MGlu5 receptor deletion reduces relapse to food-seeking and prevents the anti-relapse effects of mGlu5 receptor blockade in mice

Life Sciences

Volumn 89, Issue 23-24, 2011, Pages 862-867

  Eiler II, William J A ^a,b   Baez, Melvyn ^a   Yu, Jianliang ^a   Witkin, Jeffrey M ^a,b  

^a ELI LILLY AND COMPANY   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Food; mGlu5; MTEP; Relapse

Indexed keywords

3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; METABOTROPIC RECEPTOR 5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEEDING BEHAVIOR; FOOD; GENE DELETION; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; RELAPSE; STIMULUS; WILD TYPE;

ANIMALS; CONDITIONING, OPERANT; EATING; EXTINCTION, PSYCHOLOGICAL; FEEDING BEHAVIOR; MALE; MICE; MICE, KNOCKOUT; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; REINFORCEMENT (PSYCHOLOGY); THIAZOLES;

MUS;

EID: 81255157671     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2011.09.014     Document Type: Article

References (45)

1. F. Ambroggi, A. Ghazizadeh, S.M. Nicola, and H.L. Fields Roles of nucleus accumbens core and shell in incentive-cue responding and behavioral inhibition J Neurosci 31 18 2011 6820 6830
2. J.J. Anderson, M.J. Bradbury, D.R. Giracello, D.F. Chapman, G. Holtz, and J. Roppe In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine Eur J Pharmacol 473 1 2003 35 40 (Pubitemid 36851626)
3. P. Backstrom, D. Bachteler, S. Koch, P. Hyytia, and R. Spanagel mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior Neuropsychopharmacology 29 5 2004 921 928 (Pubitemid 38526792)
4. J. Besheer, J.J. Grondin, R. Cannady, A.C. Sharko, S. Faccidomo, and C.W. Hodge Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake Biol Psychiatry 67 9 2010 812 822
5. A.Y. Bespalov, O.A. Dravolina, I. Sukhanov, E. Zakharova, E. Blokhina, E. Zvartau, W. Danysz, G. van Heeke, and A. Markou Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats Neuropharmacology 49 Suppl 1 2005 167 178 (Pubitemid 41115903)
6. A. Bisaga, W. Danysz, and R.W. Foltin Antagonism of glutamatergic NMDA and mGluR5 receptors decreases consumption of food in baboon model of binge-eating disorder Eur Neuropsychopharmacol 18 11 2008 794 802
7. C. Chiamulera, M.P. Epping-Jordan, A. Zocchi, C. Marcon, C. Cottiny, and S. Tacconi Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice Nat Neurosci 4 2001 873 874 (Pubitemid 32801588)
8. N.D. Cosford, J. Roppe, L. Tehrani, E.J. Schweiger, T.J. Seiders, and A. Chaudary 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity J Med Chem 46 2003 204 206 (Pubitemid 36078139)
9. M.S. Cowen, E. Djouma, and A.J. Lawrence The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems J Pharmacol Exp Ther 315 2 2005 590 600 (Pubitemid 41500723)
10. M.S. Cowen, E. Krstew, and A.J. Lawrence Assessing appetitive and consummatory phases of ethanol self-administration in C57BL/6J mice under operant conditions: regulation by mGlu5 receptor antagonism Psychopharmacology (Berl) 190 1 2007 21 29 (Pubitemid 44885340)
11. H. Domin, B. Ziȩba, K. Gołembiowska, M. Kowalska, A. Dziubina, and M. Smiałowska Neuroprotective potential of mGluR5 antagonist MTEP: effects on kainate-induced excitotoxicity in the rat hippocampus Pharmacol Rep 62 6 2010 1051 1061
12. J.L. Falk, P.B. Dews, and C.R. Schuster Commonalities in the environmental control of behavior P.K. Levison, D.R. Gerstein, D.R. Maloff, Commonalities in substance abuse and habitual behavior 1983 Lexington Books Lexington, MA 47 110
13. A. Fazal, F. Parker, A.M. Palmer, and M.J. Croucher Characterisation of the actions of group I metabotropic glutamate receptor subtype selective ligands on excitatory amino acid release and sodium-dependent re-uptake in rat cerebrocortical minislices J Neurochem 86 6 2003 1346 1358 (Pubitemid 37174252)
14. M.W. Feltenstein, and R.E. See The neurocircuitry of addiction: an overview Br J Pharmacol 154 2 2008 26174
15. J.T. Gass, and M.F. Olive Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell Psychopharmacology (Berl) 204 4 2009 58797
16. J.T. Gass, M.P. Osborne, N.L. Watson, J.L. Brown, and M.F. Olive mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats Neuropsychopharmacology 34 4 2009 820 833
17. T. Gupta, Y.M. Syed, A.A. Revis, S.A. Miller, M. Martinez, and K.A. Cohn Acute effects of acamprosate and MPEP on ethanol Drinking-in-the-Dark in male C57BL/6J mice Alcohol Clin Exp Res 32 11 2008 1992 1998
18. A. Ishikawa, F. Ambroggi, S.M. Nicola, and H.L. Fields Dorsomedial prefrontal cortex contribution to behavioral and nucleus accumbens neuronal responses to incentive cues J Neurosci 28 19 2008 5088 5098
