Mechanisms of RNA interference in the HIV-1-host cell interplay

AIDS Reviews

Volumn 13, Issue 3, 2011, Pages 149-160

  Sánchez del Cojo, María ^a   López Huertas, María Rosa ^a   Mateos, Elena ^a   Alcamí, José ^a   Coiras, Mayte ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

HIV 1; MicroRNA; RNA interference; Small interference RNA; Viral RNA

Indexed keywords

ANTIRETROVIRUS AGENT; ANTIVIRUS AGENT; APOLIPOPROTEIN B; ARGININE; CYCLIN DEPENDENT KINASE 9; DNA DIRECTED RNA POLYMERASE III; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; GAG PROTEIN; HISTONE DEACETYLASE; LENTIVIRUS VECTOR; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MICRORNA; MICRORNA 122; NEF PROTEIN; PROTEIN KINASE R; RNA; RNA BINDING PROTEIN; RNA HELICASE; RNA POLYMERASE II; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; APOPTOSIS; CELL DIFFERENTIATION; CELL FUNCTION; CELL INTERACTION; CYTOPLASM; DISEASE COURSE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; HEPATITIS C VIRUS; HLA SYSTEM; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS 1; IMMEDIATE EARLY GENE; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; MACROPHAGE; MONOCYTE; MUTAGENESIS; NONHUMAN; PHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN RNA BINDING; REVIEW; RNA ANALYSIS; RNA CLEAVAGE; RNA DEGRADATION; RNA INTERFERENCE; RNA STRUCTURE; RNA VIRUS; SIGNAL TRANSDUCTION; VIRUS ACTIVATION; VIRUS CELL INTERACTION; VIRUS INHIBITION; VIRUS LATENCY; VIRUS REPLICATION;

HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNE EVASION; RNA INTERFERENCE; VIRUS REPLICATION;

EID: 80755150057     PISSN: 11396121     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (130)

1. Fire A, Albertson D, Harrison S, Moerman D. Production of antisense RNA leads to effective and specific inhibition of gene expression in C. elegans muscle. Development. 1991;113:503-14.
2. Lee R, Feinbaum R, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75:843-54. (Pubitemid 24014542)
3. Wightman B, Ha I, Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell. 1993;75:855-62. (Pubitemid 24014543)
4. Guo S, Kemphues K. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell. 1995;81:611-20.
5. Fire A, Xu S, Montgomery M, Kostas S, Driver S, Mello C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391:806-11. (Pubitemid 28099681)
6. Lewis B, Burge C, Bartel D. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120:15-20. (Pubitemid 40094598)
7. Klattenhoff C, Theurkauf W. Biogenesis and germline functions of piRNAs. Development. 2008;135:3-9. (Pubitemid 351201476)
8. Li H, Li W, Ding S. Induction and suppression of RNA silencing by an animal virus. Science. 2002;296:1319-21. (Pubitemid 34522787)
9. Voinnet O. Induction and suppression of RNA silencing: insights from viral infections. Nat Rev Genet. 2005;6:206-20. (Pubitemid 40293031)
10. Lecellier C, Dunoyer P, Arar K, et al. A cellular microRNA mediates antiviral defense in human cells. Science. 2005;308:557-60. (Pubitemid 40570587)
11. Bennasser Y, Le S, Benkirane M, Jeang K. Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing. Immunity. 2005;22:607-19. (Pubitemid 40719196)
12. Gatignol A, Lainé S, Clerzius G. Dual role of TRBP in HIV replication and RNA interference: viral diversion of a cellular pathway or evasion from antiviral immunity? Retrovirology. 2005;2:65.
13. Ding S. RNA-based antiviral immunity. Nat Rev Immunol. 2010;10: 632-44.
14. Dunoyer P, Schott G, Himber C, et al. Small RNA duplexes function as mobile silencing signals between plant cells. Science. 2010;328:912-6.
15. Molnar A, Melnyk C, Bassett A, Hardcastle T, Dunn R, Baulcombe D. Small silencing RNAs in plants are mobile and direct epigenetic modification in recipient cells. Science. 2010;328:872-5.
