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Volumn 30, Issue 21, 2011, Pages 4398-4413

Orientation-specific signalling by thrombopoietin receptor dimers

Author keywords

dimerization; hematopoiesis; JAK2; myeloproliferation; TpoR

Indexed keywords

CYSTEINE; CYTOKINE RECEPTOR; DIMER; JANUS KINASE 2; PROTEIN KINASE TYK2; THROMBOPOIETIN RECEPTOR;

EID: 80455174620     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.315     Document Type: Article
Times cited : (78)

References (63)
  • 1
    • 34249981792 scopus 로고    scopus 로고
    • Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones
    • DOI 10.1182/blood-2006-08-044503
    • Abkowitz JL, Chen J (2007) Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones. Blood 109: 5186-5190 (Pubitemid 46890535)
    • (2007) Blood , vol.109 , Issue.12 , pp. 5186-5190
    • Abkowitz, J.L.1    Chen, J.2
  • 2
    • 0029847652 scopus 로고    scopus 로고
    • Improved prediction for the structure of the dimeric transmembrane domain of glycophorin A obtained through global searching
    • DOI 10.1002/(SICI)1097-0134(199611)26:3<257::AID-PROT2>3.0.CO;2-B
    • Adams PD, Engelman DM, Brunger AT (1996) Improved prediction for the structure of the dimeric transmembrane domain of glyco-phorin A obtained through global searching. Proteins 26: 257-261 (Pubitemid 26405000)
    • (1996) Proteins: Structure, Function and Genetics , vol.26 , Issue.3 , pp. 257-261
    • Adams, P.D.1    Engelman, D.M.2    Brunger, A.T.3
  • 3
    • 0029800869 scopus 로고    scopus 로고
    • Tyrosine-599 of the c-Mpl receptor is required for Shc phosphorylation and the induction of cellular differentiation
    • Alexander WS, Maurer AB, Novak U, Harrison-Smith M (1996a) Tyrosine-599 of the c-Mpl receptor is required for Shc phosphor-ylation and the induction of cellular differentiation. EMBO J 15: 6531-6540 (Pubitemid 26413786)
    • (1996) EMBO Journal , vol.15 , Issue.23 , pp. 6531-6540
    • Alexander, W.S.1    Maurer, A.B.2    Novak, U.3    Harrison-Smith, M.4
  • 4
    • 0028832719 scopus 로고
    • Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity
    • Alexander WS, Metcalf D, Dunn AR (1995) Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity. EMBO J 14: 5569-5578
    • (1995) EMBO J , vol.14 , pp. 5569-5578
    • Alexander, W.S.1    Metcalf, D.2    Dunn, A.R.3
  • 5
    • 0029960265 scopus 로고    scopus 로고
    • Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the throm-bopoietic receptor c-Mpl
    • Alexander WS, Roberts AW, Nicola NA, Li R, Metcalf D (1996b) Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the throm-bopoietic receptor c-Mpl. Blood 87: 2162-2170
    • (1996) Blood , vol.87 , pp. 2162-2170
    • Alexander, W.S.1    Roberts, A.W.2    Nicola, N.A.3    Li, R.4    Metcalf, D.5
  • 6
    • 8444237787 scopus 로고    scopus 로고
    • Normal neutrophil maturation is associated with selective loss of MAP kinase activation by G-CSF
    • DOI 10.1016/j.leukres.2004.05.009, PII S0145212604002085
    • Baumann M, Frye T, Naqvi T, Gomez-Cambronero J (2005) Normal neutrophil maturation is associated with selective loss of MAP kinase activation by G-CSF. Leuk Res 29: 73-78 (Pubitemid 39487912)
    • (2005) Leukemia Research , vol.29 , Issue.1 , pp. 73-78
    • Baumann, M.1    Frye, T.2    Naqvi, T.3    Gomez-Cambronero, J.4
  • 7
    • 55849089247 scopus 로고    scopus 로고
    • Packing density of the erythropoietin receptor transmembrane domain correlates with amplification of biological responses
