High-frequency oscillations in circulating amylin concentrations in healthy humans

American Journal of Physiology - Endocrinology and Metabolism

Volumn 278, Issue 3 41-3, 2000, Pages

  Juhl, Claus B ^a   Pørksen, Niels ^a   Sturis, Jeppe ^b   Hansen, Åge Prange ^c   Veldhuis, Johannes D ^d   Pincus, Steven ^f   Fineman, Mark ^e   Schmitz, Ole ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c KOLDING HOSPITAL   (Denmark)

^d UNIVERSITY OF VIRGINIA   (United States)

^e AMYLIN PHARMACEUTICALS INC   (United States)

^f Århus Univ Hospital ^*

Author keywords

Amylin pulsatility; Amylin secretion; Insulin secretion

Indexed keywords

AMYLIN; GLUCOSE; INSULIN;

ADULT; ARTICLE; FEMALE; GLUCOSE BLOOD LEVEL; HIGH FREQUENCY OSCILLATION; HORMONAL REGULATION; HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; MALE; NORMAL HUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 0034015292     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2000.278.3.e484     Document Type: Article

References (34)

1. Andersen, L., B. Dinesen, P. N. Jorgensen, F. Poulsen, and M. E. Roder. Enzyme immunoassay for intact human insulin in serum or plasma. Clin. Chem. 39: 578-582, 1993.
2. Badman, M. K., K. I. Shennan, J. L. Jermany, K. Docherty, and A. Clark. Procressing of pro-islet amyloid polypeptide (proIAPP) by the pro-hormone convertase PC2. FEBS Lett. 378: 227-231, 1996.
3. Bennet, W. M., C. S. Beis, M. A. Ghatei, P. G. Byfield, and S. R. Bloom. Amylin tonally regulates arginine-stimulated insulin secretion in rats. Diabetologia 37: 436-438, 1994.
4. Chatfield, C. The Analysis of Time Series. An Introduction. London: Chapman and Hall, 1996.
5. Clodi, M., K. Thomaseth, G. Pacini, K. Hermann, A. Kautzky-Willer, W. Waldhäusl, R. Prager, and B. Ludvik. Distribution and kinetics of amylin in humans. Am. J. Physiol. Endocrinol. Metab. 274: E903-E908, 1998.
6. Cooper, G. J. Amylin compared with calcitonin gene-related peptide: structure, biology, and relevance to metabolic disease. Endocr. Rev. 15: 163-201, 1994.
7. Diggle, P. J. Time Series, A Biostatistical Introduction. Oxford, UK: Oxford Science Publication, 1990.
8. Fineman, M. S., O. G. Kolterman, R. G. Thompson, and J. E. Koda. The human analogue pramlintide inhibited glucagon secretion in type 1 diabetic subjects (Abstract). Diabetes 40: 30, 1997.
9. Goodner, C. J., B. C. Walike, D. J. Koerker, J. W. Ensinck, A. C. Brown, E. W. Chideckel, J. Palmer, and L. Kalnasy. Insulin, glucagon and glucose exhibit synchronous, sustained oscillations in fasting monkeys. Science 195: 177-179, 1977.
10. Hartter, E., T. Svoboda, B. Ludvik, M. Schuller, B. Lell, E. Kuenburg, M. Brunnbauer, W. Woloszczuk, and R. Prager. Basal and stimulated plasma levels of pancreatic amylin indicate its co-secretion with insulin in humans. Diabetologia 34: 52-54, 1991.
11. Jenkins, G. M., and D. G. Watts. Spectral Analysis and Its Applications. San Francisco: Holden-Day, 1966.
12. Kahn, S., C. B. Verchere, D. A. D. Alesio, D. L. Cook, and W. Y. Fujimoto. Evidence for selective release of rodent islet polypeptide through the constitutive secretory pathway. Diabetologia 36: 570-573, 1993.
13. Lang, D. A., D. R. Matthews, M. Burnett, and R. C. Turner. Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man. Diabetes 30: 435-439, 1981.
14. Lang, D. A., D. R. Matthews, J. Peto, and R. C. Turner. Cyclic oscillations of basal plasma glucose and insulin concentrations in human beings. N. Engl. J. Med. 301: 1023-1027, 1979.
15. Leahy, J. L., and M. S. Fineman. Impaired phasic insulin and amylin secretion in diabetic rats. Am. J. Physiol. Endocrinol. Metab. 275: E457-E462, 1998.
16. Macdonald, I. A. Amylin and the gastrointestinal tract. Diabet. Med. 14: S24-S28, 1997.
