Surfing the insulin signaling web

European Journal of Clinical Investigation

Volumn 31, Issue 11, 2001, Pages 966-977

  Van Obberghen, E ^a   Baron, V ^a   Delahaye, L ^a   Emanuelli, B ^a   Filippa, N ^a   Giorgetti Peraldi, S ^a   Lebrun, P ^a   Mothe Satney, I ^a   Peraldi, P ^a   Rocchi, S ^a   Sawka Verhelle, D ^a   Tartare Deckert, S ^a   Giudicelli, J ^a  

^a INSERM   (France)

Author keywords

IGF I; Insulin; Insulin IGF I action; Insulin IGF I receptor; Tyrosine kinases

Indexed keywords

CELL SURFACE RECEPTOR; CYTOKINE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INTEGRIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTYROSINE; PROTEIN; PROTEIN TYROSINE PHOSPHATASE; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; SUPPRESSOR OF CYTOKINE SIGNALING; TYROSINE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

BINDING SITE; CELL STIMULATION; HORMONE ACTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; TRANSCRIPTION INITIATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; DNA-BINDING PROTEINS; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; INTEGRINS; MILK PROTEINS; MODELS, BIOLOGICAL; PHOSPHOPROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RECEPTOR, IGF TYPE 1; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0035779997     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.2001.00896.x     Document Type: Review

References (87)