    • Becker V, Sengupta D, Ketteler R, Ullmann GM, Smith JC, Klingmuller U (2008) Packing density of the erythropoietin receptor transmembrane domain correlates with amplification of biological responses. Biochemistry 47: 11771-11782
    • (2008) Biochemistry , vol.47 , pp. 11771-11782
    • Becker, V.1    Sengupta, D.2    Ketteler, R.3    Ullmann, G.M.4    Smith, J.C.5    Klingmuller, U.6
  • 10
    • 0037111643 scopus 로고    scopus 로고
    • Prominent role of TGF-beta1 in thrombopoietin-induced myelofibrosis in mice
    • DOI 10.1182/blood-2002-04-1133
    • Chagraoui H, Komura E, Tulliez M, Giraudier S, Vainchenker W, Wendling F (2002) Prominent role of TGF-beta 1 in thrombopoie-tin-induced myelofibrosis in mice. Blood 100: 3495-3503 (Pubitemid 35303916)
    • (2002) Blood , vol.100 , Issue.10 , pp. 3495-3503
    • Chagraoui, H.1    Komura, E.2    Tulliez, M.3    Giraudier, S.4    Vainchenker, W.5    Wendung, F.6
  • 11
    • 77956210088 scopus 로고    scopus 로고
    • Identification of the residues in the extracellular domain of thrombopoietin receptor involved in the binding of thrombopoietin and a nuclear distribution protein (human NUDC)
    • Chen WM, Yu B, Zhang Q, Xu P (2010) Identification of the residues in the extracellular domain of thrombopoietin receptor involved in the binding of thrombopoietin and a nuclear distribution protein (human NUDC). J Biol Chem 285: 26697-26709
    • (2010) J Biol Chem , vol.285 , pp. 26697-26709
    • Chen, W.M.1    Yu, B.2    Zhang, Q.3    Xu, P.4
  • 12
    • 0035102191 scopus 로고    scopus 로고
    • The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif
    • DOI 10.1016/S1097-2765(01)00185-X
    • Constantinescu SN, Huang LJ, Nam H, Lodish HF (2001) The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif. Mol Cell 7: 377-385 (Pubitemid 32206505)
    • (2001) Molecular Cell , vol.7 , Issue.2 , pp. 377-385
    • Constantinescu, S.N.1    Huang, L.J.-S.2    Nam, H.-S.3    Lodish, H.F.4
  • 14
    • 70350452280 scopus 로고    scopus 로고
    • The Asn505 mutation of the c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimeriza-tion of the c-Mpl protein due to strong amino acid polarity
    • Ding J, Komatsu H, Iida S, Yano H, Kusumoto S, Inagaki A, Mori F, Ri M, Ito A, Wakita A, Ishida T, Nitta M, Ueda R (2009) The Asn505 mutation of the c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimeriza-tion of the c-Mpl protein due to strong amino acid polarity. Blood 114: 3325-3328
    • (2009) Blood , vol.114 , pp. 3325-3328
    • Ding, J.1    Komatsu, H.2    Iida, S.3    Yano, H.4    Kusumoto, S.5    Inagaki, A.6    Mori, F.7    Ri, M.8    Ito, A.9    Wakita, A.10    Ishida, T.11    Nitta, M.12    Ueda, R.13
  • 15
    • 2542502506 scopus 로고    scopus 로고
    • Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin
    • DOI 10.1182/blood-2003-10-3471
    • Ding J, Komatsu H, Wakita A, Kato-Uranishi M, Ito M, Satoh A, Tsuboi K, Nitta M, Miyazaki H, Iida S, Ueda R (2004) Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin. Blood 103: 4198-4200 (Pubitemid 38685363)
    • (2004) Blood , vol.103 , Issue.11 , pp. 4198-4200
    • Ding, J.1    Komatsu, H.2    Wakita, A.3    Kato-Uranishi, M.4    Ito, M.5    Satoh, A.6    Tsuboi, K.7    Nitta, M.8    Miyazaki, H.9    Iida, S.10    Ueda, R.11
  • 16
    • 0028910991 scopus 로고
    • The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl
