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Volumn 11, Issue 12, 2011, Pages 1677-1685

Novel strategy for the use of leptin for obesity therapy

Author keywords

amylin; leptin; metreleptin; obesity; pramlitide

Indexed keywords

AMYLIN; LEPTIN; METRELEPTIN; PLACEBO; PRAMLINTIDE; RECOMBINANT LEPTIN; SIBUTRAMINE; TETRAHYDROLIPSTATIN;

EID: 80555135931     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2011.619974     Document Type: Article
Times cited : (43)

References (70)
  • 1
    • 34249821944 scopus 로고    scopus 로고
    • Pharmacological treatment of the overweight patient
    • Bray GA, Greenway FL. Pharmacological treatment of the overweight patient. Pharmacol Rev 2007;59:151-84
    • (2007) Pharmacol. Rev. , vol.59 , pp. 151-184
    • Bray, G.A.1    Greenway, F.L.2
  • 2
    • 77953652112 scopus 로고    scopus 로고
    • Combination drugs for treating obesity
    • Greenway FL, Bray GA. Combination drugs for treating obesity. Curr Diab Rep 2010;10:108-15
    • (2011) Curr. Diab. Rep. , vol.10 , pp. 108-115
    • Greenway, F.L.1    Bray, G.A.2
  • 3
    • 73949153085 scopus 로고    scopus 로고
    • The medical risks of obesity
    • Pi-Sunyer X. The medical risks of obesity. Postgrad Med 2009;121:21-33
    • (2009) Postgrad. Med. , vol.121 , pp. 21-33
    • Pi-Sunyer, X.1
  • 4
    • 0026593859 scopus 로고
    • Long-term weight control study: Conclusions
    • Weintraub M. Long-term weight control study: conclusions. Clin Pharmacol Ther 1992;51:642-6
    • (1992) Clin. Pharmacol. Ther. , vol.51 , pp. 642-646
    • Weintraub, M.1
  • 5
    • 0030898516 scopus 로고    scopus 로고
    • Direct antidiabetic effect of leptin through triglyceride depletion of tissues
    • USA
    • Shimabukuro M, Koyama K, Chen G, et al. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 1997;94:4637-41
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 4637-4641
    • Shimabukuro, M.1    Koyama, K.2    Chen, G.3
  • 6
    • 0032934279 scopus 로고    scopus 로고
    • Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver
    • Nemecz M, Preininger K, Englisch R, et al. Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver. Hepatology 1999;29:166-72
    • (1999) Hepatology , vol.29 , pp. 166-172
    • Nemecz, M.1    Preininger, K.2    Englisch, R.3
  • 7
    • 0037329602 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle
    • Minokoshi Y, Kahn BB. Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle. Biochem Soc Trans 2003;31:196-201
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 196-201
    • Minokoshi, Y.1    Kahn, B.B.2
  • 8
    • 33750355471 scopus 로고    scopus 로고
    • Amylinergic control of food intake
    • Lutz TA. Amylinergic control of food intake. Physiol Behav 2006;89:465-71
    • (2006) Physiol. Behav. , vol.89 , pp. 465-471
    • Lutz, T.A.1
  • 9
    • 44449175729 scopus 로고    scopus 로고
    • Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies
    • USA
    • Roth JD, Roland BL, Cole RL, et al. Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies. Proc Natl Acad Sci USA 2008;105:7257-62
    • (2008) Proc. Natl. Acad. Sci. , vol.105 , pp. 7257-7262
    • Roth, J.D.1    Roland, B.L.2    Cole, R.L.3
  • 10
    • 54349121294 scopus 로고    scopus 로고
    • Amylin-mediated restoration of leptin responsiveness in diet-induced obesity: Magnitude and mechanisms
    • Trevaskis JL, Coffey T, Cole R, et al. Amylin-mediated restoration of leptin responsiveness in diet-induced obesity: magnitude and mechanisms. Endocrinology 2008;149:5679-87
    • (2008) Endocrinology , vol.149 , pp. 5679-5687
    • Trevaskis, J.L.1    Coffey, T.2    Cole, R.3
  • 12
    • 0034015292 scopus 로고    scopus 로고
    • High-frequency oscillations in circulating amylin concentrations in healthy humans
    • Juhl CB, Porksen N, Sturis J, et al. High-frequency oscillations in circulating amylin concentrations in healthy humans. Am J Physiol Endocrinol Metab 2000;278:E484-90
