Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: Comparison with dizocilpine

Psychopharmacology

Volumn 200, Issue 2, 2008, Pages 167-176

  Platt, Donna M ^a   Rowlett, James K ^a   Spealman, Roger D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cocaine self administration; Food self administration; Glutamate; Ionotropic glutamate receptors; Metabotropic glutamate receptors; Pharmacotherapy; Squirrel monkey (Saimiri sciureus)

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; COCAINE; DIZOCILPINE; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG SELF ADMINISTRATION; DRUG SPECIFICITY; MALE; NONHUMAN; PRIORITY JOURNAL; REINFORCEMENT; SQUIRREL MONKEY;

ANIMALS; BEHAVIOR, ANIMAL; COCAINE; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; MALE; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; REINFORCEMENT SCHEDULE; SAIMIRI; SELF ADMINISTRATION;

EID: 51249102144     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-008-1191-y     Document Type: Article

References (38)

1. RM Allen RM Carelli LA Dykstra TL Suchey CV Everett 2005 Effects of the competitive N-methyl-d-aspartate receptor antagonist, LY235959 [(-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid], on responding for cocaine under both fixed and progressive ratio schedules of reinforcement J Pharmacol Exp Ther 315 449 457
2. O Ben-Shahar JM Moscarello B Jacob MP Roarty A Ettenberg 2005 Prolonged daily exposure to i.v. cocaine results in tolerance to its stimulant effects Pharmacol Biochem Behav 82 411 416
3. C Chiamulera MP Epping-Jordan A Zocchi C Marcon C Cottiny S Tacconi M Corsi F Orzi F Conquet 2001 Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice Nat Neurosci 4 873 874
4. PJ Conn JP Pin 1997 Pharmacology and functions of metabotropic glutamate receptors Annu Rev Pharmacol Toxicol 37 205 237
5. JL Cornish PW Kalivas 2001 Cocaine sensitization and craving: differing roles for dopamine and glutamate in the nucleus accumbens J Addict Dis 20 43 54
6. F Gasparini K Lingenhöhl N Stoehr PJ Flor M Heinrich I Vranesic M Biollaz H Allgeier R Heckendorn S Urwyler MA Varney EC Johnson SD Hess SP Rao AI Sacaan EM Santori G Veliçelebi R Kuhn 1999 2-Methyl-6-(phenylethynyl)- pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist Neuropharmacology 38 1493 1503
7. MC Gonzalez-Albo J DeFelipe 2000 Colocalization of glutamate ionotropic receptor subunits in the human temporal neocortex Cereb Cortex 10 621 631
8. PR Hof P Vissavajjhala RE Rosenthal G Fiskum JH Morrison 1996 Distribution of glutamate receptor subunit proteins GluR2(4), GluR5/6/7 and NMDAR1 in the canine and primate cerebral cortex: a comparative immunohistochemical analysis Brain Res 723 77 89
9. H Homayoun MR Stefani BW Adams GD Tamagan B Moghaddam 2004 Functional interaction between NMDA and mGlu5 receptors: effects on working memory, instrumental learning, motor behaviors, and dopamine release Neuropsychopharmacology 29 1259 1269
10. GW Huntley JC Vickers JH Morrison 1997 Quantitative localization of NMDAR1 receptor subunit immunoreactivity in inferotemporal and prefrontal association cortices of monkey and human Brain Res 749 245 262
11. P Hyytia P Backstrom S Liljequist 1999 Site-specific NMDA receptor antagonists produce differential effects on cocaine self-administration in rats Eur J Pharmacol 378 9 16
12. PW Kalivas 2004 Glutamate systems in cocaine addiction Curr Opin Pharmacol 4 23 29
13. PJ Kenny A Markou 2004 The ups and downs of addiction: role of metabotropic glutamate receptors Trends Pharmacol Sci 25 265 272
14. PJ Kenny NE Paterson B Boutrel S Semenova AA Harrison F Gasparini GF Koob PD Skoubis A Markou 2003 Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats Ann NY Acad Sci 1003 415 418
15. PJ Kenny B Boutrel F Gasparini GF Koob A Markou 2005 Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats Psychopharmacology 179 247 254
16. PM Lea AI Faden 2006 Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP CNS Drug Reviews 12 149 166
