Antagonism of glutamatergic NMDA and mGluR5 receptors decreases consumption of food in baboon model of binge-eating disorder

European Neuropsychopharmacology

Volumn 18, Issue 11, 2008, Pages 794-802

  Bisaga, Adam ^a   Danysz, Wojciech ^b   Foltin, Richard W ^a  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b MERZ PHARMACEUTICALS GMBH   (Germany)

Author keywords

Baboon; Binge eating; Food intake; MGLUR; Motivation; NMDA; Satiation

Indexed keywords

3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; DEXFENFLURAMINE; MEMANTINE; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SUGAR;

ANIMAL EXPERIMENT; ANIMAL MODEL; APPETITE; ARTICLE; BABOON; BINGE EATING DISORDER; CALORIC INTAKE; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; FEEDING BEHAVIOR; FEMALE; FOOD INTAKE; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RECEPTOR BLOCKING; REINFORCEMENT; SATIETY; SEX DIFFERENCE; SUGAR INTAKE; TREATMENT INDICATION;

ANIMALS; APPETITE; BULIMIA NERVOSA; CANDY; CONDITIONING, OPERANT; CONSUMMATORY BEHAVIOR; DEXFENFLURAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; MALE; MEMANTINE; PAPIO CYNOCEPHALUS; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; REINFORCEMENT SCHEDULE; SEROTONIN AGONISTS; SEX CHARACTERISTICS; THIAZOLES; WEIGHT GAIN;

EID: 53149127661     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2008.05.004     Document Type: Article

References (59)

