메뉴 건너뛰기




Volumn 8, Issue 7, 2007, Pages 665-668

Vagaries of conditional gene targeting

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; DNA;

EID: 34250694086     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni0707-665     Document Type: Note
Times cited : (351)

References (34)
  • 1
    • 27644576914 scopus 로고    scopus 로고
    • Current issues in mouse genome engineering
    • Glaser, S., Anastassiadis, K. & Stewart, A.F. Current issues in mouse genome engineering. Nat. Genet. 37, 1187-1193 (2005).
    • (2005) Nat. Genet , vol.37 , pp. 1187-1193
    • Glaser, S.1    Anastassiadis, K.2    Stewart, A.F.3
  • 2
    • 0346503889 scopus 로고    scopus 로고
    • Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice
    • Branda, C.S. & Dymecki, S.M. Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice. Dev. Cell 6, 7-28 (2004).
    • (2004) Dev. Cell , vol.6 , pp. 7-28
    • Branda, C.S.1    Dymecki, S.M.2
  • 3
    • 0029807339 scopus 로고    scopus 로고
    • Conditional gene targeting
    • Rajewsky, K. et al. Conditional gene targeting. J. Clin. Invest. 98, 600-603 (1996).
    • (1996) J. Clin. Invest , vol.98 , pp. 600-603
    • Rajewsky, K.1
  • 4
    • 0030818183 scopus 로고    scopus 로고
    • B lymphocyte-specific, Cre-mediated mutagenesis in mice
    • Rickert, R.C., Roes, J. & Rajewsky, K. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res. 25, 1317-1318 (1997).
    • (1997) Nucleic Acids Res , vol.25 , pp. 1317-1318
    • Rickert, R.C.1    Roes, J.2    Rajewsky, K.3
  • 5
    • 3042856262 scopus 로고    scopus 로고
    • Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
    • Srinivas, S. et al. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1, 4 (2001).
    • (2001) BMC Dev. Biol , vol.1 , pp. 4
    • Srinivas, S.1
  • 6
    • 34548392767 scopus 로고    scopus 로고
    • Excision of the Frt-flanked neoR cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination
    • in the press
    • Schmidt-Supprian, M., Wunderlich, F.T. & Rajewsky, K. Excision of the Frt-flanked neoR cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination. Transgenic Res. (in the press).
    • Transgenic Res
    • Schmidt-Supprian, M.1    Wunderlich, F.T.2    Rajewsky, K.3
  • 7
    • 0348148880 scopus 로고    scopus 로고
    • Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
    • Opferman, J.T. et al. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 426, 671-676 (2003).
    • (2003) Nature , vol.426 , pp. 671-676
    • Opferman, J.T.1
  • 8
    • 24944538805 scopus 로고    scopus 로고
    • c-Myb is critical for B cell development and maintenance of follicular B cells
    • Thomas, M.D., Kremer, C.S., Ravichandran, K.S., Rajewsky, K. & Bender, T.P. c-Myb is critical for B cell development and maintenance of follicular B cells. Immunity 23, 275-286 (2005).
    • (2005) Immunity , vol.23 , pp. 275-286
    • Thomas, M.D.1    Kremer, C.S.2    Ravichandran, K.S.3    Rajewsky, K.4    Bender, T.P.5
  • 9
    • 2942582913 scopus 로고    scopus 로고
    • Survival of resting mature B lymphocytes depends on BCR signaling via the lgα/β heterodimer
    • Kraus, M., Alimzhanov, M.B., Rajewsky, N. & Rajewsky, K. Survival of resting mature B lymphocytes depends on BCR signaling via the lgα/β heterodimer. Cell 117, 787-800 (2004).
    • (2004) Cell , vol.117 , pp. 787-800
    • Kraus, M.1    Alimzhanov, M.B.2    Rajewsky, N.3    Rajewsky, K.4
  • 10
    • 30444457243 scopus 로고    scopus 로고
    • FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses
    • Victoratos, P. et al. FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses. Immunity 24, 65-77 (2006).
    • (2006) Immunity , vol.24 , pp. 65-77
    • Victoratos, P.1
  • 11
    • 0035097419 scopus 로고    scopus 로고
    • Cell-specific regulation of the CD21 gene
    • Zabel, M.D. & Weis, J.H. Cell-specific regulation of the CD21 gene. Int. Immunopharmacol. 1, 483-493 (2001).
    • (2001) Int. Immunopharmacol , vol.1 , pp. 483-493
    • Zabel, M.D.1    Weis, J.H.2
  • 12
    • 33646555754 scopus 로고    scopus 로고
    • Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting
    • Casola, S. et al. Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Proc. Natl. Acad. Sci. USA 103, 7396-7401 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 7396-7401
    • Casola, S.1
  • 13
    • 2342471358 scopus 로고    scopus 로고
    • Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein
    • Hafner, M. et al. Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein. Genesis 38, 176-181 (2004).
    • (2004) Genesis , vol.38 , pp. 176-181
    • Hafner, M.1
  • 14
    • 33748774926 scopus 로고    scopus 로고
    • Testing gene function early in the B cell lineage in mb1-cre mice
    • Hobeika, E. et al. Testing gene function early in the B cell lineage in mb1-cre mice. Proc. Natl. Acad. Sci. USA 103, 13789-13794 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 13789-13794
    • Hobeika, E.1
  • 15
    • 2942582215 scopus 로고    scopus 로고
    • A keratin K5Cre transgenic line appropriate for tissue-specific or generalized Cre-mediated recombination
    • Ramirez, A. et al. A keratin K5Cre transgenic line appropriate for tissue-specific or generalized Cre-mediated recombination. Genesis 39, 52-57 (2004).
    • (2004) Genesis , vol.39 , pp. 52-57
    • Ramirez, A.1
  • 16
    • 0035543866 scopus 로고    scopus 로고
    • Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice
    • Wagner, K.U. et al. Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice. Transgenic Res. 10, 545-553 (2001).
    • (2001) Transgenic Res , vol.10 , pp. 545-553
    • Wagner, K.U.1
  • 17
    • 0034610394 scopus 로고    scopus 로고
    • Schmidt, E.E., Taylor, D.S., Prigge, J.R., Barnett, S. & Capecchi, M.R. Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. Proc. Natl. Acad. Sci. USA 97, 13702-13707 (2000).
    • Schmidt, E.E., Taylor, D.S., Prigge, J.R., Barnett, S. & Capecchi, M.R. Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. Proc. Natl. Acad. Sci. USA 97, 13702-13707 (2000).
  • 18
    • 0343415768 scopus 로고    scopus 로고
    • Mammalian genomes contain active recombinase recognition sites
    • Thyagarajan, B., Guimaraes, M.J., Groth, A.C. & Calos, M.P. Mammalian genomes contain active recombinase recognition sites. Gene 244 47-54 (2000).
    • (2000) Gene , vol.244 , pp. 47-54
    • Thyagarajan, B.1    Guimaraes, M.J.2    Groth, A.C.3    Calos, M.P.4
  • 19
    • 34247130822 scopus 로고    scopus 로고
    • Cryptic loxP sites in mammalian genomes: Genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques
    • Semprini, S. et al. Cryptic loxP sites in mammalian genomes: genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques. Nucleic Acids Res. (2007).
    • (2007) Nucleic Acids Res
    • Semprini, S.1
  • 20
    • 0035949704 scopus 로고    scopus 로고
    • Delivery of the Cre recombinase by a self-deleting lentiviral vector: Efficient gene targeting in vivo
    • Pfeifer, A., Brandon, E.P., Kootstra, N., Gage, F.H. & Verma, I.M. Delivery of the Cre recombinase by a self-deleting lentiviral vector: efficient gene targeting in vivo. Proc. Natl. Acad Sci. USA 98 11450-11455 (2001).
    • (2001) Proc. Natl. Acad Sci. USA , vol.98 , pp. 11450-11455
    • Pfeifer, A.1    Brandon, E.P.2    Kootstra, N.3    Gage, F.H.4    Verma, I.M.5
  • 21
    • 0034888424 scopus 로고    scopus 로고
    • Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity
    • Silver, D.P. & Livingston, D.M. Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity. Mol. Cell 8, 233-243 (2001).
    • (2001) Mol. Cell , vol.8 , pp. 233-243
    • Silver, D.P.1    Livingston, D.M.2
  • 22
    • 0035129209 scopus 로고    scopus 로고
    • Analysis of C-MYC function in normal cells via conditional gene-targeted mutation
    • de Alboran, I.M. et al. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity 14, 45-55 (2001).
    • (2001) Immunity , vol.14 , pp. 45-55
    • de Alboran, I.M.1
  • 23
    • 0035979247 scopus 로고    scopus 로고
    • Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells
    • Loonstra, A. et al. Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proc. Natl. Acad. Sci. USA 98, 9209-9214 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9209-9214
    • Loonstra, A.1
  • 24
    • 21744436924 scopus 로고    scopus 로고
    • Practical range of effective dose for Cre recombinase-expressing recombinant adenovirus without cell toxicity in mammalian cells
    • Baba, Y., Nakano, M., Yamada, Y., Saito, I. & Kanegae, Y. Practical range of effective dose for Cre recombinase-expressing recombinant adenovirus without cell toxicity in mammalian cells. Microbiol. Immunol. 49, 559-570 (2005).
    • (2005) Microbiol. Immunol , vol.49 , pp. 559-570
    • Baba, Y.1    Nakano, M.2    Yamada, Y.3    Saito, I.4    Kanegae, Y.5
  • 26
    • 33846903111 scopus 로고    scopus 로고
    • Conditional mutagenesis by cell-permeable proteins: Potential, limitations and prospects
    • Patsch, C. & Edenhofer, F. Conditional mutagenesis by cell-permeable proteins: Potential, limitations and prospects. Handb. Exp. Pharmacol. 178, 203-232 (2007).
    • (2007) Handb. Exp. Pharmacol , vol.178 , pp. 203-232
    • Patsch, C.1    Edenhofer, F.2
  • 27
    • 0037007121 scopus 로고    scopus 로고
    • Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: A tool for efficient genetic engineering of mammalian genomes
    • Peitz, M., Pfannkuche, K., Rajewsky, K. & Edenhofer, F. Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: A tool for efficient genetic engineering of mammalian genomes. Proc. Natl. Acad. Sci. USA 99, 4489-4494 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 4489-4494
    • Peitz, M.1    Pfannkuche, K.2    Rajewsky, K.3    Edenhofer, F.4
  • 28
    • 0034811154 scopus 로고    scopus 로고
    • Reduction of Cre recombinase toxicity in proliferating Drosophila cells by estrogen-dependent activity regulation
    • Heidmann, D. & Lehner, C.F. Reduction of Cre recombinase toxicity in proliferating Drosophila cells by estrogen-dependent activity regulation. Dev. Genes Evol. 211, 458-465 (2001).
    • (2001) Dev. Genes Evol , vol.211 , pp. 458-465
    • Heidmann, D.1    Lehner, C.F.2
  • 29
    • 0037441645 scopus 로고    scopus 로고
    • Rapid generation of inducible mouse mutants
    • Seibler, J. et al. Rapid generation of inducible mouse mutants. Nucleic Acids Res. 31, e12 (2003).
    • (2003) Nucleic Acids Res , vol.31
    • Seibler, J.1
  • 30
    • 33646384957 scopus 로고    scopus 로고
    • RIP-Cre revisited, evidence for impairments of pancreatic β-cell function
    • Lee, J.Y. et al. RIP-Cre revisited, evidence for impairments of pancreatic β-cell function. J. Biol. Chem. 281, 2649-2653 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 2649-2653
    • Lee, J.Y.1
  • 31
    • 5144223503 scopus 로고    scopus 로고
    • Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis
    • Sato, S., Fujimoto, M., Hasegawa, M., Takehara, K. & Tedder, T.F. Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis. Mol. Immunol. 41, 1123-1133 (2004).
    • (2004) Mol. Immunol , vol.41 , pp. 1123-1133
    • Sato, S.1    Fujimoto, M.2    Hasegawa, M.3    Takehara, K.4    Tedder, T.F.5
  • 32
    • 5844299536 scopus 로고    scopus 로고
    • Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development
    • Wolfer, A. et al. Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development. Nat. Immunol. 2 235-241 (2001).
    • (2001) Nat. Immunol , vol.2 , pp. 235-241
    • Wolfer, A.1
  • 33
    • 18244365863 scopus 로고    scopus 로고
    • A critical role for Dnmt1 and DNA methylation in-T cell development, function, and survival
    • Lee, P.P. et al. A critical role for Dnmt1 and DNA methylation in-T cell development, function, and survival. Immunity 15, 763-774 (2001).
    • (2001) Immunity , vol.15 , pp. 763-774
    • Lee, P.P.1
  • 34
    • 0029155706 scopus 로고
    • Inducible gene targeting in mice
    • Kuhn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science 269, 1427-1429 (1995).
    • (1995) Science , vol.269 , pp. 1427-1429
    • Kuhn, R.1    Schwenk, F.2    Aguet, M.3    Rajewsky, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.