Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: Relations with disease activity, antibodies to double stranded DNA, and neutropenia

Annals of the Rheumatic Diseases

Volumn 58, Issue 5, 1999, Pages 309-314

  Courtney, P A ^a   Crockard, A D ^a   Williamson, K ^a   Irvine, A E ^a   Kennedy, R J ^a   Bell, A L ^a  

^a MUSGRAVE PARK HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA ANTIBODY; DOUBLE STRANDED DNA; FAS ANTIGEN; LIPOCORTIN 5;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; NEUTROPENIA; NEUTROPHIL; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0032898385     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.58.5.309     Document Type: Article

References (44)

1. 1 Herrmann M, Voll RE, Zoller OM, Hagenhoffer M, Ponner BB, Kalden JR. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998,41:1241-50.
2. 2 Herrmann M, Zoller OM, Hagenhoffer M, Voll R, Kalden JR. What triggers anti-dsDNA antibodies? Mol Biol Rep 1996;23:265-7.
3. 3 Perniok A, Wedekind F, Herrmann M, Specker C, Schneider M. High levels of circulating early apoptotic peripheral blood mononuclear cells in SLE. Lupus 1998;7: 113-18.
4. 4 Kerr JFR, Wyllie AH, Currie AR. Apoptosis; a basic biological phenomenon with wide ranging implications in tissue kinetics Br J Cancer 1972;26:239-57.
5. 5 Casciola-Rosen LA, Anhalt G, Rosen A. Autoantigens targeted in SLE are clustered in two populations surface structures on apoptotic keratinocytes, J Exp Med 1994: 179:1317-30.
6. 6 Utz PJ, Anderson P. Posttranslational protein modifications, apoptosis, and the bypass of tolerance to autoantigens. Arthritis Rheum 1998;41:1152-60.
7. 7 Koopman G, Reutlingsberger CPM, Kuitjen GAM, Keehnen RMJ, Pals ST, van Oers MHJ. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 1994;84:1415-20.
8. 8 Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, Henson PM. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 1992;148: 2207-16.
9. 9 Engeland M, Ramaekers F, Schutte B, Reutelingsperger CPM. A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture. Cytometry 1996;24:131-9.
10. 10 Liles WC, Klebanoff SJ. Regulation of apoptosis in neutrophils-Fas track to death? J Immunol 1995;155: 3289-91.
11. 11 Martin SJ, Finucane DM, Amarante-Mendes GP, O'Brien GA, Green DR. Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity. J Biol Chem 1996;271: 28753-6.
12. 12 Watanabe Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S. Lymphoproliferation disorder in mice explained by defects in fas antigen that mediates apoptosis. Nature 1992;356:314-17.
13. 13 Mysler E, Bina P, Drippa J, Ramos P, Friedman SM, Krimmer PH, et al. The APO-1/fas protein in human systemic lupus erythematosus. J Clin Invest 1994; 93:1029-34.
14. 14 Drappa J, Vaishnaw AK, Sullivan KE, Chu JI, Elkon KB, Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity. N Engl J Med 1996;335:1643-9.
15. 15 Lorenz HM, Grunke M, Hieronymus T, Herrmann M, Kuhnel A, Manger B, et al. In vitro apoptosis and expression of apoptosis related molecules in lymphocytes from patients with SLE and other autoimmune diseases. Arthritis Rheum 1997;40:306-17.
16. 16 Keeling DM, Isenberg DA, Haematological manifestations of systemic lupus erythematosus. Blood Rev 1993;7:199-207.
17. 17 Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.
18. 18 Liang MH, Socher A, Larson MG, Schur PH. Reliability and validity of six systems for the clinical assessment of disease activity in SLE. Arthritis Rheum 1989;32:1107-18.
19. 19 English D, Anderson BR. Single step separation of red blood cells, granulocytes and mononuclear cells on discontinuous density gradient of ficoll-hypaque. J Immunol Methods 1974;5:249-52.
20. 20 Emlen W, Niebur JA, Adera R. Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J Immunol 1994;152:3685-92.
21. 21 Richardson BC, Yung RL, Johnson KJ, Rowse PE, Lalwani ND. Monocyte apoptosis in patients with active lupus. Arthritis Rheum 1996;39:1432-4.
