Understanding the mechanism of IL-1β secretion

Cytokine and Growth Factor Reviews

Volumn 22, Issue 4, 2011, Pages 189-195

  Lopez Castejon, Gloria ^a   Brough, David ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Caspase 1; Cell death; Golgi; IL 1 ; Inflammation

Indexed keywords

ALKYLATING AGENT; ANION TRANSPORT INHIBITOR; BROMOENOL LACTONE; GLIBENCLAMIDE; HISTONE DEACETYLASE INHIBITOR; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; OKADAIC ACID; PEPTIDE INHIBITOR; PROTEIN INHIBITOR; SPHINGOMYELIN PHOSPHODIESTERASE INHIBITOR; SULFONYLUREA; UNCLASSIFIED DRUG;

CHRONIC DISEASE; CYTOKINE RELEASE; DISEASE EXACERBATION; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HOST RESISTANCE; IMMUNE RESPONSE; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; REVIEW; STIMULUS; TISSUE INJURY;

ANIMALS; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; SECRETORY PATHWAY;

EID: 81155134753     PISSN: 13596101     EISSN: 18790305     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2011.10.001     Document Type: Review

References (85)

1. Dinarello C.A. Biologic basis for interleukin-1 in disease. Blood 1996, 87(6):2095-2147.
2. Takeuchi O., Akira S. Pattern recognition receptors and inflammation. Cell 2010, 140(6):805-820.
3. Thornberry N.A., Bull H.G., Calaycay J.R., Chapman K.T., Howard A.D., Kostura M.J., et al. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 1992, 356(6372):768-774.
4. Schroder K., Tschopp J. The inflammasomes. Cell 2010, 140(6):821-832.
5. Brough D., Rothwell N.J. Caspase-1-dependent processing of pro-interleukin-1 beta is cytosolic and precedes cell death. J Cell Sci 2007, 120(5):772-781.
6. Rothman J.E. Mechanisms of intracellular protein transport. Nature 1994, 372(6501):55-63.
7. Nickel W., Rabouille C. Mechanisms of regulated unconventional protein secretion. Nat Rev Mol Cell Biol 2009, 10(February (2)):148-155.
8. Cross B.C., Sinning I., Luirink J., High S. Delivering proteins for export from the cytosol. Nat Rev Mol Cell Biol 2009, 10(April (4)):255-264.
9. Schwartz T.U. Origins and evolution of cotranslational transport to the ER. Adv Exp Med Biol 2007, 607:52-60.
10. Dancourt J., Barlowe C. Protein sorting receptors in the early secretory pathway. Annu Rev Biochem 2010, 79:777-802.
11. Anelli T., Sitia R. Protein quality control in the early secretory pathway. EMBO J 2008, 27(2):315-327.
12. Bonifacino J.S., Glick B.S. The mechanisms of vesicle budding and fusion. Cell 2004, 116(2):153-166.
13. Jackson C.L. Mechanisms of transport through the Golgi complex. J Cell Sci 2009, 122(Pt 4):443-452.
14. Emr S., Glick B.S., Linstedt A.D., Lippincott-Schwartz J., Luini A., Malhotra V., et al. Journeys through the Golgi - taking stock in a new era. J Cell Biol 2009, 187(4):449-453.
15. Chardin P., McCormick F. Brefeldin A: the advantage of being uncompetitive. Cell 1999, 97(2):153-155.
16. Auron P.E., Webb A.C., Rosenwasser L.J., Mucci S.F., Rich A., Wolff S.M., et al. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc Natl Acad Sci U S A 1984, 81(December (24)):7907-7911.
17. Rubartelli A., Cozzolino F., Talio M., Sitia R. A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence. EMBO J 1990, 9(5):1503-1510.
18. Solle M., Labasi J., Perregaux D.G., Stam E., Petrushova N., Koller B.H., et al. Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem 2001, 276(1):125-132.
19. Le Feuvre R.A., Brough D., Iwakura Y., Takeda K., Rothwell N.J. Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production. J Biol Chem 2002, 277(5):3210-3218.
20. Mariathasan S., Weiss D.S., Newton K., McBride J., O'Rourke K., Roose-Girma M., et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006, 440(7081):228-232.