17. Meneilly, G. S., J. D. Veldhuis, and D. Elahi. Disruption of the pulsatile and entropic modes of insulin release during an unvarying glucose stimulus in elderly individuals. J. Clin. Endocrinol. Metab. 84: 1938-1943, 1999.
18. Moore, C. X., and G. J. S. Cooper. Co-secretion of amylin and insulin from cultured islet beta-cells: modulation by nutrient secretagogues, islet hormones and hypoglycemic agents. Biochem. Biophys. Res. Commun. 179: 1-9, 1991.
19. O'Rahilly, S., R. C. Turner, and D. R. Matthews. Impaired pulsatile secretion of insulin in relatives of patients with noninsulin-dependent diabetes. N. Engl. J. Med. 318: 1225-1230, 1988.
20. Percy, A. J., D. A. Trainor, J. Rittenhouse, J. Phelps, and J. E. Koda. Development of sensitive immunoassays to detect amylin and amylin-like peptides in unextracted plasma. Clin. Chem. 42: 576-585, 1996.
21. Pincus, S. M. Approximate Entropy as a measure of system complexity. Proc. Natl. Acad. Sci. USA 88: 2297-2301, 1991.
22. Pørksen, N., S. Munn, J. Steers, J. D. Veldhuis, and P. C. Butler. Impact of sampling technique on appraisal of pulsatile insulin secretion by deconvolution and cluster analysis. Am. J. Physiol. Endocrinol. Metab. 269: E1106-E1114, 1995.
23. Pørksen, N., S. Munn, J. Steers, J. D. Veldhuis, and P. C. Butler. Effects of glucose ingestion vs. infusion on pulsatile insulin secretion. The incretin effect is achieved by amplification of insulin secretory burst mass. Diabetes 45: 1317-1323, 1996.
24. Pørksen, N., B. Nyholm, J. D. Veldhuis, P. C. Butler, and O. Schmitz. In humans at least 75% of insulin secretion arises from punctuated insulin secretory bursts. Am. J. Physiol. Endocrinol. Metab. 273: E908-E914, 1997.
25. Rorsman, P. The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint. Diabetologia 40: 487-495, 1997.
26. Salas, M., R. A. Silvestre, H. O. Garcia, T. Fontela, G. J. Rodriguez, and J. Marco. Inhibitory effect of amylin (islet amyloid polypeptide) on insulin response to non-glucose stimuli. Study in perfused rat pancreas. Diabete Metab. 21: 269-273, 1995.
27. Schmitz, O., N. Pørksen, B. Nyholm, C. Skjaerbaek, P. C. Butler, J. D. Veldhuis, and S. M. Pincus. Disorderly and nonstationary insulin secretion in relatives of patients with NIDDM. Am. J. Physiol. Endocrinol. Metab. 272: E218-E226, 1997.
28. Stagner, J. I., E. Samols, and G. C. Weir. Sustained oscillations of insulin, glucagon, and somatostatin from the isolated canine pancreas during exposure to a constant glucose concentration. J. Clin. Invest. 65: 939-942, 1980.
29. Sturis, J., N. M. O'Meara, E. T. Shapiro, J. D. Blackman, H. Tillil, K. S. Polonsky, and E. Van Cauter. Differential effects of glucose stimulation upon rapid pulses and ultradian oscillations of insulin secretion. J. Clin. Endocrinol. Metab. 76: 895-901, 1993.
30. Thomaseth, K., G. Pacini, M. Clodi, A. Kautzky Willer, J. J. Nolan, R. Prager, J. M. Olefsky, and B. Ludvik. Amylin release during oral glucose tolerance test. Diabet. Med. 14, Suppl. 2: S29-S34, 1997.
31. Tornheim, K. Are metabolic oscillations responsible for normal oscillatory insulin secretion? Diabetes 46: 1375-1380, 1997.
32. Verchere, C. B., J. Rittenhouse, A. Sofianos, J. E. Koda, and S. E. Kahn. Glycosylated amylin is secreted by human islets in vitro (Abstract). Diabetes 1, Suppl.: 357, 1997.
33. Wang, F., T. E. Adrian, G. T. Westermark, X. Ding, T. Gasslander, and J. Permert. Islet amyloid polypeptide tonally inhibits β-, α-, and δ-cell secretion in isolated rat pancreatic islets. Am. J. Physiol. Endocrinol. Metab. 276: E19-E24, 1999.
34. Young, A. Role of amylin in nutrient intake-animal studies. Diabet. Med. 14: S14-S18, 1997.