1. Van Obberghen E. Signalling through the insulin receptor and the insulin-like growth factor-I receptor. Diabetologia 1994;37 (Suppl. 2):S125-34.
2. Kahn CR, White MF. The insulin receptor and the molecular mechanism of insulin action. J Clin Invest 1988;82:1151-6.
3. Yarden Y, Ullrich A. Growth factor receptor tyrosine kinases. Annu Rev Biochem 1988;57:443-78.
4. Baron V, Gautier N, Komoriya A, Hainaut P, Scimeca JC, Mervic M et al. Insulin binding to its receptor induces a conformational change in the receptor C-terminus. Biochemistry 1990;29:4634-41.
5. Baron V, Kaliman P, Gautier N, Van Obberghen E. The insulin receptor activation process involves localized conformational changes. J Biol Chem 1992;267:23290-4.
6. Lebrun C, Baron V, Kaliman P, Gautier N, Dolais-Kitabgi J, Taylor S et al. Antibodies to the extracellular receptor domain restore the hormone-insensitive kinase and conformation of the mutant insulin receptor valine 382. J Biol Chem 1993;268:11272-7.
7. Kaliman P, Baron V, Gautier N, Van Obberghen E. Antipeptide antibody to the insulin-like growth factor-I receptor sequence 1232-1246 inhibits the receptor kinase activity. J Biol Chem 1992;267:10645-51.
8. Tartare S, Mothe I, Kowalski-Chauvel A, Breittmayer JP, Ballotti R, Van Obberghen E. Signal transduction by a chimeric insulin-like growth factor-1 (IGF-1) receptor having the carboxyl-terminal domain of the insulin receptor. J Biol Chem 1994;269:11449-55.
9. Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA et al. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 1991;352:73-7.
10. Sun XJ, Wang LM, Zhang Y, Yenush L, Myers MG, Glasheen E et al. Role of IRS-2 in insulin and cytokine signalling. Nature 1995;377:173-7.
11. Lavan BE, Lane WS, Lienhard GE. The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family. J Biol Chem 1997;272:11439-43.
12. Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR, Lienhard GE. A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family. J Biol Chem 1997;272:21403-7.
13. Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G et al. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 1992;70:93-104.
14. Holgado-Madruga M, Emlet DR, Moscatello DK, Godwin AK, Wong AJ. A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 1996;379:560-4.
15. Carpino N, Wisniewski D, Strife A, Marshak D, Kobayashi R, Stillman B et al. p62 (dok): A constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell 1997;88:197-204.
16. Lemmon MA, Ferguson KM, Schlessinger J. PH domains: Diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell 1996;85:621-4.
17. Bork P, Margolis B. A phosphotyrosine interaction domain. Cell 1995;80:693-4.
18. Kavanaugh WM, Williams LT An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. Science 1994;266:1862-5.
19. Kharitonenkov A, Chen Z, Sures I, Wang H, Schilling J, Ullrich A. A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 1997;386:181-6.
20. Fujioka Y, Matozaki T, Noguchi T, Iwamatsu A, Yamao T, Takahashi N et al. A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol Cell Biol 1996;16:6887-99.
21. Ribon V, Saltiel AR. Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes. Biochem J 1997;324:839-45.
22. Moodie SA, Alleman-Sposeto J, Gustafson TA. Identification of the APS protein as a novel insulin receptor substrate. J Biol Chem 1999;274:11186-93.
23. Tartare-Deckert S, Sawka-Verhelle D, Murdaca J, Van Obberghen E. Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system. J Biol Chem 1995;270:23456-60.
24. Rocchi S, Tartare-Deckert S, Murdaca J, Holgado-Madruga M, Wong AJ, Van Obberghen E. Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules. Mol Endocrinol 1998;12:914-23.
25. Sawka-Verhelle D, Tartare-Deckert S, White MF, Van Obberghen E. Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786. J Biol Chem 1996;271:5980-3.
26. Sawka-Verhelle D, Baron V, Mothe I, Filloux C, White MF, Van Obberghen E. Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor. J Biol Chem 1997;272:16414-20.
27. Virkamäki A, Ueki K, Kahn CR. Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 1999;103:931-43.
28. Miele C, Caruso M, Calleja V, Auricchio R, Oriente F, Formisano P et al. Differential role of insulin receptor substrate (IRS) -1 and IRS-2 in L6 skeletal muscle cells expressing the Arg1152 → Gln insulin receptor. J Biol Chem 1999;274:3094-102.
29. Caruso M, Miele C, Formisano P, Condorelli G, Bifulco G, Oliva A et al. In skeletal muscle, glucose storage and oxidation are differentially impaired by the IR1152 mutant receptor. J Biol Chem 1997;272:7290-7.
30. Araki E, Lipes MA, Patti ME, Brüning JC, Haag BL III, Johnson RS et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 1994;372:186-90.
31. Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998;391:900-4.
32. Bruning JC, Winnay J, Cheatham B, Kahn CR. Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Mol Cell Biol 1997;17:1513-21.
33. Joshi RL, Lamothe B, Cordonnier N, Mesbah K, Monthioux E, Jami J et al. Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. EMBO J 1996;15:1542-7.
34. Accili D, Drago J, Lee EJ, Johnson MD, Cool MH, Salvatore P et al. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat Genet 1996: 106-9.
35. Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 1993;75:59-72.
36. Accili D, Nakae J, Kim JJ, Park BC, Rother KI. Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development. J Pediatr Endocrinol Metab 1999;12:475-85.
37. LeRoith D. Insulin-like growth factor I receptor signaling - Overlapping or redundant pathways? Endocrinology 2000;141:1287-8.
38. Baserga R, Hongo A, Rubini M, Prisco M, Valentinis B. The IGF-I receptor in cell growth, transformation and apoptosis. Biochim Biophys Acta 1997;1332:F105-26.
39. Urso B, Cope DL, Kalloo-Hosein HE, Hayward AC, Whitehead JP, O'Rahilly S et al. Differences in signaling properties of the cytoplasmic domains of the insulin receptor and insulin-like growth factor receptor in 3T3-L1 adipocytes. J Biol Chem 1999;274:30864-73.
40. Miele C, Rochford JJ, Filippa N, Giorgetti-Peraldi S, Van Obberghen E. Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways. J Biol Chem 2000;275:21695-702.
41. Nakae J, Barr V, Accili D. Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR. EMBO J 2000;19:989-96.
42. Sawka-Verhelle D, Filloux C, Tartare-Deckert S, Mothe I, Van Obberghen E. Identification of Stat 5B as a substrate of the insulin receptor. Eur J Biochem 1997;250:411-7.