22. 22 Bootsma H, Spronk PE, Ter Borg EJ, Hummel EJ, de Boer G, Limburg PC, et al. The predictive value of fluctuations in IgM und IgG class anti-dsDNA antibodies for relapse in systemic lupus erythematosus. Ann Rheum Dis 1997;56: 661-6.
23. 23 Savill JS, Haslett C. Granulocyte clearance by apoptosis in the resolution of inflammation. Cell Biol 1995;6:385-93.
24. 24 Bell AL, Magill MK, McKane R, Irvine AE. Human blood and synovial fluid neutrophil cultured invitro undergo programmed cell death which is promoted by the addition of synovial fluid. Ann Rheum Dis 1995;54:910-15.
25. 25 Liles WC, Dale DC, Klebanoff SJ. Glucocorticoids inhibit apoptosis of human neutrophils. Blood 1995;86;3181-8.
26. 26 Cox G. Glucocorticoid treatment inhibits apoptosis in human neutrophils. J Immunol 1995;154:4719-25.
27. 27 Cohen JJ, Duke R. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J Immunol 1984;132:38-42.
28. 28 Iwai K, Miyawaki T, Takizawa T, Konno A, Ohta K, Yachie A, et al. Differential expression of bcl-2 and susceptibility to anti-fas-mediated cell death in peripheral blood lymphocytes, monocytes and neutrophils. Blood 1994;84: 1201-8.
29. 29 Yonehara S, Ishii A, Yonehara M. A cell killing monoclonal antibody (anti-fas) to a cell surface antigen co-downregulated with the receptor of tumour necrosis factor. J Exp Med 1989;169:1747-52.
30. 30 Nagata S. Apoptosis by death factor. Cell 1997;88:355-65.
31. 31 Cheng J, Zhou T, Liu C, Shapiro JP, Brauer MJ, Kiefer MC, et al. Protection from fas mediated apoptosis by a soluble form of the fas molecule. Science 1994;263:1759-62.
32. 32 Manfredi AA, Rovere P, Galati G, Heltai S, Bozzolo E, Soldini L, et al. Apoptotic cell clearance in systemic lupus erythermatosus. Arthritis Rheum 1998;41:205-14
33. 33 Savill JS, Wyllie AH, Henson JE, Walport MJ, Henson PM, Haslett C. Macrophage phagocytosis of aging neutrophils in inflammation. J Clin Invest 1989;83:865-75.
34. 34 Ren Y, Silverstein CL, Allen J, Savill J. CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis. J Exp Med 1995;181:1857-62.
35. 35 Hart SP, Dougherty GJ, Haslett C, Dransfield I. CD44 regulates phagocytosis of apoptotic neutrophil granulocytes, but not apoptotic lymphocytes by human macrophages. J Immunol 1997;159:919-25.
36. 36 Bell DA, Morrison B. The spontaneous apoptotic death of normal human lymphocytes in vitro; the release of, and immunoproliferative response to, nucleosomes in vitro. Clin Immunol Immunopathol 1991;60:13-26.
37. 37 Euler HH, Harten P, Zeuner RA, Schwab UM. Recombinant granulocyte colony stimulating factor in patients with systemic lupus erythrmatosus associated neutropenia and refractory infections. J Rheumatol 1997;24:2153-7.
38. 38 Rosenthal NS, Farhi DC. Bone marrow findings in connective tissue disease. Am J Clin Pathol 1989;92:650-4.
39. 39 Minchinton RM, Waters AH. The occurrence and significance of neutrophil antibodies. Br J Haematol 1984;56: 521-8.
40. 40 Mempel K, Pietsch T, Menzel T, Zeidler C, Welte K. Increased serum levels of granulocyte colony stimulating factor in patients with severe congenital neutropenia. Blood 1991;77:1919-22.
41. 41 Brach MA, de Vos S, Gus HJ, Herrmann P. Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death. Blood 1992;80:2920-4.
42. 42 Sallerfors B. Endogenous production and peripheral blood levels of granulocyte macrophage and granulocyte colony stimulating factors (GM-CSF and G-CSF). Leukaemia and Lymphoma 1994;13:235-47.
43. 43 Aringer M, Graninger WB, Smolen JS, Kiener HP, Steiner CW, Trautinger F, et al. Photopheresis treatment enhances CD95 (fas) expression in circulating lymphocytes of patients with systemic sclerosis and induces apoptosis. Br J Rheumatol 1997;36:1276-82.
44. 44 Graninger WB, Smolen JS. Should the clinician have interest in the deregulation of apoptosis in autoimmunity. Br J Rheumatol 1998;36:1244-5.