Dysregulated apoptosis and NFκB expression in COPD subjects

Respiratory Research

Volumn 10, Issue , 2009, Pages

  Brown, Vanessa ^a   Elborn, J Stuart ^a   Bradley, Judy ^b   Ennis, Madeleine ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; PROPIDIUM IODIDE; PROTEIN P50; SYNAPTOTAGMIN I; C REACTIVE PROTEIN; CYTOKINE; I KAPPA B; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; NFKB1 PROTEIN, HUMAN; RELA PROTEIN, HUMAN; TRANSCRIPTION FACTOR RELA;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL STRUCTURE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; HUMAN; INFLAMMATION; MALE; MICROSCOPY; NEUTROPHIL; NICK END LABELING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SPUTUM ANALYSIS; CASE CONTROL STUDY; CYTOLOGY; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY; PHOSPHORYLATION; SMOKING; SPUTUM; UPREGULATION;

AGED; APOPTOSIS; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; I-KAPPA B PROTEINS; IN SITU NICK-END LABELING; MALE; MIDDLE AGED; NEUTROPHILS; NF-KAPPA B P50 SUBUNIT; PHOSPHORYLATION; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING; SPUTUM; TRANSCRIPTION FACTOR RELA; UP-REGULATION;

EID: 65649116604     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-10-24     Document Type: Article

References (53)