    • Drachman JG, Griffin JD, Kaushansky K (1995) The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl. J Biol Chem 270: 4979-4982
    • (1995) J Biol Chem , vol.270 , pp. 4979-4982
    • Drachman, J.G.1    Griffin, J.D.2    Kaushansky, K.3
  • 18
    • 0033532069 scopus 로고    scopus 로고
    • Thrombopoietin signal transduction requires functional JAK2, not TYK2
    • Drachman JG, Millett KM, Kaushansky K (1999) Thrombopoietin signal transduction requires functional JAK2, not TYK2. J Biol Chem 274: 13480-13484
    • (1999) J Biol Chem , vol.274 , pp. 13480-13484
    • Drachman, J.G.1    Millett, K.M.2    Kaushansky, K.3
  • 19
    • 0034730141 scopus 로고    scopus 로고
    • Human interleukin-10-related T cell-derived inducible factor: Molecular cloning and functional characterization as an hepatocyte-stimu-lating factor
    • Dumoutier L, Van Roost E, Colau D, Renauld JC (2000) Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimu-lating factor. Proc Natl Acad Sci USA 97: 10144-10149
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10144-10149
    • Dumoutier, L.1    Van Roost, E.2    Colau, D.3    Renauld, J.C.4
  • 20
    • 0029742943 scopus 로고    scopus 로고
    • Activation of the erythropoietin (EPO) receptor by bivalent anti-EPO receptor antibodies
    • DOI 10.1074/jbc.271.40.24691
    • Elliott S, Lorenzini T, Yanagihara D, Chang D, Elliott G (1996) Activation of the erythropoietin (EPO) receptor by bivalent anti-EPO receptor antibodies. J Biol Chem 271: 24691-24697 (Pubitemid 26333213)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.40 , pp. 24691-24697
    • Elliott, S.1    Lorenzini, T.2    Yanagihara, D.3    Chang, D.4    Elliott, G.5
  • 22
    • 70350727161 scopus 로고    scopus 로고
    • Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors
    • Geest CR, Buitenhuis M, Groot Koerkamp MJ, Holstege FC, Vellenga E, Coffer PJ (2009) Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors. Blood 114: 3402-3412
    • (2009) Blood , vol.114 , pp. 3402-3412
    • Geest, C.R.1    Buitenhuis, M.2    Groot Koerkamp, M.J.3    Holstege, F.C.4    Vellenga, E.5    Coffer, P.J.6
  • 24
    • 0029049709 scopus 로고
    • Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation
    • Gurney AL, Wong SC, Henzel WJ, de Sauvage FJ (1995) Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation. Proc Natl Acad Sci USA 92: 5292-5296
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5292-5296
    • Gurney, A.L.1    Wong, S.C.2    Henzel, W.J.3    De Sauvage, F.J.4
  • 25
    • 0035694582 scopus 로고    scopus 로고
    • The N-terminal domain of Janus kinase 2 is required for golgi processing and cell surface expression of erythropoietin receptor
    • DOI 10.1016/S1097-2765(01)00401-4
    • Huang LJ, Constantinescu SN, Lodish HF (2001) The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol Cell 8: 1327-1338 (Pubitemid 34085003)
    • (2001) Molecular Cell , vol.8 , Issue.6 , pp. 1327-1338
    • Huang, L.J.S.1    Constantinescu, S.N.2    Lodish, H.F.3
  • 26
    • 0030711568 scopus 로고    scopus 로고
    • Thrombopoietin: More than a lineage-specific megakaryocyte growth factor
    • discussion 102-103
    • Kaushansky K (1997) Thrombopoietin: more than a lineage-specific megakaryocyte growth factor. Stem Cells 15 (Suppl 1): 97-102; discussion 102-103
    • (1997) Stem Cells , vol.15 , Issue.SUPPL. 1 , pp. 97-102
    • Kaushansky, K.1
  • 28
    • 0026034133 scopus 로고
    • Establishment and characterization of a human leukemic cell line with megakaryocytic features: Dependency on granu-locyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival
    • Komatsu N, Nakauchi H, Miwa A, Ishihara T, Eguchi M, Moroi M, Okada M, Sato Y, Wada H, Yawata Y, Suda T, Miura Y (1991) Establishment and characterization of a human leukemic cell line with megakaryocytic features: dependency on granu-locyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival. Cancer Res 51: 341-348
    • (1991) Cancer Res , vol.51 , pp. 341-348
    • Komatsu, N.1    Nakauchi, H.2    Miwa, A.3    Ishihara, T.4    Eguchi, M.5    Moroi, M.6    Okada, M.7    Sato, Y.8    Wada, H.9    Yawata, Y.10    Suda, T.11    Miura, Y.12
  • 29
    • 16444366687 scopus 로고    scopus 로고
    • Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function
    • DOI 10.1074/jbc.M411251200
    • Kubatzky KF, Liu W, Goldgraben K, Simmerling C, Smith SO, Constantinescu SN (2005) Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function. J Biol Chem 280: 14844-14854 (Pubitemid 40562834)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.15 , pp. 14844-14854
    • Kubatzky, K.F.1    Liu, W.2    Goldgraben, K.3    Simmerling, C.4    Smith, S.O.5    Constantinescu, S.N.6
  • 33
    • 78651254183 scopus 로고    scopus 로고
    • Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Ralpha cytokine receptor complex, and the receptor-Jak1 holocomplex
    • Lupardus PJ, Skiniotis G, Rice AJ, Thomas C, Fischer S, Walz T, Garcia KC (2011) Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Ralpha cytokine receptor complex, and the receptor-Jak1 holocomplex. Structure 19: 45-55
    • (2011) Structure , vol.19 , pp. 45-55
    • Lupardus, P.J.1    Skiniotis, G.2    Rice, A.J.3    Thomas, C.4    Fischer, S.5    Walz, T.6    Garcia, K.C.7
  • 36
    • 0035963317 scopus 로고    scopus 로고
    • Identification of the transmembrane dimer interface of the bovine papillomavirus E5 protein
    • DOI 10.1038/sj.onc.1204523
    • Mattoon D, Gupta K, Doyon J, Loll PJ, DiMaio D (2001) Identification of the transmembrane dimer interface of the bovine papillomavirus E5 protein. Oncogene 20: 3824-3834 (Pubitemid 32646193)
    • (2001) Oncogene , vol.20 , Issue.29 , pp. 3824-3834
    • Mattoon, D.1    Gupta, K.2    Doyon, J.3    Loll, P.J.4    Dimaio, D.5
  • 38
    • 0347627263 scopus 로고    scopus 로고
    • Differential signalling of NH2-terminal flag-labelled thrombopoietin receptor activated by TPO or anti-FLAG antibodies
    • DOI 10.1016/j.cellsig.2003.08.010
    • Millot GA, Vainchenker W, Dumenil D, Svinarchuk F (2004) Differential signalling of NH2-terminal flag-labelled thrombopoie-tin receptor activated by TPO or anti-FLAG antibodies. Cell Signal 16: 355-363 (Pubitemid 37542410)
    • (2004) Cellular Signalling , vol.16 , Issue.3 , pp. 355-363
    • Millot, G.A.1    Vainchenker, W.2    Dumenil, D.3    Svinarchuk, F.4
  • 39
    • 0029052479 scopus 로고
    • Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets
    • Miyakawa Y, Oda A, Druker BJ, Kato T, Miyazaki H, Handa M, Ikeda Y (1995) Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets. Blood 86: 23-27
    • (1995) Blood , vol.86 , pp. 23-27
    • Miyakawa, Y.1    Oda, A.2    Druker, B.J.3    Kato, T.4    Miyazaki, H.5    Handa, M.6    Ikeda, Y.7
  • 40
    • 0030052617 scopus 로고    scopus 로고
    • Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets
    • Miyakawa Y, Oda A, Druker BJ, Miyazaki H, Handa M, Ohashi H, Ikeda Y (1996) Thrombopoietin induces tyrosine phosphoryla-tion of Stat3 and Stat5 in human blood platelets. Blood 87: 439-446 (Pubitemid 26030298)
