Apoptosis and bax, Bcl-2, Mcl-1 expression in neutrophils of Crohn's disease patients

Inflammatory Bowel Diseases

Volumn 14, Issue 6, 2008, Pages 819-825

  Catarzi, Serena ^a   Marcucci, Tommaso ^b   Papucci, Laura ^c   Favilli, Fabio ^a   Donnini, Martino ^c   Tonelli, Francesco ^b   Vincenzini, Maria Teresa ^a   Iantomasi, Teresa ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Dipartimento di Fisiopatologia Clinica   (Italy)

^c Dipartimento di Patologia e Oncologia Sperimentali   (Italy)

Author keywords

Apoptosis; Bcl 2 family protein expression; Crohn's disease; Polymorphonuclear neutrophils

Indexed keywords

FIBRONECTIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MCL 1;

ADULT; APOPTOSIS; ARTICLE; CELL ADHESION; CELL SUSPENSION; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; FEMALE; HUMAN; HUMAN CELL; MALE; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION;

ADULT; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CROHN DISEASE; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUTROPHILS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 46049093650     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.20397     Document Type: Article

References (48)

1. Shanahan F. Crohn's disease. Lancet. 2002;359:62-69.
2. Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol. 2003;3:521-533.
3. Sartor RB. Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol. 2006;3:390-407.
4. Weiss SJ. Tissue destruction by neutrophils. N Engl J Med. 1989;320:365-376.
5. Korzenik JR, Dieckgraefe BK. Is Crohn's disease an immunodeficiency? A hypothesis suggesting possible early events in the pathogenesis of Crohn's disease. Dig Dis Sci. 2000;45:1121-1129.
6. Brannigan AE, O'Connell PR, Hurley H, et al. Neutrophil apoptosis is delayed in patients with inflammatory bowel disease. Shock. 2000;13:361-366.
7. Ina K, Kusugami K, Hosokawa T, et al. Increased mucosal production of granulocyte colony-stimulating factor is related to a delay in neutrophil apoptosis in inflammatory bowel disease. J Gastroenterol Hepatol. 1999;14:46-53.
8. Whyte MK, Meagher LC, MacDermot J, et al. Impairment of function in aging neutrophils is associated with apoptosis. J Immunol. 1993;150:5124-5134.
9. Fadeel B, Ahlin A, Henter JI, et al. Involvement of caspases in neutrophil apoptosis: regulation by reactive oxygen species. Blood. 1998;92:4808-4818.
10. Edwards SW. Biochemistry and physiology of the neutrophil. New York: Cambridge University Press; 1994.
11. Kobayashi SD, Deleo FR. An apoptosis differentiation programme in human polymorphonuclear leucocytes. Biochem Soc Trans. 2004;32:474-476.
12. Weinmann P, Scharffetter-Kochanek K, Forlow SB, et al. A role for apoptosis in the control of neutrophil homeostasis in the circulation: insights from CD18-deficient mice. Blood. 2003;101:739-746.
13. Akgul C, Moulding DA, Edwards SW. Molecular control of neutrophil apoptosis. FEBS Lett. 2001;487:318-322.
14. Wang LG, Liu XM, Kreis W, et al. The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review. Cancer Chemother Pharmacol. 1999;44:355-361.
15. Weinmann P, Gaehtgens P, Walzog B. Bcl-XI- and Bax-alpha-mediated regulation of apoptosis of human neutrophils via caspase-3. Blood. 1999;93:3106-3115.
16. Mayadas TN, Cullere X. Neutrophil beta2 integrins: moderators of life or death decisions. Trends Immunol. 2005;26:388-395.
17. Biagioni C, Favilli F, Catarzi S, et al. Redox state and O2*- production in neutrophils of Crohn's disease patients. Exp Biol Med (Maywood). 2006;231:186-195.
18. Best WR, Becktel JM, Singleton JW, et al. Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology. 1976;70:439-444.
19. Perianayagam MC, Balakrishnan VS, Guo D, et al. Quantification of Bax and Bcl2 in polymorphonuclear leukocytes from haemodialysis patients: relation to hydrogen peroxide. Eur J Clin Invest. 2003;33:905-911.