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.278
    • Juhl, C.B.1    Porksen, N.2    Sturis, J.3
  • 13
    • 85079954544 scopus 로고    scopus 로고
    • Available from Accessed 9 August
    • Available from: http://online. factsandcomparisons.com [Accessed 9 August 2011]
    • (2011)
  • 14
    • 79956109928 scopus 로고    scopus 로고
    • Pramlintide and the treatment of diabetes: A review of the data since its introduction
    • Younk LM, Mikeladze M, Davis SN. Pramlintide and the treatment of diabetes: a review of the data since its introduction. Expert Opin Pharmacother 2011;12:1439-51
    • (2011) Expert Opin. Pharmacother. , vol.12 , pp. 1439-1451
    • Younk, L.M.1    Mikeladze, M.2    Davis, S.N.3
  • 15
    • 0034850444 scopus 로고    scopus 로고
    • Amylin replacement with pramlintide as an adjunct to insulin therapy in type 1 and type 2 diabetes mellitus: A physiological approach toward improved metabolic control
    • Weyer C, Maggs DG, Young AA, Kolterman OG. Amylin replacement with pramlintide as an adjunct to insulin therapy in type 1 and type 2 diabetes mellitus: a physiological approach toward improved metabolic control. Curr Pharm Des 2001;7:1353-73
    • (2001) Curr. Pharm. Des. , vol.7 , pp. 1353-1373
    • Weyer, C.1    Maggs, D.G.2    Young, A.A.3    Kolterman, O.G.4
  • 16
    • 0030878110 scopus 로고    scopus 로고
    • Congenital leptin deficiency is associated with severe early-onset obesity in humans
    • Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997;387:903-8
    • (1997) Nature , vol.387 , pp. 903-908
    • Montague, C.T.1    Farooqi, I.S.2    Whitehead, J.P.3
  • 17
    • 0036800760 scopus 로고    scopus 로고
    • Beneficial effects of leptin on obesity T cell hyporesponsiveness and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    • Farooqi IS, Matarese G, Lord GM, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002;110:1093-103
    • (2002) J. Clin. Invest. , vol.110 , pp. 1093-1103
    • Farooqi, I.S.1    Matarese, G.2    Lord, G.M.3
  • 18
    • 0033575993 scopus 로고    scopus 로고
    • Effects of recombinant leptin therapy in a child with congenital leptin deficiency
    • Farooqi IS, Jebb SA, Langmack G, et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999;341:879-84
    • (1999) N. Engl. J. Med. , vol.341 , pp. 879-884
    • Farooqi, I.S.1    Jebb, S.A.2    Langmack, G.3
  • 19
    • 76149128662 scopus 로고    scopus 로고
    • Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients
    • Galgani JE, Greenway FL, Caglayan S, et al. Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients. J Clin Endocrinol Metab 2010;95:851-5
    • (2011) J. Clin. Endocrinol. Metab. , vol.95 , pp. 851-855
    • Galgani, J.E.1    Greenway, F.L.2    Caglayan, S.3
  • 20
    • 0037148928 scopus 로고    scopus 로고
    • Leptin-replacement therapy for lipodystrophy
    • Oral EA, Simha V, Ruiz E, et al. Leptin-replacement therapy for lipodystrophy. N Engl J Med 2002;346:570-8
    • (2002) N. Engl. J. Med. , vol.346 , pp. 570-578
    • Oral, E.A.1    Simha, V.2    Ruiz, E.3
  • 21
    • 16244363679 scopus 로고    scopus 로고
    • Leptin reverses non-alcoholic steatohepatitis in patients with severe lipodystrophy
    • Javor ED, Ghany MG, Cochran EK, et al. Leptin reverses non-alcoholic steatohepatitis in patients with severe lipodystrophy. Hepatology 2005;41:753-60
    • (2005) Hepatology , vol.41 , pp. 753-760
    • Javor, E.D.1    Ghany, M.G.2    Cochran, E.K.3
  • 22
    • 4344690525 scopus 로고    scopus 로고
    • Recombinant human leptin in women with hypothalamic amenorrhea
    • Welt CK, Chan JL, Bullen J, et al. Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med 2004;351:987-97
    • (2004) N. Engl. J. Med. , vol.351 , pp. 987-997
    • Welt, C.K.1    Chan, J.L.2    Bullen, J.3
  • 23
    • 79955620729 scopus 로고    scopus 로고
    • Leptin is an effective treatment for hypothalamic amenorrhea
    • USA