1. Backstrom P., and Hyytia P. Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology 31 (2006) 778-786
2. Backstrom P., Bachteler D., Koch S., Hyytia P., and Spanagel R. mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 29 (2004) 921-928
3. Berthoud H.R. Neural control of appetite: cross-talk between homeostatic and non-homeostatic systems. Appetite 43 (2004) 315-317
4. Bienkowski P., Krzascik P., Koros E., Kostowski W., Scinska A., and Danysz W. Effects of a novel uncompetitive NMDA receptor antagonist, MRZ 2/579 on ethanol self-administration and ethanol withdrawal seizures in the rat. Eur. J. Pharmacol. 413 (2001) 81-89
5. Blokhina E.A., Kashkin V.A., Zvartau E.E., Danysz W., and Bespalov A.Y. Effects of nicotinic and NMDA receptor channel blockers on intravenous cocaine and nicotine self-administration in mice. Eur Neuropsychopharmacol 15 (2005) 219-225
6. Blundell J.E., and Finlayson G. Is susceptibility to weight gain characterized by homeostatic or hedonic risk factors for overconsumption?. Physiol. Behav. 82 (2004) 21-25
7. Bradbury M.J., Campbell U., Giracello D., Chapman D., King C., Tehrani L., Cosford N.D., Anderson J., Varney M.A., and Strack A.M. Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice. J. Pharmacol. Exp. Ther. 313 (2005) 395-402
8. Burns G.A., and Ritter R.C. The non-competitive NMDA antagonist MK-801 increases food intake in rats. Pharmacol. Biochem. Behav. 56 (1997) 145-149
9. Busse C.S., Brodkin J., Tattersall D., Anderson J.J., Warren N., Tehrani L., Bristow L.J., Varney M.A., and Cosford N.D. The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety. Neuropsychopharmacology 29 (2004) 1971-1979
10. Centers for Disease Control and Prevention, C. Cardiac valvulopathy associated with exposure to fenfluramine or dexfenfluramine: U.S. Department of Health and Human Services interim public health recommendations, November 1997. Morb. Mortal. Wkly. Rep. 46 (1997) 1061-1066
11. Cooper S.J., and Al-Naser H.A. Dopaminergic control of food choice: contrasting effects of SKF 38393 and quinpirole on high-palatability food preference in the rat. Neuropharmacology 50 (2006) 953-963
12. Corwin R.L., and Buda-Levin A. Behavioral models of binge-type eating. Physiol. Behav. 82 (2004) 123-130
13. Corwin R.L., Wojnicki F.H., Fisher J.O., Dimitriou S.G., Rice H.B., and Young M.A. Limited access to a dietary fat option affects ingestive behavior but not body composition in male rats. Physiol. Behav. 65 (1998) 545-553
14. Devlin M.J., Goldfein J.A., and Dobrow I. What is this thing called BED? Current status of binge eating disorder nosology. Int. J. Eat. Disord. 34 Suppl (2003) S2-18
15. Doane D.F., Lawson M.A., Meade J.R., Kotz C.M., and Beverly J.L. Orexin-induced feeding requires Nmda receptor activation in the perifornical region of the lateral hypothalamus. Am. J. Physiol., Regul. Integr. Comp. Physiol. 293 (2007) R1022-R1016
16. Drewnowski A. Energy density, palatability, and satiety: implications for weight control. Nutr. Rev. 56 (1998) 347-353
17. Echo J.A., Lamonte N., Christian G., Znamensky V., Ackerman T.F., and Bodnar R.J. Excitatory amino acid receptor subtype agonists induce feeding in the nucleus accumbens shell in rats: opioid antagonist actions and interactions with [mu]-opioid agonists. Brain Res. 921 (2001) 86-97
18. Erlanson-Albertsson C. How palatable food disrupts appetite regulation. Basic Clin. Pharmacol. Toxicol. 97 (2005) 61-73
19. Fairburn C.G., Cooper Z., Doll H.A., Norman P., and O'connor M. The natural course of bulimia nervosa and binge eating disorder in young women. Arch. Gen. Psychiatry 57 (2000) 659-665
20. Foltin R.W. Effects of amphetamine, dexfenfluramine, diazepam, and other pharmacological and dietary manipulations on food "seeking" and "taking" behavior in non-human primates. Psychopharmacology (Berl) 158 (2001) 28-38
21. Foltin R.W. Effects of sibutramine on the appetitive and consummatory aspects of feeding in non-human primates. Physiol. Behav. 87 (2006) 280-286
22. Foltin R.W. "Tasting and wasting" behavior in non-human primates: aberrant behavior or normal behavior in "times of plenty". Physiol. Behav. 89 (2006) 587-597
23. Foltin R.W., and Haney M. Effects of the cannabinoid antagonist SR141716 (rimonabant) and d-amphetamine on palatable food and food pellet intake in non-human primates. Pharmacol. Biochem. Behav. 86 (2007) 766-773
24. Foltin R.W., Haney M., Comer S.D., and Fischman M.W. Effect of fenfluramine on food intake, mood, and performance of humans living in a residential laboratory. Physiol. Behav. 59 (1996) 295-305
25. Gillespie B.R., Burns G.A., and Ritter R.C. NMDA channels control meal size via central vagal afferent terminals. Am. J. Physiol., Regul. Integr. Comp. Physiol. 289 (2005) R1504-1511
26. Glick S.D., Maisonneuve I.M., Dickinson H.A., and Kitchen B.A. Comparative effects of dextromethorphan and dextrorphan on morphine, methamphetamine, and nicotine self-administration in rats. Eur. J. Pharmacol. 422 (2001) 87-90
27. Goodall E., Feeney S., Mcguirk J., and Silverstone T. A comparison of the effects of d-and l-fenfluramine and d-amphetamine on energy and macronutrient intake in human subjects. Psychopharmacology (Berl) 106 (1992) 221-227
28. Guy-Grand B., Apfelbaum M., Crepaldi G., Gries A., Lefebvre P., and Turner P. International trial of long-term dexfenfluramine in obesity. Lancet 2 (1989) 1142-1145
29. Halford J.C., and Blundell J.E. Separate systems for serotonin and leptin in appetite control. Ann. Med. 32 (2000) 222-232