16. Umbach J, Cullen B. The role of RNAi and microRNAs in animal virus replication and antiviral immunity. Genes Dev. 2009;23:1151-64.
17. Emery J, Floyd S, Alvarez J, et al. Radial patterning of Arabidopsis shoots by class III HD-ZIP and KANADI genes. Curr Biol. 2003;13: 1768-74. (Pubitemid 37269117)
18. Bao N, Lye K, Barton M. MicroRNA binding sites in Arabidopsis class III HD-ZIP mRNAs are required for methylation of the template chromosome. Dev Cell. 2004;7:653-62. (Pubitemid 39462686)
19. Lohmann J, Weigel D. Building beauty: the genetic control of floral patterning. Dev Cell. 2002;2:135-42. (Pubitemid 38351578)
20. Zhang B, Pan X, Wang Q, Cobb G, Anderson T. Identification and characterization of new plant microRNAs using EST analysis. Cell Res. 2005;15:336-60. (Pubitemid 41653929)
21. Provost P, Barat C, Plante I, Tremblay M. HIV-l and the microRNA-guided silencing pathway: an intricate and multifaceted encounter. Virus Res. 2006;121:107-15. (Pubitemid 44444849)
22. Zhang B, Wang Q, Pan X. MicroRNAs and their regulatory roles in animals and plants. J Cell Physiol. 2007;210:279-89. (Pubitemid 44956872)
23. Houbaviy H, Murray M, Sharp P. Embryonic stem cell-specific MicroRNAs. Dev Cell. 2003;5:351-8. (Pubitemid 37006477)
24. Guo H, Xie Q, Fei J, Chua N. MicroRNA directs mRNA cleavage of the transcription factor NAC1 to downregulate auxin signals for arabidopsis lateral root development. Plant Cell. 2005;17:1376-86. (Pubitemid 43138191)
25. Krichevsky A, King K, Donahue C, Khrapko K, Kosik K. A microRNA array reveals extensive regulation of microRNAs during brain development. RNA. 2003;9:1274-81. (Pubitemid 37151681)
26. Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T. Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002;12:735-9. (Pubitemid 34455427)
27. Kloosterman W, Wienholds E, Ketting R, Plasterk R. Substrate requirements for let-7 function in the developing zebrafish embryo. Nucleic Acids Res. 2004;32:6284-91. (Pubitemid 40202087)
28. Landgraf P, Rusu M, Sheridan R, et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell. 2007;129: 1401-14. (Pubitemid 46970709)
29. Haase A, Jaskiewicz L, Zhang H, et al. TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Rep. 2005;6:961-7. (Pubitemid 41521952)
30. Kok K, Ng M, Ching Y, Jin D. Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA. J Biol Chem. 2007;282:17649-57. (Pubitemid 47100277)
31. Chendrimada T, Gregory R, Kumaraswamy E, et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature. 2005;436:740-4. (Pubitemid 41117280)
32. Lee Y, Hur I, Park S, Kim Y, Suh M, Kim V. The role of PACT in the RNA silencing pathway. EMBO J. 2006;25:522-32. (Pubitemid 43237659)
33. Lai E. Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Nat Genet. 2002;30: 363-4.
34. Forman J, Legesse-Miller A, Coller H. A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence. Proc Natl Acad Sci USA. 2008;105: 14879-84.
35. Tay Y, Zhang J, Thomson A, Lim B, Rigoutsos I. MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature. 2008;455:1124-8.
36. Liu J, Rivas F, Wohlschlegel J, Yates J, Parker R, Hannon G. A role for the P-body component GW182 in microRNA function. Nat Cell Biol. 2005;7:1261-6.
37. Eulalio A, Behm-Ansmant I, Schweizer D, Izaurralde E. P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Mol Cell Biol. 2007;27:3970-81. (Pubitemid 47010995)
38. Zeng Y, Yi R, Cullen B. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc Natl Acad Sci USA. 2003;100:9779-84. (Pubitemid 37087018)
39. Lim L, Lau N, Garrett-Engele P, et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 2005;433:769-73. (Pubitemid 40292988)
40. Coley W, Van Duyne R, Carpio L, et al. Absence of DICER in monocytes and its regulation by HIV-1. J Biol Chem. 2010;285:31930-43.