    • Chou SH, Chamberland JP, Liu X, et al. Leptin is an effective treatment for hypothalamic amenorrhea. Proc Natl Acad Sci USA 2011;108:6585-90
    • (2011) Proc. Natl. Acad. Sci. , vol.108 , pp. 6585-6590
    • Chou, S.H.1    Chamberland, J.P.2    Liu, X.3
  • 24
    • 0031766810 scopus 로고    scopus 로고
    • Leptin in relation to resumption of menses in women with anorexia nervosa
    • Audi L, Mantzoros CS, Vidal-Puig A, et al. Leptin in relation to resumption of menses in women with anorexia nervosa. Mol Psychiatry 1998;3:544-7
    • (1998) Mol. Psychiatry , vol.3 , pp. 544-547
    • Audi, L.1    Mantzoros, C.S.2    Vidal-Puig, A.3
  • 25
    • 0031759898 scopus 로고    scopus 로고
    • Decreased leptin levels in normal weight women with hypothalamic amenorrhea: The effects of body composition and nutritional intake
    • Miller KK, Parulekar MS, Schoenfeld E, et al. Decreased leptin levels in normal weight women with hypothalamic amenorrhea: the effects of body composition and nutritional intake. J Clin Endocrinol Metab 1998;83:2309-12
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 2309-2312
    • Miller, K.K.1    Parulekar, M.S.2    Schoenfeld, E.3
  • 26
    • 0032747280 scopus 로고    scopus 로고
    • Recombinant leptin for weight loss in obese and lean adults: A randomized controlled dose-escalation trial
    • Heymsfield SB, Greenberg AS, Fujioka K, et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 1999;282:1568-75
    • (1999) JAMA , vol.282 , pp. 1568-1575
    • Heymsfield, S.B.1    Greenberg, A.S.2    Fujioka, K.3
  • 27
    • 0028959193 scopus 로고
    • Changes in energy expenditure resulting from altered body weight
    • Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med 1995;332:621-8
    • (1995) N. Engl. J. Med. , vol.332 , pp. 621-628
    • Leibel, R.L.1    Rosenbaum, M.2    Hirsch, J.3
  • 28
    • 80052544134 scopus 로고    scopus 로고
    • The fall in leptin concentration is a major determinant of the metabolic adaptation induced by caloric restriction independently of the changes in leptin circadian rhythms
    • published online July 21 2011 10.1210/jc
    • Lecoultre V, Ravussin E, Redman LM. The fall in leptin concentration is a major determinant of the metabolic adaptation induced by caloric restriction independently of the changes in leptin circadian rhythms. J Clin Endocrinol Metab 2011;published online July 21, 2011; doi: 10.1210/jc.2011-1286
    • (2011) J. Clin. Endocrinol. Metab. , pp. 2011-1286
    • Lecoultre, V.1    Ravussin, E.2    Redman, L.M.3
  • 29
    • 0038342685 scopus 로고    scopus 로고
    • Greater than predicted decrease in energy expenditure during exercise after body weight loss in obese men
    • Doucet E, Imbeault P, St-Pierre S, et al. Greater than predicted decrease in energy expenditure during exercise after body weight loss in obese men. Clin Sci (Lond) 2003;105:89-95
    • (2003) Clin. Sci. Lond. , vol.105 , pp. 89-95
    • Doucet, E.1    Imbeault, P.2    St-Pierre, S.3
  • 30
    • 0034458463 scopus 로고    scopus 로고
    • Changes in energy expenditure and substrate oxidation resulting from weight loss in obese men and women: Is there an important contribution of leptin
    • Doucet E, St PS, Almeras N, et al. Changes in energy expenditure and substrate oxidation resulting from weight loss in obese men and women: is there an important contribution of leptin? J Clin Endocrinol Metab 2000;85:1550-6
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 1550-1556
    • Doucet, E.1    St, P.S.2    Almeras, N.3
  • 31
    • 3442892766 scopus 로고    scopus 로고
    • Thermogenesis and weight loss in obese individuals: A primary association with organochlorine pollution
    • Tremblay A, Pelletier C, Doucet E, Imbeault P. Thermogenesis and weight loss in obese individuals: a primary association with organochlorine pollution. Int J Obes Relat Metab Disord 2004;28:936-9
    • (2004) Int. J. Obes. Relat. Metab. Disord , vol.28 , pp. 936-939