17. PM Lea VA Movsesyan AI Faden 2005 Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors Br J Pharmacol 145 527 534
18. B Lee DM Platt JK Rowlett AS Adewale RD Spealman 2005 Attenuation of behavioral effects of cocaine by the metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine J Pharmacol Exp Ther 312 1232 1240
19. Y Liu DCS Roberts D Morgan 2005 Sensitization of the reinforcing effects of self-administered cocaine in rats: effects of dose and intravenous injection speed Eur J Neurosci 22 195 200
20. NK Mello SS Negus 1996 Preclinical evaluation of pharmacotherapies for treatment of cocaine and opioid abuse using drug self-administration procedures Neuropsychopharmacology 14 375 424
21. 3H]MK-801 binding and the mRNA for the NMDAR1 subunit of the NMDA receptor are differentially distributed in human and rat forebrain Mol Brain Res 54 13 23
22. VA Movsesyan DM O'Leary L Fan W Bao PGM Mullins SM Knoblach AI Faden 2001 mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2- phenylethyenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-d-aspartate receptors J Pharmacol Exp Ther 296 41 47
23. EC Muly M Maddox Y Smith 2003 Distribution of mGluR1alpha and mGluR5 immunolabeling in primate prefrontal cortex J Comp Neurol 467 521 535
24. NH Mutschler HE 3 rd Covington KA Miczek 2001 Repeated self-administered cocaine "binges" in rats: effects on cocaine intake and withdrawal Psychopharmacology 154 292 300
25. RE Nordquist S Durkin G Jaeschke W Spooren 2007 Stress-induced hypothermia: effects of acute and repeated dosing of MPEP Eur J Pharmacol 568 199 202
26. DM O'Leary V Movsesyan S Vicini AI Faden 2000 Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism Br J Pharmacol 131 1429 1437
27. NE Paterson A Markou 2005 The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats Psychopharmacology 179 255 261
28. RC Pierce WM Meil PW Kalivas 1997 The NMDA antagonist, dizocilpine, enhances cocaine reinforcement without influencing mesoaccumbens dopamine transmission Psychopharmacology 133 188 195
29. Platt DM, Carey GJ, Spealman RD (2005) Intravenous self-administration techniques in monkeys. In: Enna S, Williams M, Ferkany J, Kenakin T, Porsolt R, Sullivam J (eds) Current protocols in neuroscience. Wiley, New York, pp 9.21.1-9.21.15
30. L Pulvirenti C Balducci GF Koob 1997 Dextromethorphan reduces intravenous cocaine self-administration in the rat Eur J Pharmacol 321 279 283
31. R Ranaldi E French DCS Roberts 1996 Systemic pretreatment with MK-801 (dizocilpine) increases breaking points for self-administration of cocaine on a progressive-ratio schedule in rats Psychopharmacology 128 83 88
32. S Schenk A Valadez CM Worley C McNamara 1993 Blockade of the acquisition of cocaine self-administration by the NMDA antagonist MK-801 (dizocilpine) Behav Pharmacol 4 652 659
33. N Sevostianova W Danysz 2006 Analgesic effects of mGlu1 and mGlu5 receptor antagonists in the rat formalin test Neuropharmacology 51 623 630
34. M Shoaib TS Shippenberg SR Goldberg CW Schindler 1995 Behavioral studies with the glycine partial agonist (+)-HA966 on cocaine-induced locomotor activity and reinforcement Behav Pharmacol 6 568 576
35. WP Spooren F Gasparini TE Salt R Kuhn 2001 Novel allosteric antagonists shed light on mGlu(5) receptors and CNS disorders Trends Pharmacol Sci 22 331 337
36. M Tessari M Pilla M Andreoli DM Hutcheson CA Heidbreder 2004 Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking Eur J Pharmacol 499 121 133
37. LS Thomas DE Jane F Gasparini MJ Croucher 2001 Glutamate release inhibiting properties of the novel mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyrridine (MPEP): complimentary in vitro and in vivo evidence Neuropharmacology 41 523 527
38. JJ Yap HE Covington 3rd MC Gale R Datta KA Miczek 2005 Behavioral sensitization due to social defeat stress in mice: antagonism at mGluR5 and NMDA receptors Psychopharmacology 179 230 239