    • (1996) Blood , vol.87 , Issue.2 , pp. 439-446
    • Miyakawa, Y.1    Oda, A.2    Druker, B.J.3    Miyazaki, H.4    Handa, M.5    Ohashi, H.6    Ikeda, Y.7
  • 41
    • 0035951790 scopus 로고    scopus 로고
    • Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes
    • Miyakawa Y, Rojnuckarin P, Habib T, Kaushansky K (2001) Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes. J Biol Chem 276: 2494-2502
    • (2001) J Biol Chem , vol.276 , pp. 2494-2502
    • Miyakawa, Y.1    Rojnuckarin, P.2    Habib, T.3    Kaushansky, K.4
  • 42
    • 10544225380 scopus 로고    scopus 로고
    • Crkl is constitutively tyrosine phosphorylated in platelets from chronic myelogenous leukemia patients and inducibly phosphorylated in normal platelets stimulated by thrombopoietin
    • Oda A, Miyakawa Y, Druker BJ, Ishida A, Ozaki K, Ohashi H, Wakui M, Handa M, Watanabe K, Okamoto S, Ikeda Y (1996) Crkl is constitutively tyrosine phosphorylated in platelets from chronic myelogenous leukemia patients and inducibly phosphorylated in normal platelets stimulated by thrombopoietin. Blood 88: 4304-4313 (Pubitemid 26399178)
    • (1996) Blood , vol.88 , Issue.11 , pp. 4304-4313
    • Oda, A.1    Miyakawa, Y.2    Druker, B.J.3    Ishida, A.4    Ozaki, K.5    Ohashi, H.6    Wakui, M.7    Handa, M.8    Watanabe, K.9    Okamoto, S.10    Ikeda, Y.11
  • 43
    • 0029794142 scopus 로고    scopus 로고
    • Identification of an oncogenic form of the thrombopoietin receptor MPL using retrovirus-mediated gene transfer
    • Onishi M, Mui AL, Morikawa Y, Cho L, Kinoshita S, Nolan GP, Gorman DM, Miyajima A, Kitamura T (1996) Identification of an oncogenic form of the thrombopoietin receptor MPL using retrovirus-mediated gene transfer. Blood 88: 1399-1406 (Pubitemid 26276816)
    • (1996) Blood , vol.88 , Issue.4 , pp. 1399-1406
    • Onishi, M.1    Mui, A.L.-F.2    Morikawa, Y.3    Cho, L.4    Kinoshita, S.5    Nolan, G.P.6    Gorman, D.M.7    Miyajima, A.8    Kitamura, T.9
  • 47
    • 0029963565 scopus 로고    scopus 로고
    • Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: Evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin
    • Porteu F, Rouyez MC, Cocault L, Benit L, Charon M, Picard F, Gisselbrecht S, Souyri M, Dusanter-Fourt I (1996) Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin. Mol Cell Biol 16: 2473-2482 (Pubitemid 26123769)
    • (1996) Molecular and Cellular Biology , vol.16 , Issue.5 , pp. 2473-2482
    • Porteu, F.1    Rouyez, M.-C.2    Cocault, L.3    Benit, L.4    Charon, M.5    Picard, F.6    Gisselbrecht, S.7    Souyri, M.8    Dusanter-Fourt, I.9
  • 50
    • 0344413478 scopus 로고    scopus 로고
    • Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer
    • DOI 10.1016/S1097-2765(03)00389-7
    • Seubert N, Royer Y, Staerk J, Kubatzky KF, Moucadel V, Krishnakumar S, Smith SO, Constantinescu SN (2003) Active and inactive orientations of the transmembrane and cytosolic domains of the erythro-poietin receptor dimer. Mol Cell 12: 1239-1250 (Pubitemid 37487931)
    • (2003) Molecular Cell , vol.12 , Issue.5 , pp. 1239-1250
    • Seubert, N.1    Royer, Y.2    Staerk, J.3    Kubatzky, K.F.4    Moucadel, V.5    Krishnakumar, S.6    Smith, S.O.7    Constantinescu, S.N.8
  • 51
    • 50249158577 scopus 로고    scopus 로고
    • Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex
    • Skiniotis G, Lupardus PJ, Martick M, Walz T, Garcia KC (2008) Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Mol Cell 31 : 737-748