    • Tremblay, A.1    Pelletier, C.2    Doucet, E.3    Imbeault, P.4
  • 32
    • 0036791464 scopus 로고    scopus 로고
    • The role of leptin in the control of body weight
    • Leibel RL. The role of leptin in the control of body weight. Nutr Rev 2002;60:S15-19
    • (2002) Nutr. Rev. , vol.60
    • Leibel, R.L.1
  • 33
    • 0029131574 scopus 로고
    • Expression of ob mRNA and its encoded protein in rodents impact of nutrition and obesity
    • Frederich RC, Lollmann B, Hamann A, et al. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest 1995;96:1658-63
    • (1995) J. Clin. Invest. , vol.96 , pp. 1658-1663
    • Frederich, R.C.1    Lollmann, B.2    Hamann, A.3
  • 34
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
    • Frederich RC, Hamann A, Anderson S, et al. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1995;1:1311-14
    • (1995) Nat. Med. , vol.1 , pp. 1311-1314
    • Frederich, R.C.1    Hamann, A.2    Anderson, S.3
  • 35
    • 0029896530 scopus 로고    scopus 로고
    • Role of leptin in the neuroendocrine response to fasting
    • Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996;382:250-2
    • (1996) Nature , vol.382 , pp. 250-252
    • Ahima, R.S.1    Prabakaran, D.2    Mantzoros, C.3
  • 36
    • 79958807282 scopus 로고    scopus 로고
    • Effects of chronic weight perturbation on energy homeostasis and brain structure in mice
    • Ravussin Y, Gutman R, Diano S, et al. Effects of chronic weight perturbation on energy homeostasis and brain structure in mice. Am J Physiol Regul Integr Comp Physiol 2011;300:R1352-62
    • (2011) Am. J. Physiol. Regul Integr. Comp. Physiol. , vol.300
    • Ravussin, Y.1    Gutman, R.2    Diano, S.3
  • 37
    • 0036093071 scopus 로고    scopus 로고
    • Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones
    • Rosenbaum M, Murphy EM, Heymsfield SB, et al. Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab 2002;87:2391-4
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 2391-2394
    • Rosenbaum, M.1    Murphy, E.M.2    Heymsfield, S.B.3
  • 38
    • 31044444463 scopus 로고    scopus 로고
    • Low-dose leptin reverses skeletal muscle autonomic and neuroendocrine adaptations to maintenance of reduced weight
    • Rosenbaum M, Goldsmith R, Bloomfield D, et al. Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest 2005;115:3579-86
    • (2005) J. Clin. Invest. , vol.115 , pp. 3579-35486
    • Rosenbaum, M.1    Goldsmith, R.2    Bloomfield, D.3
  • 39
    • 79960182100 scopus 로고    scopus 로고
    • Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet
    • Shetty GK, Matarese G, Magkos F, et al. Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet. Eur J Endocrinol 2011;165:249-54
    • (2011) Eur. J. Endocrinol. , vol.165 , pp. 249-254
    • Shetty, G.K.1    Matarese, G.2    Magkos, F.3
  • 40
    • 0347988175 scopus 로고    scopus 로고
    • Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset
    • Levin BE, Dunn-Meynell AA, Banks WA. Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset. Am J Physiol Regul Integr Comp Physiol 2004;286:R143-50
    • (2004) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.286
    • Levin, B.E.1    Dunn-Meynell, A.A.2    Banks, W.A.3
  • 41
    • 9244219587 scopus 로고    scopus 로고
    • Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    • Munzberg H, Flier JS, Bjorbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 2004;145:4880-9
    • (2004) Endocrinology , vol.145 , pp. 4880-4889
    • Munzberg, H.1    Flier, J.S.2    Bjorbaek, C.3
  • 43
    • 80052748828 scopus 로고    scopus 로고
    • Combined amylin-leptin treatment lowers blood pressure and adiposity in lean and obese rats
    • published online 21 December 2010 10.1038/ijo.2010.262
    • Seth R, Knight WD, Overton JM. Combined amylin-leptin treatment lowers blood pressure and adiposity in lean and obese rats. Int J Obes (Lond) 2010;published online 21 December 2010; doi:10.1038/ijo.2010.262
    • (2011) Int. J. Obes. Lond.