19. Y. Iso, E. Grajkowska, J.T. Wroblewski, J. Davis, N.E. Goeders, and K.M. Johnson Synthesis and structure-activity relationships of 3-[(2-methyl-1,3- thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications J Med Chem 49 3 2006 1080 1100 (Pubitemid 43221655)
20. Z. Jia, Y. Lu, J. Henderson, F. Taverna, C. Romano, and W. Abramow-Newerly Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5 Learn Mem 5 1998 331 343 (Pubitemid 29115263)
21. P.W. Kalivas, and C. O'Brien Drug addiction as a pathology of staged neuroplasticity Neuropsychopharmacology 33 1 2008 166 180 (Pubitemid 350191316)
22. P.J. Kenny, B. Boutrel, F. Gasparini, G.F. Koob, and A. Markou Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats Psychopharmacology (Berl) 179 1 2005 24754
23. V. Kumaresan, M. Yuan, J. Yee, K.R. Famous, S.M. Anderson, and H.D. Schmidt Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocainepriming- and cue-induced reinstatement of cocaine seeking Behav Brain Res 202 2 2009 23844
24. V. Kumaresan, M. Yuan, J. Yee, K.R. Famous, S.M. Anderson, and H.D. Schmidt Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking Behav Brain Res 202 2 2010 238 244 [4]
25. B. Lee, D.M. Platt, J.K. Rowlett, A.S. Adewale, and R.D. Spealman Attenuation of behavioral effects of cocaine by the metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine J Pharmacol Exp Ther 312 3 2005 123240
26. M.E. Liechti, and A. Markou Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats Eur J Pharmacol 554 2-3 2007 164 174 (Pubitemid 44879414)
27. R. Martin-Fardon, M.A. Baptista, C.V. Dayas, and F. Weiss Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer J Pharmacol Exp Ther 329 3 2009 108490
28. E.C. O'Connor, H.S. Crombag, A.N. Mead, and D.N. Stephens The mGluR5 antagonist MTEP dissociates the acquisition of predictive and incentive motivational properties of reward-paired stimuli in mice Neuropsychopharmacology 35 8 2010 1807 1817
29. M.P. Osborne, and M.F. Olive A role for mGluR5 receptors in intravenous methamphetamine self-administration Ann N Y Acad Sci 1139 2008 20611
30. M.I. Palmatier, X. Liu, E.C. Donny, and A.F. Caggiula ARSved Metabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotine Neuropsychopharmacology 33 9 2008 213947
31. N.E. Paterson, and A. Markou The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats Psychopharmacology (Berl) 179 1 2005 25561
32. N.E. Paterson, S. Semenova, F. Gasparini, and A. Markou The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice Psychopharmacology (Berl) 167 3 2003 25764
33. A. Pisani, P. Bonsi, B. Picconi, M. Tolu, P. Giacomini, and E. Scarnati Role of tonically-active neurons in the control of striatal function: cellular mechanisms and behavioral correlates Prog Neuropsychopharmacol Biol Psychiatry 25 1 2001 21130
34. D.M. Platt, J.K. Rowlett, and R.D. Spealman Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine Psychopharmacology (Berl) 200 2 2008 167 176
35. P. Popik, T. Kos, Y. Zhang, and A. Bisaga Memantine reduces consumption of highly palatable food in a rat model of binge eating Amino Acids 40 2 2011 477 485
36. J.J. Reilly Assessment of obesity in children and adolescents: synthesis of recent systematic reviews and clinical guidelines J Hum Nutr Diet 23 3 2010 205 211
37. D.D. Schoepp, and P.J. Conn Metabotropic glutamate receptors in brain function and pathology Trends Pharmacol Sci 14 1993 13 20 (Pubitemid 23034602)
38. J.P. Schroeder, D.H. Overstreet, and C.W. Hodge The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats Psychopharmacology (Berl) 179 1 2005 262 270 (Pubitemid 40576714)
39. M.T. Taber, and H.C. Fibiger Electrical stimulation of the prefrontal cortex increases dopamine release in the nucleus accumbens of the rat: modulation by metabotropic glutamate receptors J Neurosci 15 5 Pt 2 1995 3896 3904
40. M. Tessari, M. Pilla, M. Andreoli, D.M. Hutcheson, and C.A. Heidbreder Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking Eur J Pharmacol 499 1-2 2004 12133
41. V. Tronci, S. Vronskaya, N. Montgomery, D. Mura, and D.J. Balfour The effects of the mGluR5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) on behavioural responses to nicotine Psychopharmacology (Berl) 211 1 2010 33 42
42. E.L. van der Kam, J. de Vry, and T.M. Tzschentke Effect of 2-methyl-6-(phenylethynyl) pyridine on intravenous self-administration of ketamine and heroin in the rat Behav Pharmacol 18 8 2007 71724
43. N.D. Volkow, G.J. Wang, J.S. Fowler, and F. Telang Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology Philos Trans R Soc Lond B Biol Sci 363 1507 2008 3191 3200
44. J. Xu, Y. Zhu, A. Contractor, and S.F. Heinemann mGluR5 has a critical role in inhibitory learning J Neurosci 29 12 2009 3676 3684
45. A. Wikler, and R.W. Rasor Psychiatric aspects of drug addiction Am J Med 14 5 1953 566 570