21. Martinon F., Petrilli V., Mayor A., Tardivel A., Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006, 440(7081):237-241.
22. Duewell P., Kono H., Rayner K.J., Sirois C.M., Vladimer G., Bauernfeind F.G., et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 2010, 464(7293):1357-1361.
23. Hornung V., Bauernfeind F., Halle A., Samstad E.O., Kono H., Rock K.L., et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 2008, 9(August (8)):847-856.
24. Halle A., Hornung V., Petzold G.C., Stewart C.R., Monks B.G., Reinheckel T., et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol 2008, 9(August (8)):857-865.
25. Mariathasan S., Newton K., Monack D.M., Vucic D., French D.M., Lee W.P., et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 2004, 430(6996):213-218.
26. Suzuki T., Franchi L., Toma C., Ashida H., Ogawa M., Yoshikawa Y., et al. Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathogens 2007, 3(8):e111.
27. Amer A., Franchi L., Kanneganti T.D., Body-Malapel M., Ozoren N., Brady G., et al. Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem 2006, 281(46):35217-35223.
28. Franchi L., Stoolman J., Kanneganti T.D., Verma A., Ramphal R., Nunez G. Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation. Eur J Immunol 2007, 37(November (11)):3030-3039.
29. Faustin B., Lartigue L., Bruey J.M., Luciano F., Sergienko E., Bailly-Maitre B., et al. Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. Mol Cell 2007, 25(5):713-724.
30. Boyden E.D., Dietrich W.F. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet 2006, 38(February (2)):240-244.
31. Burckstummer T., Baumann C., Bluml S., Dixit E., Durnberger G., Jahn H., et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 2009, 10(March (3)):266-272.
32. Fernandes-Alnemri T., Yu J.W., Datta P., Wu J., Alnemri E.S. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 2009, 458(7237):509-513.
33. Poeck H., Bscheider M., Gross O., Finger K., Roth S., Rebsamen M., et al. Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nat Immunol 2010, 11(January (1)):63-69.
34. Wu J., Fernandes-Alnemri T., Alnemri E.S. Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes. J Clin Immunol 2010, 30(September (5)):693-702.
35. Singer I.I., Scott S., Hall G.L., Limjuco G., Chin J., Schmidt J.A. Interleukin 1 beta is localized in the cytoplasmic ground substance but is largely absent from the Golgi apparatus and plasma membranes of stimulated human monocytes. J Exp Med 1988, 167(2):389-407.
36. Stevenson F.T., Torrano F., Locksley R.M., Lovett D.H. Interleukin 1: the patterns of translation and intracellular distribution support alternative secretory mechanisms. J Cell Physiol 1992, 152(August (2)):223-231.
37. Matsushima K., Taguchi M., Kovacs E.J., Young H.A., Oppenheim J.J. Intracellular localization of human monocyte associated interleukin 1 (IL 1) activity and release of biologically active IL 1 from monocytes by trypsin and plasmin. J Immunol 1986, 136(8):2883-2891.
38. Andrei C., Dazzi C., Lotti L., Torrisi M.R., Chimini G., Rubartelli A. The secretory route of the leaderless protein interleukin 1beta involves exocytosis of endolysosome-related vesicles. Mol Biol Cell 1999, 10(5):1463-1475.
39. Harris J., Hartman M., Roche C., Zeng S.G., O'Shea A., Sharp F.A., et al. Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J Biol Chem 2011, 286(11):9587-9597.
40. Moreau K., Luo S., Rubinsztein D.C. Cytoprotective roles for autophagy. Curr Opin Cell Biol 2010, 22(April (2)):206-211.
41. MacKenzie A., Wilson H.L., Kiss-Toth E., Dower S.K., North R.A., Surprenant A. Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity 2001, 15(5):825-835.