1. Keatings VM, Barnes PJ. Granulocyte activation markers in induced sputum: comparison between chronic obstructive pulmonary disease, asthma, and normal subjects. Am J Respir Crit Care Med 1997, 155:449-453.
2. Di Stefano A, Capelli A, Lusuardi M, Balbo P, Vecchio C, Maestrelli P, Mapp CE, Fabbri LM, Donner CF, Saetta M. Severity of airflow limitation is associated with severity of airway inflammation in smokers. Am J Respir Crit Care Med 1998, 158:1277-1285.
3. Confalonieri M, Mainardi E, Della Porta R, Bernorio S, Gandola L, Beghe B, Spanevello A. Inhaled corticosteroids reduce neutrophilic bronchial inflammation in patients with chronic obstructive pulmonary disease. Thorax 1998, 53:583-585. 1745263, 9797758.
4. Bhowmik A, Seemungal TA, Sapsford RJ, Wedzicha JA. Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations. Thorax 2000, 55:114-120. 1745686, 10639527, 10.1136/thorax.55.2.114.
5. Saba S, Soong G, Greenberg S, Prince A. Bacterial stimulation of epithelial G-CSF and GM-CSF expression promotes PMN survival in CF airways. Am J Respir Cell Mol Biol 2002, 27:561-567.
6. Matute-Bello G, Liles WC, Radella F, Steinberg KP, Ruzinski JT, Jonas M, Chi EY, Hudson LD, Martin TR. Neutrophil apoptosis in the acute respiratory distress syndrome. Am J Respir Crit Care Med 1997, 156:1969-1977.
7. Pletz MW, Ioanas M, de Roux A, Burkhardt O, Lode H. Reduced spontaneous apoptosis in peripheral blood neutrophils during exacerbation of COPD. Eur Respir J 2004, 23:532-537. 10.1183/09031936.04.00089004, 15083750.
8. Noguera A, Sala E, Pons AR, Iglesias J, MacNee W, Agusti AG. Expression of adhesion molecules during apoptosis of circulating neutrophils in COPD. Chest 2004, 125:1837-1842. 10.1378/chest.125.5.1837, 15136398.
9. Rytila P, Plataki M, Bucchieri F, Uddin M, Nong G, Kinnula VL, Djukanovic R. Airway neutrophilia in COPD is not associated with increased neutrophil survival. Eur Respir J 2006, 28:1163-1169. 10.1183/09031936.00149005, 16971404.
10. Marti GE, Zenger VE, Vogt R, Gaigalas A. Quantitative flow cytometry: history, practice, theory, consensus, inter-laboratory variation and present status. Cytotherapy 2002, 4:97-98. 10.1080/146532402317251626, 11953051.
11. Yasuda N, Gotoh K, Minatoguchi S, Asano K, Nishigaki K, Nomura M, Ohno A, Watanabe M, Sano H, Kumada H, Sawa T, Fujiwara H. An increase of soluble Fas, an inhibitor of apoptosis, associated with progression of COPD. Respir Med 1998, 92:993-999. 10.1016/S0954-6111(98)90343-2, 9893764.
12. Takabatake N, Nakamura H, Inoue S, Terashita K, Yuki H, Kato S, Yasumura S, Tomoike H. Circulating levels of soluble Fas ligand and soluble Fas in patients with chronic obstructive pulmonary disease. Respir Med 2000, 94:1215-1220. 10.1053/rmed.2000.0941, 11192958.
13. Kucharczak J, Simmons MJ, Fan Y, Gelinas C. To be, or not to be: NF-kappaB is the answer - role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene 2003, 22:8961-8982. 10.1038/sj.onc.1207230, 14663476.
14. Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997, 336:1066-1071. 10.1056/NEJM199704103361506, 9091804.
15. Tak PP, Firestein GS. NF-kappaB: a key role in inflammatory diseases. J Clin Invest 2001, 107:7-11. 198552, 11134171, 10.1172/JCI11830.
16. Rothwarf DM, Karin M. The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus. Sci STKE 1999, 1999:RE1. 10.1126/stke.1999.5.re1, 11865184.
17. Drost EM, Richie HE, Skwarska E, Newman W, Barr J, Donaldson K. NF-kB activation in airway leucocytes in COPD subjects. Eur Respir J Suppl 2000, 16:260s.
18. Caramori G, Romagnoli M, Casolari P, Bellettato C, Casoni G, Boschetto P, Fan Chung K, Barnes PJ, Adcock IM, Ciaccia A, Fabbri LM, Papi A. Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations. Thorax 2003, 58:348-351. 1746629, 12668802, 10.1136/thorax.58.4.348.
19. Szulakowski P, Crowther AJ, Jimenez LA, Donaldson K, Mayer R, Leonard TB, Macnee W, Drost EM. The effect of smoking on the transcriptional regulation of lung inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006, 174:41-50. 10.1164/rccm.200505-725OC, 16574938.
20. Pierrou S, Broberg P, O'Donnell RA, Pawlowski K, Virtala R, Lindqvist E, Richter A, Wilson SJ, Angco G, Moller S, Bergstrand H, Koopmann W, Wieslander E, Stromstedt PE, Holgate ST, Davies DE, Lund J, Djukanovic R. Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007, 175:577-586. 10.1164/rccm.200607-931OC, 17158281.
21. BTS guidelines for the management of chronic obstructive pulmonary disease. The COPD Guidelines Group of the Standards of Care Committee of the BTS. Thorax 1997, 52(Suppl 5):S1-28. 1765890, 9474238.
22. Pavord ID, Pizzichini MM, Pizzichini E, Hargreave FE. The use of induced sputum to investigate airway inflammation. Thorax 1997, 52:498-501. 1758588, 9227713.
23. Kelly MG, Brown V, Martin SL, Ennis M, Elborn JS. Comparison of sputum induction using high-output and low-output ultrasonic nebulizers in normal subjects and patients with COPD. Chest 2002, 122:955-959. 10.1378/chest.122.3.955, 12226038.
24. Hebert MJ, Takano T, Holthofer H, Brady HR. Sequential morphologic events during apoptosis of human neutrophils. Modulation by lipoxygenase-derived eicosanoids. J Immunol 1996, 157:3105-3115.
25. Payne CM, Glasser L, Tischler ME, Wyckoff D, Cromey D, Fiederlein R, Bohnert O. Programmed cell death of the normal human neutrophil: an in vitro model of senescence. Microsc Res Tech 1994, 28:327-344. 10.1002/jemt.1070280408, 7919520.