    • Seth, R.1    Knight, W.D.2    Overton, J.M.3
  • 44
    • 54349121294 scopus 로고    scopus 로고
    • Amylin-mediated restoration of leptin responsiveness in diet-induced obesity: magnitude and mechanisms
    • Trevaskis JL, Coffey T, Cole R, et al. Amylin-mediated restoration of leptin responsiveness in diet-induced obesity: magnitude and mechanisms. Endocrinology 2008;149:5679-87
    • (2008) Endocrinology , vol.149 , pp. 5679-5687
    • Trevaskis, J.L.1    Coffey, T.2    Cole, R.3
  • 45
    • 73949151936 scopus 로고    scopus 로고
    • Interaction of leptin and amylin in the long-term maintenance of weight loss in diet-induced obese rats
    • Trevaskis JL, Lei C, Koda JE, et al. Interaction of leptin and amylin in the long-term maintenance of weight loss in diet-induced obese rats. Obesity (Silver Spring) 2010;18:21-6
    • (2011) Obesity Silver Spring , vol.18 , pp. 21-26
    • Trevaskis, J.L.1    Lei, C.2    Koda, J.E.3
  • 46
    • 73649137524 scopus 로고    scopus 로고
    • Mechanisms of amylin/leptin synergy in rodent models
    • Turek VF, Trevaskis JL, Levin BE, et al. Mechanisms of amylin/leptin synergy in rodent models. Endocrinology 2010;151:143-52
    • (2011) Endocrinology , vol.151 , pp. 143-152
    • Turek, V.F.1    Trevaskis, J.L.2    Levin, B.E.3
  • 47
    • 79959409408 scopus 로고    scopus 로고
    • Efficacy of metreleptin in obese patients with type 2 diabetes: Cellular and molecular pathways underlying leptin tolerance
    • Moon HS, Matarese G, Brennan AM, et al. Efficacy of metreleptin in obese patients with type 2 diabetes: cellular and molecular pathways underlying leptin tolerance. Diabetes 2011;60:1647-56
    • (2011) Diabetes , vol.60 , pp. 1647-1656
    • Moon, H.S.1    Matarese, G.2    Brennan, A.M.3
  • 48
    • 69749086148 scopus 로고    scopus 로고
    • Enhanced weight loss with pramlintide/ metreleptin: An integrated neurohormonal approach to obesity pharmacotherapy
    • Ravussin E, Smith SR, Mitchell JA, et al. Enhanced weight loss with pramlintide/ metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy. Obesity (Silver Spring) 2009;17:1736-43
    • (2009) Obesity Silver Spring , vol.17 , pp. 1736-1743
    • Ravussin, E.1    Smith, S.R.2    Mitchell, J.A.3
  • 49
    • 0029883859 scopus 로고    scopus 로고
    • Effect of 14 days' subcutaneous administration of the human amylin analogue, pramlintide AC137 on an intravenous insulin challenge and response to a standard liquid meal in patients with IDDM
    • Kolterman OG, Schwartz S, Corder C, et al. Effect of 14 days' subcutaneous administration of the human amylin analogue, pramlintide (AC137), on an intravenous insulin challenge and response to a standard liquid meal in patients with IDDM. Diabetologia 1996;39:492-9
    • (1996) Diabetologia , vol.39 , pp. 492-499
    • Kolterman, O.G.1    Schwartz, S.2    Corder, C.3
  • 50
    • 0030067187 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of AC137 25 28 29 tripro-amylin, human after intravenous bolus and infusion doses in patients with insulin-dependent diabetes
    • Colburn WA, Gottlieb AB, Koda J, Kolterman OG. Pharmacokinetics and pharmacodynamics of AC137 (25,28,29 tripro-amylin, human) after intravenous bolus and infusion doses in patients with insulin-dependent diabetes. J Clin Pharmacol 1996;36:13-24
    • (1996) J. Clin. Pharmacol. , vol.36 , pp. 13-24
    • Colburn, W.A.1    Gottlieb, A.B.2    Koda, J.3    Kolterman, O.G.4
  • 51
    • 4544286790 scopus 로고    scopus 로고
    • Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficiency
    • McDuffie JR, Riggs PA, Calis KA, et al. Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficiency. J Clin Endocrinol Metab 2004;89:4258-63
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 4258-4263
    • McDuffie, J.R.1    Riggs, P.A.2    Calis, K.A.3
