Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression

Journal of Medicinal Chemistry

Volumn 44, Issue 6, 2001, Pages 988-1002

  Stewart, A O ^a   Bhatia, P A ^a   McCarty, C M ^a   Patel, M V ^a   Staeger, M A ^a   Arendsen, D L ^a   Gunawardana, I W ^a   Melcher, L M ^a   Zhu, G D ^a   Boyd, S A ^a   Fry, D G ^a   Cool, B L ^a   Kiflie, L ^a   Lartey, K ^a   Marsh, K C ^a   Kempf Grote, A J ^a   Kilgannon, P ^b   Wisdom, W ^b   Meyer, J ^b   Gallatin, W M ^b   Okasinskit, G F ^a   more..

^a ABBOTT LABORATORIES   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A 155918; A 205804; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; PYRIDINE DERIVATIVE; THIENO[2,3 C]PYRIDINE DERIVATIVE; THIENO[2,3 D]PYRIMIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOTHELIUM CELL; INFLAMMATION; LEUKOCYTE ADHERENCE; METABOLIC INHIBITION; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; CELL ADHESION; CELL LINE; DEPRESSION, CHEMICAL; E-SELECTIN; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENES, REPORTER; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LUCIFERASES; PROMOTER REGIONS (GENETICS); PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL VEINS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0035866587     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000452m     Document Type: Article

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