Amylin-mediated restoration of leptin responsiveness in diet-induced obesity: Magnitude and mechanisms

Endocrinology

Volumn 149, Issue 11, 2008, Pages 5679-5687

  Trevaskis, James L ^a   Coffey, Todd ^a   Cole, Rebecca ^a   Lei, Chunli ^a   Wittmer, Carrie ^a   Walsh, Brandon ^a   Weyer, Christian ^a   Koda, Joy ^a   Baron, Alain D ^a   Parkes, David G ^a   Roth, Jonathan D ^a  

^a AMYLIN PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; LEPTIN; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTINUOUS INFUSION; CONTROLLED STUDY; DIET; DRUG MECHANISM; DRUG POTENTIATION; ENERGY EXPENDITURE; FOOD INTAKE; GENE EXPRESSION; LIPOGENESIS; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; WEIGHT REDUCTION;

AMYLOID; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CALORIC RESTRICTION; DIET; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE; DRUG SYNERGISM; EATING; LEPTIN; LIPIDS; LIPOGENESIS; LIVER; OBESITY; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 54349121294     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0770     Document Type: Article

References (36)

1. Chen H, Roth JD, Schroeder BE, Weyer C 2008 Role of islet-, gut-, and adipocyte-derived hormones in the central control of food intake and body weight: implications for an integrated neurohormonal approach to obesity pharmacotherapy. Curr Diabetes Rev 4:79-91
2. Roth JD, Mack CM, Kesty NC, Parkes DG, Weyer C 2008 Integrated neurohormonal approaches to the treatment of obesity: the amylin agonist pramlintide and its interaction with leptin and PYY signaling pathways. In: Bray G, ed. Handbook of obesity. 3rd ed. New York: Informa Healthcare; 341-361
3. Rosenbaum M, Murphy EM, Heymsfield SB, Matthews DE, Leibel RL 2002 Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab 87:2391-2394
4. Lutz TA, Senn M, Althaus J, DelPrete E, Ehrensperger F, Scharrer E 1998 Lesion of the area postrema nucleus of the solitary tract (AP/NTS) attenuates the anorectic effects of amylin and calcitonin gene-related peptide (CGRP) in rats. Peptides 19:309-317
5. Lutz TA, Mollet A, Rushing PA, Riediger T, Scharrer E 2001 The anorectic effect of a chronic peripheral infusion of amylin is abolished in area postrema/nucleus of the solitary tract (AP/NTS) lesioned rats. Int J Obes Relat Metab Disord 25:1005-1011
6. Chapman I, Parker B, Doran S, Feinle-Bisset C, Wishart J, Lush CW, Chen K, LaCerte C, Burns C, McKay R, Weyer C, Horowitz M 2007 Low-dose pramlintide reduced food intake and meal duration in healthy, normal weight subjects. Obesity (Silver Spring) 15:1179-1186
7. Aronne L, Fujioka K, Aroda V, Chen K, Halseth A, Kesty NC, Burns C, Lush CW, Weyer C 2007 Progressive reduction in body weight after treatment with the amylin analog pramlintide in obese subjects: a phase 2, randomized, placebo-controlled, dose-escalation study. J Clin Endocrinol Metab 92:2977-2983
8. Wadden T, Klein S, Aronne L, Smith S, Halseth A, Kesty N, Burns C, Weyer C 2006 Pramlintide treatment in obesity elicited progressive weight loss when used with a structured lifestyle intervention program: a randomized controlled trial. Obes Rev 7(Suppl 2):112-113 (Abstract PP0056)
9. Smith SR, Blundell JE, Burns C, Ellero C, Schroeder BE, Kesty NC, Chen K, Halseth AE, Lush CW, Weyer C 2007 Pramlintide treatment reduces 24-hour caloric intake and meal sizes, and improves control of eating in obese subjects: a 6-week translational research study. Am J Physiol Endocrinol Metab 293:E620-E627
10. Lutz TA, Del Prete E, Scharrer E 1994 Reduction of food intake in rats by intraperitoneal injection of low doses of amylin. Physiol Behav 55:891-895
11. Rushing PA, Hagan MM, Seeley RJ, Lutz TA, Woods SC 2000 Amylin: a novel action in the brain to reduce body weight. Endocrinology 141:850-853
12. Roth JD, Hughes H, Kendall E, Baron AD, Anderson CM 2006 Anti-obesity effects of the β-cell hormone amylin in diet induced obese rats: effects on food intake, body weight, composition, energy expenditure and gene expression. Endocrinology 147:5855-5864
13. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546