  • 52
    • 12144288571 scopus 로고    scopus 로고
    • Changes in body composition in patients with severe lipodystrophy after leptin replacement therapy
    • Moran SA, Patten N, Young JR, et al. Changes in body composition in patients with severe lipodystrophy after leptin replacement therapy. Metabolism 2004;53:513-19
    • (2004) Metabolism , vol.53 , pp. 513-519
    • Moran, S.A.1    Patten, N.2    Young, J.R.3
  • 53
    • 0036114844 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
    • Petersen KF, Oral EA, Dufour S, et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J Clin Invest 2002;109:1345-50
    • (2002) J. Clin. Invest. , vol.109 , pp. 1345-1350
    • Petersen, K.F.1    Oral, E.A.2    Dufour, S.3
  • 54
    • 0037015026 scopus 로고    scopus 로고
    • PPARalpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue
    • USA
    • Lee Y, Yu X, Gonzales F, et al. PPARalpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue. Proc Natl Acad Sci USA 2002;99:11848-53
    • (2002) Proc. Natl. Acad. Sci. , vol.99 , pp. 11848-53
    • Lee, Y.1    Yu, X.2    Gonzales, F.3
  • 55
    • 1242274390 scopus 로고    scopus 로고
    • Rapid transformation of white adipocytes into fat-oxidizing machines
    • USA
    • Orci L, Cook WS, Ravazzola M, et al. Rapid transformation of white adipocytes into fat-oxidizing machines. Proc Natl Acad Sci USA 2004;101:2058-63
    • (2004) Proc. Natl. Acad. Sci. , vol.101 , pp. 2058-2063
    • Orci, L.1    Cook, W.S.2    Ravazzola, M.3
  • 56
    • 0034714051 scopus 로고    scopus 로고
    • Leptin physiology: A second look
    • Unger RH. Leptin physiology: a second look. Regul Pept 2000;92:87-95
    • (2000) Regul. Pept. , vol.92 , pp. 87-95
    • Unger, R.H.1
  • 57
    • 0345374579 scopus 로고    scopus 로고
    • Minireview: Weapons of lean body mass destruction: The role of ectopic lipids in the metabolic syndrome
    • Unger RH. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 2003;144:5159-65
    • (2003) Endocrinology , vol.144 , pp. 5159-5165
    • Unger, R.H.1
  • 58
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • Minokoshi Y, Kim YB, Peroni OD, et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002;415:339-43
    • (2002) Nature , vol.415 , pp. 339-343
    • Minokoshi, Y.1    Kim, Y.B.2    Peroni, O.D.3
  • 59
    • 21344447493 scopus 로고    scopus 로고
    • Long-term efficacy of leptin replacement in patients with generalized lipodystrophy
    • Javor ED, Cochran EK, Musso C, et al. Long-term efficacy of leptin replacement in patients with generalized lipodystrophy. Diabetes 2005;54:1994-2002
    • (2005) Diabetes , vol.54 , pp. 1994-2002
    • Javor, E.D.1    Cochran, E.K.2    Musso, C.3
  • 60
    • 33947283865 scopus 로고    scopus 로고
    • Long-term efficacy of leptin replacement in patients with Dunnigan-type familial partial lipodystrophy
    • Park JY, Javor ED, Cochran EK, et al. Long-term efficacy of leptin replacement in patients with Dunnigan-type familial partial lipodystrophy. Metabolism 2007;56:508-16
    • (2007) Metabolism , vol.56 , pp. 508-516
    • Park, J.Y.1    Javor, E.D.2    Cochran, E.K.3
  • 61
    • 77953939677 scopus 로고    scopus 로고
    • Clinical classification and treatment of congenital and acquired lipodystrophy
    • Chan JL, Oral EA. Clinical classification and treatment of congenital and acquired lipodystrophy. Endocr Pract 2010;16:310-23
    • (2011) Endocr. Pract. , vol.16 , pp. 310-323
    • Chan, J.L.1    Oral, E.A.2
  • 63
    • 53549113349 scopus 로고    scopus 로고
    • Pharmacokinetics of subcutaneous recombinant methionyl human leptin administration in healthy subjects in the fed and fasting states: Regulation by gender and adiposity