26. Foulds S. Novel flow cytometric method for quantifying nuclear binding of the transcription factor nuclear factor kappa B in unseparated human monocytes and polymorphonuclear cells. Cytometry 1997, 29:182-186. 10.1002/(SICI)1097-0320(19971001)29:2<182::AID-CYTO12>3.0.CO;2-S, 9332826.
27. Falcieri E, Martelli AM, Bareggi R, Cataldi A, Cocco L. The protein kinase inhibitor staurosporine induces morphological changes typical of apoptosis in MOLT-4 cells without concomitant DNA fragmentation. Biochem Biophys Res Commun 1993, 193:19-25. 10.1006/bbrc.1993.1584, 8503906.
28. Cohen GM, Sun XM, Snowden RT, Dinsdale D, Skilleter DN. Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. Biochem J 1992, 286(Pt 2):331-334. 1132900, 1530564.
29. Grasl-Kraupp B, Ruttkay-Nedecky B, Koudelka H, Bukowska K, Bursch W, Schulte-Hermann R. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology 1995, 21:1465-1468.
30. Hall PA. Assessing apoptosis: a critical survey. Endocr Relat Cancer 1999, 6:3-8. 10.1677/erc.0.0060003, 10732778.
31. Jerome KR, Vallan C, Jaggi R. The tunel assay in the diagnosis of graft-versus-host disease: caveats for interpretation. Pathology 2000, 32:186-190. 10.1080/713688927, 10968392.
32. Saetta M, Turato G, Maestrelli P, Mapp CE, Fabbri LM. Cellular and structural bases of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001, 163:1304-1309.
33. Dibbert B, Weber M, Nikolaizik WH, Vogt P, Schoni MH, Blaser K, Simon HU. Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation. Proc Natl Acad Sci USA 1999, 96:13330-13335. 23947, 10557320, 10.1073/pnas.96.23.13330.
34. Mecklenburgh K, Murray J, Brazil T, Ward C, Rossi AG, Chilvers ER. Role of neutrophil apoptosis in the resolution of pulmonary inflammation. Monaldi Arch Chest Dis 1999, 54:345-349.
35. Ruiz LM, Bedoya G, Salazar J, Garcia de OD, Patino PJ. Dexamethasone inhibits apoptosis of human neutrophils induced by reactive oxygen species. Inflammation 2002, 26:215-222. 10.1023/A:1019714618068, 12238564.
36. Perttunen H, Moilanen E, Zhang X, Barnes PJ, Kankaanranta H. Beta2-agonists potentiate corticosteroid-induced neutrophil survival. COPD 2008, 5:163-169.
37. Chung KF. Cytokines in chronic obstructive pulmonary disease. Eur Respir J Suppl 2001, 34:50s-59s. 10.1183/09031936.01.00229701, 12392035.
38. Lee A, Whyte MK, Haslett C. Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators. J Leukoc Biol 1993, 54:283-288.
39. Leuenroth S, Lee C, Grutkoski P, Keeping H, Simms HH. Interleukin-8-induced suppression of polymorphonuclear leukocyte apoptosis is mediated by suppressing CD95 (Fas/Apo-1) Fas-1 interactions. Surgery 1998, 124:409-417.
40. Brach MA, deVos S, Gruss HJ, Herrmann F. Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death. Blood 1992, 80:2920-2924.
41. Biffl WL, Moore EE, Moore FA, Barnett CC, Carl VS, Peterson VN. Interleukin-6 delays neutrophil apoptosis. Arch Surg 1996, 131:24-9. discussion 29-30..
42. Castro-Alcaraz S, Miskolci V, Kalasapudi B, Davidson D, Vancurova I. NF-kappa B regulation in human neutrophils by nuclear I kappa B alpha: correlation to apoptosis. J Immunol 2002, 169:3947-3953.
43. Di Stefano A, Caramori G, Oates T, Capelli A, Lusuardi M, Gnemmi I, Ioli F, Chung KF, Donner CF, Barnes PJ, Adcock IM. Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD. Eur Respir J 2002, 20:556-563. 10.1183/09031936.02.00272002, 12358328.
44. Wu M, Lee H, Bellas RE, Schauer SL, Arsura M, Katz D, FitzGerald MJ, Rothstein TL, Sherr DH, Sonenshein GE. Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells. EMBO J 1996, 15:4682-4690. 452200, 8887559.
45. Grimm S, Bauer MK, Baeuerle PA, Schulze-Osthoff K. Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis. J Cell Biol 1996, 134:13-23. 2120920, 8698809, 10.1083/jcb.134.1.13.
46. Grutkoski PS, Graeber CT, Ayala A, Simms HH. Paracrine suppression of apoptosis by cytokine-stimulated neutrophils involves divergent regulation of NF-kappaB, Bcl-X(L), and Bak. Shock 2002, 17:47-54. 10.1097/00024382-200201000-00009, 11795669.
47. Biffl WL, Moore EE, Moore FA, Barnett CC. Interleukin-6 suppression of neutrophil apoptosis is neutrophil concentration dependent. J Leukoc Biol 1995, 58:582-584.
48. Willemse BW, Postma DS, Timens W, ten Hacken NH. The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation. Eur Respir J 2004, 23:464-476. 10.1183/09031936.04.00012704, 15065840.
49. Rutgers SR, Postma DS, ten Hacken NH, Kauffman HF, Mark TW, Koeter GH, Timens W. Ongoing airway inflammation in patients with COPD who do not currently smoke. Thorax 2000, 55:12-18. 1745599, 10607796, 10.1136/thorax.55.1.12.
50. Nishikawa M, Kakemizu N, Ito T, Kudo M, Kaneko T, Suzuki M, Udaka N, Ikeda H, Okubo T. Superoxide mediates cigarette smoke-induced infiltration of neutrophils into the airways through nuclear factor-kappaB activation and IL-8 mRNA expression in guinea pigs in vivo. Am J Respir Cell Mol Biol 1999, 20:189-198.
51. Karimi K, Sarir H, Mortaz E, Smit JJ, Hosseini H, De Kimpe SJ, Nijkamp FP, Folkerts G. Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages. Respir Res 2006, 7:66. 1481582, 16620395, 10.1186/1465-9921-7-66.
52. Finkelstein EI, Nardini M, Vliet A. Inhibition of neutrophil apoptosis by acrolein: a mechanism of tobacco-related lung disease?. Am J Physiol Lung Cell Mol Physiol 2001, 281:L732-9.
53. Gamble E, Grootendorst DC, Hattotuwa K, O'Shaughnessy T, Ram FS, Qiu Y, Zhu J, Vignola AM, Kroegel C, Morell F, Pavord ID, Rabe KF, Jeffery PK, Barnes NC. Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis. Eur Respir J 2007, 30:467-471. 10.1183/09031936.00013006, 17504799.