    • (2008) Mol Cell , vol.31 , pp. 737-748
    • Skiniotis, G.1    Lupardus, P.J.2    Martick, M.3    Walz, T.4    Garcia, K.C.5
  • 53
    • 0029115584 scopus 로고
    • The membrane proximal region of the cytoplasmic domain of the growth hormone receptor is involved in the activation of Stat 3
    • Sotiropoulos A, Moutoussamy S, Binart N, Kelly PA, Finidori J (1995) The membrane proximal region of the cytoplasmic domain of the growth hormone receptor is involved in the activation of Stat 3. FEBS Lett 369: 169-172
    • (1995) FEBS Lett , vol.369 , pp. 169-172
    • Sotiropoulos, A.1    Moutoussamy, S.2    Binart, N.3    Kelly, P.A.4    Finidori, J.5
  • 54
    • 0025674093 scopus 로고
    • A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors
    • Souyri M, Vigon I, Penciolelli JF, Heard JM, Tambourin P, Wendling F (1990) A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hemato-poietic progenitors. Cell 63: 1137-1147 (Pubitemid 120035063)
    • (1990) Cell , vol.63 , Issue.6 , pp. 1137-1147
    • Souyri, M.1    Vigon, I.2    Penciolelli, J.-F.3    Heard, J.-M.4    Tambourin, P.5    Wendling, F.6
  • 55
    • 33344455687 scopus 로고    scopus 로고
    • An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor
    • DOI 10.1182/blood-2005-06-2600
    • Staerk J, Lacout C, Smith SO, Vainchenker W, Constantinescu SN (2006) An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor. Blood 107: 1864-1871 (Pubitemid 43289364)
    • (2006) Blood , vol.107 , Issue.5 , pp. 1864-1871
    • Staerk, J.1    Lacout, C.2    Sato, T.3    Smith, S.O.4    Vainchenker, W.5    Constantinescu, S.N.6
  • 56
    • 0345148324 scopus 로고    scopus 로고
    • A cellular reporter assay to monitor insulin receptor kinase activity based on STAT 5-dependent luciferase gene expression
    • Storz P, Doppler H, Horn-Muller J, Groner B, Pfizenmaier K, Muller G (1999) A cellular reporter assay to monitor insulin receptor kinase activity based on STAT 5-dependent luciferase gene expression. Anal Biochem 276: 97-104
    • (1999) Anal Biochem , vol.276 , pp. 97-104
    • Storz, P.1    Doppler, H.2    Horn-Muller, J.3    Groner, B.4    Pfizenmaier, K.5    Muller, G.6
  • 57
    • 0030831985 scopus 로고    scopus 로고
    • 6 binuclear cluster
    • DOI 10.1038/nsb0997-751
    • Swaminathan K, Flynn P, Reece RJ, Marmorstein R (1997) Crystal structure of a PUT3-DNA complex reveals a novel mechanism for DNA recognition by a protein containing a Zn2Cys6 binuclear cluster. Nat Struct Biol 4: 751-759 (Pubitemid 27382436)
    • (1997) Nature Structural Biology , vol.4 , Issue.9 , pp. 751-759
    • Swaminathan, K.1    Flynn, P.2    Reece, R.J.3    Marmorstein, R.4
  • 59
    • 0028803402 scopus 로고
    • Journey to the surface of the cell: Fos regulation and the SRE
    • Treisman R (1995) Journey to the surface of the cell: Fos regulation and the SRE. EMBO J 14: 4905-4913
    • (1995) EMBO J , vol.14 , pp. 4905-4913
    • Treisman, R.1
  • 60
    • 52949089050 scopus 로고    scopus 로고
    • JAKs in pathology: Role of Janus kinases in hematopoietic malignancies and immunodeficiencies
    • Vainchenker W, Dusa A, Constantinescu SN (2008) JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies. Semin Cell Dev Biol 19: 385-393
    • (2008) Semin Cell Dev Biol , vol.19 , pp. 385-393
    • Vainchenker, W.1    Dusa, A.2    Constantinescu, S.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.