    • Chan JL, Wong SL, Mantzoros CS. Pharmacokinetics of subcutaneous recombinant methionyl human leptin administration in healthy subjects in the fed and fasting states: regulation by gender and adiposity. Clin Pharmacokinet 2008;47:753-64
    • (2008) Clin. Pharmacokinet , vol.47 , pp. 753-764
    • Chan, J.L.1    Wong, S.L.2    Mantzoros, C.S.3
  • 64
    • 85080022739 scopus 로고    scopus 로고
    • San Diego CA: Amylin Pharmaceuticals Inc. Available from: Last accessed 24 August 2011
    • SYMLINA (pramlintide acetate injection. San Diego, CA: Amylin Pharmaceuticals, Inc., 2010. Available from: http://documents/symlin.com/ SYMLIN-PI.pdf [Last accessed 24 August 2011]
    • (2011) SYMLINA Pramlintide Acetate Injection
  • 65
    • 0036548068 scopus 로고    scopus 로고
    • A randomized study and open-label extension evaluating the long-term efficacy of pramlintide as an adjunct to insulin therapy in type 1 diabetes
    • Whitehouse F, Kruger DF, Fineman M, et al. A randomized study and open-label extension evaluating the long-term efficacy of pramlintide as an adjunct to insulin therapy in type 1 diabetes. Diabetes Care 2002;25:724-30
    • (2002) Diabetes Care , vol.25 , pp. 724-730
    • Whitehouse, F.1    Kruger, D.F.2    Fineman, M.3
  • 66
    • 33747763918 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial assessing pramlintide treatment in the setting of intensive insulin therapy in type 1 diabetes
    • Edelman S, Garg S, Frias J, et al. A double-blind, placebo-controlled trial assessing pramlintide treatment in the setting of intensive insulin therapy in type 1 diabetes. Diabetes Care 2006;29:2189-95
    • (2006) Diabetes Care , vol.29 , pp. 2189-2195
    • Edelman, S.1    Garg, S.2    Frias, J.3
  • 67
    • 8144228619 scopus 로고    scopus 로고
    • Amylin replacement with pramlintide as an adjunct to insulin therapy improves long-term glycaemic and weight control in Type 1 diabetes mellitus: A 1-year randomized controlled trial
    • Ratner RE, Dickey R, Fineman M, et al. Amylin replacement with pramlintide as an adjunct to insulin therapy improves long-term glycaemic and weight control in Type 1 diabetes mellitus: a 1-year, randomized controlled trial. Diabet Med 2004;21:1204-12
    • (2004) Diabet. Med. , vol.21 , pp. 1204-1212
    • Ratner, R.E.1    Dickey, R.2    Fineman, M.3
  • 68
    • 69549130787 scopus 로고    scopus 로고
    • Randomized comparison of pramlintide or mealtime insulin added to basal insulin treatment for patients with type 2 diabetes
    • Riddle M, Pencek R, Charenkavanich S, et al. Randomized comparison of pramlintide or mealtime insulin added to basal insulin treatment for patients with type 2 diabetes. Diabetes Care 2009;32:1577-82
    • (2009) Diabetes Care , vol.32 , pp. 1577-1582
    • Riddle, M.1    Pencek, R.2    Charenkavanich, S.3
  • 69
    • 36048998480 scopus 로고    scopus 로고
    • Pramlintide improved glycemic control and reduced weight in patients with type 2 diabetes using basal insulin
    • Riddle M, Frias J, Zhang B, et al. Pramlintide improved glycemic control and reduced weight in patients with type 2 diabetes using basal insulin. Diabetes Care 2007;30:2794-9
    • (2007) Diabetes Care , vol.30 , pp. 2794-2799
    • Riddle, M.1    Frias, J.2    Zhang, B.3
  • 70
    • 0042167233 scopus 로고    scopus 로고
    • Pramlintide as an adjunct to insulin therapy improves long-term glycemic and weight control in patients with type 2 diabetes: A 1-year randomized controlled trial
    • Hollander PA, Levy P, Fineman MS, et al. Pramlintide as an adjunct to insulin therapy improves long-term glycemic and weight control in patients with type 2 diabetes: a 1-year randomized controlled trial. Diabetes Care 2003;26:784-790
    • (2003) Diabetes Care , vol.26 , pp. 784-790
    • Hollander, P.A.1    Levy, P.2    Fineman, M.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.