41. Kim V, Han J, Siomi M. Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol. 2009;10:126-39.
42. Vagin V, Sigova A, Li C, Seitz H, Gvozdev V, Zamore P. A distinct small RNA pathway silences selfish genetic elements in the germline. Science. 2006;313:320-4. (Pubitemid 44480950)
43. Grimson A, Farh K, Johnston W, Garrett-Engele P, Lim L, Bartel D. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell. 2007;27:91-105. (Pubitemid 46991392)
44. Sharma A, Nelson M, Brandt J, et al. Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi. Blood. 2001;97:426-34. (Pubitemid 32060327)
45. Sugimoto K, Kage H, Aki N, et al. The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus. Biochem Biophys Res Commun. 2007;359:497-502. (Pubitemid 46898979)
46. Aravin A, Hannon G. Small RNA silencing pathways in germ and stem cells. Cold Spring Harb Symp Quant Biol. 2008;73:283-90.
47. Yeung M, Bennasser Y, Watashi K, Le S, Houzet L, Jeang K. Pyrosequencing of small non-coding RNAs in HIV-1 infected cells: evidence for the processing of a viral-cellular double-stranded RNA hybrid. Nucleic Acids Res. 2009;37:6575-86.
48. Berezikov E, Chung W, Willis J, Cuppen E, Lai E. Mammalian mirtron genes. Mol Cell. 2007;28:328-36. (Pubitemid 47600007)
49. Ruby J, Jan C, Bartel D. Intronic microRNA precursors that bypass Drosha processing. Nature. 2007;448:83-6. (Pubitemid 47037009)
50. Coiras M, López-Huertas M, Sánchez del Cojo M, Mateos E, Alcamí J. Dual role of host cell factors in HIV-1 replication: restriction and enhancement of the viral cycle. AIDS Rev. 2010;12:103-12.
51. Yeung M, Bennasser Y, LE S, Jeang K. siRNA, miRNA and HIV: promises and challenges. Cell Res. 2005;15:935-46. (Pubitemid 41826263)
52. Yeung M, Bennasser Y, Myers T, Jiang G, Benkirane M, Jeang K. Changes in microRNA expression profiles in HIV-1-transfected human cells. Retrovirology. 2005;2:81.
53. Bennasser Y, Le S, Yeung M, Jeang K. HIV-1 encoded candidate micro- RNAs and heir cellular targets. Retrovirology. 2004;1:43.
54. Triboulet R, Mari B, Lin Y, et al. Suppression of microRNA-silencing pathway by HIV-1 during virus replication. Science. 2007;315:1579-82. (Pubitemid 46449475)
55. Chable-Bessia C, Meziane O, Latreille D, et al. Suppression of HIV-1 replication by microRNA effectors. Retrovirology. 2009;6:26.
56. Burdick R, Smith J, Chaipan C, et al. P body-associated protein Mov10 inhibits HIV-1 replication at multiple stages. J Virol. 2010;84:10241-53.
57. Nathans R, Chu C, Serquina A, Lu C, Cao H, Rana T. Cellular microRNA and P bodies modulate host-HIV-1 interactions. Mol Cell. 2009;34:696-709.
58. Gatignol A, Buckler-White A, Berkhout B, Jeang K. Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR. Science. 1991;251:1597-1600. (Pubitemid 21916930)
59. Christensen H, Daher A, Soye K, et al. Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production. J Virol. 2007;81:5121-31. (Pubitemid 46744423)
60. Daher A, Longuet M, Dorin D, et al. Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression. J Biol Chem. 2001;276:33899-905.
61. Ong C, Thorpe J, Gorry P, et al. Low TRBP levels support an innate human immunodeficiency virus type 1 resistance in astrocytes by enhancing the PKR antiviral response. J Virol. 2005;79:12763-72. (Pubitemid 41433196)
62. Dorr A, Kiermer V, Pedal A, et al. Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J. 2002;21:2715-23. (Pubitemid 34619387)
63. Coiras M, López-Huertas M, Pérez-Olmeda M, Alcamí J. Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs. Nat Rev Microbiol. 2009;7:798-812.
