Thrombopoietin receptor activation: Transmembrane helix dimerization, rotation, and allosteric modulation

FASEB Journal

Volumn 25, Issue 7, 2011, Pages 2234-2244

  Matthews, Erin E ^a,c   Thévenin, Damien ^a   Rogers, Julia M ^a   Gotow, Lisa ^b,d   Lira, Paul D ^b   Reiter, Lawrence A ^b   Brissette, William H ^b   Engelman, Donald M ^a  

^a YALE UNIVERSITY   (United States)

^b PFIZER INC   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

Disulfide bond cross linking; Small molecule agonist; TOXCAT; Transmembrane domain

Indexed keywords

THROMBOPOIETIN RECEPTOR;

ALLOSTERISM; ARTICLE; CROSS LINKING; DIMERIZATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN STRUCTURE; SIMULATION;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; COMPUTER SIMULATION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTATION; PIPERIDINES; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, THROMBOPOIETIN; ROTATION;

EID: 79960190017     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-178673     Document Type: Article

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