42. Lindemann S., Tolley N.D., Dixon D.A., McIntyre T.M., Prescott S.M., Zimmerman G.A., et al. Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis. J Cell Biol 2001, 154(3):485-490.
43. Bianco F., Perrotta C., Novellino L., Francolini M., Riganti L., Menna E., et al. Acid sphingomyelinase activity triggers microparticle release from glial cells. EMBO J 2009, 28(8):1043-1054.
44. Bianco F., Pravettoni E., Colombo A., Schenk U., Moller T., Matteoli M., et al. Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. J Immunol 2005, 174(11):7268-7277.
45. Pizzirani C., Ferrari D., Chiozzi P., Adinolfi E., Sandona D., Savaglio E., et al. Stimulation of P2 receptors causes release of IL-1beta-loaded microvesicles from human dendritic cells. Blood 2007, 109(9):3856-3864.
46. Qu Y., Franchi L., Nunez G., Dubyak G.R. Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages. J Immunol 2007, 179(3):1913-1925.
47. Qu Y., Ramachandra L., Mohr S., Franchi L., Harding C.V., Nunez G., et al. P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1. J Immunol 2009, 182(8):5052-5062.
48. Record M., Subra C., Silvente-Poirot S., Poirot M. Exosomes as intercellular signalosomes and pharmacological effectors. Biochem Pharmacol 2011, 81(10):1171-1182.
49. Kudo S., Mizuno K., Hirai Y., Shimizu T. Clearance and tissue distribution of recombinant human interleukin 1 beta in rats. Cancer Res 1990, 50(18):5751-5755.
50. Thery C., Ostrowski M., Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 2009, 9(August (8)):581-593.
51. Bergsbaken T., Fink S.L., Cookson B.T. Pyroptosis: host cell death and inflammation. Nat Rev Microbiol 2009, 7(February (2)):99-109.
52. Monack D.M., Detweiler C.S., Falkow S. Salmonella pathogenicity island 2-dependent macrophage death is mediated in part by the host cysteine protease caspase-1. Cell Microbiol 2001, 3(December (12)):825-837.
53. Miao E.A., Leaf I.A., Treuting P.M., Mao D.P., Dors M., Sarkar A., et al. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol 2010, 11(December (12)):1136-1142.
54. Brodsky I.E., Medzhitov R. Pyroptosis: macrophage suicide exposes hidden invaders. Curr Biol 2011, 21(2):R72-R75.
55. Fink S.L., Cookson B.T. Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol 2006, 8(November (11)):1812-1825.
56. Hogquist K.A., Nett M.A., Unanue E.R., Chaplin D.D. Interleukin 1 is processed and released during apoptosis. Proc Nat Acad Sci U S A 1991, 88(19):8485-8489.
57. Perregaux D., Gabel C.A. Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J Biol Chem 1994, 269(21):15195-15203.
58. Perregaux D., Barberia J., Lanzetti A.J., Geoghegan K.F., Carty T.J., Gabel C.A. IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin. J Immunol 1992, 149(4):1294-1303.
59. Laliberte R.E., Eggler J., Gabel C.A. ATP treatment of human monocytes promotes caspase-1 maturation and externalization. J Biol Chem 1999, 274(52):36944-36951.
60. Verhoef P.A., Kertesy S.B., Lundberg K., Kahlenberg J.M., Dubyak G.R. Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor. J Immunol 2005, 175(11):7623-7634.
61. Singer I.I., Scott S., Chin J., Bayne E.K., Limjuco G., Weidner J., et al. The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy. J Exp Med 1995, 182(5):1447-1459.
62. Martin U., Scholler J., Gurgel J., Renshaw B., Sims J.E., Gabel C.A. Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages. J Immunol 2009, 183(6):4021-4030.
63. Fantuzzi G., Ku G., Harding M.W., Livingston D.J., Sipe J.D., Kuida K., et al. Response to local inflammation of IL-1 beta-converting enzyme-deficient mice. J Immunol 1997, 158(4):1818-1824.
64. Joosten L.A., Netea M.G., Fantuzzi G., Koenders M.I., Helsen M.M., Sparrer H., et al. Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta. Arthritis Rheum 2009, 60(December (12)):3651-3662.