64. Huang J, Wang F, Argyris E, et al. Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes. Nat Med. 2007;13:1241-7. (Pubitemid 47530631)
65. Colin L, Van Lint C. Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies. Retrovirology. 2009;6:111.
66. Coiras M, Lopez-Huertas M, Alcami J. HIV-1 latency and eradication of long-term viral reservoirs. Discov Med. 2010;9:185-91.
67. Sung T, Rice A. miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1. PLoS Pathog. 2009;5:e1000263.
68. Wei P, Garber M, Fang S, Fischer W, Jones K. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell. 1998;92:451-62. (Pubitemid 28101109)
69. Isel C, Karn J. Direct evidence that HIV-1 Tat stimulates RNA polymerase II carboxyl-terminal domain hyperphosphorylation during transcriptional elongation. J Mol Biol. 1999;290:929-41. (Pubitemid 29371730)
70. Doehle B, Schäfer A, Cullen B. Human APOBEC3B is a potent inhibitor of HIV-1 infectivity and is resistant to HIV-1 Vif. Virology. 2005;339:281-8. (Pubitemid 41169795)
71. Jopling C. Regulation of hepatitis C virus by microRNA-122. Biochem Soc Trans. 2008;36:1220-3.
72. Lakatos L, Szittya G, Silhavy D, Burgyán J. Molecular mechanism of RNA silencing suppression mediated by p19 protein of tombusviruses. EMBO J. 2004;23:876-84. (Pubitemid 38418754)
73. Wang X, Aliyari R, Li W, et al. RNA interference directs innate immunity against viruses in adult Drosophila. Science. 2006;312:452-4.
74. Haas G, Azevedo J, Moissiard G, et al. Nuclear import of CaMV P6 is required for infection and suppression of the RNA silencing factor DRB4. EMBO J. 2008;27:2102-12.
75. Martín-Hernández A, Baulcombe D. Tobacco rattle virus 16-kilodalton protein encodes a suppressor of RNA silencing that allows transient viral entry in meristems. J Virol. 2008;82:4064-71. (Pubitemid 351521241)
76. Singh G, Popli S, Hari Y, Malhotra P, Mukherjee S, Bhatnagar R. Suppression of RNA silencing by Flock house virus B2 protein is mediated through its interaction with the PAZ domain of Dicer. FASEB J. 2009;23:1845-57.
77. Bucher E, Hemmes H, de Haan P, Goldbach R, Prins M. The influenza A virus NS1 protein binds small interfering RNAs and suppresses RNA silencing in plants. J Gen Virol. 2004;85:983-91. (Pubitemid 38489563)
78. Li W, Li H, Lu R, et al. Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing. Proc Natl Acad Sci USA. 2004;101:1350-5. (Pubitemid 38182692)
79. Haasnoot J, de Vries W, Geutjes E, Prins M, de Haan P, Berkhout B. The Ebola virus VP35 protein is a suppressor of RNA silencing. PLoS Pathog. 2007;3:e86.
80. Bennasser Y, Jeang K. HIV-1 Tat interaction with Dicer: requirement for RNA. Retrovirology. 2006;3:95.
81. Qian S, Zhong X, Yu L, Ding B, de Haan P, Boris-Lawrie K. HIV-1 Tat RNA silencing suppressor activity is conserved across kingdoms and counteracts translational repression of HIV-1. Proc Natl Acad Sci USA. 2009;106:605-10.
82. Lin J, Cullen B. Analysis of the interaction of primate retroviruses with the human RNA interference machinery. J Virol. 2007;81:12218-26. (Pubitemid 350085837)
83. Abe M, Suzuki H, Nishitsuji H, Shida H, Takaku H. Interaction of human T-cell lymphotropic virus type I Rex protein with Dicer suppresses RNAi silencing. FEBS Lett. 2010;584:4313-8.
84. Yan K, Yan S, Farooq A, Han A, Zeng L, Zhou M. Structure and conserved RNA binding of the PAZ domain. Nature. 2003;426:468-74.
