apoptosis 2010 15 219 229
126. Serhan C. N., Hong S., Gronert K., Colgan S. P., Devchand P. R., Mirick G., Moussignac R. L., Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals Journal of Experimental Medicine 2002 196 8 1025 1037 (Pubitemid 35231761)
127. Seki H., Fukunaga K., Arita M., Arai H., Nakanishi H., Taguchi R., Miyasho T., Takamiya R., Asano K., Ishizaka A., Takeda J., Levy B. D., The anti-inflammatory and proresolving mediator resolving E1 protects mice from bacterial pneumonia and acute lung injury The Journal of Immunology 2010 184 836 843
128. Spite M., Norling L. V., Summers L., Yang R., Cooper D., Petasis N. A., Flower R. J., Perretti M., Serhan C. N., Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis Nature 2009 461 7268 1287 1291
129. Rossi A. G., Sawatzky D. A., Walker A., Ward C., Sheldrake T. A., Riley N. A., Caldicott A., Martinez-Losa M., Walker T. R., Duffin R., Gray M., Crescenzi E., Martin M. C., Brady H. J., Savill J. S., Dransfield I., Haslett C., Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis Nature Medicine 2006 12 9 1056 1064 (Pubitemid 44353387)
130. Rosales J. L., Ernst J. D., Hallows J., Lee K. Y., GTP-dependent secretion from neutrophils is regulated by Cdk5 Journal of Biological Chemistry 2004 279 52 53932 53936 (Pubitemid 40053123)
131. Koedel U., Frankenberg T., Kirschnek S., Obermaier B., Hcker H., Paul R., Hcker G., Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis PLoS Pathogens 2009 5 5
132. Moriceau S., Lenoir G., Witko-Sarsat V., In cystic fibrosis homozygotes and heterozygotes, neutrophil apoptosis is delayed and modulated by diamide or roscovitine: evidence for an innate neutrophil disturbance Journal of Innate Immunity 2010 2 3 260 266
133. Paunel-Grgl A., Zrnig M., Lgters T., Altrichter J., Rabenhorst U., Cinatl J., Windolf J., Scholz M., Mcl-1-mediated impairment of the intrinsic apoptosis pathway in circulating neutrophils from critically ill patients can be overcome by Fas stimulation Journal of Immunology 2009 183 10 6198 6206
134. Opferman J. T., Letai A., Beard C., Sorcinelli M. D., Ong C. C., Korsmeyer S. J., Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1 Nature 2003 426 6967 671 676 (Pubitemid 38009376)
135. Opferman J. T., Iwasaki H., Ong C. C., Suh H., Mizuno S. I., Akashi K., Korsmeyer S. J., Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells Science 2005 307 5712 1101 1104 (Pubitemid 40262114)