14. Halaas JL, Boozer C, Blair-West J, Fidahusein N, Denton DA, Friedman JM 1997 Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 94:8878-8883
15. Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T, Lubina JA, Patane J, Self B, Hunt P, McCamish M 1999 Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 282:1568-1575
16. Farooqi IS 2002 Leptin and the onset of puberty: insights from rodent and human genetics. Semin Reprod Med 20:139-144
17. Roth JD, Roland BL, Cole RL, Trevaskis JL, Weyer C, Koda J, Anderson CM, Parkes DG, Baron AD 2008 Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies. Proc Natl Acad Sci USA 105:7257-7262
18. Levin BE, Dunn-Meynell AA, Balkan B, Keesey RE 1997 Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats. Am J Physiol 273:R725-R730
19. Even PC, Nicolaidis S 1993 Adaptive changes in energy expenditure during mild and severe feed restriction in the rat. Br J Nutr 70:421-431
20. Forsum E, Hillman PE, Nesheim MC 1981 Effect of energy restriction on total heat production, basal metabolic rate, and specific dynamic action of food in rats. J Nutr 111:1691-1697
21. Jacobsson A, Stadler U, Glotzer MA, Kozak LP 1985 Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression. J Biol Chem 260:16250-16254
22. Leibel RL, Rosenbaum M, Hirsch J 1995 Changes in energy expenditure resulting from altered body weight. N Engl J Med 332:621-628
23. Weyer C, Pratley RE, Salbe AD, Bogardus C, Ravussin E, Tataranni PA 2000 Energy expenditure, fat oxidation, and body weight regulation: a study of metabolic adaptation to long-term weight change. J Clin Endocrinol Metab 85:1087-1094
24. Patick AK, Boritzki TJ, Bloom LA 1997 Activities of the human immunodeficiency virus type 1 (HIV-1) protease inhibitor nelfinavir mesylate in combination with reverse transcriptase and protease inhibitors against acute HIV-1 infection in vitro. Antimicrob Agents Chemother 41:2159-2164
25. Pool JL, Cushman WC, Saini RK, Nwachuku CE, Battikha JP 1997 Use of the factorial design and quadratic response surface models to evaluate the fosinopril and hydrochlorothiazide combination therapy in hypertension. Am J Hypertens 10:117-123
26. Carter Jr WH, Wampler GL 1986 Review of the application of response surface methodology in the combination therapy of cancer. Cancer Treat Rep 70:133-140
27. Roth J, Coffey T, Jodka C, Maier H, Athanacio J, Mack C, Weyer C, Parkes D 2007 Combination therapy with amylin and PYY[3-36] in obese rodents: anorexigenic synergy and weight loss additivity. Endocrinology 148:6054-6061
28. Rosenbaum M, Goldsmith R, Bloomfield D, Magnano A, Weimer L, Heymsfield S, Gallagher D, Mayer L, Murphy E, Leibel RL 2005 Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest 115:3579-3586
29. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543
30. Wielinga PY, Alder B, Lutz TA 2007 The acute effect of amylin and salmon calcitonin on energy expenditure. Physiol Behav 91:212-217
31. Cohen P, Miyazaki M, Socci ND, Hagge-Greenberg A, Liedtke W, Soukas AA, Sharma R, Hudgins LC, Ntambi JM, Friedman JM 2002 Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297:240-243
32. Liang CP, Tall AR 2001 Transcriptional profiling reveals global defects in energy metabolism, lipoprotein, and bile acid synthesis and transport with reversal by leptin treatment in ob/ob mouse liver. J Biol Chem 276:49066-49076
33. Ntambi JM, Miyazaki M, Stoehr JP, Lan H, Kendziorski CM, Yandell BS, Song Y, Cohen P, Friedman JM, Attie AD 2002 Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci USA 99:11482-11486
34. Lee SH, Dobrzyn A, Dobrzyn P, Rahman SM, Miyazaki M, Ntambi JM 2004 Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment. J Lipid Res 45:1674-1682
35. Roth JD, Hughes H, Coffey T, Maier H, Trevaskis JL, Anderson CM 2007 Effects of prior or concurrent food restriction on amylin-induced changes in body weight and body composition in high-fat-fed female rats. Am J Physiol Endocrinol Metab 293:E1112-E1117
36. Gutierrez-Juarez R, Obici S, Rossetti L 2004 Melanocortin- independent effects of leptin on hepatic glucose fluxes. J Biol Chem 279:49704-49715