85. Pfeffer S, Sewer A, Lagos-Quintana M, et al. Identification of microRNAs of the herpesvirus family. Nat Methods. 2005;2:269-76. (Pubitemid 41131008)
86. Klase Z, Kale P, Winograd R, et al. HIV-1 TAR element is processed by Dicer to yield a viral micro-RNA involved in chromatin remodeling of the viral LTR. BMC Mol Biol. 2007;8:63.
87. Klase Z, Winograd R, Davis J, et al. HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expression. Retrovirology. 2009; 6:18.
88. Lau N. Analysis of small endogenous RNAs. Curr Protoc Mol Biol. 2008;Chapter 26:Unit26.7.
89. Yamamoto T, Omoto S, Mizuguchi M, et al. Double-stranded nef RNA interferes with human immunodeficiency virus type 1 replication. Microbiol Immunol. 2002;46:809-17. (Pubitemid 35428959)
90. Kirchhoff F. Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses. Cell Host Microbe. 2010;8:55-67
91. Omoto S, Ito M, Tsutsumi Y, et al. HIV-1 nef suppression by virally encoded microRNA. Retrovirology. 2004;1:44.
92. Omoto S, Fujii Y. Regulation of human immunodeficiency virus 1 transcription by nef microRNA. J Gen Virol. 2005;86:751-5. (Pubitemid 40331255)
93. Ahluwalia J, Khan S, Soni K, et al. Human cellular microRNA hsa-miR- 29a interferes with viral nef protein expression and HIV-1 replication. Retrovirology. 2008;5:117.
94. Kaul D, Ahlawat A, Gupta S. HIV-1 genome-encoded hiv1-mir-H1 impairs cellular responses to infection. Mol Cell Biochem. 2009;323:143-8.
95. Muthumani K, Choo A, Zong W, et al. The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1. Nat Cell Biol. 2006;8:170-9.
96. Gunnery S, Rice A, Robertson H, Mathews M. Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA activated protein kinase. Proc Natl Acad Sci USA. 1990;87:8687-91. (Pubitemid 120007573)
97. Wu Q, Luo Y, Lu R, et al. Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAs. Proc Natl Acad Sci USA. 2010;107:1606-11.
98. Houzet L, Yeung ML, de Lame V, Desai D, Smith S, Jeang K. MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) sero-positive individuals. Retrovirology. 2008;5:118.
99. Jacque J, Triques K, Stevenson M. Modulation of HIV-1 replication by RNA interference. Nature. 2002;418:435-8. (Pubitemid 34826845)
100. Subramanya S, Kim S, Manjunath N, Shankar P. RNA interference-based therapeutics for human immunodeficiency virus HIV-1 treatment: synthetic siRNA or vector-based shRNA? Expert Opin Biol Ther. 2010; 10:201-13.
101. Boden D, Pusch O, Silbermann R, Lee F, Tucker L, Ramratnam B. Enhanced gene silencing of HIV-1 specific siRNA using microRNA designed hairpins. Nucleic Acids Res. 2004;32:1154-8. (Pubitemid 38854717)
102. Aagaard L, Zhang J, von Eije K, et al. Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs. Gene Ther. 2008;15:1536-49.
103. Unwalla H, Rossi J. A dual function TAR Decoy serves as an anti-HIV siRNA delivery vehicle. Virol J. 2010;7:33.
104. Ehsani A, Saetrom P, Zhang J, et al. Rational design of micro-RNA-like bifunctional siRNAs targeting HIV and the HIV coreceptor CCR5. Mol Ther. 2010;18:796-802.
105. Zhang H. Reversal of HIV-1 latency with anti-microRNA inhibitors. Int J Biochem Cell Biol. 2009;41:451-4.
106. von Eije K, Berkhout B. RNA-interference-based gene therapy approaches to HIV type-1 treatment: tackling the hurdles from bench to bedside. Antivir Chem Chemother. 2009;19:221-33.