30. Heal D.J., Cheetham S.C., Prow M.R., Martin K.F., and Buckett W.R. A comparison of the effects on central 5-HT function of sibutramine hydrochloride and other weight-modifying agents. Br. J. Pharmacol. 125 (1998) 301-308
31. Hermanussen M., and Tresguerres J.A. A new anti-obesity drug treatment: first clinical evidence that, antagonising glutamate-gated Ca2+ ion channels with memantine normalises binge-eating disorders. Econ. Hum. Biol. 3 (2005) 329-337
32. Higgins G.A., and Fletcher P.J. Serotonin and drug reward: focus on 5-HT2C receptors. Eur. J. Pharmacol. 480 (2003) 151-162
33. Hill J.O., Wyatt H.R., Reed G.W., and Peters J.C. Obesity and the environment: where do we go from here?. Science 299 (2003) 853-855
34. Holter S.M., Danysz W., and Spanagel R. Novel uncompetitive N-methyl-d-aspartate (NMDA)-receptor antagonist MRZ 2/579 suppresses ethanol intake in long-term ethanol-experienced rats and generalizes to ethanol cue in drug discrimination procedure. J. Pharmacol. Exp. Ther. 292 (2000) 545-552
35. Kenny P.J., Boutrel B., Gasparini F., Koob G.F., and Markou A. Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats. Psychopharmacology (Berl) 179 (2005) 247-254
36. Khan A.M., Cheung H.H., Gillard E.R., Palarca J.A., Welsbie D.S., Gurd J.W., and Stanley B.G. Lateral hypothalamic signaling mechanisms underlying feeding stimulation: differential contributions of Src family tyrosine kinases to feeding triggered either by NMDA injection or by food deprivation. J. Neurosci. 24 (2004) 10603-10615
37. Lee S.W., and Stanley B.G. NMDA receptors mediate feeding elicited by neuropeptide Y in the lateral and perifornical hypothalamus. Brain Res. 1063 (2005) 1-8
38. Martel P., and Fantino M. Mesolimbic dopaminergic system activity as a function of food reward: a microdialysis study. Pharmacol. Biochem. Behav. 53 (1996) 221-226
39. Mcshane R., Areosa Sastre A., and Minakaran N. Memantine for dementia. Cochrane Database Syst. Rev. (2006) CD003154
40. Newman J.L., and Beardsley P.M. Effects of memantine, haloperidol, and cocaine on primary and conditioned reinforcement associated with cocaine in rhesus monkeys. Psychopharmacology (Berl) 185 (2006) 142-149
41. Ninan I., and Kulkarni S.K. Dopamine receptor sensitive effect of dizocilpine on feeding behaviour. Brain Res. 812 (1998) 157-163
42. Ogden C.L., Yanovski S.Z., Carroll M.D., and Flegal K.M. The epidemiology of obesity. Gastroenterology 132 (2007) 2087-2102
43. Parsons C.G., Danysz W., and Zieglgansberger W. Excitatory amino acid neurotransmission. Handb. Exp. Pharmacol. (2005) 249-303
44. Paterson N.E., and Markou A. The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats. Psychopharmacology (Berl) 179 (2005) 255-261
45. Paterson N.E., Semenova S., Gasparini F., and Markou A. The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice. Psychopharmacology (Berl) 167 (2003) 257-264
46. Raben A., Vasilaras T.H., Moller A.C., and Astrup A. Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects. Am. J. Clin. Nutr. 76 (2002) 721-729
47. Saper C.B., Chou T.C., and Elmquist J.K. The need to feed: homeostatic and hedonic control of eating. Neuron 36 (2002) 199-211
48. Semenova S., and Markou A. The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task. Neuropharmacology 52 (2007) 863-872
49. Semenova S., Kuzmin A.V., Danysz W., and Bespalov A.Y. Low affinity NMDA receptor channel blockers inhibit initiation of intravenous morphine self-administration in naive mice. Eur. J. Pharmacol. 378 (1999) 1-8
50. Stanley B.G., Willett III V.L., Donias H.W., Ha L.H., and Spears L.C. The lateral hypothalamus: a primary site mediating excitatory amino acid-elicited eating. Brain Res. 630 (1993) 41-49
51. Stanley B.G., Willett III V.L., Donias H.W., Dee II M.G., and Duva M.A. Lateral hypothalamic NMDA receptors and glutamate as physiological mediators of eating and weight control. Am. J. Physiol. 270 (1996) R443-R449
52. Stunkard A., Berkowitz R., Tanrikut C., Reiss E., and Young L. d-fenfluramine treatment of binge eating disorder. Am. J. Psychiatry 153 (1996) 1455-1459
53. Tanofsky-Kraff M., Cohen M.L., Yanovski S.Z., Cox C., Theim K.R., Keil M., Reynolds J.C., and Yanovski J.A. A prospective study of psychological predictors of body fat gain among children at high risk for adult obesity. Pediatrics 117 (2006) 1203-1209
54. Tessari M., Pilla M., Andreoli M., Hutcheson D.M., and Heidbreder C.A. Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking. Eur. J. Pharmacol. 499 (2004) 121-133
55. Vartanian L.R., Schwartz M.B., and Brownell K.D. Effects of soft drink consumption on nutrition and health: a systematic review and meta-analysis. Am. J. Public Health 97 (2007) 667-675
56. Wozniak D.F., Olney J.W., Kettinger III L., Price M., and Miller J.P. Behavioral effects of MK-801 in the rat. Psychopharmacology (Berl) 101 (1990) 47-56
57. Xi Z.X., and Stein E.A. Blockade of ionotropic glutamatergic transmission in the ventral tegmental area reduces heroin reinforcement in rat. Psychopharmacology (Berl) 164 (2002) 144-150
58. Yanovski S.Z. Binge eating disorder and obesity in 2003: could treating an eating disorder have a positive effect on the obesity epidemic?. Int. J. Eat. Disord. 34 Suppl (2003) S117-120
59. Zeni L.A., Seidler H.B., De Carvalho N.A., Freitas C.G., Marino-Neto J., and Paschoalini M.A. Glutamatergic control of food intake in pigeons: effects of central injections of glutamate, NMDA, and AMPA receptor agonists and antagonists. Pharmacol. Biochem. Behav. 65 (2000) 67-74