20. Hammill AK, Uhr JW, Scheuermann RH. Annexin V staining due to loss of membrane asymmetry can be reversible and precede commitment to apoptotic death. Exp Cell Res. 1999;251:16-21.
21. Schmid I, Krall WJ, Uittenbogaart CH, et al. Dead cell discrimination with 7-amino-actinomycin D in combination with dual color immunofluorescence in single laser flow cytometry. Cytometry. 1992;13:204-208.
22. Sedlak TW, Oltvai ZN, Yang E, et al. Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci U S A. 1995;92:7834-7838.
23. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 1998;281:1322-1326.
24. Yang E, Korsmeyer SJ. Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood. 1996;88:386-401.
25. Korsmeyer SJ, Shutter JR, Veis DJ, et al. Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. Semin Cancer Biol. 1993;4:327-332.
26. Michels J, Johnson PW, Packham G. Mcl-1. Int J Biochem Cell Biol. 2005;37:267-271.
27. Harter L, Mica L, Stocker R, et al. Mcl-1 correlates with reduced apoptosis in neutrophils from patients with sepsis. J Am Coll Surg. 2003;197:964-973.
28. Leuenroth SJ, Grutkoski PS, Ayala A, et al. The loss of Mcl-1 expression in human polymorphonuclear leukocytes promotes apoptosis. J Leukoc Biol. 2000;68:158-166.
29. Moulding DA, Quayle JA, Hart CA, et al. Mcl-1 expression in human neutrophils: regulation by cytokines and correlation with cell survival. Blood. 1998;92:2495-2502.
30. Kettritz R, Xu YX, Kerren T, et al. Extracellular matrix regulates apoptosis in human neutrophils. Kidney Int. 1999;55:562-571.
31. Frisch SM, Screaton RA. Anoikis mechanisms. Curr Opin Cell Biol. 2001;13:555-562.
32. Ding ZM, Babensee JE, Simon SI, et al. Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol. 1999;163:5029-5038.
33. Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev. 1999;13:2905-2927.
34. Francois S, El Benna J, Dang PM, et al. Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad. J Immunol. 2005;174:3633-3642.
35. Jamnicki-Abegg M, Weihrauch D, Pagel PS, et al. Isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating Akt and enhancing Bcl-2 expression. Anesthesiology. 2005;103:1006-1014.
36. Maianski NA, Maianski AN, Kuijpers TW, et al. Apoptosis of neutrophils. Acta Haematol. 2004;111:56-66.
37. Moulding DA, Akgul C, Derouet M, et al. BCL-2 family expression in human neutrophils during delayed and accelerated apoptosis. J Leukoc Biol. 2001;70:783-792.
38. O'Neill AJ, Doyle BT, Molloy E, et al. Gene expression profile of inflammatory neutrophils: alterations in the inhibitors of apoptosis proteins during spontaneous and delayed apoptosis. Shock. 2004;21:512-518.
39. Vander Heiden MG, Thompson CB. Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nat Cell Biol. 1999;1:E209-E216.
40. Simon HU. Neutrophil apoptosis pathways and their modifications in inflammation. Immunol Rev. 2003;193:101-110.
41. Dibbert B, Weber M, Nikolaizik WH, et al, Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation. Proc Natl Acad Sci U S A. 1999;96:13330-13335.
42. Webb PR, Wang KQ, Scheel-Toellner D, et al. Regulation of neutrophil apoptosis: a role for protein kinase C and phosphatidylinositol-3-kinase. Apoptosis. 2000;5:451-458.
43. Sunil VR, Connor AJ, Zhou P, et al. Activation of adherent vascular neutrophils in the lung during acute endotoxemia. Respir Res. 2002;3:21.
44. Knudson CM, Korsmeyer SJ. Bcl-2 and Bax function independently to regulate cell death. Nat Genet. 1997;16:358-363.
45. Lugering A, Lebiedz P, Koch S, et al. Apoptosis as a therapeutic tool in IBD? Ann N Y Acad Sci. 2006;1072:62-77.
46. Liu CY, Liu YH, Lin SM, et al. Apoptotic neutrophils undergoing secondary necrosis induce human lung epithelial cell detachment. J Biomed Sci. 2003;10:746-756.
47. Owen TA, Carter R, Whitman MM, et al. Evidence that density-dependent growth arrest is a two-stage process in WI-38 cells. J Cell Physiol. 1990;142:137-148.
48. Squier MK, Sehnert AJ, Sellins KS, et al. Calpain and calpastatin regulate neutrophil apoptosis. J Cell Physiol. 1999;178:311-319.