107. Liu Y, Berkhout B. Lentiviral delivery of RNAi effectors against HIV-1. Curr Top Med Chem. 2009;9:1130-43.
108. Kumar P, Ban H, Kim S, et al. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell. 2008;134:577-86.
109. Kim S, Peer D, Kumar P, et al. RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice. Mol Ther. 2010;18:370-6.
110. Naldini L, Blömer U, Gallay P, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science. 1996;272:263-7. (Pubitemid 26119138)
111. Qin X, An D, Chen I, Baltimore D. Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci USA. 2003;100:183-8. (Pubitemid 36078049)
112. Grimm D, Streetz K, Jopling C, et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature. 2006; 441:537-41. (Pubitemid 44050158)
113. Shimizu S, Kamata M, Kittipongdaja P, et al. Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5. Genet Vaccines Ther. 2009;7:8.
114. Lo H, Chang T, Yam P, et al. Inhibition of HIV-1 replication with designed miRNAs expressed from RNA polymerase II promoters. Gene Ther. 2007;14:1503-12. (Pubitemid 47570709)
115. Buchschacher G, Panganiban A. Human immunodeficiency virus vectors for inducible expression of foreign genes. J Virol. 1992;66:2731-9.
116. Fraisier C, Irvine A, Wrighton C, Craig R, Dzierzak E. High level inhibition of HIV replication with combination RNA decoys expressed from an HIV-Tat inducible vector. Gene Ther. 1998;5:1665-76. (Pubitemid 29008337)
117. Humeau L, Binder G, Lu X, et al. Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load. Mol Ther. 2004;9:902-13. (Pubitemid 38878136)
118. Levine B, Humeau L, Boyer J, et al. Gene transfer in humans using a conditionally replicating lentiviral vector. Proc Natl Acad Sci USA. 2006;103:17372-7. (Pubitemid 44788976)
119. Unwalla H, Li H, Bahner I, Li M, Kohn D, Rossi J. Novel Pol II fusion promoter directs human immunodeficiency virus type 1-inducible coexpression of a short hairpin RNA and protein. J Virol. 2006;80: 1863-73. (Pubitemid 43228726)
120. Park J, Nadeau P, Mergia A. Activity of TAR in inducible inhibition of HIV replication by foamy virus vector expressing siRNAs under the control of HIV LTR. Virus Res. 2009;140:112-20.
121. Manilla P, Rebello T, Afable C, et al. Regulatory considerations for novel gene therapy products: a review of the process leading to the first clinical lentiviral vector. Hum Gene Ther. 2005;16:17-25. (Pubitemid 40250328)
122. Sanghvi V, Steel L. Expression of interfering RNAs from an HIV-1 Tatinducible chimeric promoter. Virus Res. 2011;155:106-11.
123. Hahn B, Shaw G, Taylor M, et al. Genetic variation in HTLV-III/LAV over time in patients with AIDS or at risk for AIDS. Science. 1986;232: 1548-53. (Pubitemid 16061564)
124. Westerhout E, Ooms M, Vink M, Das A, Berkhout B. HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome. Nucleic Acids Res. 2005;33:796-804.
125. ter Brake O, Konstantinova P, Ceylan M, Berkhout B. Silencing of HIV-1 with RNA interference: a multiple shRNA approach. Mol Ther. 2006;14:883-92.
126. Liu Y, von Eije K, Schopman N, et al. Combinatorial RNAi against HIV-1 using extended short hairpin RNAs. Mol Ther. 2009;17:1712-23.
127. Liu Y, Gruber J, Haasnoot J, Konstantinova P, Berkhout B. RNAi-mediated inhibition of HIV-1 by targeting partially complementary viral sequences. Nucleic Acids Res. 2009;37:6194-204.
128. Scherer L, Rossi J, Weinberg M. Progress and prospects: RNA-based therapies for treatment of HIV infection. Gene Ther. 2007;14:1057-64. (Pubitemid 47029489)
129. Zhou J, Shu Y, Guo P, Smith D, Rossi J. Dual functional RNA nanoparticles containing phi29 motor pRNA and anti-gp120 aptamer for cell-type specific delivery and HIV-1 Inhibition. Methods. 2011 Jan 20.
130. Castanotto D, Li H, Rossi J. Functional siRNA expression from transfected PCR products. RNA. 2002;8:1454-60. (Pubitemid 35332968)