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Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 54, Issue 12, 2011, Pages 763-768

Synthesis of potent lymphocyte function-associated antigen-1 inhibitors labeled with carbon-14 and deuterium, part 1

(5) Latli, Bachir a Byrne, Denis a Nummy, Larry a Krishnamurthy, Dhileepkumar a Senanayake, Chris H a

a BOEHRINGER INGELHEIM PHARMACEUTICALS INC (United States)

Author keywords

carbon 14; deuterium; LFA 1 antagonists; metabolism; synthesis

Indexed keywords

CARBON; CHLORINE COMPOUNDS; DEUTERIUM; ESTERS; METABOLISM; PHYSIOLOGY; T-CELLS;

CARBON 14; DRUG DISCOVERY; DRUG METABOLISMS; IMIDAZOL; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1 ANTAGONIST; PHARMACOKINETIC STUDIES; RADIOCHEMICAL YIELD; SPECIFIC ACTIVITY; SULFONYL CHLORIDES; SYSTEM FUNCTIONS;

ANTIGENS;

1 ACETYL 5 (4 BROMOBENZYL) 3 (3,5 DICHLOROPHENYL) 5 METHYL IMIDAZOLIDINE 2,4 DIONE; 1 [7 (3,5 DICHLOROPHENYL) 5 METHYL 6 OXO 5 (4 PYRIMIDIN 5 YL BENZYL) 6,7 DIHYDRO 5H IMIDAZO[1,2 A]IMIDAZOLE 3 SULFONYL]PIPERIDIN 4 CARBOXYLIC ACID AMIDE; 5 (1 PIPERAZINYLSULFONYL) 1 (3,5 DICHLOROPHENYL) 3 [4 (5 PYRIMIDINYL)BENZYL] 3 METHYL 1H IMIDAZO[1,2A]IMIDAZOL 2 ONE; ANTIINFLAMMATORY AGENT; CARBON 14; DEUTERIUM; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; UNCLASSIFIED DRUG;

ARTICLE; CATALYST; CHEMICAL REACTION; CYCLIZATION; DRUG METABOLISM; DRUG SYNTHESIS; ISOTOPE LABELING; RADIOCHEMISTRY; SUZUKI REACTION;

EID: 81155133142 PISSN: 03624803 EISSN: 10991344 Source Type: Journal
DOI: 10.1002/jlcr.1920 Document Type: Article

Times cited : (5)

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