65. Guma M., Ronacher L., Liu-Bryan R., Takai S., Karin M., Corr M. Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum 2009, 60(December (12)):3642-3650.
66. Stehlik C. Multiple interleukin-1beta-converting enzymes contribute to inflammatory arthritis. Arthritis Rheum 2009, 60(December (12)):3524-3530.
67. Black R.A., Kronheim S.R., Cantrell M., Deeley M.C., March C.J., Prickett K.S., et al. Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor. J Biol Chem 1988, 263(19):9437-9442.
68. Beausejour A., Grenier D., Goulet J.P., Deslauriers N. Proteolytic activation of the interleukin-1beta precursor by Candida albicans. Infect Immun 1998, 66(February (2)):676-681.
69. Rubartelli A., Bajetto A., Allavena G., Cozzolino F., Sitia R. Post-translational regulation of interleukin 1 beta secretion. Cytokine 1993, 5(March (2)):117-124.
70. Tassi S., Carta S., Delfino L., Caorsi R., Martini A., Gattorno M., et al. Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion. Proc Natl Acad Sci U S A 2010, 107(21):9789-9794.
71. Carta S., Tassi S., Pettinati I., Delfino L., Dinarello C.A., Rubartelli A. The rate of interleukin-1{beta} secretion in different myeloid cells varies with the extent of redox response to toll-like receptor triggering. J Biol Chem 2011, 286(31):27069-27080.
72. Perregaux D.G., Laliberte R.E., Gabel C.A. Human monocyte interleukin-1beta posttranslational processing. Evidence of a volume-regulated response. J Biol Chem 1996, 271(47):29830-29838.
73. Laliberte R.E., Perregaux D.G., McNiff P., Gabel C.A. Human monocyte ATP-induced IL-1 beta posttranslational processing is a dynamic process dependent on in vitro growth conditions. J Leukocyte Biol 1997, 62(August (2)):227-239.
74. Pelegrin P., Surprenant A. Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates. EMBO J 2009, 28(14):2114-2127.
75. Bergsbaken T., Fink S.L., den Hartigh A.B., Loomis W.P., Cookson B.T. Coordinated host responses during pyroptosis: caspase-1-dependent lysosome exocytosis and inflammatory cytokine maturation. J Immunol 2011, 187:2748-2754.
76. Dinarello C.A. Anti-inflammatory agents: present and future. Cell 2010, 140(6):935-950.
77. 2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages. J Immunol 2003, 170(6):3029-3036.
78. Sanz J.M., Di Virgilio F. Kinetics and mechanism of ATP-dependent IL-1 beta release from microglial cells. J Immunol 2000, 164(9):4893-4898.
79. Perregaux D.G., McNiff P., Laliberte R., Hawryluk N., Peurano H., Stam E., et al. Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. J Pharmacol Exp Ther 2001, 299(October (1)):187-197.
80. Lamkanfi M., Mueller J.L., Vitari A.C., Misaghi S., Fedorova A., Deshayes K., et al. Glyburide inhibits the cryopyrin/Nalp3 inflammasome. J Cell Biol 2009, 187(1):61-70.
81. Andrei C., Margiocco P., Poggi A., Lotti L.V., Torrisi M.R., Rubartelli A. Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: implications for inflammatory processes. Proc Natl Acad Sci U S A 2004, 101(26):9745-9750.
82. Franchi L., Chen G., Marina-Garcia N., Abe A., Qu Y., Bao S., et al. Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone. J Innate Immun 2009, 1(October (6)):607-617.
83. Perregaux D.G., Svensson L., Gabel C.A. Tenidap and other anion transport inhibitors disrupt cytolytic T lymphocyte-mediated IL-1 beta post-translational processing. J Immunol 1996, 157(1):57-64.
84. Carta S., Tassi S., Semino C., Fossati G., Mascagni P., Dinarello C.A., et al. Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules. Blood 2006, 108(5):1618-1626.
85. Stinchcombe J.C., Griffiths G.M. Regulated secretion from hemopoietic cells. J Cell Biol 1999, 147(1):1-6.