A practical synthesis of LFA-1 inhibitors utilizing CuCl-promoted intramolecular cyclization of thiohydantoins

Tetrahedron Letters

Volumn 46, Issue 2, 2005, Pages 273-276

  Wang, Xiao Jun ^a   Zhang, Li ^a   Xu, Yibo ^a   Krishnamurthy, Dhileepkumar ^a   Varsolona, Richard ^a   Nummy, Laurence ^a   Shen, Sherry ^a   Frutos, Rogelio P ^a   Byrne, Denis ^a   Chung, J C ^a   Farina, Vittorio ^a   Senanayake, Chris H ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Bicyclic guanidine; Imidazolidinone; LFA 1 inhibitor; Thiohydantoin

Indexed keywords

COPPER CHLORIDE; IMIDAZOLE DERIVATIVE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; THIOHYDANTOIN DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CYCLIZATION; DRUG SYNTHESIS; MOLECULAR INTERACTION; REACTION ANALYSIS;

EID: 10044244671     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.11.065     Document Type: Article

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14. 2: C, 58.13; H, 3.41; Cl, 17.16; N, 13.56. Found: C, 57.93; H, 3.45; Cl, 17.24; N, 13.56