43. Sawka-Verhelle D, Tartare-Deckert S, Decaux JF, Girard J, Van Obberghen E. Stat 5B, activated by insulin in a Jak-independent fashion, plays a role in glucokinase gene transcription. Endocrinology 2000;141:1977-88.
44. Foretz M, Guichard C, Ferre P, Foufelle F. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc Natl Acad Sci U S A 1999;96:12737-42.
45. Ohya Ki Kajiyaga S, Yamashita Y, Miyazoto A, Hatake K, Miura Y, Ikeda U et al. SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase. J Biol Chem 1997;272:27178-82.
46. Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 1997;387:921-4.
47. Starr R, Willson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ et al. A family of cytokine-inducible inhibitors of signalling. Nature 1997;387:917-21.
48. Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS et al. Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc Natl Acad Sci U S A 1998;95:114-9.
49. Chen XP, Losman JA, Rothman P. SOCS proteins, regulators of intracellular signaling. Immunity 2000;13:287-90.
50. Emanuelli B, Peraldi P, Filloux C, Sawka-Verhelle D, Hilton D, Van Obberghen E. SOCS-3 is an insulin-induced negative regulator of insulin signaling. J Biol Chem 2000;275:15985-91.
51. Luger A, Prager R, Gaube S, Graf H, Klauser R, Schernthaner G. Decreased peripheral insulin sensitivity in acromegalic patients. Exp Clin Endocrinol 1990;95:339-43.
52. Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science 1996;274:1185-8.
53. Muller G, Ertl J, Gerl M, Preibisch G. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem 1997;272:10585-93.
54. Kumar CC. Signaling by integrin receptors. Oncogene 1998;17:1365-73.
55. McDonald JA. Integrins minireview series. J Biol Chem 2000;275:21783.
56. 3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF. EMBO J 1997;16:5600-7.
57. Vuori K, Ruoslahti E. Association of insulin receptor substrate-1 with integrins. Science 1994;266:1576-8.
58. Schwartz MA, Baron V. Interactions between mitogenic stimuli, or, a thousand and one connections. Curr Opin Cell Biol 1999;11:197-202.
59. Lebrun P, Baron V, Hauck CR, Schlaepfer DD, Van Obberghen E. Cell adhesion and focal adhesion kinase regulate insulin receptor substrate-1 expression. J Biol Chem 2000;275:38371-7.
60. Miyamoto S, Teramoto H, Coso OA, Gutkind JS, Burbelo PD, Akiyama SK et al. Integrin function. Molecular hierarchies of cytoskeletal and signaling molecules. J Cell Biol 1995;131:791-805.
61. Araki E, Haag BL, Matsuda K, Shichiri M, Kahn CR. Characterization and regulation of the mouse insulin receptor substrate gene promoter. Mol Endocrinol 1995;9:1367-79.
62. Matsuda K, Araki E, Yoshimura R, Tsuruzoe K, Furukawa N, Kaneko K et al. Cell-specific regulation of IRS-1 gene expression: Role of E box and C/EBP binding site in HepG2 cells and CHO cells. Diabetes 1997;46:354-62.
63. Lebrun P, Mothe-Satney I, Delahaye L, Van Obberghen E, Baron V. Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp125 (FAK) and pp60 (src). J Biol Chem 1998;273:32244-53.
64. Baron V, Calleja V, Ferrari P, Alengrin F, Van Obberghen E. p125Fak focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors. J Biol Chem 1998;273:7162-8.
65. Zheng B, Clemmons DR. Blocking ligand occupancy of the alphavbeta3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells. Proc Natl Acad Sci U S A 1998;95:11217-22.
66. Guilherme A, Czech MP. Stimulation of IRS-1-associated phosphatidylinositol 3-kinase and Akt/protein kinase B but not glucose transport by beta1-integrin signaling in rat adipocytes. J Biol Chem 1998;273:33119-22.
67. White MF. The IRS-signalling system. A network of docking proteins that mediate insulin action. Mol Cell Biochem 1998;182:3-11.
68. Pessin JE, Saltiel AR. Signaling pathways in insulin action. Molecular targets of insulin resistance. J Clin Invest 2000;106:165-9.
69. Inoue G, Cheatham B, Emkey R, Kahn CR. Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS) -1 and IRS-2. J Biol Chem 1998;273:11548-55.
70. Kelly KL, Ruderman NB. Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle. J Biol Chem 1993;268:4391-8.
71. Ricort JM, Tanti JF, Van Obberghen E, Le Marchand-Brustel Y. Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport. Eur J Biochem 1996;239:17-22.
72. Conricode KM. Involvement of phosphatidylinositol 3-kinase in stimulation of glucose transport by growth factors in 3T3-L1 adipocytes. Biochem Mol Biol Int 1995;36:835-43.
73. Hill MM, Clark SF, Tucker DF, Birnbaum MJ, James DE, Macaulay SL. A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes. Mol Cell Biol 1999;19:7771-81.
74. Summers SA, Whiteman EL, Cho H, Lipfert L, Birnbaum MJ. Differentiation-dependent suppression of platelet-derived growth factor signaling in cultured adipocytes. J Biol Chem 1999;274:23858-67.
75. Staubs PA, Nelson JG, Reichart DR, Olefsky JM. Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated phosphatidylinositol 3-kinase in 3T3-L1 adipocytes without affecting glucose transport. J Biol Chem 1998;273:25139-47.
76. Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 1996;271:665-8.
77. Tanti JF, Gremeaux T, Van Obberghen E, Le Marchand-Brustel Y. Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling. J Biol Chem 1994;269:6051-7.
78. Freund GG, Wittig JG, Mooney RA. The PI3-kinase serine kinase phosphorylates its p85 subunit and IRS-1 in PI3-kinase/IRS-1 complexes. Biochem Biophys Res Commun 1995;206:272-8.
79. Tanti JF, Gremeaux T, Van Obberghen E, Le Marchand-Brustel Y. Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase. Biochem J 1994;304:17-21.
80. Li J, DeFea K, Roth RA. Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway. J Biol Chem 1999;274:9351-6.
81. De Fea K, Roth RA. Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase. J Biol Chem 1997;272:31400-6.
82. Eldar-Finkelman H, Krebs EG. Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action. Proc Natl Acad Sci U S A 1997;94:9660-4.
83. Summers SA, Kao AW, Kohn AD, Backus GS, Roth RA, Pessin JE et al. The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism. J Biol Chem 1999;274:17934-40.
84. Mothe I, Delahaye L, Filloux C, Pons S, White MF, Van Obberghen E. Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins. Mol Endocrinol 1997;11:1911-23.
85. Qiao LY, Goldberg JL, Russell JC, Sun XJ. Identification of enhanced serine kinase activity in insulin resistance. J Biol Chem 1999;274:10625-32.
86. Clark SF, Molero JC, James DE. Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance. J Biol Chem 2000;275:3819-26.
87. Whitehead JP, Clark SF, Urso B, James DE. Signalling through the insulin receptor. Curr Opin Cell Biol 2000;12:222-8.